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The epigenetics of frailty
The conceptual change of frailty, from a physical to a biopsychosocial phenotype, expanded the field of frailty, including...
Epigenomics
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SET protein as an epigenetics target
The SET gene has four transcripts reported in NCBI, coding two isoforms of SET proteins. The most known function of SET pr...
Epigenomics
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DNA methylation as a window into female reproductive aging
People with ovaries experience reproductive aging as their reproductive function and system declines. This has significant...
Epigenomics
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Hypomethylation of Wnt signaling regulator genes in developmental language disorder
Background: Developmental language disorder (DLD) is a neurodevelopmental disorder. Considering the pivotal role of epigen...
Epigenomics
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Twin study: genotype-dependent epigenetic factors affecting free thyroxine levels in the normal range
Aim: To explore the clinical application of DNA methylation affecting thyroid function, we evaluated the association of DN...
Epigenomics
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Integrated analysis of transcriptome and epigenome reveals ENSR00000272060 as a potential biomarker in gastric cancer
Background: Enhancer RNAs (eRNAs) are involved in gene expression regulation. Although functional roles of eRNAs in the pa...
Epigenomics
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microRNAs and their therapeutic strategy in phase I and phase II clinical trials
miRNAs play a crucial therapeutic role in diseases such as cancer, diabetes and viral infections, with around 1900 identif...
Epigenomics
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Mitochondrial D-loop methylation levels inversely correlate with disease duration in amyotrophic lateral sclerosis
Aim: To correlate mitochondrial D-loop region methylation levels and mtDNA copy number with disease duration in familial a...
Epigenomics
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Data science using the human epigenome for predicting multifactorial diseases and symptoms
Tweetable abstract This article reviews machine learning models that leverages epigenomic data for predicting multifactori...
Epigenomics
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POU2F2-mediated upregulation of lncRNA PTPRG-AS1 inhibits ferroptosis in breast cancer via miR-376c-3p/SLC7A11 axis
Background: Triple-negative breast cancer (TNBC) is a subtype of BC with high rates of mortality. The mechanism of PTPRG-A...
Epigenomics
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Unlocking the epigenetic symphony: histone acetylation's impact on neurobehavioral change in neurodegenerative disorders
Recent genomics and epigenetic advances have empowered the exploration of DNA/RNA methylation and histone modifications cr...
Epigenomics
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LncRNA-ENST00000421645 promotes T cells to secrete IFN-γ by sponging PCM-1 in neurosyphilis
Aim: Neurosyphilis patients exhibited significant expression of long noncoding RNA (lncRNA) in peripheral blood T lymphocy...
Epigenomics
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DNA methylation detection technology and plasma-based methylation biomarkers in screening of gastrointestinal carcinoma
DNA methylation is of paramount importance for the evolution of human cancers. Its high sensitivity and specificity make i...
Epigenomics
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Novel epigenetic link between gestational diabetes mellitus and macrosomia
Background & objectives: Examine maternal gestational diabetes mellitus (GDM), macrosomia and DNA methylation in candi...
Epigenomics
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NEAT1 functions as a key mediator of BMP2 to promote osteogenic differentiation of renal interstitial fibroblasts
Aim: To clarify the mechanism of NEAT1, an aberrantly upregulated lncRNA in Randall's plaques (RP) similar to biomineraliz...
Epigenomics
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DNA methylation differences in cortical grey and white matter in schizophrenia
Aim: Identify grey- and white-matter-specific DNA-methylation differences between schizophrenia (SCZ) patients and control...
Epigenomics
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LINC01133 hampers the development of gastric cancer through increasing SST via binding to microRNA-576-5p
Aim: Our study aimed at investigating how LINC01133 functions in gastric cancer (GC) progression. Materials & methods:...
Epigenomics
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Cataloging recent advances in epigenetic alterations in major mental disorders and autism
During the last two decades, diverse epigenetic modifications including DNA methylation, histone modifications, RNA editin...
Epigenomics
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Predicting outcome in higher-risk myelodysplastic syndrome patients treated with azacitidine
5-Azacitidine (5-AZA) is widely used for the treatment of higher-risk myelodysplastic syndromes. However, response and sur...
Epigenomics
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A method of sample-wise region-set enrichment analysis for DNA methylomics
Aim: Gene set analysis has commonly been used to interpret DNA methylome data. However, summarizing the DNA methylation le...
Epigenomics
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Implication of epitranscriptomics in trained innate immunity and COVID-19
This study was supported by Indian Council of Medical Research (DHR-GIA, 2020-9530 to A. Paramasivam), Government of India...
Epigenomics
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DNA methylation in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD), a complex disease with polygenetic tendency, is one of the most important he...
Epigenomics
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External validation of integrated genetic-epigenetic biomarkers for predicting incident coronary heart disease
Aim: The Framingham Risk Score (FRS) and ASCVD Pooled Cohort Equation (PCE) for predicting risk for incident coronary hear...
Epigenomics
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Comprehensive analysis of differentially expressed long noncoding RNAs, miRNAs and mRNAs in breast cancer brain metastasis
Aim: To delineate the transcriptomic landscape and potential molecular mechanisms of breast cancer brain metastasis (BCBM)...
Epigenomics
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Intergenerational effects of maternal post-traumatic stress disorder on offspring epigenetic patterns and cortisol levels
Aim: To investigate the association between maternal post-traumatic stress disorder (PTSD) during pregnancy and offspring ...
Epigenomics
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Genome-wide associations between alcohol consumption and blood DNA methylation: evidence from twin study
Aim: Alcohol intake alters DNA methylation profiles and methylation might mediate the association between alcohol and dise...
Epigenomics
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HDL-enriched miR-30a-5p is associated with HDL-cholesterol levels and glucose metabolism in healthy men and women
Aim: To investigate the associations between high-density lipoprotein (HDL)-enriched miRNAs and the cardiometabolic profil...
Epigenomics
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Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence
Aim: We investigated DNA methylation of BDNF in methamphetamine (METH) dependence in humans and an animal model. Materials...
Epigenomics
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Early-life stress induces genome-wide sex-dependent miRNA expression and correlation across limbic brain areas in rats
Aims: The aim of this study was to assess regional- and sex-dependent changes in miRNA expression resulting from early-lif...
Epigenomics
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High-throughput miRNA sequencing of the human placenta: expression throughout gestation
Aim: To understand miRNA changes across gestation in healthy human placentae. This is essential before miRNAs can be used ...
Epigenomics
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