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Towards the era of biological biomarkers for Parkinson disease
Since its instigation in cancer research in the 1930s, the disease-staging concept has become a crucial tool in clinical r...
Neurological care for LGBT+ people
Neurological care for LGBT+ people
Sexual and gender minority (LGBT+) people face unique health disparities that must be considered by health-care providers ...
Approval of omaveloxolone for Friedreich ataxia
The recent approval of omaveloxolone for the treatment of Friedreich ataxia in the USA and Europe represents an important ...
Neurostimulation for treatment of post-stroke impairments
Neurostimulation for treatment of post-stroke impairments
Neurostimulation, the use of electrical stimulation to modulate the activity of the nervous system, is now commonly used f...
Insights into epileptogenesis from post-traumatic epilepsy
Insights into epileptogenesis from post-traumatic epilepsy
Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies. The incidence of PTE after traumatic brain injury (TBI) d...
Diversity, equity and inclusion in neurology
In this issue of Nature Reviews Neurology, we launch a Series to highlight the importance of diversity, equity and inclusi...
Addressing disparities in neurology by building the workforce in LMICs
Addressing disparities in neurology by building the workforce in LMICs
Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a...
Support for network theories of schizophrenia
Support for network theories of schizophrenia
A computational neuroimaging study has shed new light on the relationship between morphological changes in the brain in sc...
Improved quality of life with MS treatment
Cladribine tablets can improve quality of life in people with highly active relapsing multiple sclerosis (MS), according t...
IGFBP2 levels associated with Alzheimer disease
A study published in Brain has found correlations between serum and cerebrospinal fluid levels of insulin-like growth fact...
A multiple hits hypothesis for memory dysfunction in Parkinson disease
A multiple hits hypothesis for memory dysfunction in Parkinson disease
Cognitive disorders are increasingly recognized in Parkinson disease (PD), even in early disease stages, and memory is one...
Restoring synaptic plasticity after stroke
Gamma oscillations induced by optogenetic stimulation restore functional synaptic plasticity in a mouse model of stroke, a...
CD11c+ macrophages mediate brain-to-gut α-synuclein trafficking
CD11c+ macrophages mediate brain-to-gut α-synuclein trafficking
New research indicates that in a mouse model of Parkinson disease, α-synuclein is trafficked from the brain to the gu...
ALS pathogenesis linked to actin barrier collapse
Repulsive guidance molecule A (RGMa) regulates actin dynamics via neogenin 1 signalling. A new study found that the cerebr...
A tale of race and B cells in multiple sclerosis
A new study indicates that African American people with multiple sclerosis have higher markers of humoral disease patholog...
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
Understanding rare genetic brain disorders with overlapping neurological and psychiatric phenotypes is of increasing impor...
A new biological classification for Parkinson disease
In a plenary lecture at the XXVI World Congress of Neurology, Anthony Lang presented a new biological classification model...
Metformin protects against dementia in diabetes
Use of metformin in people aged ≥60 years with type 2 diabetes mellitus (T2DM) is associated with a reduced risk of develo...
Glioblastoma tackled with oncolytic virus
A first-in-human trial indicates that treatment with an oncolytic virus is associated with increased survival in people wi...
Myelination mediates benefits of ketamine
Restoration of impaired myelination underlies the long-lasting antidepressant effects of ketamine, new research suggests. ...
Peripheral B cells altered in Parkinson disease
The findings of an immunophenotyping study suggest that abnormal peripheral B cell responses could contribute to Parkinson...
Biomarkers in amyotrophic lateral sclerosis: current status and future prospects
Biomarkers in amyotrophic lateral sclerosis: current status and future prospects
Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug development. Categorization b...
Molecular biomarkers for vascular cognitive impairment and dementia
Molecular biomarkers for vascular cognitive impairment and dementia
As disease-specific interventions for dementia are being developed, the ability to identify the underlying pathology and d...
Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms
Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms
The understanding of idiopathic intracranial hypertension (IIH) has evolved over the past few years. Previously, IIH was c...
PD pathology spread linked to mtDNA damage
A new study suggests that damaged mitochondrial DNA (mtDNA) can trigger and aid the spread of Parkinson disease (PD)-like ...
Neuropsychological impairment in amyotrophic lateral sclerosis–frontotemporal spectrum disorder
Neuropsychological impairment in amyotrophic lateral sclerosis–frontotemporal spectrum disorder
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a rapid course, characterized by motor neuron dysf...
Seizure-associated changes in the Golgi apparatus
Seizure activity in the brain induces reversible structural changes in the neuronal Golgi apparatus, according to new rese...
Prodromal psychiatric symptoms in MS
Psychiatric symptoms such as mood and anxiety disorders are common in the years leading up to multiple sclerosis (MS) onse...
ApoE attracts microglia to amyloid-β plaques
ApoE attracts microglia to amyloid-β plaques
A new study reveals that VCAM1–ApoE signalling directs microglia to amyloid-β plaques, mediating removal of the...
Vaccine shows promise in diffuse midline glioma
A small first-in-human trial indicates that a vaccine targeting the histone H3 mutation H3K27M is safe and can induce a mu...
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