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Corrigendum to “Lack of Gαi2 proteins in adipocytes attenuates diet-induced obesity” [Mol Metab 40 (2020 Oct) 101029]
Corrigendum to “Lack of Gαi2 proteins in adipocytes attenuates diet-induced obesity” [Mol Metab 40 (2020 Oct) 101029]
Available online 2 March 2024, 101910Author links open overlay panelVeronika Leiss 1 9, Annika Schönsiegel 1 9, Thorsten G...
Corrigendum to “Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice” [Mol Metab 82 (2024 April) 101906]
Corrigendum to “Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice” [Mol Metab 82 (2024 April) 101906]
Available online 16 March 2024, 101917Author links open overlay panelKanikkai Raja Aseer 1 2, Caio Henrique Mazucanti 1, J...
Intestinal Acyl-CoA synthetase 5 (ACSL5) deficiency potentiates postprandial GLP-1 & PYY secretion, reduces food intake, and protects against diet-induced obesity
Intestinal Acyl-CoA synthetase 5 (ACSL5) deficiency potentiates postprandial GLP-1 & PYY secretion, reduces food intake, and protects against diet-induced obesity
ObjectiveIn the small intestine, the products of digestion of dietary triacylglycerol (TAG), fatty acids (FA) and monoacyl...
Response to letter-to-the-editor: “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”
Response to letter-to-the-editor: “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Letter-to-the-editor on “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”
Letter-to-the-editor on “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota
GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota
ObjectivesTheut microbiota increases energy availability through fermentation of dietary fibers to short-chain fatty acids...
A practical and robust method to evaluate metabolic fluxes in primary pancreatic islets
A practical and robust method to evaluate metabolic fluxes in primary pancreatic islets
Keywordsmitochondrial respirationoxidative phosphorylationoxygen consumptionpancreatic isletsAbbreviationsKATPATP-sensitiv...
Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration
Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration
Available online 22 March 2024, 101923Author links open overlay panel, , , , Highlights•Macrophages recruited to the injur...
Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice
Effects of chronic high fat diet on mediobasal hypothalamic satiety neuron function in POMC-Cre mice
ObjectiveThe prevalence of obesity has increased over the past three decades. Proopiomelanocortin (POMC) neurons in the hy...
Role of human Kallistatin in glucose and energy homeostasis in mice
Role of human Kallistatin in glucose and energy homeostasis in mice
ObjectiveKallistatin (KST), also known as SERPIN A4, is a circulating, broadly acting human plasma protein with pleiotropi...
Atlas of exercise-induced brain activation in mice
Atlas of exercise-induced brain activation in mice
ObjectivesThere is significant interest in uncovering the mechanisms through which exercise enhances cognition, memory, an...
Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice
Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice
ObjectiveType 1 diabetes (T1D) occurs because of islet infiltration by autoreactive immune cells leading to destruction of...
VCD-induced menopause mouse model reveals reprogramming of hepatic metabolism
VCD-induced menopause mouse model reveals reprogramming of hepatic metabolism
ObjectiveMenopause adversely impacts systemic energy metabolism and increases the risk of metabolic disease(s) including h...
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
ObjectiveSkeletal muscle plasticity and remodeling are critical for adapting tissue function to use, disuse, and regenerat...
Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis
Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis
ObjectiveAdipose tissue mass is maintained by a balance between lipolysis and lipid storage. The contribution of adipose t...
Maternal exercise preserves offspring cardiovascular health via oxidative regulation of the ryanodine receptor
Maternal exercise preserves offspring cardiovascular health via oxidative regulation of the ryanodine receptor
ObjectiveThe intrauterine environment during pregnancy is a critical factor in the development of obesity, diabetes, and c...
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice
Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice
ObjectiveThe glucose-dependent insulinotropic polypeptide (GIP) decreases body weight via central GIP receptor (GIPR) sign...
Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytes
Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytes
KeywordsScd1Stearoyl CoA Desaturase 1ADCDAutophagy-dependent cell deathBMATBone marrow adipose tissueBMAdsBone marrow adip...
Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis
Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis
Available online 9 December 2023, 101851Author links open overlay panel, , , , , , Highlights•High ORMDL3 overexpression i...
Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion
Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion
ObjectiveLipoprotein assembly and secretion in the small intestine are critical for dietary fat absorption. Surfeit locus ...
Farnesoid X receptor activation protects against renal fibrosis via modulation of β-catenin signaling
Farnesoid X receptor activation protects against renal fibrosis via modulation of β-catenin signaling
ObjectiveActivation of farnesoid X receptor (FXR), a bile acid nuclear receptor, may be implicated in the pathophysiology ...
Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation
Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation
ObjectiveAlthough individual steps have been characterized, there is little understanding of the overall process whereby g...
Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes
Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes
KeywordsChREBPMycPvt1Beta cellsGlucose-mediated gene expressionChromatin conformation captureDNA loopingGlucose-stimulated...
Evaluation of long acting GLP1R/GCGR agonist in a DIO and biopsy-confirmed mouse model of NASH suggest a beneficial role of GLP-1/glucagon agonism in NASH patients.
Evaluation of long acting GLP1R/GCGR agonist in a DIO and biopsy-confirmed mouse model of NASH suggest a beneficial role of GLP-1/glucagon agonism in NASH patients.
The metabolic benefits of GLP-1 receptor (GLP-1R) agonists on glycemic and weight control are well established as therapy ...
Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
Hepatocellular carcinoma (HCC) is characterized by a low and variable response to chemotherapeutic treatments. One contrib...
Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury
Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury
Available online 4 December 2023, 101849Author links open overlay panel, , , , , , , , , , , , , , , , , Highlights•Severa...
Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib
Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib
ObjectiveCarbohydrate Response Element Binding Protein (ChREBP) is a glucose 6-phosphate (G6P)-sensitive transcription fac...
GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity
GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity
ObjectiveG-protein-signaling modulator 1 (GPSM1) has been proved the potential role in brain tissues, however, whether GPS...
Short-term consumption of highly processed diets varying in macronutrient content impair the sense of smell and brain metabolism in mice
Short-term consumption of highly processed diets varying in macronutrient content impair the sense of smell and brain metabolism in mice
ObjectiveFood processing greatly contributed to increased food safety, diversity, and accessibility. However, the prevalen...
Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity
Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity
KeywordsMacrophage migration inhibitory factor (MIF)Hormone-sensitive lipase (HSL)Adipose tissueObesityAMP activated prote...
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