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The role of skin testing, drug challenge and IFN-γ ELISpot in delayed hypersensitivity to iodinated contrast media
The role of skin testing, drug challenge and IFN-γ ELISpot in delayed hypersensitivity to iodinated contrast media
The use of in vivo and ex vivo diagnostic tools for delayed hypersensitivity reactions (DHRs) associated with iodinated co...
Characterizing the symptomatology and pathophysiology of allergic rhinitis using a nasal allergen challenge model – a subset of the allergic rhinitis microbiome study
Characterizing the symptomatology and pathophysiology of allergic rhinitis using a nasal allergen challenge model – a subset of the allergic rhinitis microbiome study
Since 2015, our nasal allergen challenge (NAC) protocol has been used to investigate the pathophysiology of allergic rhini...
NOURISH-US: a mixed-methods, randomized crossover study of a program designed to reduce the financial burden of food allergy
NOURISH-US: a mixed-methods, randomized crossover study of a program designed to reduce the financial burden of food allergy
Food allergy imposes considerable financial costs on families, but few programs are available in Canada to offset these co...
Clinicopathological and Immunogenetic Characterization in 8 Patients with Familial Hemophagocytic Lymphohistiocytosis Type 2: A Study from North India with Literature Review
Clinicopathological and Immunogenetic Characterization in 8 Patients with Familial Hemophagocytic Lymphohistiocytosis Type 2: A Study from North India with Literature Review
Familial hemophagocytic lymphohistiocytosis type 2 (FHL2) is the commonest cause of familial hemophagocytic lymphohistiocy...
BK Virus-Specific T Cell Response Associated with HLA Genotypes, RhD Status, and CMV or EBV Serostatus in Healthy Donors for Optimized Cell Therapy
BK Virus-Specific T Cell Response Associated with HLA Genotypes, RhD Status, and CMV or EBV Serostatus in Healthy Donors for Optimized Cell Therapy
The increasing application of virus-specific T cell therapy for treating BK virus infections in immunocompromised patients...
Somatic Mosaic Variants in Autoinflammatory Diseases: Functional Characterization and Correlation of Mosaicism Levels with Disease Age of Onset and Severity
Somatic Mosaic Variants in Autoinflammatory Diseases: Functional Characterization and Correlation of Mosaicism Levels with Disease Age of Onset and Severity
Autoinflammatory diseases (AIDs) are a group of disorders caused by a dysregulation of the innate immune system, among whi...
Evaluation of a Multiplex Electrochemiluminescence Assay for Detection of Anti-Pneumococcal Antibodies in the Diagnosis of Selective Polysaccharide Antibody Deficiency
Evaluation of a Multiplex Electrochemiluminescence Assay for Detection of Anti-Pneumococcal Antibodies in the Diagnosis of Selective Polysaccharide Antibody Deficiency
Streptococcus pneumoniae can be responsible for severe infections, especially in patients with primary antibody deficienci...
Reassessing Polysaccharide Responsiveness: Unveiling Limitations of Current Guidelines and Introducing the Polysaccharide Responsiveness Percentile Approach
Reassessing Polysaccharide Responsiveness: Unveiling Limitations of Current Guidelines and Introducing the Polysaccharide Responsiveness Percentile Approach
The assessment of polysaccharide responsiveness via vaccination is pivotal in the evaluation of patients for primary immun...
Discordant Restoration of TCR Expression and Function by CD247 Somatic Reversions
Discordant Restoration of TCR Expression and Function by CD247 Somatic Reversions
The CD247 chain of the T-cell receptor (TCR) is essential for normal T cell development and function. Reported CD247-defic...
Pilot Study of Anti-PD-1 Antibody Combined with L-DEP Regimens in the Treatment of Relapsed/Refractory EBV-HLH in Children
Pilot Study of Anti-PD-1 Antibody Combined with L-DEP Regimens in the Treatment of Relapsed/Refractory EBV-HLH in Children
Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a commo...
Molecular Interactions Between NK Cells and Acute Leukemic Cells: KIR2DL5 Drastically Limits NK Cell Responses
Molecular Interactions Between NK Cells and Acute Leukemic Cells: KIR2DL5 Drastically Limits NK Cell Responses
Natural Killer (NK) cells naturally recognize and eliminate leukemic cells. However, the molecular interactions that gover...
Loss of MALT1 Function in a Patient With Combined Immunodeficiency: a Novel Pathogenic Variant and Immunological Insights
Loss of MALT1 Function in a Patient With Combined Immunodeficiency: a Novel Pathogenic Variant and Immunological Insights
Germline pathogenic variants in the mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) encodes a casp...
β-Actin Deficiency in Baraitser-Winter Syndrome Type 1 Disrupts T-Cell Function and Immune Regulation: Implications for Targeted Therapy in Actinopathies
β-Actin Deficiency in Baraitser-Winter Syndrome Type 1 Disrupts T-Cell Function and Immune Regulation: Implications for Targeted Therapy in Actinopathies
Baraitser-Winter syndrome type 1 (BRWS1) is a rare disorder characterized by intellectual disability, short stature, facia...
A Novel R140S γc Variant Alters Cellular Distribution, Reduces Surface Expression, and Impairs Cytokine Signaling in Atypical X-SCID
A Novel R140S γc Variant Alters Cellular Distribution, Reduces Surface Expression, and Impairs Cytokine Signaling in Atypical X-SCID
The interleukin-2 receptor γ (IL-2Rγ, or γc) is a crucial component of several cytokine receptor complexes....
