SCI Abstract

search
+
Rasal2 inhibits autophagic-exosomes secretion via regulating Rab27a in triple-negative breast cancer progression
Rasal2 inhibits autophagic-exosomes secretion via regulating Rab27a in triple-negative breast cancer progression
Triple-negative breast cancer (TNBC) is a subtype with the worst prognosis and there is still a lack of effective treatmen...
Characteristics of the vaginal microbiota associated with recurrent spontaneous preterm birth: a prospective cohort study
Characteristics of the vaginal microbiota associated with recurrent spontaneous preterm birth: a prospective cohort study
Failure to understand the causes of recurrent spontaneous preterm birth (sPTB) has limited effective interventions. This s...
Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study
Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study
Genome-wide association studies (GWAS) and subsequent functional interpretation have been used to identify susceptible gen...
The surface protein Gbp of Fusobacterium nucleatum inhibits osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2
The surface protein Gbp of Fusobacterium nucleatum inhibits osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2
Periodontitis is a chronic inflammatory disease that significantly impacts periodontal bone regeneration, yet the distinct...
Role of tumor microenvironment in ovarian cancer metastasis and clinical advancements
Role of tumor microenvironment in ovarian cancer metastasis and clinical advancements
Ovarian cancer (OC) is the most lethal gynecological malignancy worldwide, characterized by heterogeneity at the molecular...
Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders
Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders
Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune conditions that affect the central nervous system. The cont...
The causal effects of lifestyle, circulating, pigment, and metabolic factors on early age-related macular degeneration: a comprehensive Mendelian randomization study
The causal effects of lifestyle, circulating, pigment, and metabolic factors on early age-related macular degeneration: a comprehensive Mendelian randomization study
Early detection of lifestyle factors, skin and hair color, circulating parameters, and metabolic comorbidities is crucial ...
Therapeutic potential of omaveloxolone in counteracting muscle atrophy post-denervation: a multi-omics approach
Therapeutic potential of omaveloxolone in counteracting muscle atrophy post-denervation: a multi-omics approach
Muscle atrophy caused by denervation is common in neuromuscular diseases, leading to loss of muscle mass and function. How...
Exosomal circRNAs in the plasma serve as novel biomarkers for IPF diagnosis and progression prediction
Exosomal circRNAs in the plasma serve as novel biomarkers for IPF diagnosis and progression prediction
Idiopathic Pulmonary Fibrosis (IPF) is a type of chronic interstitial pneumonia, often fatal, with elusive causes and a bl...
A strategy to pioneer key agent(s) in Cephalotaxus alkaloids against pan-cancer via filtering methodology based on integrated pharmacology
A strategy to pioneer key agent(s) in Cephalotaxus alkaloids against pan-cancer via filtering methodology based on integrated pharmacology
Over the past few decades, Cephalotaxus alkaloids (CAs) have been considered as significant natural agents with their intr...
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury
Proteomic analysis of mitochondria associated membranes in renal ischemic reperfusion injury
The mitochondria and endoplasmic reticulum (ER) communicate via contact sites known as mitochondria associated membranes (...
Routine evaluation of HBV-specific T cell reactivity in chronic hepatitis B using a broad-spectrum T-cell epitope peptide library and ELISpot assay
Routine evaluation of HBV-specific T cell reactivity in chronic hepatitis B using a broad-spectrum T-cell epitope peptide library and ELISpot assay
The clinical routine test of HBV-specific T cell reactivity is still limited due to the high polymorphisms of human leukoc...
Predicting long-term progression of Alzheimer’s disease using a multimodal deep learning model incorporating interaction effects
Predicting long-term progression of Alzheimer’s disease using a multimodal deep learning model incorporating interaction effects
Identifying individuals with mild cognitive impairment (MCI) at risk of progressing to Alzheimer’s disease (AD) prov...
The role of AMPK in macrophage metabolism, function and polarisation
The role of AMPK in macrophage metabolism, function and polarisation
AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status in eukaryotic cells. It plays ...
Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway
Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway
Gout pain seriously affects the quality of patients' life. There is still no effective treatment. The inflammatory res...
Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment
Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment
Chronic lung diseases include an array of conditions that impact airways and lung structures, leading to considerable soci...
The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses
The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses
Glioblastoma (GBM) comprises 45.6% of all primary malignant brain cancers and is one of the most common and aggressive int...
Preliminary analysis of immune-related markers in thymic carcinoid
Preliminary analysis of immune-related markers in thymic carcinoid
The immune-related microenvironment of thymic carcinoid has rarely been reported. We analyzed the expression of PD-L1 and ...
Multifunctional gold nanoparticles for osteoporosis: synthesis, mechanism and therapeutic applications
Multifunctional gold nanoparticles for osteoporosis: synthesis, mechanism and therapeutic applications
Osteoporosis is currently the most prevalent bone disorder worldwide and is characterized by low bone mineral density and ...
Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer
Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer
The role of cholesterol metabolism in gastric cancer (GC) and its implications for tumor characteristics and immunotherapy...
M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics
M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics
Right ventricle failure (RVF) is a progressive heart disease that has yet to be fully understood at the molecular level. E...
Tri©DB: an integrated platform of knowledgebase and reporting system for cancer precision medicine
Tri©DB: an integrated platform of knowledgebase and reporting system for cancer precision medicine
With the development of cancer precision medicine, a huge amount of high-dimensional cancer information has rapidly accumu...
Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis
Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis
Sepsis-caused multi-organ failure remains the major cause of morbidity and mortality in intensive care units with limited ...
Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathway
Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathway
Advanced prostate cancer (PCa) will develop into castration-resistant prostate cancer (CRPC) and lead to poor prognosis. A...
GATA6-AS1 suppresses epithelial–mesenchymal transition of pancreatic cancer under hypoxia through regulating SNAI1 mRNA stability
GATA6-AS1 suppresses epithelial–mesenchymal transition of pancreatic cancer under hypoxia through regulating SNAI1 mRNA stability
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a hypoxic microenvironment, a high rate of heterogeneity as we...
Endothelial progenitor cells systemic administration alleviates multi-organ senescence by down-regulating USP7/p300 pathway in chronic obstructive pulmonary disease
Endothelial progenitor cells systemic administration alleviates multi-organ senescence by down-regulating USP7/p300 pathway in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) has impacted approximately 390 million people worldwide and the morbidity is ...
Cucurbitacin E reduces IL-1β-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes
Cucurbitacin E reduces IL-1β-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes
Osteoarthritis is a degenerative joint disease. Cartilage degeneration is the earliest and most important pathological cha...
Non-invasive biomarkers for early diagnosis of pancreatic cancer risk: metabolite genomewide association study based on the KCPS-II cohort
Non-invasive biomarkers for early diagnosis of pancreatic cancer risk: metabolite genomewide association study based on the KCPS-II cohort
Pancreatic cancer is a lethal disease with a high mortality rate. The difficulty of early diagnosis is one of its primary ...
Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery
Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery
Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of tumors ranging from indolent lesions with good ...
ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003
ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003
ND630 is believed to be a new therapy pharmacologic molecule in targeting the expression of ACACA and regulating the lipid...
Load More
format_indent_increase