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STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response
STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response
Hematopoietic stem and progenitor cells (HSPCs) maintain blood-forming and immune activity, yet intrinsic regulators of HS...
Why are not all eligible chronic myeloid leukemia patients willing to attempt tyrosine kinase inhibitor discontinuation? A Czech nationwide analysis related to the TKI stopping trial HALF
Why are not all eligible chronic myeloid leukemia patients willing to attempt tyrosine kinase inhibitor discontinuation? A Czech nationwide analysis related to the TKI stopping trial HALF
Tyrosine kinase inhibitor (TKI) therapy discontinuation with the aim of achieving treatment-free remission (TFR) is becomi...
Allogeneic haematopoietic cell transplantation for advanced systemic mastocytosis: Best practice recommendations on behalf of the EBMT Practice Harmonisation and Guidelines Committee
Allogeneic haematopoietic cell transplantation for advanced systemic mastocytosis: Best practice recommendations on behalf of the EBMT Practice Harmonisation and Guidelines Committee
Systemic Mastocytosis (SM) is a multifaceted clinically heterogeneous disease. Advanced SM (AdvSM) comprises three entitie...
Flow cytometric analysis of peripheral blood neutrophil myeloperoxidase expression in myelodysplastic neoplasms
Oelschlaegel U, Winter S, Sockel K, Epp K, Schadt J, Röhnert MA, et al. MDS-PB13 score—blood based detection of aberrancie...
CD22 CAR T cells demonstrate high response rates and safety in pediatric and adult B-ALL: Phase 1b results
CD22 CAR T cells demonstrate high response rates and safety in pediatric and adult B-ALL: Phase 1b results
Chimeric antigen receptor (CAR) T cells targeting CD22 (CD22-CAR) provide a therapeutic option for patients with CD22+ mal...
Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease
Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease
Thrombopoietin (Tpo), which binds to its specific receptor, the Mpl protein, is the major cytokine regulator of megakaryop...
NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia
NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia
Loss-of-function mutations in NFKBIE, which encodes for the NF-κB inhibitor IκBε, are frequent in chronic l...
Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors
Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors
Extramedullary multiple myeloma (EMM) is an aggressive form of multiple myeloma (MM). This study represents the most compr...
Profound sympathetic neuropathy in the bone marrow of patients with acute myeloid leukemia
Profound sympathetic neuropathy in the bone marrow of patients with acute myeloid leukemia
Acute myeloid leukemia (AML) is a malignancy with a poor prognosis. The expansion of leukemic cells is associated with the...
Luigi (Gino) Chieco-Bianchi: a man linking hematological and virological research
Luigi (Gino) Chieco-Bianchi: a man linking hematological and virological research
Credit: Courtesy of G. PizzoloLuigi Chieco Bianchi, called Gino by his friends, died in Padua on June 23rd 20...
ACOX1-mediated peroxisomal fatty acid oxidation contributes to metabolic reprogramming and survival in chronic lymphocytic leukemia
ACOX1-mediated peroxisomal fatty acid oxidation contributes to metabolic reprogramming and survival in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is still an incurable disease, with many patients developing resistance to conventional...
Predictors of early morbidity and mortality in newly diagnosed multiple myeloma: data from five randomized, controlled, phase III trials in 3700 patients
Predictors of early morbidity and mortality in newly diagnosed multiple myeloma: data from five randomized, controlled, phase III trials in 3700 patients
Early morbidity and mortality affect patient outcomes in multiple myeloma. Thus, we dissected the incidence and causes of ...
Development of osteonecrosis and improved survival in B-ALL: results of Children’s Oncology Group Trial AALL0232
Development of osteonecrosis and improved survival in B-ALL: results of Children’s Oncology Group Trial AALL0232
Osteonecrosis is a significant toxicity of acute lymphoblastic leukemia (ALL) therapy. In retrospective analyses, superior...
