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Patterns of Ciliation and Ciliary Signaling in Cancer
Patterns of Ciliation and Ciliary Signaling in Cancer
Among the factors that have been strongly implicated in regulating cancerous transformation, the primary monocilium (ciliu...
Endo-Lysosomal Cation Channels and Infectious Diseases
Endo-Lysosomal Cation Channels and Infectious Diseases
Among the infectious diseases caused by pathogenic microorganisms such as bacteria, viruses, parasites, or fungi, the most...
Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases
Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases
Neurodegenerative disorders are debilitating and largely untreatable conditions that pose a significant burden to affected...
Cancer-Related Increases and Decreases in Calcium Signaling at the Endoplasmic Reticulum-Mitochondria Interface (MAMs)
Cancer-Related Increases and Decreases in Calcium Signaling at the Endoplasmic Reticulum-Mitochondria Interface (MAMs)
Endoplasmic reticulum (ER)-mitochondria regions are specialized subdomains called also mitochondria-associated membranes (...
Autocrine, Paracrine, and Endocrine Signals That Can Alter Alveolar Macrophages Function
Autocrine, Paracrine, and Endocrine Signals That Can Alter Alveolar Macrophages Function
Alveolar macrophages (AMs) are extremely versatile cells with complex functions involved in health or diseases such as pne...
Role of Oxytocin in Different Neuropsychiatric, Neurodegenerative, and Neurodevelopmental Disorders
Role of Oxytocin in Different Neuropsychiatric, Neurodegenerative, and Neurodevelopmental Disorders
Oxytocin has recently gained significant attention because of its role in the pathophysiology and management of dominant n...
The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4
The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4
Transient receptor potential vanilloid type 4 (TRPV4) channels are Ca2+-permeable non-selective cation channels which medi...
Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications
Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications
People suffering from obesity and associated metabolic disorders including diabetes are increasing exponentially around th...
Roles of Intramolecular Interactions in the Regulation of TRP Channels
Roles of Intramolecular Interactions in the Regulation of TRP Channels
The transient receptor potential (TRP) channels, classified into six (-A, -V, -P, -C, -M, -ML, -N and -Y) subfamilies, are...
Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer
Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer
The expression and function of many ion channels and transporters in cancer cells display major differences in comparison ...
Ion Transport and Radioresistance
Ion Transport and Radioresistance
Neoplastic transformation is associated with alterations of the ion transports across plasma and intracellular membranes. ...
Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research
Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research
The intracellular Ca2+ concentration is mainly controlled by Ca2+ channels. These channels form complexes with K+ channels...
Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions
Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions
Members of the solute carrier (SLC) family of transporters are responsible for the cellular influx of a broad range of end...
Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer
Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer
Prostate cancer is the fourth most commonly diagnosed cancer, and although it is often a slow-growing malignancy, it is th...
How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression
How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression
Solid tumors comprise two major components: the cancer cells and the tumor stroma. The stroma is a mixture of cellular and...
Patch Clamp: The First Four Decades of a Technique That Revolutionized Electrophysiology and Beyond
Patch Clamp: The First Four Decades of a Technique That Revolutionized Electrophysiology and Beyond
Forty years ago, the introduction of a new electrophysiological technique, the patch clamp, revolutionized the fields of C...
Cell-to-Cell Crosstalk: A New Insight into Pulmonary Hypertension
Cell-to-Cell Crosstalk: A New Insight into Pulmonary Hypertension
Pulmonary hypertension (PH) is a disease with high pulmonary arterial pressure, pulmonary vasoconstriction, pulmonary vasc...
A Review: Uses of Chitosan in Pharmaceutical Forms
A Review: Uses of Chitosan in Pharmaceutical Forms
Chitosan is a natural polysaccharide widespread in nature. It has many unique and attractive properties for the pharmaceut...
Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?
Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?
Survival in the circulation, extravasation from vasculature, and colonizing new tissues represent major steps of the metas...
The Biochemistry and Physiology of A Disintegrin and Metalloproteinases (ADAMs and ADAM-TSs) in Human Pathologies
The Biochemistry and Physiology of A Disintegrin and Metalloproteinases (ADAMs and ADAM-TSs) in Human Pathologies
Metalloproteinases are a group of proteinases that plays a substantial role in extracellular matrix remodeling and its mol...
Ion Transporting Proteins and Cancer: Progress and Perspectives
Ion Transporting Proteins and Cancer: Progress and Perspectives
Ion transporting proteins (ITPs) comprise a wide range of ion channels, exchangers, pumps and ionotropic receptors many of...
Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application
Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application
Head and neck cancers are a highly complex and heterogeneous group of malignancies that involve very diverse anatomical st...
Transportome Malfunctions and the Hallmarks of Pancreatic Cancer
Transportome Malfunctions and the Hallmarks of Pancreatic Cancer
Ion channels and transporters (ICT) play important roles in almost all basic cellular processes. During last decades, abun...
Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening
Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening
In the last three decades, a growing number of studies have implicated ion channels in all essential processes of prostate...
Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer
Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer
The body homeostasis is maintained mainly by the function of the kidneys, which regulate salt and water balance and excret...
The Endocannabinoid System in Caenorhabditis elegans
The Endocannabinoid System in Caenorhabditis elegans
The existence of a formal Endocannabinoid System in C. eleganshas been questioned due to data showing the absence of typic...
The Placenta as a Target for Alcohol During Pregnancy: The Close Relation with IGFs Signaling Pathway
The Placenta as a Target for Alcohol During Pregnancy: The Close Relation with IGFs Signaling Pathway
Alcohol is one of the most consumed drugs in the world, even during pregnancy. Its use is a risk factor for developing adv...
Neuronal Nitric Oxide Synthase (nNOS) in Neutrophils: An Insight
Neuronal Nitric Oxide Synthase (nNOS) in Neutrophils: An Insight
NO (nitric oxide) is an important regulator of neutrophil functions and has a key role in diverse pathophysiological condi...
Role of Histone Deacetylases in Monocyte Function in Health and Chronic Inflammatory Diseases
Role of Histone Deacetylases in Monocyte Function in Health and Chronic Inflammatory Diseases
Histone deacetylases (HDACs) are a family of 18 members that participate in the epigenetic regulation of gene expression. ...
Inherited Ventricular Arrhythmia in Zebrafish: Genetic Models and Phenotyping Tools
Inherited Ventricular Arrhythmia in Zebrafish: Genetic Models and Phenotyping Tools
In the last years, the field of inheritable ventricular arrhythmia disease modelling has changed significantly with a push...
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