The Immunodeficiency Profile of Lymphocytes in the Patient with Gene Mutation During Different Infection
The Immunodeficiency Profile of Lymphocytes in the Patient with Gene Mutation During Different Infection
The Ezrin-Radixin-Moesin (ERM) family member moesin (MSN) plays a crucial role in reversibly linking F-actin to the cell m...
Expanding the Genetic and Clinical Spectrum of Hereditary Angioedema with Normal C1 Inhibitor: Novel Variants and Treatment Insights
Expanding the Genetic and Clinical Spectrum of Hereditary Angioedema with Normal C1 Inhibitor: Novel Variants and Treatment Insights
Hereditary angioedema with normal C1 inhibitor (HAE-nC1-INH) is a rare and genetically heterogeneous disorder with an inco...
Self-reported Clinical Outcomes and Quality of Life in Agammaglobulinemia: the Importance of an Early Diagnosis
Self-reported Clinical Outcomes and Quality of Life in Agammaglobulinemia: the Importance of an Early Diagnosis
Patients with (X-linked) agammaglobulinemia (XLA) suffer from severe, recurrent infections potentially leading to life-thr...
To The Editor a Novel Mutation in MALT1 Deficiency
To The Editor a Novel Mutation in MALT1 Deficiency
A 1-year-old girl from a consanguineous family, known for experiencing recurrent infections, was diagnosed with agammaglob...
Common Variable Immunodeficiency Disorder: A Decade of Insights from a Cohort of 150 Patients in India and the Use of Machine Learning Algorithms to Predict Severity
Common Variable Immunodeficiency Disorder: A Decade of Insights from a Cohort of 150 Patients in India and the Use of Machine Learning Algorithms to Predict Severity
Common Variable Immunodeficiency (CVID) is a heterogeneous disorder characterized by impaired antibody production and recu...
Metabolic-associated enthesitis: a review on pathophysiology, clinical relevance, diagnostic challenges, and perspective on target treatments
Metabolic-associated enthesitis: a review on pathophysiology, clinical relevance, diagnostic challenges, and perspective on target treatments
Entheses are specialized tissues that connect ligaments and tendons to the bone surface and are frequently involved in ser...
The impact of neddylation on prognosis in the immune microenvironment of neuroblastoma: a single-cell transcriptomic analysis
The impact of neddylation on prognosis in the immune microenvironment of neuroblastoma: a single-cell transcriptomic analysis
Neuroblastoma (NB) is a prevalent malignant tumor in children, primarily affecting the nervous system, with a high mortali...
knockdown suppresses the phenotype of house dust mite-induced allergic asthma in mice and cells
knockdown suppresses the phenotype of house dust mite-induced allergic asthma in mice and cells
Allergic asthma is a chronic inflammatory disease of the airways. The objective of this study was to identify potential th...
The role of dendritic cells in recurrent pregnancy loss
The role of dendritic cells in recurrent pregnancy loss
Recurrent pregnancy loss (RPL), defined as ≥ 2 consecutive losses, remains a significant clinical challe...
PS77: a novel peptide with α-helical structure for targeted anti-inflammatory therapy in biomaterials design
PS77: a novel peptide with α-helical structure for targeted anti-inflammatory therapy in biomaterials design
Chronic inflammation underlies many diseases, posing challenges in therapeutic management due to the limitations and side ...
Molecular mechanisms and treatment strategies for discogenic lumbar pain
Molecular mechanisms and treatment strategies for discogenic lumbar pain
Discogenic low back pain (DLBP) is one of the main causes of chronic low back pain, and its core pathological mechanism is...
SPP1 + macrophages facilitate pancreatic cancer progression via ITGB6-mediated interactions: evidence from integrated multi-omics analysis and experimental validation
SPP1 + macrophages facilitate pancreatic cancer progression via ITGB6-mediated interactions: evidence from integrated multi-omics analysis and experimental validation
Basement membranes (BMs) and tumor-associated macrophages (TAMs) are crucial stromal components in pancreatic cancer (PC),...
Severe interstitial lung disease as the first manifestation of a variant in a familial case
Severe interstitial lung disease as the first manifestation of a variant in a familial case
STING-associated vasculopathy with onset in infancy (SAVI) is a very rare autosomal-dominant Mendelian autoinflammatory di...
Exploring the role of the Th9/IL-9 axis in atopic dermatitis: analysis of Th9 cells, PU.1 expression and serum IL-9 levels
Exploring the role of the Th9/IL-9 axis in atopic dermatitis: analysis of Th9 cells, PU.1 expression and serum IL-9 levels
Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting from complex interactions between genetic, environ...
SOCS1 improves abnormal IgA galactosylation in IgA nephropathy by regulating the TLR9/MyD88 pathway
SOCS1 improves abnormal IgA galactosylation in IgA nephropathy by regulating the TLR9/MyD88 pathway
Abnormal galactosylation of IgA is a core factor in the development of IgA nephropathy (IgAN). Suppressor of cytokine sign...
Immunoglobulin G4-related sclerosing mastitis: MRI findings and the literature review
Immunoglobulin G4-related sclerosing mastitis: MRI findings and the literature review
Immunoglobulin G4-related disease (IgG4-RD) is a rare immune-mediated fibro-inflammatory condition that can affect nearly ...
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