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Parecoxib sodium attenuates acute lung injury following burns by regulating M1/M2 macrophage polarization through the TLR4/NF-κB pathway
Parecoxib sodium attenuates acute lung injury following burns by regulating M1/M2 macrophage polarization through the TLR4/NF-κB pathway
Burn injury is a devastating injury that functionally affects multiple organ systems, including the lungs, and is one of t...
Ginsenoside Rg1 promotes fetal hemoglobin production in vitro: A potential therapeutic avenue for β-thalassemia
Ginsenoside Rg1 promotes fetal hemoglobin production in vitro: A potential therapeutic avenue for β-thalassemia
β-thalassemia, a globally prevalent genetic disorder, urgently requires innovative treatment options. Fetal hemoglobin (Hb...
Contribution of chemical and electrical transmission to the low delta-like intrinsic retinal oscillation in mice: A role for daylight-activated neuromodulators
Contribution of chemical and electrical transmission to the low delta-like intrinsic retinal oscillation in mice: A role for daylight-activated neuromodulators
While the first evidence of spontaneous oscillatory activity in the central nervous system dates back almost 150 years (Ad...
Tenacissoside H repressed the progression of glioblastoma by inhibiting the PI3K/Akt/mTOR signaling pathway
Tenacissoside H repressed the progression of glioblastoma by inhibiting the PI3K/Akt/mTOR signaling pathway
Glioma, the most lethal malignant tumor in the central nervous system (CNS), is well-known for its difficulty in treatment...
Ruxolitinib attenuates microglial inflammatory response by inhibiting NF-κB/MAPK signaling pathway
Ruxolitinib attenuates microglial inflammatory response by inhibiting NF-κB/MAPK signaling pathway
Neuroinflammation is a self-defensive response of the central nervous system (CNS) to factors that interfere with its home...
Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification
Regulation mechanisms of sea cucumber peptides against scopolamine-induced memory disorder and novel memory-improving peptides identification
Memory impairment is a common sub-health condition mainly induced by stress, unhealthy eating habits, aging, physical inju...
Catalpol alleviates hypoxia ischemia-induced brain damage by inhibiting ferroptosis through the PI3K/NRF2/system Xc-/GPX4 axis in neonatal rats
Catalpol alleviates hypoxia ischemia-induced brain damage by inhibiting ferroptosis through the PI3K/NRF2/system Xc-/GPX4 axis in neonatal rats
KeywordsHypoxic-ischemic encephalopathyCatalpolFerroptosisPI3K/NRF2/System Xc-/GPX4 axisAbbreviationsHIEhypoxic ischemic e...
Inhibition of Alzheimer's disease by 4-octyl itaconate revealed by RNA-seq transcriptome analysis
Inhibition of Alzheimer's disease by 4-octyl itaconate revealed by RNA-seq transcriptome analysis
Alzheimer's disease (AD) is a multi-factor neurodegenerative disease characterized by the deposition of amyloid plaques in...
Tet1/DLL3/Notch1 signal pathway affects hippocampal neurogenesis and regulates depression-like behaviour in mice
Tet1/DLL3/Notch1 signal pathway affects hippocampal neurogenesis and regulates depression-like behaviour in mice
Major depressive disorder (MDD) is a major public health concern affecting 30 billion people worldwide (Deussing and Arzt,...
Effects of nitrous oxide and ketamine on electrophysiological and molecular responses in the prefrontal cortex of mice: A comparative study
Effects of nitrous oxide and ketamine on electrophysiological and molecular responses in the prefrontal cortex of mice: A comparative study
KeywordsDual specificity phosphatases (DUSPs)KetamineMitogen-activated protein kinases (MAPKs)Nitrous oxideMedial prefront...
Terazosin attenuates abdominal aortic aneurysm formation by downregulating Peg3 expression to inhibit vascular smooth muscle cell apoptosis and senescence
Terazosin attenuates abdominal aortic aneurysm formation by downregulating Peg3 expression to inhibit vascular smooth muscle cell apoptosis and senescence
Abdominal aortic aneurysm (AAA), a vascular degenerative disease, is a potentially life-threatening condition characterise...
Suramin inhibits phenotypic transformation of vascular smooth muscle cells and neointima hyperplasia by suppressing transforming growth factor beta receptor 1 /Smad2/3 pathway activation
Suramin inhibits phenotypic transformation of vascular smooth muscle cells and neointima hyperplasia by suppressing transforming growth factor beta receptor 1 /Smad2/3 pathway activation
It is widely acknowledged that cardiovascular diseases constitute the leading cause of global mortality (Bikbov et al., 20...
Tetrahydroberberine alleviates high-fat diet-induced hyperlipidemia in mice via augmenting lipoprotein assembly-induced clearance of low-density lipoprotein and intermediate-density lipoprotein
Tetrahydroberberine alleviates high-fat diet-induced hyperlipidemia in mice via augmenting lipoprotein assembly-induced clearance of low-density lipoprotein and intermediate-density lipoprotein
Hyperlipidemia, a metabolic disorder, is considered a risk factor for cardiovascular and cerebrovascular diseases (Xie et ...
