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Revealing the anti-senescence effects and related mechanisms of flavonoid extracts from the buds of Wikstroemia chamaedaphne Meisn on D-galactose-induced PC12 cells based on network pharmacology and transcriptomics
Revealing the anti-senescence effects and related mechanisms of flavonoid extracts from the buds of Wikstroemia chamaedaphne Meisn on D-galactose-induced PC12 cells based on network pharmacology and transcriptomics
Natural products are an important source of drugs or lead compounds for the treatment of senescence. The buds of Wikstroem...
Unveiling metabolome heterogeneity in three species from Coccoloba and Ruprechtia through multiple approaches of UPLC/HRMS and chemometric analysis in relation to antidiabetic, antioxidant and antiglycation activities
Unveiling metabolome heterogeneity in three species from Coccoloba and Ruprechtia through multiple approaches of UPLC/HRMS and chemometric analysis in relation to antidiabetic, antioxidant and antiglycation activities
Diabetes mellitus (DM) is a major intricate metabolic disorder, being one of the chief causes of mortality worldwide. Cocc...
Therapeutic potential of ursolic acid (UA) and their derivatives with nanoformulations to combat nosocomial pathogens
Therapeutic potential of ursolic acid (UA) and their derivatives with nanoformulations to combat nosocomial pathogens
Ursolic acid (UA) is a natural pentacyclic triterpene derived from fruit, herbs, and other plants of the terpenoid categor...
Repurposing the antimalarial chloroquine: a potential therapy for hepatic injury in a rat model of hindlimb ischemia–reperfusion by modulating apoptosis, autophagy, inflammation, and oxidative stress
Repurposing the antimalarial chloroquine: a potential therapy for hepatic injury in a rat model of hindlimb ischemia–reperfusion by modulating apoptosis, autophagy, inflammation, and oxidative stress
Besides its local injurious effect, hindlimb hypoxia/reperfusion (HL-H/R) can escalate leading to multiple organ dysfuncti...
Allosteric modulation of laeviganoid-based clerodane diterpenes derivatives in muscarinic acetylcholine M1 receptor against tinnitus: a structure-based virtual screening approach
Allosteric modulation of laeviganoid-based clerodane diterpenes derivatives in muscarinic acetylcholine M1 receptor against tinnitus: a structure-based virtual screening approach
Chronic tinnitus is a complication that affects the central nervous system, specifically the auditory cortex, causing a ph...
Ameliorative activity of standardized Coccoloba uvifera leaves extract against streptozotocin-induced diabetic rats via activation of IRS-1/PI3K/AKT/GLUT2 pathway in liver
Ameliorative activity of standardized Coccoloba uvifera leaves extract against streptozotocin-induced diabetic rats via activation of IRS-1/PI3K/AKT/GLUT2 pathway in liver
Coccoloba uvifera L. (Family: Polygonaceae) known as sea grape is natively distributed in middle and south America. The aq...
In vitro and in vivo evaluation of crosslinked wound dressing loaded with combined rosuvastatin calcium and levofoxacin simultaneously determined by eco-friendly spectrophotometric method
In vitro and in vivo evaluation of crosslinked wound dressing loaded with combined rosuvastatin calcium and levofoxacin simultaneously determined by eco-friendly spectrophotometric method
Wound healing is a natural but complex process that can be delayed by infection. Rosuvastatin calcium (RVS) is an anti-hyp...
Exhaustive computational studies on pyrimidine derivatives as GPR119 agonist for the development of compounds against NIDDM
Exhaustive computational studies on pyrimidine derivatives as GPR119 agonist for the development of compounds against NIDDM
Type-2 Diabetes (T2DM) is a long-term medical disorder characterized by Insulin deficiency and high blood glucose levels. ...
