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Does ‘sub-threshold’ ventilatory stress promote healing after lung injury?
Does ‘sub-threshold’ ventilatory stress promote healing after lung injury?
Excessive tidal stretching may initiate damage or retard healing after lung injury. However, it is seldom considered wheth...
Effects of sodium-glucose transporter-2 inhibition on systemic hemodynamics, renal function, and intra-renal oxygenation in sepsis-associated acute kidney injury
Effects of sodium-glucose transporter-2 inhibition on systemic hemodynamics, renal function, and intra-renal oxygenation in sepsis-associated acute kidney injury
People with type 2 diabetes mellitus treated with sodium-glucose transporter-2 inhibitors (SGLT2i) have lower rates of acu...
Ventriculo-arterial (VA) coupling and fQRS as new selection criteria for primary prevention ICD placement
Ventriculo-arterial (VA) coupling and fQRS as new selection criteria for primary prevention ICD placement
For decades, left ventricular ejection fraction (LVEF < 35%) has been a mainstay for identifying heart ...
Impact of tracheostomy tube modalities on ventilatory mechanics: a bench study
Impact of tracheostomy tube modalities on ventilatory mechanics: a bench study
Tracheostomized patients often present with muscle weakness, altered consciousness, or swallowing difficulties. Hence, the...
Mitochondrial oxygen tension in critically ill patients receiving red blood cell transfusions: a multicenter observational cohort study
Mitochondrial oxygen tension in critically ill patients receiving red blood cell transfusions: a multicenter observational cohort study
Currently, there is no marker of efficacy of red blood cell (RBC) transfusion. This study describes the impact of RBC tran...
Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis
Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis
Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young a...
The ESICM datathon and the ESICM and ICMx data science strategy
The ESICM datathon and the ESICM and ICMx data science strategy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Flow-controlled ventilation decreases mechanical power in postoperative ICU patients
Flow-controlled ventilation decreases mechanical power in postoperative ICU patients
Mechanical power (MP) is the energy delivered by the ventilator to the respiratory system and combines factors related to ...
Determinants of acute kidney injury during high-power mechanical ventilation: secondary analysis from experimental data
Determinants of acute kidney injury during high-power mechanical ventilation: secondary analysis from experimental data
The individual components of mechanical ventilation may have distinct effects on kidney perfusion and on the risk of devel...
Reinforcement learning for intensive care medicine: actionable clinical insights from novel approaches to reward shaping and off-policy model evaluation
Reinforcement learning for intensive care medicine: actionable clinical insights from novel approaches to reward shaping and off-policy model evaluation
Reinforcement learning (RL) holds great promise for intensive care medicine given the abundant availability of data and fr...
Pathophysiological implications of ventriculoarterial coupling in septic shock
Pathophysiological implications of ventriculoarterial coupling in septic shock
The left ventricular (LV) ejection phase interaction between the cardiac function and the arterial system is called ventri...
Identifying a target group for selenium supplementation in high-risk cardiac surgery: a secondary analysis of the SUSTAIN CSX trial
Identifying a target group for selenium supplementation in high-risk cardiac surgery: a secondary analysis of the SUSTAIN CSX trial
Recent data from the randomized SUSTAIN CSX trial could not confirm clinical benefits from perioperative selenium treatmen...
Interobserver reliability for manual analysis of sidestream darkfield videomicroscopy clips after resizing in ImageJ
Interobserver reliability for manual analysis of sidestream darkfield videomicroscopy clips after resizing in ImageJ
Direct assessment of microcirculatory function remains a critical care research tool but approaches for analysis of microc...
Robotic-assisted early mobilization and virtual reality: a perspective on innovative support strategies for critically ill patients
Robotic-assisted early mobilization and virtual reality: a perspective on innovative support strategies for critically ill patients
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Circulating endothelial extracellular vesicle signatures correspond with ICU requirement: an exploratory study in COVID-19 patients
Circulating endothelial extracellular vesicle signatures correspond with ICU requirement: an exploratory study in COVID-19 patients
Extracellular vesicles (EVs) represent nanometer-sized, subcellular spheres, that are released from almost any cell type a...
