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Anti-cancer drug-mediated increase in mitochondrial mass limits the application of metabolic viability-based MTT assay in cytotoxicity screening
Anti-cancer drug-mediated increase in mitochondrial mass limits the application of metabolic viability-based MTT assay in cytotoxicity screening
The high-throughput metabolic viability-based colorimetric MTT test is commonly employed to screen the cytotoxicity of dif...
Schizandrin A enhances the sensitivity of gastric cancer cells to 5-FU by promoting ferroptosis
Schizandrin A enhances the sensitivity of gastric cancer cells to 5-FU by promoting ferroptosis
Schizandrin A (Sch A) exert anticancer and multidrug resistance-reversing effects in a variety of tumors, but its effect o...
LncRNA MIR181A2HG negatively regulates human keratinocytes proliferation by binding SRSF1
LncRNA MIR181A2HG negatively regulates human keratinocytes proliferation by binding SRSF1
Psoriasis is a common chronic inflammatory skin disease. Abnormal proliferation of keratinocytes plays an important role i...
Fructobacillus fructosus OS-1010 strain stimulates intestinal cells to secrete exosomes that activate muscle cells
Fructobacillus fructosus OS-1010 strain stimulates intestinal cells to secrete exosomes that activate muscle cells
Fructobacillus is a lactic-acid bacterium recently identified in fructose-rich environments. Fructobacillus is also known ...
LncRNA HOTAIR accelerates free fatty acid-induced inflammatory response in HepG2 cells by recruiting SRSF1 to stabilize MLXIPL mRNA
LncRNA HOTAIR accelerates free fatty acid-induced inflammatory response in HepG2 cells by recruiting SRSF1 to stabilize MLXIPL mRNA
LncRNA HOTAIR has been reported to be associated with metabolic diseases of the liver. However, the effect of HOTAIR on no...
Evodiamine ameliorates intervertebral disc degeneration through the Nrf2 and MAPK pathways
Evodiamine ameliorates intervertebral disc degeneration through the Nrf2 and MAPK pathways
Degradation of extracellular matrix (ECM), reactive oxygen species (ROS) production, and inflammation are critical players...
NEAT1 promotes the progression of prostate cancer by targeting the miR-582-5p/EZH2 regulatory axis
NEAT1 promotes the progression of prostate cancer by targeting the miR-582-5p/EZH2 regulatory axis
In several forms of malignant tumors, nuclear enriched abundant transcript 1 (NEAT1), a lncRNA, has been identified to pla...
Selective elimination of tumorigenic cells from mixed culture of normal and tumorigenic cells using hybrid liposomes aimed at realizing of cell therapy
Selective elimination of tumorigenic cells from mixed culture of normal and tumorigenic cells using hybrid liposomes aimed at realizing of cell therapy
While induced pluripotent stem (iPS) cells are expected to be a cell source for regenerative medicine, they also have tumo...
Therapeutic potential of exosome derived from hepatocyte growth factor-overexpressing adipose mesenchymal stem cells in TGFβ1-stimulated hepatic stellate cells
Therapeutic potential of exosome derived from hepatocyte growth factor-overexpressing adipose mesenchymal stem cells in TGFβ1-stimulated hepatic stellate cells
Cirrhosis is a familiar end-stage of multiple chronic liver diseases. The gene-modified mesenchymal stem cells (MSCs) have...
Degranulation of RBL-2H3 rat basophilic leukemia cells is synergistically inhibited by combined treatment with nobiletin and lactoferrin
Degranulation of RBL-2H3 rat basophilic leukemia cells is synergistically inhibited by combined treatment with nobiletin and lactoferrin
The aim of this study was to elucidate the anti-allergic effects of polymethoxyflavonoids in combination with milk protein...
Stable two- and three-dimensional cholangiocyte culture systems from extrahepatic bile ducts of biliary atresia patients: use of structural and functional bile duct epithelium models for in vitro analyses
Stable two- and three-dimensional cholangiocyte culture systems from extrahepatic bile ducts of biliary atresia patients: use of structural and functional bile duct epithelium models for in vitro analyses
We herein report two- (2D) and three-dimensional (3D) culture methods of cholangiocytes originating from extrahepatic bile...
The effect of TFAP2A/ANXA8 axis on ferroptosis of cervical squamous cell carcinoma (CESC) in vitro
The effect of TFAP2A/ANXA8 axis on ferroptosis of cervical squamous cell carcinoma (CESC) in vitro
Potential role and associated mechanisms of Annexin A8 (ANXA8), a member of the Annexins family, in cervical squamous cell...
Pyrroloquinoline quinone protects against murine hepatitis virus strain 3-induced fulminant hepatitis by inhibiting the Keap1/Nrf2 signaling
Pyrroloquinoline quinone protects against murine hepatitis virus strain 3-induced fulminant hepatitis by inhibiting the Keap1/Nrf2 signaling
Fulminant hepatitis (FH) is a life-threatening clinical liver syndrome characterized by substantial hepatocyte necrosis an...
PABPC1 silencing inhibits pancreatic cancer cell proliferation and EMT, and induces apoptosis via PI3K/AKT pathway
PABPC1 silencing inhibits pancreatic cancer cell proliferation and EMT, and induces apoptosis via PI3K/AKT pathway
Pancreatic cancer is difficult to manage owing to the challenges involved in its treatment and nursing. This study aimed t...