In vitro evaluation of the clinical utility of Apitolisib/Vorinostat combination in Apitolisib-resistant H1975 lung adenocarcinoma cells
In vitro evaluation of the clinical utility of Apitolisib/Vorinostat combination in Apitolisib-resistant H1975 lung adenocarcinoma cells
The PI3K signalling pathway regulates the metabolic activity of cells. Disruption by PI3K inhibitors causes an aerobic/ana...
Assessment of Piper longum L. (Piperaceae) leaves toxicity on the adults of Tribolium castaneum (Herbst, 1797) (Coleoptera: Tenebrionidae)
Assessment of Piper longum L. (Piperaceae) leaves toxicity on the adults of Tribolium castaneum (Herbst, 1797) (Coleoptera: Tenebrionidae)
Numerous insect pests attack stored grains causing both qualitative and quantitative losses. The most damaging pest that i...
Unlocking the power of precision medicine: exploring the role of biomarkers in cancer management
Unlocking the power of precision medicine: exploring the role of biomarkers in cancer management
Personalized or Precision medicine (PM) is a promising approach for the cancer treatment that tailors treatment to a patie...
Nanocrystals: an emerging paradigm for cancer therapeutics
Nanocrystals: an emerging paradigm for cancer therapeutics
Medical fraternity are continuously pitching toward the development of novel mechanisms to combat the menace of cancer and...
Antioxidant and acetylcholinesterase inhibitory activities, in silico analyses, and anti-Alzheimer’s disease potential of leaf extracts of three Nigerian endemic medicinal plants (Spondias mombin, Carica papaya and Kalanchoe crenata)
Antioxidant and acetylcholinesterase inhibitory activities, in silico analyses, and anti-Alzheimer’s disease potential of leaf extracts of three Nigerian endemic medicinal plants (Spondias mombin, Carica papaya and Kalanchoe crenata)
The evaluation of the correlations between antioxidant and anti-acetylcholinesterase activities of methanol leaf extracts ...
In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma
In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma
Diffuse astrocytoma (a type of glioma) and its prevalence are matters of concern worldwide. Patients with this type of tum...
A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study
A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study
Carivalan® dosage form containing carvedilol and ivabradine is widely indicated for patients with stable angina. Thre...
Chemical profiling of antifungal Dicerocaryum senecioides and Diospyros mespiliformis extracts using TLC-p-iodonitrotetrazolium violet assay and GC–MS/MS
Chemical profiling of antifungal Dicerocaryum senecioides and Diospyros mespiliformis extracts using TLC-p-iodonitrotetrazolium violet assay and GC–MS/MS
Despite the availability of conventional medication for fungal skin diseases, dermatophytic infections are now a major cri...
Inhibitory capacity of extracts and main constituents of hop flowers
Inhibitory capacity of extracts and main constituents of hop flowers
Hops (Humulus lupulus Linn.) produce flowers that are used on an industrial scale to impart sensory properties to beer and...
QbD-driven RP-HPLC method for novel chemo-herbal combination, in-silico, force degradation studies, and characterization of dual drug-loaded polymeric and lipidic nanocarriers
QbD-driven RP-HPLC method for novel chemo-herbal combination, in-silico, force degradation studies, and characterization of dual drug-loaded polymeric and lipidic nanocarriers
In cancer therapies, chemo-herbal combinations are receiving increased attention. A multiple tyrosine kinase inhibitor, le...
Development of novel gradient RP-HPLC method for separation of dapagliflozin and its process-related impurities: insight into stability profile and degradation pathway, identification of degradants using LCMS
Development of novel gradient RP-HPLC method for separation of dapagliflozin and its process-related impurities: insight into stability profile and degradation pathway, identification of degradants using LCMS
In the dapagliflozin (DPF) synthesis, 5-Bromo-2-chlorobenzoic acid (5-BC impurity) and 4-Bromo-1-chloro-2-(4-ethoxybenzyl)...
