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Proansamycin B derivatives from the post-PKS modification gene deletion mutant of Amycolatopsis mediterranei S699
Proansamycin B derivatives from the post-PKS modification gene deletion mutant of Amycolatopsis mediterranei S699
Ten new proansamycin B congeners (1–10) together with one known (11) were isolated and characterized on the basis of...
New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292
New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292
Two new antimalarial compounds, named prenylpyridones A (1) and B (2), were discovered from the actinomycete cultured mate...
Biofilm formation and antimicrobial resistance pattern of uropathogenic E. coli ST131 isolated from children with malignant tumors
Biofilm formation and antimicrobial resistance pattern of uropathogenic E. coli ST131 isolated from children with malignant tumors
The multidrug-resistant clone identified as Escherichia coli sequence type 131 (E. coli ST131) has spread world-wide. This...
In vitro and ex vivo activity of the fluoroquinolone DC-159a against mycobacteria
In vitro and ex vivo activity of the fluoroquinolone DC-159a against mycobacteria
Antimicrobial resistance is a global health problem. In 2021, it was estimated almost half a million of multidrug-resistan...
Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds
Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds
The biosynthetic gene clusters (BGCs) for the macrocyclic lactone-based polyketide compounds are extremely large-sized bec...
Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa
Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa
The emergence and spread of antimicrobial resistance are global threats. Pseudomonas aeruginosa (P. aeruginosa) is respons...
Correlation between the spread of IMP-producing bacteria and the promoter strength of blaIMP genes
Correlation between the spread of IMP-producing bacteria and the promoter strength of blaIMP genes
The first report of transmissible carbapenem resistance encoded by blaIMP-1 was discovered in Pseudomonas aeruginosa GN172...
Pharmacokinetics, tissue distribution, bioavailability and excretion of the anti-virulence drug Fluorothiazinon in rats and rabbits
Pharmacokinetics, tissue distribution, bioavailability and excretion of the anti-virulence drug Fluorothiazinon in rats and rabbits
Growing antimicrobial resistance has accelerated the development of anti-virulence drugs to suppress bacterial toxicity wi...
Anti-microbial efficacy of l-glutaminase (EC 3.5.1.2) against multidrug-resistant Pseudomonas aeruginosa infection
Anti-microbial efficacy of l-glutaminase (EC 3.5.1.2) against multidrug-resistant Pseudomonas aeruginosa infection
The aims of this study were isolation-purification and characterization of l-glutaminase from L. gasseri BRLHM clinical is...
Antimicrobial resistance rates of urogenital Mycoplasma hominis and Ureaplasma species before and during the COVID-19 pandemic: results from a Greek survey, 2014 to 2022
Antimicrobial resistance rates of urogenital Mycoplasma hominis and Ureaplasma species before and during the COVID-19 pandemic: results from a Greek survey, 2014 to 2022
The prevalence of antibiotic-resistant urogenital mycoplasmas and ureaplasmas has been gradually increasing over the years...
Remembering Dr. Shinichi Kondo (15 June 1928–8 October 2022)
Remembering Dr. Shinichi Kondo (15 June 1928–8 October 2022)
Dr. Shinichi Kondo, an Emeritus Member of the Journal of Antibiotics, died on October 8, 2022 at his ...
Chromatin-modifying protein 4C (CHMP4C) affects breast cancer cell growth and doxorubicin resistance as a potential breast cancer therapeutic target
Chromatin-modifying protein 4C (CHMP4C) affects breast cancer cell growth and doxorubicin resistance as a potential breast cancer therapeutic target
Breast cancer (BCa) is one of the common malignancies among women. Doxorubicin (Dox), a type of anthracycline anti-tumor d...
Retraction Note: Molecular docking simulation, drug-likeness assessment, and pharmacokinetic study of some cephalosporin analogues against a penicillin-binding protein of Salmonella typhimurium
Retraction to: The Journal of AntibioticsThe Editor-in-chief has retracted this article because after the publication of t...
Two new adenopeptins B and C inhibit sphere formation of pancreatic cancer cells
Two new adenopeptins B and C inhibit sphere formation of pancreatic cancer cells
Cancer remains one of the leading causes of death worldwide, particularly pancreatic cancer being lethal because of its ag...
Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1
Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1
A set of triterpene A-ring hydroxymethylene-amino-derivatives was synthesized and their antiviral activity was studied. Th...
Catenulopyrizomicins, new anti-Hepatitis B virus compounds, from the rare actinomycete Catenuloplanes sp. MM782L-181F7
Catenulopyrizomicins, new anti-Hepatitis B virus compounds, from the rare actinomycete Catenuloplanes sp. MM782L-181F7
Hepatitis B virus (HBV) causes chronic hepatitis in humans, and current antiviral therapies rarely treat viral infections....
Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis
Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis
Cancer cells including colorectal cancer cells are resistant to anoikis, an anchorage-independent programmed death, which ...
Correction: Antibiotics in the clinical pipeline as of December 2022
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Antiviral potency of lupane and oleanane alkynyl-derivatives against human cytomegalovirus and papillomavirus
Antiviral potency of lupane and oleanane alkynyl-derivatives against human cytomegalovirus and papillomavirus
A library of 18 structurally diverse semisynthetic lupane, oleanane, and ursane types triterpenoids, including C19- or C28...
Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation
Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation
We screened a library of microbial extracts and compounds library using our constructed assay cells and found pulicatins F...
Identification of siderophores blocking infection of Pseudomonas aeruginosa from Kitasatospora sp. LS1784
Identification of siderophores blocking infection of Pseudomonas aeruginosa from Kitasatospora sp. LS1784
Siderophores are low-molecular-mass, high-affinity chelators of Fe3+ ions that are critical for the survival of bacteria i...
Bioactive ambuic acid congeners from endophytic fungus Pestalotiopsis trachicarpicola SC-J551
Bioactive ambuic acid congeners from endophytic fungus Pestalotiopsis trachicarpicola SC-J551
New ambuic acid derivatives, pestallic acids R–V (1−5), together with ambuic acid (6), were isolated from the ...
A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides
A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides
Three new compounds, including one steroid named penivariod A (1) and two polyketides penivarides A and B (2 and 3), as we...
Potent Rifampicin derivatives can clear MRSA infections at single low doses when concomitantly dosed with Vancomycin
Potent Rifampicin derivatives can clear MRSA infections at single low doses when concomitantly dosed with Vancomycin
For a number of years, antimicrobial resistance (AMR) has been a critical issue for humanity. Drug discovery efforts have ...
Eleuthemarins A and B, two new isocoumarin derivatives from the Arctic fungus Eleutheromyces sp. CPCC 401592
Eleuthemarins A and B, two new isocoumarin derivatives from the Arctic fungus Eleutheromyces sp. CPCC 401592
Two new isocoumarin derivatives, eleuthemarins A (1) and B (2), were isolated from the Arctic fungus Eleutheromyces sp. CP...
Formanilides from the culture broth of Perenniporia fraxinea
Formanilides from the culture broth of Perenniporia fraxinea
A new formanilide dimer, fraxinin (1), and three known formanilides (2‒4) were isolated from the culture broth of Pe...
Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242
Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242
Two new nonadride derivatives, namely, talarodrides G and H (1 and 2), and one new depsidone derivative, botryorhodine K (...
Unveiling synergism of polymyxin B with chloramphenicol derivatives against multidrug-resistant (MDR) Klebsiella pneumoniae
Unveiling synergism of polymyxin B with chloramphenicol derivatives against multidrug-resistant (MDR) Klebsiella pneumoniae
Polymyxins are last-line antibiotics against multidrug-resistant Klebsiella pneumoniae but using polymyxins alone may not ...
Rv1255c, a dormancy-related transcriptional regulator of TetR family in Mycobacterium tuberculosis, enhances isoniazid tolerance in Mycobacterium smegmatis
Rv1255c, a dormancy-related transcriptional regulator of TetR family in Mycobacterium tuberculosis, enhances isoniazid tolerance in Mycobacterium smegmatis
Mycobacterium tuberculosis is exposed to diverse stresses inside the host during dormancy. Meanwhile, many metabolic and t...
Two new diketopiperazines from the Cordyceps fungus Samsoniella sp. XY4
Two new diketopiperazines from the Cordyceps fungus Samsoniella sp. XY4
Two new diketopiperazines, namely samsoniellain A (1) and samsoniellain B (2), together with two known compounds (3, 4) we...
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