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NEC versus NET G3—is there a grey zone? Case report of pancreatic NET G3 with rapid disease progression
NEC versus NET G3—is there a grey zone? Case report of pancreatic NET G3 with rapid disease progression
Patients with well-differentiated neuroendocrine tumors of grade 3 (NET G3) exhibit a significa...
Importance of genetic clarification in cytopenia syndromes (childhood myelodysplastic syndrome forms)
Importance of genetic clarification in cytopenia syndromes (childhood myelodysplastic syndrome forms)
Childhood myelodysplastic syndrome (cMDS) is a rare clonal hematopoietic disorder characterized by peripheral cytopenia, w...
State-of-the-art therapy and innovative treatment strategies in esophageal squamous cell cancer
State-of-the-art therapy and innovative treatment strategies in esophageal squamous cell cancer
Recent advances in the development of new therapeutic agents and the execution of numerous randomized controlled trials ha...
Alternating chemotherapy with VDC-IE as effective first-line treatment in a patient with SMARCA4-deficient undifferentiated tumor
Alternating chemotherapy with VDC-IE as effective first-line treatment in a patient with SMARCA4-deficient undifferentiated tumor
SMARCA4-deficient undifferentiated tumor (SMARCA4-UTs) is an extremely rare and aggressive entity where no consensus on sy...
Impact of the WHO-5 classification of haematolymphoid tumours on clinical practice
Impact of the WHO-5 classification of haematolymphoid tumours on clinical practice
The long-awaited 2022 World Health Organization Classification of Haematolymphoid Tumours (WHO-5-HAEM) has finally been pu...
Treatment sequencing in gastroenteropancreatic neuroendocrine tumors
Treatment sequencing in gastroenteropancreatic neuroendocrine tumors
The oncological treatment of neuroendocrine tumors (NET) has improved significantly in the last few years. Several informa...
Unraveling (K)RAS in pancreatic ductal adenocarcinoma
Unraveling (K)RAS in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a poor 5‑year survival ...
KRAS (Kirsten rat sarcoma) in modern oncology—The molecular pathological point of view
KRAS (Kirsten rat sarcoma) in modern oncology—The molecular pathological point of view
The Rat sarcoma protein (RAS) was the first proto-oncogene to be discovered and is one of the best researched tumor driver...
Pulmonary puzzles: salivary gland-type tumors of the lung and their metastatic equivalents
Pulmonary puzzles: salivary gland-type tumors of the lung and their metastatic equivalents
In the last decade, the understanding of lung neoplasms, particularly rare salivary gland-type tumors (SGT), has deepened ...
Liquid profiling for patients with advanced cancer is ready for clinical integration
Liquid profiling for patients with advanced cancer is ready for clinical integration
Molecular profiling of circulating tumor DNA (ctDNA) to guide treatment decisions has found its way into routine managemen...
GATA2 deficiency: a mystery myelodysplasia
GATA2 deficiency: a mystery myelodysplasia
GATA2 deficiency, arising from mutations in the GATA2 gene, is a rare genetic disorder with profound implications...
Novel mutated Dubin–Johnson syndrome diagnosed during acute promyelocytic leukemia treatment
Novel mutated Dubin–Johnson syndrome diagnosed during acute promyelocytic leukemia treatment
Coexistence of acute promyelocytic leukemia and Dubin–Johnson syndrome (DJS) has not been previously reported in the...
Acute myeloid leukemia patient with active disseminated tuberculosis bridged to transplant with reduced 14-day venetoclax and azacitidine schedule
Acute myeloid leukemia patient with active disseminated tuberculosis bridged to transplant with reduced 14-day venetoclax and azacitidine schedule
A 59-year-old female patient was diagnosed with acute myeloid leukemia and tuberculosis. As a further co...
Molecular typing—new targets and therapy options for upper GI carcinomas with a focus on adenocarcinomas of the esophagus, gastroesophageal junction, and stomach
Molecular typing—new targets and therapy options for upper GI carcinomas with a focus on adenocarcinomas of the esophagus, gastroesophageal junction, and stomach
The biomarker developments in adenocarcinomas of the esophagus, gastroesophageal junction, and stomach are currently very ...
