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Prognostic tools and risk factors in early-stage CLL—time for a change in treatment paradigm?
Prognostic tools and risk factors in early-stage CLL—time for a change in treatment paradigm?
Chronic lymphocytic leukemia (CLL) is one of the most common lymphoid malignancies. Due to its biological heterogeneity, t...
Evaluating antifungal prophylaxis strategies in pediatric acute myeloid leukemia: a retrospective, single-center analysis of amphotericin B, itraconazole, and voriconazole
Evaluating antifungal prophylaxis strategies in pediatric acute myeloid leukemia: a retrospective, single-center analysis of amphotericin B, itraconazole, and voriconazole
Invasive fungal disease (IFD) represents a major cause of morbidity and mortality in pediatric patients with acut...
Cure for multiple myeloma?
Cure for multiple myeloma?
Advances in our knowledge of the pathogenesis of multiple myeloma and the resultant development of novel therapies have si...
EffiXane—Non-interventional study on safety and effectiveness of -paclitaxel (Abraxane®) + gemcitabine as first-line treatment of metastatic PDAC in a daily routine setting
EffiXane—Non-interventional study on safety and effectiveness of -paclitaxel (Abraxane®) + gemcitabine as first-line treatment of metastatic PDAC in a daily routine setting
Metastatic adenocarcinoma of the pancreas (PDAC) was one of the most common causes of cancer-associated death in Europe an...
Too frail or not too frail? Prognosis and treatment options in older CLL patients
Too frail or not too frail? Prognosis and treatment options in older CLL patients
Chronic lymphocytic leukemia (CLL) is a disease that primarily affects older patients, with a median age...
A short review on the current status of PSMA ligands used for PSMA-PET/CT imaging
A short review on the current status of PSMA ligands used for PSMA-PET/CT imaging
In recent years, prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/...
Epidermal radionuclide therapy with rhenium—the new treatment for skin squamous cell carcinoma
Epidermal radionuclide therapy with rhenium—the new treatment for skin squamous cell carcinoma
Nonmelanoma skin cancer (NMSC), including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), is the ...
Proposed prognostic score including circulating free DNA concentration in diffuse large B-cell lymphoma
Proposed prognostic score including circulating free DNA concentration in diffuse large B-cell lymphoma
Non-Hodgkin’s lymphomas (NHLs) are common types of hematological malignancies. Due to the heterogeneity of the prese...
Drug-eluting bead transarterial chemoembolization combined with cryoablation for renal cell carcinoma
Drug-eluting bead transarterial chemoembolization combined with cryoablation for renal cell carcinoma
Treatment approaches available to manage small renal masses (SRMs) include active surveillance, SRM ablation, partial neph...
Disseminated tuberculosis in a patient treated with ruxolitinib for primary myelofibrosis
Disseminated tuberculosis in a patient treated with ruxolitinib for primary myelofibrosis
Ruxolitinib, a selective inhibitor of Janus kinase 1 and 2, has emerged as a pivotal t...
NEC versus NET G3—is there a grey zone? Case report of pancreatic NET G3 with rapid disease progression
NEC versus NET G3—is there a grey zone? Case report of pancreatic NET G3 with rapid disease progression
Patients with well-differentiated neuroendocrine tumors of grade 3 (NET G3) exhibit a significa...
Importance of genetic clarification in cytopenia syndromes (childhood myelodysplastic syndrome forms)
Importance of genetic clarification in cytopenia syndromes (childhood myelodysplastic syndrome forms)
Childhood myelodysplastic syndrome (cMDS) is a rare clonal hematopoietic disorder characterized by peripheral cytopenia, w...
State-of-the-art therapy and innovative treatment strategies in esophageal squamous cell cancer
State-of-the-art therapy and innovative treatment strategies in esophageal squamous cell cancer
Recent advances in the development of new therapeutic agents and the execution of numerous randomized controlled trials ha...
Alternating chemotherapy with VDC-IE as effective first-line treatment in a patient with SMARCA4-deficient undifferentiated tumor
Alternating chemotherapy with VDC-IE as effective first-line treatment in a patient with SMARCA4-deficient undifferentiated tumor
SMARCA4-deficient undifferentiated tumor (SMARCA4-UTs) is an extremely rare and aggressive entity where no consensus on sy...
