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Response by Owens and Deaton to Letter Regarding Article, “Dichotomous Roles of Smooth Muscle Cell–Derived MCP1 (Monocyte Chemoattractant Protein 1) in Development of Atherosclerosis”
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Hypercholesterolemic Dysregulation of Calpain in Lymphatic Endothelial Cells Interferes With Regulatory T-Cell Stability and Trafficking
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Bicuspid Aortic Valve–Associated Regulatory Regions Reveal GATA4 Regulation and Function During Human-Induced Pluripotent Stem Cell–Based Endothelial-Mesenchymal Transition
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Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4–Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis
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New Autosomal Myh11-CreER T2 Smooth Muscle Cell Lineage Tracing and Gene Knockout Mouse Model
Background: The Myh11 promoter is extensively used as a smooth muscle cell (SMC) Cre-driver and is regarded as the most re...
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Blood Pressure Responses During Exercise: Physiological Correlates and Clinical Implications
Background: Abnormal blood pressure (BP) responses to exercise can predict adverse cardiovascular outcomes, but their opti...
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Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels
Background: The harmful vascular effects of smoking are well established, but the effects of chronic use of electronic cig...
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How Irritating! Electronic Cigarettes Not “95% Safer” Than Combustible Cigarettes: Recent Mechanistic Insights Into Endothelial Dysfunction
Daniel J. Conklin Correspondence to: Daniel J. Conklin, PhD, Center for Cardiometabolic Science, 580 S. Preston St, Delia ...
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TMEM100, a Lung-Specific Endothelium Gene
Zhiyu Dai Correspondence to: Zhiyu Dai, PhD, Department of Internal Medicine, College of Medicine-Phoenix, University of A...
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Arginase-1 Deletion in Erythrocytes Promotes Vascular Calcification via Enhanced GSNOR (S-Nitrosoglutathione Reductase) Expression and NO Signaling in Smooth Muscle Cells
BACKGROUND: Erythrocytes (red blood cells) participate in the control of vascular NO bioavailability. The purpose of this ...
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Specific Loss of ABCA1 (ATP-Binding Cassette Transporter A1) Suppresses TCR (T-Cell Receptor) Signaling and Provides Protection Against Atherosclerosis
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Cellular Landscapes of Nondiseased Human Cardiac Valves From End-Stage Heart Failure–Explanted Heart
Background: Exploring the mechanisms of valvular heart disease at the cellular level may be useful to identify new therape...
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New Genomic Techniques Provide Novel Insights Into Ascending Aortic Aneurysm Pathology
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Nonproteolytic Intracellular Domain of MT1-MMP (Membrane-Type 1 Matrix Metalloproteinase) Coordinately Modulates Abdominal Aortic Aneurysm and Atherosclerosis to Mice
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Novel Target for Limiting VEGF-A (Vascular Endothelial Growth Factor A)–Induced Vascular Permeability
Joyce Bischoff Correspondence to: Joyce Bischoff, PhD, Karp Family Research Laboratories 12.212, Boston Children’s Hospita...
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Inhibition of the Renin-Angiotensin System Fails to Suppress β-Aminopropionitrile–Induced Thoracic Aortopathy in Mice
BACKGROUND: Cross-linking of lysine residues in elastic and collagen fibers is a vital process in aortic development. Inhi...
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High-Density Lipoprotein and Long-Term Incidence and Progression of Aortic Valve Calcification: The Multi-Ethnic Study of Atherosclerosis
Background: Aortic valve calcification (AVC) shares pathological features with atherosclerosis. Lipoprotein components hav...
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Calcium-Controlled Reactive Oxygen Species Afterburner Perpetuates Endothelial Damage After Radiation Therapy
Ralf P. Brandes Correspondence to: Ralf P. Brandes, Institute Kardiovaskuläre Physiologie, Fachbereich Medizin, Goethe-Uni...
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Mitochondrial Ca2+ Uptake Drives Endothelial Injury By Radiation Therapy
Background: Radiation therapy strongly increases the risk of atherosclerotic vascular disease, such as carotid stenosis. R...
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Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic Aneurysm
Background: Aortic root smooth muscle cells (SMC) develop from both the second heart field (SHF) and neural crest. Dispara...
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Lgals3-Transitioned Inflammatory Smooth Muscle Cells: Major Regulators of Atherosclerosis Progression and Inflammatory Cell Recruitment
Mary C.M. Weiser-Evans Correspondence to: Mary C.M. Weiser-Evans, Department of Medicine, Division of Renal Diseases and H...
Arteriosclerosis Thrombosis And Vascular Biology
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ENPP2 (Endothelial Ectonucleotide Pyrophosphatase/Phosphodiesterase 2) Increases Atherosclerosis in Female and Male Mice
BACKGROUND: Maladapted endothelial cells (ECs) secrete ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2; autotaxi...
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Epicardial Adipose Tissue Ceramides Are Related to Lipoprotein Lipase Activity in Coronary Artery Disease: Unfolding a Missing Link
Background: Epicardial adipose tissue (EAT) contributes to coronary artery disease (CAD). EAT presents a specific lipidomi...
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PIKfyve-Dependent Phosphoinositide Dynamics in Megakaryocyte/Platelet Granule Integrity and Platelet Functions
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Preventing Cholesterol-Induced Perk (Protein Kinase RNA-Like Endoplasmic Reticulum Kinase) Signaling in Smooth Muscle Cells Blocks Atherosclerotic Plaque Formation
BACKGROUND: Vascular smooth muscle cells (SMCs) undergo complex phenotypic modulation with atherosclerotic plaque formatio...
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Microarchitectural Changes of Cardiovascular Calcification in Response to In Vivo Interventions Using Deep-Learning Segmentation and Computed Tomography Radiomics
BACKGROUND: Coronary calcification associates closely with cardiovascular risk, but its progress is accelerated in respons...
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Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists With Platelet PAR (Protease-Activated Receptor)-1 and PAR-4–Mediated Thrombin Resistance
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