Activation of MAL2 by RAD21 inhibits the expression of MHC-I in immune evasion of endometrial cancer
Activation of MAL2 by RAD21 inhibits the expression of MHC-I in immune evasion of endometrial cancer
CD8+ T cells are the primary mediators of anticancer immunity, and modulation of the CD8+ T cell response has been a centr...
Activation of the Nrf2/HO-1 axis by glutaredoxin 2 overexpression antagonizes vascular endothelial cell oxidative injury and inflammation under LPS exposure
Activation of the Nrf2/HO-1 axis by glutaredoxin 2 overexpression antagonizes vascular endothelial cell oxidative injury and inflammation under LPS exposure
Atherosclerosis constitutes a proverbial pathogenic mechanism for cardio-cerebrovascular disease that accounts for the mos...
MiR-4763-3p accelerates lipopolysaccharide-induced cardiomyocyte apoptosis and inflammatory response by targeting IL10RA
MiR-4763-3p accelerates lipopolysaccharide-induced cardiomyocyte apoptosis and inflammatory response by targeting IL10RA
In order to investigate miR-4763-3p and associated genes’ roles in myocarditis, AC16 cell line was divided into LPS&...
Proteases and Cancer
Proteases and Cancer
This volume details bioinformatics analysis, biochemical assays, recombinant protein expression and purification, methods ...
Nrf2 activator Diethyl Maleate attenuates ROS mediated NLRP3 inflammasome activation in murine microglia
Nrf2 activator Diethyl Maleate attenuates ROS mediated NLRP3 inflammasome activation in murine microglia
Microglia are the tissue-resident immune cells of the central nervous system. As a part of the innate immune response, NLR...
Effects of wasp (Vespa crabro) nest extracts on virus replication of Autographa californica nuclear polyhedrosis virus on Spodoptera frugiperda cell culture
Effects of wasp (Vespa crabro) nest extracts on virus replication of Autographa californica nuclear polyhedrosis virus on Spodoptera frugiperda cell culture
The antiviral properties of the extracts of Vespa crabro nests collected from the Black Sea, Turkey have been investigated...
Evaluation of the PrimeFlow RNA assay as a method of detection of SARS-CoV-2 single and dual Infections
Evaluation of the PrimeFlow RNA assay as a method of detection of SARS-CoV-2 single and dual Infections
Given the implications of increased transmissibility, virulence, host range, and immune escapes of emerging variants of SA...
Fish cell line: depositories, web resources and future applications
Fish cell line: depositories, web resources and future applications
Cell lines are important bioresources to study the key biological processes in the areas like virology, pathology, immunol...
Study on the mechanism of CXCL12/CXCR4-axis-mediated upregulation of IL-8 and IL-6 on the biological function of acute T lymphocyte leukaemia cells
Study on the mechanism of CXCL12/CXCR4-axis-mediated upregulation of IL-8 and IL-6 on the biological function of acute T lymphocyte leukaemia cells
Blocking the CXCL12/CXCR4 axis can alter the biological functions of leukaemia cells. We hypothesise that interleukin (IL)...
Nitric oxide-cyclic GMP role in Ang II induced hyperpolarization in bovine aortic endothelium cell line (BAE-1)
Nitric oxide-cyclic GMP role in Ang II induced hyperpolarization in bovine aortic endothelium cell line (BAE-1)
Angiotensin II (Ang II), a mitogen-activated peptide, exerts numerous effects on the cardiovascular system including the r...
Pulsed electrical stimulation and amino acid derivatives promote collagen gene expression in human dermal fibroblasts
Pulsed electrical stimulation and amino acid derivatives promote collagen gene expression in human dermal fibroblasts
Several collagen types are important for maintaining skin structure and function. Previous reports show that l-hydroxyprol...
Construction of a novel kinetic model for the production process of a CVA6 VLP vaccine in CHO cells
Construction of a novel kinetic model for the production process of a CVA6 VLP vaccine in CHO cells
Bioprocess development benefits from kinetic models in many aspects, including scale-up, optimization, and process underst...
Exosome-mediated circGMPS facilitates the development of gastric cancer cells through miR-144-3p/PUM1
Exosome-mediated circGMPS facilitates the development of gastric cancer cells through miR-144-3p/PUM1
In recent years, gastric cancer (GC) is still one of the major public health burdens in the world. It is reported that exo...
PRPF19 functions in DNA damage repair and gemcitabine sensitivity via regulating DDB1 in bladder cancer cells
PRPF19 functions in DNA damage repair and gemcitabine sensitivity via regulating DDB1 in bladder cancer cells
PRPF19 seems to play either tumor-promoting or anti-tumor roles depending on cancer types. This study aimed to clarify the...
Effective methods for immobilization of non-adherent Pv11 cells while maintaining their desiccation tolerance
Effective methods for immobilization of non-adherent Pv11 cells while maintaining their desiccation tolerance
Pv11 was derived from embryos of the sleeping chironomid Polypedilum vanderplanki, which displays an extreme form of desic...
Reconstruction of ovarian follicular-like structure by recellularization of a cell-free human ovarian scaffold with mouse fetal ovarian cells
Reconstruction of ovarian follicular-like structure by recellularization of a cell-free human ovarian scaffold with mouse fetal ovarian cells
The present study assessed the supportive roles of the decellularized human ovarian tissue in homing of mouse fetal ovaria...
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