Impact of the WHO-5 classification of haematolymphoid tumours on clinical practice
Impact of the WHO-5 classification of haematolymphoid tumours on clinical practice
The long-awaited 2022 World Health Organization Classification of Haematolymphoid Tumours (WHO-5-HAEM) has finally been pu...
Treatment sequencing in gastroenteropancreatic neuroendocrine tumors
Treatment sequencing in gastroenteropancreatic neuroendocrine tumors
The oncological treatment of neuroendocrine tumors (NET) has improved significantly in the last few years. Several informa...
Unraveling (K)RAS in pancreatic ductal adenocarcinoma
Unraveling (K)RAS in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a poor 5‑year survival ...
KRAS (Kirsten rat sarcoma) in modern oncology—The molecular pathological point of view
KRAS (Kirsten rat sarcoma) in modern oncology—The molecular pathological point of view
The Rat sarcoma protein (RAS) was the first proto-oncogene to be discovered and is one of the best researched tumor driver...
Pulmonary puzzles: salivary gland-type tumors of the lung and their metastatic equivalents
Pulmonary puzzles: salivary gland-type tumors of the lung and their metastatic equivalents
In the last decade, the understanding of lung neoplasms, particularly rare salivary gland-type tumors (SGT), has deepened ...
Liquid profiling for patients with advanced cancer is ready for clinical integration
Liquid profiling for patients with advanced cancer is ready for clinical integration
Molecular profiling of circulating tumor DNA (ctDNA) to guide treatment decisions has found its way into routine managemen...
GATA2 deficiency: a mystery myelodysplasia
GATA2 deficiency: a mystery myelodysplasia
GATA2 deficiency, arising from mutations in the GATA2 gene, is a rare genetic disorder with profound implications...
Novel mutated Dubin–Johnson syndrome diagnosed during acute promyelocytic leukemia treatment
Novel mutated Dubin–Johnson syndrome diagnosed during acute promyelocytic leukemia treatment
Coexistence of acute promyelocytic leukemia and Dubin–Johnson syndrome (DJS) has not been previously reported in the...
Acute myeloid leukemia patient with active disseminated tuberculosis bridged to transplant with reduced 14-day venetoclax and azacitidine schedule
Acute myeloid leukemia patient with active disseminated tuberculosis bridged to transplant with reduced 14-day venetoclax and azacitidine schedule
A 59-year-old female patient was diagnosed with acute myeloid leukemia and tuberculosis. As a further co...
Molecular typing—new targets and therapy options for upper GI carcinomas with a focus on adenocarcinomas of the esophagus, gastroesophageal junction, and stomach
Molecular typing—new targets and therapy options for upper GI carcinomas with a focus on adenocarcinomas of the esophagus, gastroesophageal junction, and stomach
The biomarker developments in adenocarcinomas of the esophagus, gastroesophageal junction, and stomach are currently very ...
β-adrenergic modulation of IL-6/gp130 and SOCS-1 in multiple myeloma: therapeutic strategy for stress induced-inflammatory response
β-adrenergic modulation of IL-6/gp130 and SOCS-1 in multiple myeloma: therapeutic strategy for stress induced-inflammatory response
Multiple Myeloma (MM) is considered an incurable, biologically heterogeneous disease of the plasma cells. The clinical dat...
Seminal vesicle metastasis from transverse colon adenocarcinoma: a unique case report
Seminal vesicle metastasis from transverse colon adenocarcinoma: a unique case report
Seminal vesicle metastasis from colon adenocarcinoma is very rare, with only two case reports in the literature. Also, pos...
Prediction of epidermal growth factor receptor mutation status by textural features in stage IV lung adenocarcinoma
Prediction of epidermal growth factor receptor mutation status by textural features in stage IV lung adenocarcinoma
The purpose of this study was to assess the correlation between textural features from 18fluorodeoxyglucose positron emiss...
American Society of Hematology (ASH) update 2023—chronic lymphocytic leukemia
American Society of Hematology (ASH) update 2023—chronic lymphocytic leukemia
In recent years, there has been massive advances in the treatment of chronic lymphocytic leukemia (CLL) from chemoimmunoth...
ASCO 2023: highlights in breast cancer
ASCO 2023: highlights in breast cancer
The 2023 annual meeting of the American Society of Clinical Oncology (ASCO) was again held in June 2023 in Chicag...
Cancer of unknown primary—state of the art
Cancer of unknown primary—state of the art
The Cancer of Unknown Primary (CUP) syndrome does not represent a single clinical entity but comprises a diverse group of ...
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