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N-methyladenosine (mA) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N-methyladenosine (mA) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N6-methyladenosine (m6A) modification is, a more common epigenetic modification, mainly found in mRNA. More and more resea...
Modifications of the respiratory chain of as an alkalophilic and cyanide-degrading microorganism
Modifications of the respiratory chain of as an alkalophilic and cyanide-degrading microorganism
Bacillus licheniformis can use cyanide as a nitrogen source for its growth. However, it can also carry out aerobic respira...
TRIM46 accelerates H1N1 influenza virus-induced ferroptosis and inflammatory response by regulating SLC7A11 ubiquitination
TRIM46 accelerates H1N1 influenza virus-induced ferroptosis and inflammatory response by regulating SLC7A11 ubiquitination
Influenza A (H1N1) virus is an acute respiratory infection responsible for enormous morbidity and mortality worldwide. The...
LncRNA UCA1 enhances NRF2 expression through the mA pathway to mitigate oxidative stress and ferroptosis in aging cardiomyocytes
LncRNA UCA1 enhances NRF2 expression through the mA pathway to mitigate oxidative stress and ferroptosis in aging cardiomyocytes
To explore the regulatory mechanism of lncRNA UCA1 and NRF2 in cardiomyocyte aging. In this study, we explored how lncRNA ...
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress
Oxidative stress-induced lens epithelial cells (LECs) death plays a pivotal role in pathogenesis of age-related cataract (...
Acute CCl-induced intoxication reduces complex I, but not complex II-based mitochondrial bioenergetics – protective role of succinate
Acute CCl-induced intoxication reduces complex I, but not complex II-based mitochondrial bioenergetics – protective role of succinate
The main therapeutic strategy for the treatment of patients with toxic liver failure is the elimination of the toxic agent...
Nigericin modifies the mechanism of the uncoupling action of bile acids in rat liver mitochondria by converting ΔpH into Δψ
Nigericin modifies the mechanism of the uncoupling action of bile acids in rat liver mitochondria by converting ΔpH into Δψ
Cholestasis caused by impaired bile secretion in the liver is associated with the accumulation of primary bile acids (BA):...
Sirt6 regulates the Notch signaling pathway and mediates autophagy and regulates podocyte damage in diabetic nephropathy
Sirt6 regulates the Notch signaling pathway and mediates autophagy and regulates podocyte damage in diabetic nephropathy
To investigate the role of silent information regulator 6 (SIRT6) in regulating podocyte injury in diabetic nephropathy (D...
Amyloid beta (Aβ) fibrillation kinetics and its impact on membrane polarity
Amyloid beta (Aβ) fibrillation kinetics and its impact on membrane polarity
Fibrillation of the amyloid beta (Aβ) peptide has often been associated with neurodegenerative pathologies such as Al...
Lithium compromises the bioenergetic reserve of cardiomyoblasts mitochondria
Lithium compromises the bioenergetic reserve of cardiomyoblasts mitochondria
Lithium is used in the long-term treatment of bipolar disorder, exhibiting a beneficial effect on the neuronal cells. The ...
Mitochondrial glutamic-oxaloacetic transaminase (GOT2) in the growth of C2C12 myoblasts
Mitochondrial glutamic-oxaloacetic transaminase (GOT2) in the growth of C2C12 myoblasts
Glutamine is well recognized as critical to the growth of most cell types. Within mitochondria glutamine is converted to g...
METTL3 mediates CPB1 expression by regulating transcription factor BACH2 to promote apoptosis and oxidative stress of lens epithelial cells
METTL3 mediates CPB1 expression by regulating transcription factor BACH2 to promote apoptosis and oxidative stress of lens epithelial cells
Background: Cataracts are a significant cause of vision loss, adversely affecting the quality of human life. Numerous stud...
Dexmedetomidine activates mitophagy and protects against pyroptosis in oxygen-glucose deprivation/reperfusion-induced brain damage PINK1/Parkin pathway activation
Dexmedetomidine activates mitophagy and protects against pyroptosis in oxygen-glucose deprivation/reperfusion-induced brain damage PINK1/Parkin pathway activation
Accumulating studies have unraveled that dexmedetomidine (DEX) is neuroprotective against brain damage. However, it remain...
Anti-inflammatory effects of Esomeprazole in septic lung injury by mediating endoplasmic reticulum stress
Anti-inflammatory effects of Esomeprazole in septic lung injury by mediating endoplasmic reticulum stress
Acute lung injury characterized by overactive pulmonary inflammation is a common and serious complication of sepsis. Esome...
Targeting hypoxia-induced HIF-1α/JMJD3/Notch axis in gastric cancer therapy
Targeting hypoxia-induced HIF-1α/JMJD3/Notch axis in gastric cancer therapy
Hypoxia has been reported to induce high expression of HIF-1α in multiple cancer tissues, and HIF-1α significant...