Real world analysis on the determinants of survival in primary plasma cell leukemia in the United States
Real world analysis on the determinants of survival in primary plasma cell leukemia in the United States
Gundesen MT, Lund T, Moeller HEH, Abildgaard N. Plasma cell leukemia: definition, presentation, and treatment. Curr Oncol ...
Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients
Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients
Patients with multiple myeloma (MM) routinely receive mRNA-based vaccines to reduce COVID-19-related mortality. However, w...
Correction: Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
The exon-junction complex helicase eIF4A3 holds therapeutic potential in acute myeloid leukemia
Acute myeloid leukemia (AML) is a diverse hematological cancer characterized by uncontrolled proliferation of myeloid blas...
RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment
RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment
The fate of leukaemia stem cells (LSCs) is determined by both their inherent mechanisms and crosstalk with their niches. A...
Correction to: MARCKS regulates tonic and chronic active B cell receptor signaling
Author notesThese authors contributed equally: Chenguang Xu, Yan FangAuthors and AffiliationsMOE Key Laboratory of Protein...
Chronic lymphocytic leukemia patient-derived xenografts recapitulate clonal evolution to Richter transformation
Chronic lymphocytic leukemia patient-derived xenografts recapitulate clonal evolution to Richter transformation
Chronic lymphocytic leukemia (CLL) is a B-cell neoplasm with a heterogeneous clinical behavior. In 5–10% of patients...
Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study
Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study
Measurable residual disease (MRD) monitoring in childhood acute myeloid leukemia (AML) is used to assess response to treat...
A positive feedback loop regulation between NOTCH1 and USP11 in T-cell leukemia
A positive feedback loop regulation between NOTCH1 and USP11 in T-cell leukemia
NOTCH1 is a transmembrane receptor in a highly conserved signaling pathway that controls cell fate decisions in various or...
Prognostic implications of CD9 in childhood acute lymphoblastic leukemia: insights from a nationwide multicenter study in China
Prognostic implications of CD9 in childhood acute lymphoblastic leukemia: insights from a nationwide multicenter study in China
The outcomes of children with acute lymphoblastic leukemia (ALL) have been incrementally improved with risk-directed chemo...
Impact of age and comorbidities on the efficacy and tolerability of bosutinib in previously treated patients with chronic myeloid leukemia: results from the phase 4 BYOND study
Impact of age and comorbidities on the efficacy and tolerability of bosutinib in previously treated patients with chronic myeloid leukemia: results from the phase 4 BYOND study
In the phase 4 BYOND trial, patients with pretreated chronic myeloid leukemia (CML) received bosutinib (starting dose: 500...
TP-0184 inhibits FLT3/ACVR1 to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax
TP-0184 inhibits FLT3/ACVR1 to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax
We identified activin A receptor type I (ACVR1), a member of the TGF-β superfamily, as a factor favoring acute myeloi...
Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution
Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution
T follicular helper (TFH) cell lymphomas (TFHLs) are characterized by TFH-like properties and accompanied by substantial i...
SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis
SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis
Gelsi-Boyer V, Trouplin V, Roquain J, Adelaide J, Carbuccia N, Esterni B, et al. ASXL1 mutation is associated with poor pr...
Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG)
Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG)
Clinical outcome of patients with acute myeloid leukemia (AML) is associated with demographic and genetic features. Althou...
Monitoring clone dynamics and reversibility in clonal haematopoiesis and myelodysplastic neoplasm associated with PARP inhibitor therapy—a role for early monitoring and intervention
Monitoring clone dynamics and reversibility in clonal haematopoiesis and myelodysplastic neoplasm associated with PARP inhibitor therapy—a role for early monitoring and intervention
Poly ADP-ribose polymerase inhibitors (PARPi) are widely used as maintenance treatment for ovarian cancer (OC) after respo...
Perspective on measurable residual disease testing in acute myeloid leukemia
Hourigan CS, Gale RP, Gormley NJ, Ossenkoppele GJ, Walter RB. Measurable residual disease testing in acute myeloid leukaem...
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