β-adrenergic modulation of IL-6/gp130 and SOCS-1 in multiple myeloma: therapeutic strategy for stress induced-inflammatory response
β-adrenergic modulation of IL-6/gp130 and SOCS-1 in multiple myeloma: therapeutic strategy for stress induced-inflammatory response
Multiple Myeloma (MM) is considered an incurable, biologically heterogeneous disease of the plasma cells. The clinical dat...
Seminal vesicle metastasis from transverse colon adenocarcinoma: a unique case report
Seminal vesicle metastasis from transverse colon adenocarcinoma: a unique case report
Seminal vesicle metastasis from colon adenocarcinoma is very rare, with only two case reports in the literature. Also, pos...
Prediction of epidermal growth factor receptor mutation status by textural features in stage IV lung adenocarcinoma
Prediction of epidermal growth factor receptor mutation status by textural features in stage IV lung adenocarcinoma
The purpose of this study was to assess the correlation between textural features from 18fluorodeoxyglucose positron emiss...
American Society of Hematology (ASH) update 2023—chronic lymphocytic leukemia
American Society of Hematology (ASH) update 2023—chronic lymphocytic leukemia
In recent years, there has been massive advances in the treatment of chronic lymphocytic leukemia (CLL) from chemoimmunoth...
ASCO 2023: highlights in breast cancer
ASCO 2023: highlights in breast cancer
The 2023 annual meeting of the American Society of Clinical Oncology (ASCO) was again held in June 2023 in Chicag...
Cancer of unknown primary—state of the art
Cancer of unknown primary—state of the art
The Cancer of Unknown Primary (CUP) syndrome does not represent a single clinical entity but comprises a diverse group of ...
Emerging treatment strategies in chronic B-cell malignancies—News from ICML 2023
Emerging treatment strategies in chronic B-cell malignancies—News from ICML 2023
Implementation of targeted drugs in the treatment landscape of indolent B‑cell malignancies has facilitated long-ter...
Supportive management
Supportive management
The introduction of checkpoint inhibitor therapy and advances in targeted therapy...
Prostate cancer special—part 1
Prostate cancer special—part 1
Conflict of interest S.F. Shariat declares the following competing interes...
HER2 in focus—gastric cancer
HER2 in focus—gastric cancer
Conflict of interest A. Ilhan-Mutlu: Participation in advisory boards orga...
ASCO 2023—partnering with patients: the cornerstone of cancer care and research
ASCO 2023—partnering with patients: the cornerstone of cancer care and research
For the 2023 annual meeting of the American Society of Clinical Oncology (ASC...
WNT3 and LEF1 as markers for diagnosis and survival prediction in chronic lymphocytic leukemia patients
WNT3 and LEF1 as markers for diagnosis and survival prediction in chronic lymphocytic leukemia patients
The Wnt pathway is aberrantly activated in chronic lymphocytic leukemia (CLL) and contributes to the antiapoptotic and mit...
A CONGRESS DIGEST ON RADIOLABELED THERANOSTICS FOR SOLID TUMORS. Report from the 36th Annual Congress of the European Association of Nuclear Medicine (EANM), September 9th – 13th, 2023, Vienna
A CONGRESS DIGEST ON RADIOLABELED THERANOSTICS FOR SOLID TUMORS. Report from the 36th Annual Congress of the European Association of Nuclear Medicine (EANM), September 9th – 13th, 2023, Vienna
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A GLOBAL CONGRESS DIGEST ON LUNG CANCER. Report from the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer, September 9th-12th , hybrid congress
A GLOBAL CONGRESS DIGEST ON LUNG CANCER. Report from the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer, September 9th-12th , hybrid congress
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Decitabine combined with low-dose cytarabine, aclarubicin and rhG-CSF regimen may be a potential alternative for relapsed/refractory acute myeloid leukemia: A single-center study
Decitabine combined with low-dose cytarabine, aclarubicin and rhG-CSF regimen may be a potential alternative for relapsed/refractory acute myeloid leukemia: A single-center study
To analyze the effectiveness of decitabine combined with low-dose Ara‑C, aclarubicin, and rhG-CSF (DCAG) as a&nb...
Genetic testing and management of prostate cancer patients with pathogenic germline variants
Genetic testing and management of prostate cancer patients with pathogenic germline variants
Prostate cancer (PCa) is an androgen-receptor signaling-dependent disease with a subset of patients harboring pat...
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