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Discovery of potent anti-MRSA components from Dalbergia odorifera through UPLC-Q-TOF-MS and targeting PBP2a protein through in-depth transcriptomic, in vitro, and in-silico studies
Discovery of potent anti-MRSA components from Dalbergia odorifera through UPLC-Q-TOF-MS and targeting PBP2a protein through in-depth transcriptomic, in vitro, and in-silico studies
Available online 23 January 2024Author links open overlay panel, , , , , , Highlights•Dalbergia Odorifera heartwood extrac...
PEG-PLGA nanoparticles deposited in Pseudomonas aeruginosa and Burkolderia cenocepacia
PEG-PLGA nanoparticles deposited in Pseudomonas aeruginosa and Burkolderia cenocepacia
Available online 26 January 2024Author links open overlay panel, , , , , , Highlights•Tracking deposition of organic nanop...
Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells
Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells
Inhibiting the death receptor 3 (DR3) signaling pathway in group 3 innate lymphoid cells (ILC3s) presents a promising appr...
Melatonin enhances the efficacy of anti-PD-L1 by improving hypoxia in residual tumors after insufficient radiofrequency ablation
Melatonin enhances the efficacy of anti-PD-L1 by improving hypoxia in residual tumors after insufficient radiofrequency ablation
The hypoxic microenvironment and inflammatory state of residual tumors caused by insufficient radiofrequency ablation (iRF...
In situ repolarization of Tumor-Associated Macrophages with synergic nanoformulation to reverse immunosuppressive TME in mouse breast cancer for cancer therapy
In situ repolarization of Tumor-Associated Macrophages with synergic nanoformulation to reverse immunosuppressive TME in mouse breast cancer for cancer therapy
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Dual mass spectrometry imaging and spatial metabolomics to investigate the metabolism and nephrotoxicity of nitidine chloride
Dual mass spectrometry imaging and spatial metabolomics to investigate the metabolism and nephrotoxicity of nitidine chloride
Evaluating toxicity and decoding the underlying mechanisms of active compounds are crucial for drug development. In this s...
A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by Autodisplay-based screening
A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by Autodisplay-based screening
Available online 5 February 2024Author links open overlay panel, , , , , , , , , , , , Highlights•Surface display of ligan...
Natural compounds improve diabetic nephropathy by regulating the TLR4 signaling pathway
Natural compounds improve diabetic nephropathy by regulating the TLR4 signaling pathway
Diabetic nephropathy (DN), a severe complication of diabetes, is widely recognized as a primary contributor to end-stage r...
Global hotspots and future directions for drugs to improve the skin flap survival: A bibliometric and visualized review
Global hotspots and future directions for drugs to improve the skin flap survival: A bibliometric and visualized review
Available online 6 February 2024Author links open overlay panel, , , , , , , Highlights•The bibliometric method was used t...
Bio-soft matter derived from traditional Chinese medicine: characterizations of hierarchical structure, assembly mechanism, and beyond
Bio-soft matter derived from traditional Chinese medicine: characterizations of hierarchical structure, assembly mechanism, and beyond
Structural and functional explorations on bio-soft matter such as micelles, vesicles, nanoparticles, aggregates or polymer...
Non-coding RNAs as therapeutic targets in cancer and its clinical application
Non-coding RNAs as therapeutic targets in cancer and its clinical application
Available online 8 February 2024Author links open overlay panel, , , , , , , , , , , Highlights•The classification, synthe...
Automated and integrated ultrahigh throughput industrial strain screening enabled by acoustic-droplet-ejection mass spectrometry
Automated and integrated ultrahigh throughput industrial strain screening enabled by acoustic-droplet-ejection mass spectrometry
Available online 10 February 2024Author links open overlay panel, , , , , , , , , , Highlights•UTPA, with ADE-OPI-MS and s...
MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer
MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer
Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer (...
IR-EcoSpectra: Exploring sustainable ex situ and in situ FTIR applications for green chemical and pharmaceutical analysis
IR-EcoSpectra: Exploring sustainable ex situ and in situ FTIR applications for green chemical and pharmaceutical analysis
In various industries, particularly the chemical and pharmaceutical fields, Fourier transform infrared spectroscopy (FTIR)...
β-glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects
β-glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects
Particle size and surface properties are crucial for lymphatic drainage (LN), dendritic cell (DC) uptake, DC maturation, a...
Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy
Signal interference between drugs and metabolites in LC-ESI-MS quantitative analysis and its evaluation strategy
Liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS) is a widely utilized technique for in v...
Multiple roles of arsenic compounds in phase separation and membraneless organelles formation determine their therapeutic efficacy in tumors
Multiple roles of arsenic compounds in phase separation and membraneless organelles formation determine their therapeutic efficacy in tumors
Available online 24 February 2024Author links open overlay panel, , , , , , , Highlights•ATO induces PML-RARa degradation ...
An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy
An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy
Available online 27 February 2024Author links open overlay panel, , , , , , Highlights•We synthesized an Fe-Cu bimetallic ...
Oxalate regulates crystal-cell adhesion and macrophage metabolism via JPT2/PI3K/AKT signaling to promote the progression of kidney stones
Oxalate regulates crystal-cell adhesion and macrophage metabolism via JPT2/PI3K/AKT signaling to promote the progression of kidney stones
Available online 27 February 2024Author links open overlay panel, , , , , , , , , , Highlights•Oxalate exposure increases ...
Recent Trends and Impact of Localized Surface Plasmon Resonance (LSPR) and Surface-Enhanced Raman Spectroscopy (SERS) in Modern Analysis
Recent Trends and Impact of Localized Surface Plasmon Resonance (LSPR) and Surface-Enhanced Raman Spectroscopy (SERS) in Modern Analysis
An optical biosensor is a specialized analytical device that utilizes the principles of optics and light bimolecular proce...
GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation
GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Many medical conditions, including hypertension, diabetes,...
Model informed Precision Medicine of Chinese Herbal Medicines Formulas- A Multi-scale Mechanistic Intelligent Model
Model informed Precision Medicine of Chinese Herbal Medicines Formulas- A Multi-scale Mechanistic Intelligent Model
Recent trends suggest that Chinese herbal medicine formulas (CHM formulas) are promising treatments for complex diseases. ...
Basic Regulatory Science Behind Drug Substance and Drug Product Specifications of Monoclonal Antibodies and Other Protein Therapeutics
Basic Regulatory Science Behind Drug Substance and Drug Product Specifications of Monoclonal Antibodies and Other Protein Therapeutics
In this review, we focus on providing basics and examples for each component of the protein therapeutic specifications to ...
Traditional Chinese Medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signaling
Traditional Chinese Medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signaling
Available online 10 December 2023Author links open overlay panel, , , , , , , , , , , Highlights•PZH ameliorates LPS-induc...
MEOX2 promotes glioma growth and temozolomide chemoresistance
MEOX2 promotes glioma growth and temozolomide chemoresistance
Available online 10 December 2023Author links open overlay panel, , , , , , , , , Highlights•MEOX2 correlates with glioma ...
Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice
Alginate oligosaccharide-mediated butyrate-HIF-1α axis improves skin aging in mice
Available online 8 December 2023Author links open overlay panel, , , Highlights•Alginate oligosaccharide-mediated gut-skin...
Sonodynamic therapy for the treatment of atherosclerosis
Sonodynamic therapy for the treatment of atherosclerosis
Available online 29 November 2023Author links open overlay panel, , , , , , , , , Highlights•Sonodynamic therapy, as a non...
Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis
Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis
Liver fibrosis is primarily driven by the activation of hepatic stellate cells (HSCs), a process associated with ferroptos...
An integrated strategy of UPLC-Q-TOF/MS and HPTLC/PAD-DESI-MSI for the analysis of chemical variations: A case study of Tibetan medicine Tiebangchui
An integrated strategy of UPLC-Q-TOF/MS and HPTLC/PAD-DESI-MSI for the analysis of chemical variations: A case study of Tibetan medicine Tiebangchui
Available online 29 November 2023Author links open overlay panel, , , , Highlights•An integrated strategy was established ...
Apatinib and gamabufotalin co-loaded lipid/prussian blue nanoparticles for synergistic therapy to gastric cancer with metastasis
Apatinib and gamabufotalin co-loaded lipid/prussian blue nanoparticles for synergistic therapy to gastric cancer with metastasis
Due to the non-targeted release and low solubility of anti-gastric cancer agent, apatinib (Apa), a first-line drug with lo...
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