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Does Endoplasmic Reticulum (ER) Stress Contribute to T-cell Exhaustion in B-ALL?
Background: Glucose deprivation in T lymphocytes can trigger compensatory metabolic pathways, potentially contributing to ...
Comments on "Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice"
Saffaei, A., Amani, J., Salimian, J., Alishiri, G., Abolghasemi, H. (2024). 'Comments on "Com...
IgG4-Related Disease in a 90-Year-Old Man with an 18-Year Disease Course: A Case Report
IgG4-related disease (IgG4-RD) is a multi-organ inflammatory immune-mediated illness caused by IgG4-secreting plasma cells...
The Impact of Wharton’s Jelly-derived Exosomes on the Production of Inflammatory Mediators from HIG-82 Synoviocytes
Background: Osteoarthritis (OA) is the most common joint disease worldwide. Routine treatment options are limited, and tot...
Prognostic Value of CD14 Expression in Peripheral Blood Mononuclear Cell Membrane in Patients with Severe COPD Complicated with Pulmonary Infection
Background: Severe chronic obstructive pulmonary disease (COPD) patients with pulmonary infections face higher morbidity a...
Modulation of M1/M2 Cytokines and Inflammatory Enzymes by Persicaria Species Leaf Extracts in Lipopolysaccharide-stimulated RAW 264.7 Cell Macrophages
Background: Investigating the impacts of plant-based substances on the regulation of pro-inflammatory M1 and anti-inflamma...
miR-196b-5p Affects Macrophage Polarization and Inflammation in Endometriosis
Background: miR-196b-5p was found to be significantly reduced in endometriosis, but its function and the mechanisms involv...
JAK/STAT Signaling Pathway Mediates Anti-Tumor Immunity of CD8+ T Cells in Renal Cancer
Background: CD8+ T cells play a crucial role in immune responses, and have significant potential in tumor immunotherapy. T...
Letter to the Editor Regarding “Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice”
Dear EditorWe are writing to discuss the article titled “Comparative Immunogenicity and Neutralization Potency of Four App...
Outcome of Cyclophosphamide Treatment Following Hematopoietic Stem Cell Transplantation in a Thalassemia Patient: A Case Study
Hematopoietic stem cell transplantation (HSCT) is the only curative therapy for β-thalassemia major in children. However, ...
Evaluation of PD-1 Gene Expression Profile and Methylation of the Regulatory Regions in Patients with Ankylosing Spondylitis
Background: Ankylosing spondylitis (AS) is a chronic autoimmune disorder characterized by the fusion of vertebral joints ...
The Effect of Interferon Beta and Natalizumab on miR-20b Expression in Patients with Relapsing-Remitting Multiple Sclerosis is Potentially Mediated by Modulation of the Jak–STAT Signaling Pathway: A Case-control Study
Background: The mechanisms of the function of interferon beta (IFN-β) and natalizumab (NTZ) in multiple sclerosis (MS) pat...
Evaluation of Monocyte Subpopulations in Patients with Systemic Sclerosis and its Association with Clinical Manifestations of the Disease: a Cross-sectional Controlled Study
Background: Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized not only by fibrosis and vasculopathy ...
Glycyrrhiza Glabra Extract Modulates Type 1 T Helper (TH1) and Regulatory T Cell-Related Immune Responses in an Animal Model of Breast Cancer
Background: It is well-known that TH1 and Treg cells exert anti- and pro-tumorigenic activity, respectively. Thus, TH1 cel...
Natural Killer Cell Subsets in Tumor Draining Lymph Nodes of Patients with Bladder Cancer and Their Clinical Implications
Background: Natural killer (NK) cells are crucial innate components in anti-tumor immunity. However, the clinical impacts ...
Functional Property and Regulatory Mechanism of Macrophages in Complementary and Alternative Medicine: From Bench to Clinic
Complementary and alternative medicine (CAM) includes a wide range of treatments that are gaining acceptance among the pub...
The Protective Role of IL-17 and IL-22 in COVID-19 Infection
Background: The development of a cytokine storm in Coronavirus Disease 2019 (COVID-19) infection can make the disease fata...
Letter to the Editor Regarding “Antibody Production after COVID-19 Vaccination in Patients with Inborn Errors of Immunity”
Dear Editor I am writing in response to the recently published study titled "Antibody Production after COVID-19 Vacc...
MicroRNA-150 Deletion Reduces the Occurrence and Severity of Rheumatoid Arthritis by Inhibiting IL-17
Background: Understanding the effects of epigenetic factors on the pathogenesis of rheumatoid arthritis (RA) is important ...
Abnormal Changes in IL-13 and IL-17A Serum Levels in Children with Adenovirus Pneumonia and their Diagnostic Value
Background: Human adenovirus (HAdV) is an enveloped icosahedral DNA virus. HAdV infection can lead to immune system damage...
IL-27 Levels in Bronchoalveolar Lavage Fluid in Children with Post-infectious Bronchiolitis Obliterans
Background: Pulmonary neutrophils may play a crucial role in the development of bronchiolitis obliterans (BO) following me...
Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in Primary Brain Tumors
Background: Tumor-infiltrating lymphocytes (TILs) and brain stromal cells produce immunosuppressive cytokines, contributin...
Intervention with ICOSL Antibodies Alleviates Inflammatory Infiltrations in Mice with Neutrophilic Asthma
Background: Neutrophilic asthma is characterized by the predominant infiltration of neutrophils in airway inflammation.Obj...
Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment
Background: The imbalance between M1 and M2 macrophage activation is closely associated with the pathogenesis of inflammat...
Immunohistochemical Evaluation of NKP46 Receptor Expression and the Number of NK Cells in the Endometrium of Patients with Endometriosis
Background: Endometriosis is a medical condition that can cause infertility in women. Women with endometriosis experience ...
The Ratio of Peripheral Blood Natural Killer Cells is not a Solid Surrogate Immune Index in Unexplained Recurrent Miscarriage
Background: Immunotherapies targeting peripheral natural killer (pbNK) cells in unexplained recurrent miscarriage (uRM) re...
Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice
Background: Since the outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several vaccine ...
Human Umbilical Cord Mesenchymal Stem Cells and Their Extracellular Vesicles Modulate Pro- and Anti-Inflammatory Cytokines in Ligature-induced Periodontitis
Background: Periodontitis is a persistent inflammatory condition that impacts the tissues supporting the teeth, ultimately...
Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia
Background: Thymocyte selection-associated high mobility group box protein (TOX) and members of the nuclear receptor 4A (N...
Rescue of HLH with T and B Lymphocyte Involvement Due to Epstein-Barr Virus by PD-1 Inhibitor/Ruxolitinib and Rituximab Combination Regimens: A Case Report
Hemophagocytic lymphohistiocytosis (HLH) is a fatal clinical syndrome. The most common cause of secondary HLH is Epstein-B...
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