SIRT6-mediated Runx2 downregulation inhibits osteogenic differentiation of human aortic valve interstitial cells in calcific aortic valve disease
SIRT6-mediated Runx2 downregulation inhibits osteogenic differentiation of human aortic valve interstitial cells in calcific aortic valve disease
Calcific aortic valve disease (CAVD) is a progressive cardiovascular disorder involving multiple pathogenesis. Effective p...
Phenanthroline relaxes uterine contractions induced by diverse contractile agents by decreasing cytosolic calcium concentration
Phenanthroline relaxes uterine contractions induced by diverse contractile agents by decreasing cytosolic calcium concentration
Appropriate uterine contraction is vital for normal reproduction, encompassing processes that include menstruation, embryo...
Protective effects of Prussian blue nanozyme against sepsis-induced acute lung injury by activating HO-1
Protective effects of Prussian blue nanozyme against sepsis-induced acute lung injury by activating HO-1
Sepsis is a serious global medical issue with high mortality in intensive care units, and can cause dysfunction in multipl...
Metformin improves obesity-related oligoasthenospermia via regulating the expression of HSL in testis in mice
Metformin improves obesity-related oligoasthenospermia via regulating the expression of HSL in testis in mice
Obesity is a pathological condition resulting from an excessive accumulation of fat. With the prevalence of unhealthy life...
A peripheral blood mononuclear cell-based in vitro model: A tool to explore indoleamine 2, 3-dioxygenase-1 (IDO1)
A peripheral blood mononuclear cell-based in vitro model: A tool to explore indoleamine 2, 3-dioxygenase-1 (IDO1)
BackgroundProinflammatory cytokines powerfully induce the rate-limiting enzyme indoleamine 2, 3-dioxygenase-1 (IDO-1) in d...
Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling
Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling
G protein-coupled receptors (GPCRs) are transmembrane domain proteins. GPCRs activate G protein (Gαs/Gαi/Gαq, Gβγ complex)...
Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs
Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs
CCR4 and CD25 are highly expressed on the surface of cutaneous T-cell lymphoma (CTCL). The two receptors can be used for t...
Celastrol, which targets IL-2/CD25 binding inhibition, induces T cell-mediated antitumor activity in melanoma
Celastrol, which targets IL-2/CD25 binding inhibition, induces T cell-mediated antitumor activity in melanoma
Melanoma is the most aggressive skin cancer and tends to metastasize to other tissues; therefore appropriate treatment in ...
Protective effect of the natural flavonoid naringenin in mouse models of retinal injury
Protective effect of the natural flavonoid naringenin in mouse models of retinal injury
One of the most common causes of irreversible blindness worldwide is glaucoma, which is characterized by cupping or excava...
Beyond neuromuscular activity: botulinum toxin type A exerts direct central action on spinal control of movement
Beyond neuromuscular activity: botulinum toxin type A exerts direct central action on spinal control of movement
Used as a pharmaceutical-grade purified low dose preparation, botulinum neurotoxin serotype A (BoNT-A) is employed in vari...
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of Aβ1-42 and tau through regulation of PI3K/Akt signaling pathway
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of Aβ1-42 and tau through regulation of PI3K/Akt signaling pathway
Alzheimer's disease (AD), a common neurodegenerative disease, is characterized by a progressive decline in both cognitive ...
Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats
Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats
Our previous study reported that the heterodimer of Angiotensin II Type I Receptor (AT1R) and Mu-Opioid Receptor 1 (MOR1) ...
Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways
Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways
Myocardial remodeling, which is a widely recognized independent risk factor for cardiac events (Xie et al., 2022; Yin et a...
maresin2 fine-tunes ULK1 O-GlcNAcylation to improve post myocardial infarction remodeling
maresin2 fine-tunes ULK1 O-GlcNAcylation to improve post myocardial infarction remodeling
Myocardial infarction with a pathogenic basis of thrombosis or vascular occlusion remains a global medical concern charact...
OXM-104, a potential candidate for the treatment of obesity, NASH and type 2 diabetes
OXM-104, a potential candidate for the treatment of obesity, NASH and type 2 diabetes
Non-alcoholic fatty liver disease (NAFLD) is an umbrella term representing two subtypes: non-alcoholic fatty liver and non...
Targets, trials and tribulations in Alzheimer therapeutics
Targets, trials and tribulations in Alzheimer therapeutics
Developing disease-modifying drugs for the treatment of neurodegenerative dis-eases such as Alzheimer's disease (AD) has t...
Vanin1 (VNN1) in chronic diseases: Future directions for targeted therapy
Vanin1 (VNN1) in chronic diseases: Future directions for targeted therapy
Vanin1 (VNN1) is an exogenous enzyme with pantetheinase activity that mainly exerts physiological functions through enzyme...
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