Peptide-modified PAMAM-based bone-targeting RNA delivery system
Peptide-modified PAMAM-based bone-targeting RNA delivery system
Osteoporosis, among other bone diseases, has become a prevalent cause of decreased quality of life in older and postmenopa...
A validated RP-UPLC method for estimation of Samidorphan and Olanzapine in mixed powder and combined tablets
A validated RP-UPLC method for estimation of Samidorphan and Olanzapine in mixed powder and combined tablets
The key objective of the research study is to develop a new stability-indicating RP-UPLC approach to determine the presenc...
A study of impurity profiling via method development and force degradation in hydrocortisone butyrate at low concentration
A study of impurity profiling via method development and force degradation in hydrocortisone butyrate at low concentration
Since long, triamcinolone and fluocinolone, fluorinated derivatives, have been used for treating various types of dermatit...
Development of stability-indicating HPLC method for quantification of pharmacopeia impurities of Zuclopenthixol and characterization of its stress degradation products by LCMS/MS
Development of stability-indicating HPLC method for quantification of pharmacopeia impurities of Zuclopenthixol and characterization of its stress degradation products by LCMS/MS
The present study focused to develop a simple and sensitive HPLC method for resolution and estimation process-related impu...
IVIVC assessment, pharmacokinetic evaluation, and X-ray radiography mapping of Novel Parteck® SRP 80 and hypromellose-loaded LTD4 receptor antagonist chronosystem
IVIVC assessment, pharmacokinetic evaluation, and X-ray radiography mapping of Novel Parteck® SRP 80 and hypromellose-loaded LTD4 receptor antagonist chronosystem
The current research aims to determine the pharmacokinetic parameters, mucoadhesive strength, and IVIVC correlation of the...
Biomimetic microneedles: exploring the recent advances on a microfabricated system for precision delivery of drugs, peptides, and proteins
Biomimetic microneedles: exploring the recent advances on a microfabricated system for precision delivery of drugs, peptides, and proteins
Despite its popularity, acceptability, and convenience, the oral route is not the classical route for the administration o...
Multi-wavelength fusion spectral extraction-assisted HPLC for simultaneous quantification of multiple secondary metabolites in herbal matrices
Multi-wavelength fusion spectral extraction-assisted HPLC for simultaneous quantification of multiple secondary metabolites in herbal matrices
The existing HPLC methods for the assaying of multiple markers in standardized herbal extracts use a single wavelength for...
Exploration of the aptitude to alleviate oxidative impairment and curb colorectal cancer manifestation by Nostoc calcicola in HT-29 adenocarcinoma cells
Exploration of the aptitude to alleviate oxidative impairment and curb colorectal cancer manifestation by Nostoc calcicola in HT-29 adenocarcinoma cells
Marine cyanobacteria have been known to contain several unique bioactive compounds which have different therapeutic potent...
Therapeutic benefits of gossypin as an emerging phytoconstituents of Hibiscus spp.: a critical review
Therapeutic benefits of gossypin as an emerging phytoconstituents of Hibiscus spp.: a critical review
Flavonoids are one of the crucial secondary metabolites as several functions are carried out by flavonoids, including regu...
Efficient in vitro oxaliplatin delivery with functionalized single-walled carbon nanotube for enhanced colon cancer treatment
Efficient in vitro oxaliplatin delivery with functionalized single-walled carbon nanotube for enhanced colon cancer treatment
Site-specific transport of medicinal products to malignant cells and tissues is an intriguing area since it has an ability...
Method operable design region for robust RP-HPLC analysis of pioglitazone hydrochloride and teneligliptin hydrobromide hydrate: incorporating hybrid principles of white analytical chemistry and design of experiments
Method operable design region for robust RP-HPLC analysis of pioglitazone hydrochloride and teneligliptin hydrobromide hydrate: incorporating hybrid principles of white analytical chemistry and design of experiments
A combination of pioglitazone hydrochloride with teneligliptin hydrobromide hydrate is used to treat type-2 diabe...
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