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Dexmedetomidine mitigates lidocaine-induced spinal cord injury by repressing ferritinophagy-mediated ferroptosis by increasing CISD2 expression in rat models
Dexmedetomidine mitigates lidocaine-induced spinal cord injury by repressing ferritinophagy-mediated ferroptosis by increasing CISD2 expression in rat models
Dexmedetomidine (DEX) has been confirmed to exert neuroprotective effects in various nerve injury models by regulating fer...
The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta
The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta
The current study explored melatonin (MEL) and its receptors, including MEL type 1 receptor (MT1) receptor and MEL type 2 ...
Reduction in mitochondrial ATP synthesis mimics the effect of low glucose in depolarizing neurons from the subpostremal nucleus of the solitary tract of rats
Reduction in mitochondrial ATP synthesis mimics the effect of low glucose in depolarizing neurons from the subpostremal nucleus of the solitary tract of rats
Neurons of the subpostremal nucleus of the solitary tract (NTS) respond to changes in extracellular glucose with alteratio...
WTAP promotes fibroblast-like synoviocyte pyroptosis in Rheumatoid arthritis by upregulating N6-methyladenosine modification of NLRP3
WTAP promotes fibroblast-like synoviocyte pyroptosis in Rheumatoid arthritis by upregulating N6-methyladenosine modification of NLRP3
Rheumatoid arthritis (RA) is a chronic condition characterized by inflammation and an abnormal immune response. N6-methyla...
The effect of intra spinal administration of cerium oxide nanoparticles on central pain mechanism: An experimental study
The effect of intra spinal administration of cerium oxide nanoparticles on central pain mechanism: An experimental study
This study investigated Cerium oxide nanoparticles (CeONPs) effect on central neuropathic pain (CNP). The compressive meth...
NFS1 inhibits ferroptosis in gastric cancer by regulating the STAT3 pathway
NFS1 inhibits ferroptosis in gastric cancer by regulating the STAT3 pathway
Cysteine desulfurase (NFS1) is highly expressed in a variety of tumors, which is closely related to ferroptosis of tumor c...
CircRNA Arf3 suppresses glomerular mesangial cell proliferation and fibrosis in diabetic nephropathy via miR-107-3p/Tmbim6 axis
CircRNA Arf3 suppresses glomerular mesangial cell proliferation and fibrosis in diabetic nephropathy via miR-107-3p/Tmbim6 axis
Diabetic nephropathy (DN) is one of microvascular complication associated with diabetes. Circular RNAs (circRNAs) have bee...
N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N6-methyladenosine (m6A) reader HNRNPA2B1 accelerates the cervical cancer cells aerobic glycolysis
N6-methyladenosine (m6A) modification is, a more common epigenetic modification, mainly found in mRNA. More and more resea...
Modifications of the respiratory chain of Bacillus licheniformis as an alkalophilic and cyanide-degrading microorganism
Modifications of the respiratory chain of Bacillus licheniformis as an alkalophilic and cyanide-degrading microorganism
Bacillus licheniformis can use cyanide as a nitrogen source for its growth. However, it can also carry out aerobic respira...
WTAP-mediated N6-methyladenosine modification promotes the inflammation, mitochondrial damage and ferroptosis of kidney tubular epithelial cells in acute kidney injury by regulating LMNB1 expression and activating NF-κB and JAK2/STAT3 pathways
WTAP-mediated N6-methyladenosine modification promotes the inflammation, mitochondrial damage and ferroptosis of kidney tubular epithelial cells in acute kidney injury by regulating LMNB1 expression and activating NF-κB and JAK2/STAT3 pathways
Acute kidney injury (AKI) is a serious complication of sepsis patients, but the pathogenic mechanisms underlying AKI are s...
DSC and FTIR study on the interaction between pentacyclic triterpenoid lupeol and DPPC membrane
DSC and FTIR study on the interaction between pentacyclic triterpenoid lupeol and DPPC membrane
Natural products are a great resource for physiologically active substances. It is widely recognized that a major percenta...
Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells
Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells
Miltefosine (MLT) is a broad-spectrum drug included in the alkylphospholipids (APL) used against leishmania and various ty...
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Energy metabolism has always been a hot topic in cancer progression and targeted therapy, and exploring the role of genes ...
Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cancer cell biology
Roles of lysophosphatidic acid (LPA) receptor-mediated signaling in cancer cell biology
Lysophosphatidic acid (LPA) is a simple lipid which is endogenously synthesized from lysophosphatidylcholine (LPC) by auto...
Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 (VAMP8), a soluble n-ethylmaleimide-sensitive factor receptor protein, acts as an on...
Modelling spatio-temporal interactions between second messengers Ca $$^{2+}$$ and cAMP in a pancreatic $$\beta $$ -cell
Modelling spatio-temporal interactions between second messengers Ca $$^{2+}$$ and cAMP in a pancreatic $$\beta $$ -cell
Calcium serves as a widespread second messenger in almost every human and animal cell. The regulation of various cellular ...
METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
Numerous studies have indicated that N6-methyladenosine (m6A) and lncRNAs play pivotal roles in human cancer. However, the...
Electrocontractile remodeling of isolated cardiomyocytes induced during early-stage hypercholesterolemia
Electrocontractile remodeling of isolated cardiomyocytes induced during early-stage hypercholesterolemia
Hypercholesterolemia is one of the most important risk factors for cardiovascular diseases. However, it is mostly associat...
The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson’s disease model using SH-SY5Y cells depends on their differentiation state
The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson’s disease model using SH-SY5Y cells depends on their differentiation state
Inward rectifying potassium channels sensitive to ATP levels (KATP) have been the subject of investigation for several dec...
Mir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA stability
Mir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA stability
Ferritinophagy-mediated ferroptosis plays a crucial role in fighting pathogen aggression. The long non-coding RNA Mir22hg ...
Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis
Dapagliflozin attenuates LPS-induced myocardial injury by reducing ferroptosis
Septic cardiomyopathy is a severe cardiovascular disease with a poor prognosis. Previous studies have reported the involve...
Changes in ATPase activity, antioxidant enzymes and proline biosynthesis in yeast Candida guilliermondii NP-4 under X-irradiation
Changes in ATPase activity, antioxidant enzymes and proline biosynthesis in yeast Candida guilliermondii NP-4 under X-irradiation
This study investigates the effects of X-radiation on ATPase activity and antioxidant enzyme activity, particularly enzyme...
Silencing of METTL3 suppressed ferroptosis of myocardial cells by m6A modification of SLC7A11 in a YTHDF2 manner
Silencing of METTL3 suppressed ferroptosis of myocardial cells by m6A modification of SLC7A11 in a YTHDF2 manner
Myocardial infarction (MI) is the main cause of heart failure (HF). N6-methyladenosine (m6A) methylation is associated wit...
Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats
Metabolic dysfunction induced by HFD + L-NAME preferentially affects hippocampal mitochondria, impacting spatial memory in rats
High-fat diet-induced metabolic changes are not restricted to the onset of cardiovascular diseases, but also include effec...
LINC00665 promotes glycolysis in lung adenocarcinoma cells via the let-7c-5p/HMMR axis
LINC00665 promotes glycolysis in lung adenocarcinoma cells via the let-7c-5p/HMMR axis
Lung adenocarcinoma (LUAD) is one of the most lethal and common malignancies. The energy metabolism of LUAD is a critical ...
Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis
Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis
Downregulation of circ_0044226 has been demonstrated to reduce pulmonary fibrosis, but the role of circ_0044226 in liver f...
USP48 deubiquitination stabilizes SLC1A5 to inhibit retinal pigment epithelium cell inflammation, oxidative stress and ferroptosis in the progression of diabetic retinopathy
USP48 deubiquitination stabilizes SLC1A5 to inhibit retinal pigment epithelium cell inflammation, oxidative stress and ferroptosis in the progression of diabetic retinopathy
Background: Diabetic retinopathy is one of the complications of diabetes mellitus. The aim of this study was to explore th...
CircACTR2 attenuated the effects of tetramethylpyrazine on human kidney cell injury
CircACTR2 attenuated the effects of tetramethylpyrazine on human kidney cell injury
Tetramethylpyrazine (TMP) is one of the active ingredients of Chuan Xiong that has been reported to have effects on numero...
Analysis of cholesterol-recognition motifs of the plasma membrane Ca2+-ATPase
Analysis of cholesterol-recognition motifs of the plasma membrane Ca2+-ATPase
The plasma membrane Ca2+-ATPase (PMCA) is crucial for the fine tuning of intracellular calcium levels in eukaryotic cells....
The SOX2/PDIA6 axis mediates aerobic glycolysis to promote stemness in non-small cell lung cancer cells
The SOX2/PDIA6 axis mediates aerobic glycolysis to promote stemness in non-small cell lung cancer cells
Non-small cell lung cancer (NSCLC) is an aggressive and rapidly expanding lung cancer. Abnormal upregulation or knockdown ...
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