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Ghrelin restores D1 receptor-mediated dopamine neurotransmission and enhances attentive behaviour in Mecp2 KO mice
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked methyl-CpG-binding-protein-2 (MEC...
NF-κB/TOM6/PINK1-mediated mitophagy attenuates vascular calcification: Luteolin as a therapeutic modulator
Vascular calcification (VC), a pathological condition marked by aberrant mineral deposition in the arterial wall, elevates...
ALOX15 and ALOX15B regulate autophagy to promote pulmonary arterial hypertension via the PI3K/AKT/mTOR pathway
Pulmonary arterial hypertension (PAH) is a progressive and life-threatening cardiovascular disorder characterized by susta...
MicroRNAs as key paracrine factors in stem cell therapy: Molecular mechanisms, therapeutic applications, and future perspectives
Stem cell therapy, as a transformative approach in the field of regenerative medicine, has demonstrated tremendous potenti...
The METTL family as regulators of methylation and therapeutic targets in cardiovascular diseases
Cardiovascular diseases (CVDs) remain as the leading global health challenge, responsible for the highest mortality rates ...
Impaired Gq signaling underlies oxytocin hyporesponsiveness in LPS and poly I:C-induced preterm labor in mice
The regulation of oxytocin signaling in preterm labor remains poorly understood. In this study, we investigated uterine re...
Qushi Huayu decoction alleviates NAFLD in mice by regulating gut microbiota homeostasis in the gut-liver axis via the pregnane X receptor
Globally, non-alcoholic fatty liver disease (NAFLD) represents the most prevalent chronic liver condition, estimated to af...
Activation of autophagy as a strategy to overcome Osimertinib-resistance in non-small cell lung cancer
Lung cancer remains the leading cause of cancer-related mortality worldwide, with most patients not surviving beyond a yea...
Coral Hydrate improves renal fibrosis by inhibiting indoxyl sulfate-induced ROS-mediated NLRP3 inflammasome activation
Chronic kidney disease (CKD) has become a prevalent health condition, affecting roughly 14.3 % of people globally (Liu, 20...
Crosstalk between M1 muscarinic acetylcholine receptor and endocannabinoid system promotes attenuation of inflammation in ulcerative colitis
Ulcerative colitis (UC), a chronic inflammatory condition that the gastrointestinal tract (Tripathi and Feuerstein, 2019),...
17-α-ethinyl estradiol in vitro treatment of rat primary hippocampal neurons shapes glutamatergic developmental program: molecular and morphological dynamics at the postsynapse
17-α-ethinyl-estradiol (EE2) is the estrogen-like semi-synthetic hormone contained in most combined contraceptives and dru...
Neuroprotective effects of Gnetin H from Paeonia lactiflora via CREB-BDNF pathway restoration in a scopolamine-induced memory deficit model
Alzheimer's disease (AD) accounts for 60–80 % of dementia cases (Organization, 2022), and is defined biologically as the d...
Dipyridamole alleviates necroptosis and renal inflammation via cAMP/CREB signaling pathways in septic AKI mice
Sepsis-associated acute kidney injury (SA-AKI) is a devastating critical care complication, affecting ∼60 % of septic pati...
Trimetazidine alleviates heart failure after myocardial infarction by promoting PINK1/parkin-mediated mitophagy and suppressing GPX4-dependent ferroptosis
Heart failure (HF) remains a prevalent complication following myocardial infarction (MI), characterized by mitochondrial d...
Unlocking dexmedetomidine's therapeutic potential in multiple sclerosis: Dual modulation of PI3K/Akt/BDNF and TLR4/NF-κB pathways in EAE rats
Multiple sclerosis (MS) is an enduring, immune-mediated condition of the central nervous system (CNS) and a major reason f...
Hypericin alleviates depression via the microbiota-gut-brain Axis: Role of Akkermansia muciniphila and glycerophospholipid metabolism
Depression and anxiety disorders exhibit high comorbidity and share overlapping biological mechanisms, with more than 60 %...
Selection and validation of a cell-internalizing DNA aptamer targeting esophageal squamous cell carcinoma
The pathological types of esophageal cancer are mainly divided into squamous cell carcinoma and adenocarcinoma, and esopha...
Cinobufotalin ameliorates ulcerative colitis by modulating gut microbiota, restoring Th17/Treg balance, and inhibiting MAPK/NF-κB signaling pathways
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by continuous mucosal inflammation ext...
Curcumol ameliorates alcoholic liver disease through regulation of SIRT1 signaling pathway
Alcoholic liver disease (ALD), one of the most common causes of liver-related morbidity and mortality, is induced by chron...
Evaluation of the hepatoprotective effects and pharmacokinetics of pedunculoside in vitro and in vivo
Pedunculoside (PE), a triterpenoid saponin isolated from Ilex rotunda Thunb., exhibits an anti-inflammatory effect; howeve...
Toll-like receptor 9 contributes to perivascular adipose tissue dysfunction in spontaneously hypertensive rats
Arterial hypertension is a persistent global health issue increasingly identified as a low-grade chronic inflammatory cond...
Alectinib causes sinus bradycardia by suppressing L-type calcium current in sinus node
Alectinib is a highly selective tyrosine kinase inhibitor (TKI). It has been approved by over 80 countries for the current...
Irisin attenuates liver fibrosis by regulating energy metabolism and HMGB1/β-catenin signaling in hepatic stellate cells
Liver fibrosis, characterized by excessive accumulation of extracellular matrix proteins, represents a critical pathologic...
Relaxing effect of ramelteon on the uterus of non-pregnant and pregnant rats: Importance of melatonin receptors and BKCa
Melatonin is produced and released by pineal gland into the bloodstream in response to a hypothalamic circadian clock. All...
Melatonin induces urethral contraction and increases intraurethral pressure via MT1 receptor activation in female rats
The hormone melatonin is primarily produced by the pineal gland and released into blood circulation during the dark period...
Nicotinic acid increases adipose tissue dietary fatty acid trapping and reduces postprandial hepatic and cardiac fatty acid uptake in prediabetes
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 or its licensors and contributor...
Cath-HG exhibits anti-acne activities via multiple mechanisms
Acne vulgaris is one of the most prevalent dermatological conditions worldwide, which is characterized by androgen-induced...
Erythromycin repurposing for hepatocellular carcinoma treatment: Targeting CD24 to enhance anti-tumor immunity
Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancers and is the third leading cause of cancer-related ...
Evolocumab ameliorates myocardial fibrosis and improves metabolic syndrome–induced cardiac dysfunction in rats via inhibiting PCSK9/NLRP3 inflammasome and Caspase-1 / IL-1β pathways
Metabolic syndrome (syndrome X, MetS) is a multifactorial disease with multiple risk factors that arises from insulin resi...
Impact of sodium butyrate on stroke-related intestinal injury in diabetic mice: Interference with Caspase-1/GSDMD pyroptosis pathway and preservation of intestinal barrier
Stroke remains a significant global health challenge, causing 93.8 million prevalent cases and 11.9 million incident strok...
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