KunMingShanHaiTang formula reprograms macrophage metabolism and promotes M2 polarization via the HIF-1α pathway to alleviate ulcerative colitis symptoms in a rat model
KunMingShanHaiTang formula reprograms macrophage metabolism and promotes M2 polarization via the HIF-1α pathway to alleviate ulcerative colitis symptoms in a rat model
The KunMingShanHaiTang Formula (KMSHTF), adjusted by Professor Zhong Chuanhua for the treatment of ulcerative colitis (UC)...
The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer
The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer
Otto Warburg originally proposed that cancer arose from a two-step process. The first step involved a chronic insufficienc...
Mechanism of LncRNA CBR3-AS1 in regulating pyroptosis of intestinal epithelial cells in ulcerative colitis
Mechanism of LncRNA CBR3-AS1 in regulating pyroptosis of intestinal epithelial cells in ulcerative colitis
Ulcerative colitis (UC) is a common chronic relapsing inflammatory disease that threatens human life. This study aims to e...
Differences in metabolite profiling by cold atmospheric plasma in normal and cancer cells
Differences in metabolite profiling by cold atmospheric plasma in normal and cancer cells
Cold atmospheric plasma (CAP) recently it has been introduced as an innovative therapeutic approach for cancer cell treatm...
Dexmedetomidine mitigates lidocaine-induced spinal cord injury by repressing ferritinophagy-mediated ferroptosis by increasing CISD2 expression in rat models
Dexmedetomidine mitigates lidocaine-induced spinal cord injury by repressing ferritinophagy-mediated ferroptosis by increasing CISD2 expression in rat models
Dexmedetomidine (DEX) has been confirmed to exert neuroprotective effects in various nerve injury models by regulating fer...
The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta
The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta
The current study explored melatonin (MEL) and its receptors, including MEL type 1 receptor (MT1) receptor and MEL type 2 ...
Reduction in mitochondrial ATP synthesis mimics the effect of low glucose in depolarizing neurons from the subpostremal nucleus of the solitary tract of rats
Reduction in mitochondrial ATP synthesis mimics the effect of low glucose in depolarizing neurons from the subpostremal nucleus of the solitary tract of rats
Neurons of the subpostremal nucleus of the solitary tract (NTS) respond to changes in extracellular glucose with alteratio...
WTAP promotes fibroblast-like synoviocyte pyroptosis in Rheumatoid arthritis by upregulating N6-methyladenosine modification of NLRP3
WTAP promotes fibroblast-like synoviocyte pyroptosis in Rheumatoid arthritis by upregulating N6-methyladenosine modification of NLRP3
Rheumatoid arthritis (RA) is a chronic condition characterized by inflammation and an abnormal immune response. N6-methyla...
The effect of intra spinal administration of cerium oxide nanoparticles on central pain mechanism: An experimental study
The effect of intra spinal administration of cerium oxide nanoparticles on central pain mechanism: An experimental study
This study investigated Cerium oxide nanoparticles (CeONPs) effect on central neuropathic pain (CNP). The compressive meth...
NFS1 inhibits ferroptosis in gastric cancer by regulating the STAT3 pathway
NFS1 inhibits ferroptosis in gastric cancer by regulating the STAT3 pathway
Cysteine desulfurase (NFS1) is highly expressed in a variety of tumors, which is closely related to ferroptosis of tumor c...
CircRNA Arf3 suppresses glomerular mesangial cell proliferation and fibrosis in diabetic nephropathy via miR-107-3p/Tmbim6 axis
CircRNA Arf3 suppresses glomerular mesangial cell proliferation and fibrosis in diabetic nephropathy via miR-107-3p/Tmbim6 axis
Diabetic nephropathy (DN) is one of microvascular complication associated with diabetes. Circular RNAs (circRNAs) have bee...
N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N6-methyladenosine (m6A) modification is, a more common epigenetic modification, mainly found in mRNA. More and more resea...
Modifications of the respiratory chain of Bacillus licheniformis as an alkalophilic and cyanide-degrading microorganism
Modifications of the respiratory chain of Bacillus licheniformis as an alkalophilic and cyanide-degrading microorganism
Bacillus licheniformis can use cyanide as a nitrogen source for its growth. However, it can also carry out aerobic respira...
WTAP-mediated N6-methyladenosine modification promotes the inflammation, mitochondrial damage and ferroptosis of kidney tubular epithelial cells in acute kidney injury by regulating LMNB1 expression and activating NF-κB and JAK2/STAT3 pathways
WTAP-mediated N6-methyladenosine modification promotes the inflammation, mitochondrial damage and ferroptosis of kidney tubular epithelial cells in acute kidney injury by regulating LMNB1 expression and activating NF-κB and JAK2/STAT3 pathways
Acute kidney injury (AKI) is a serious complication of sepsis patients, but the pathogenic mechanisms underlying AKI are s...
DSC and FTIR study on the interaction between pentacyclic triterpenoid lupeol and DPPC membrane
DSC and FTIR study on the interaction between pentacyclic triterpenoid lupeol and DPPC membrane
Natural products are a great resource for physiologically active substances. It is widely recognized that a major percenta...
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