Impact of critical illness on cholesterol and fatty acids: insights into pathophysiology and therapeutic targets
Impact of critical illness on cholesterol and fatty acids: insights into pathophysiology and therapeutic targets
Critical illness is characterized by a hypercatabolic response encompassing endocrine and metabolic alterations. Not only ...
Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach
Precision net ultrafiltration dosing in continuous kidney replacement therapy: a practical approach
Murugan R, Balakumar V, Kerti SJ, Priyanka P, Chang CH, Clermont G, Bellomo R, Palevsky PM, Kellum JA (2018) Net ultrafilt...
Understanding the mechanisms of ventilator-induced lung injury using animal models
Understanding the mechanisms of ventilator-induced lung injury using animal models
Mechanical ventilation is a life-saving therapy in several clinical situations, promoting gas exchange and providing rest ...
Agreement of pCO2 in venous to arterial blood gas conversion models in undifferentiated emergency patients
Agreement of pCO2 in venous to arterial blood gas conversion models in undifferentiated emergency patients
Venous blood gas sampling has replaced arterial sampling in many critically ill patients, though interpretation of venous ...
Ultra-low tidal volume ventilation during cardiopulmonary resuscitation shows no mitigating effect on pulmonary end-organ damage compared to standard ventilation: insights from a porcine model
Ultra-low tidal volume ventilation during cardiopulmonary resuscitation shows no mitigating effect on pulmonary end-organ damage compared to standard ventilation: insights from a porcine model
This study aimed to determine whether ultra-low tidal volume ventilation (ULTVV) applied during cardiopulmonary resuscitat...
Current knowledge gaps in extracorporeal respiratory support
Current knowledge gaps in extracorporeal respiratory support
Extracorporeal life support (ECLS) for acute respiratory failure encompasses veno-venous extracorporeal membrane oxygenati...
Body position to optimize mechanics in ARDS: to which degree does the angle matter?
Body position to optimize mechanics in ARDS: to which degree does the angle matter?
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Protective effect of canagliflozin on post-resuscitation myocardial function in a rat model of cardiac arrest
Protective effect of canagliflozin on post-resuscitation myocardial function in a rat model of cardiac arrest
Currently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemi...
Diaphragm excursions as proxy for tidal volume during spontaneous breathing in invasively ventilated ICU patients
Diaphragm excursions as proxy for tidal volume during spontaneous breathing in invasively ventilated ICU patients
There is a need to monitor tidal volume in critically ill patients with acute respiratory failure, given its relation with...
Extracorporeal cardiopulmonary resuscitation in 2023
Extracorporeal cardiopulmonary resuscitation in 2023
Kennedy JH (1966) The role of assisted circulation in cardiac resuscitation. JAMA 197:615–618Article  CAS  PubMed ...
Continuous chest compressions are associated with higher peak inspiratory pressures when compared to 30:2 in an experimental cardiac arrest model
Continuous chest compressions are associated with higher peak inspiratory pressures when compared to 30:2 in an experimental cardiac arrest model
Ventilation during cardiopulmonary resuscitation (CPR) has long been a part of the standard treatment during cardiac arres...
Hemodynamic effects of supplemental oxygen versus air in simulated blood loss in healthy volunteers: a randomized, controlled, double-blind, crossover trial
Hemodynamic effects of supplemental oxygen versus air in simulated blood loss in healthy volunteers: a randomized, controlled, double-blind, crossover trial
Trauma patients frequently receive supplemental oxygen, but its hemodynamic effects in blood loss are poorly understood. W...
ESICM LIVES 2023
ESICM LIVES 2023
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Comparison of whole blood cytokine immunoassays for rapid, functional immune phenotyping in critically ill patients with sepsis
Comparison of whole blood cytokine immunoassays for rapid, functional immune phenotyping in critically ill patients with sepsis
Sepsis is characterized by highly heterogeneous immune responses associated with a spectrum of disease severity. Methods t...
Neurovirulent cytokines increase neuronal excitability in a model of coronavirus-induced neuroinflammation
Neurovirulent cytokines increase neuronal excitability in a model of coronavirus-induced neuroinflammation
Neurological manifestations of severe coronavirus infections, including SARS-CoV-2, are wide-ranging and may persist follo...
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