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Purinergic signaling in liver disease: calcium signaling and induction of inflammation
Purinergic signaling in liver disease: calcium signaling and induction of inflammation
Purinergic signaling regulates many metabolic functions and is implicated in liver physiology and pathophysiology. Liver f...
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation
Acute stress causes depressive-like reactions in the tail suspension (TST) and forced swim tests (FST) of mice. Similarly,...
Molecular insights into P2X signalling cascades in acute kidney injury
Molecular insights into P2X signalling cascades in acute kidney injury
Acute kidney injury (AKI) is a critical health issue with high mortality and morbidity rates in hospitalized indi...
Purines and purinergic receptors in primary tumors of the central nervous system
Purines and purinergic receptors in primary tumors of the central nervous system
Purine nucleotides and nucleosides play critical roles in various pathological conditions, including tumor cell growth. Ad...
Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice
Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice
Sepsis is life-threatening condition that can trigger long-term neurological sequelae, including cognitive impairment in s...
P2 purinergic receptor expression and function in tumor-related immune cells
P2 purinergic receptor expression and function in tumor-related immune cells
P2 purinergic receptor expression is dysregulated in multiple cancer subtypes and is associated with worse outcomes. Studi...
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior
Tumor-associated macrophages (TAMs) exhibit antitumor or protumor responses related to inflammatory (or M1) and alternativ...
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7
 P2X7 is an emerging therapeutic target for several disorders and diseases due to its role in inflammatory signal...
A2B adenosine receptor signaling and regulation
A2B adenosine receptor signaling and regulation
The A2B adenosine receptor (A2BR) is one of the four adenosine-activated G protein-coupled receptors. In addition to adeno...
Role and recent progress of P2Y12 receptor in cancer development
Role and recent progress of P2Y12 receptor in cancer development
P2Y12 receptor (P2Y12R) is an adenosine-activated G protein-coupled receptor (GPCR) that plays a central role in platelet ...
Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools
Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools
The human equilibrative nucleoside transporter 1 (SLC29A1, hENT1) is a solute carrier that modulates the passive transport...
Microglial purinergic signaling in Alzheimer’s disease
Microglial purinergic signaling in Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disease. The prevalent features of AD pathogen...
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain
Although multiple purinergic receptors mediate the analgesic effects of acupuncture, it remains unclear whether there is m...
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain
Acupuncture is a traditional medicinal practice in China that has been increasingly recognized in other countries in recen...
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity
Retinopathy of prematurity (ROP) continues to pose a significant threat to the vision of numerous children worldwide, prim...
The impact of purine nucleosides on neuroplasticity in the adult brain
The impact of purine nucleosides on neuroplasticity in the adult brain
Neuroplasticity refers to the nervous system’s ability to adapt and reorganize its cell structures and neuronal netw...
Regulation of nerve-evoked contractions of the murine vas deferens
Regulation of nerve-evoked contractions of the murine vas deferens
Stimulation of sympathetic nerves in the vas deferens yields biphasic contractions consisting of a rapid transient compone...
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells
The A3 adenosine receptor (AR) is an important inflammatory and immunological target. However, the underlying mechanisms a...
P2X7 receptors: a bibliometric review from 2002 to 2023
P2X7 receptors: a bibliometric review from 2002 to 2023
For many years, there has been ongoing research on the P2X7 receptor (P2X7R). A comprehensive, systematic, and objective e...
Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells
Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells
The development of ionizable lipid (IL) was necessary to enable the effective formulation of small interfering RNA (siRNA)...
Purinergic pathways and their clinical use in the treatment of acute myeloid leukemia
Purinergic pathways and their clinical use in the treatment of acute myeloid leukemia
Despite the use of various therapies such as hematopoietic stem cell transplantation and chimeric antigen receptor T cell ...
Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration
Implications of COVID-19 in Parkinson’s disease: the purinergic system in a therapeutic-target perspective to diminish neurodegeneration
The pathophysiology of Parkinson’s disease (PD) is marked by degeneration of dopaminergic neurons in the substantia ...
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye
Dry eye (DE) is a prevalent ocular surface disease in patients with type 2 diabetes (T2DM). However, current medications a...
The functional role of P2 purinergic receptors in the progression of gastric cancer
The functional role of P2 purinergic receptors in the progression of gastric cancer
Studies have confirmed that P2 purinergic receptors (P2X receptors and P2Y receptors) expressed in gastric cancer (GC) cel...
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine
Berberine (BBR) is a Chinese herb with antioxidant and anti-inflammatory properties. In a previous study, we found that BB...
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors
P2X7 receptors (P2X7Rs) are membrane-bound ATP-gated ion channels that are composed of three subunits. Different subunit s...
Purinergic signaling in the battlefield of viral infections
Purinergic signaling in the battlefield of viral infections
Purinergic signaling has been associated with immune defenses against pathogens such as bacteria, protozoa, fungi, and vir...
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis
Leishmania braziliensis is a pathogenic protozoan parasite that causes American Tegumentary Leishmaniasis (ATL), an import...
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing
Inflammatory pain, sustained by a complex network of inflammatory mediators, is a severe and persistent illness affecting ...
Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A2A and A2B receptors
Modafinil exerts anti-inflammatory and anti-fibrotic effects by upregulating adenosine A2A and A2B receptors
Adenosine receptor (AR) suppresses inflammation and fibrosis by activating cyclic adenosine monophosphate (cAMP) signaling...
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