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Role of interferon-induced transmembrane protein family in cancer progression: a special focus on pancreatic cancer
Role of interferon-induced transmembrane protein family in cancer progression: a special focus on pancreatic cancer
Human interferon-induced transmembrane protein family (IFITMs) consists of five main proteins. IFITM1, IFITM2, and IFITM3 ...
High expression of CD9 and Epidermal Growth Factor Receptor promotes the development of tongue cancer
High expression of CD9 and Epidermal Growth Factor Receptor promotes the development of tongue cancer
Tongue cancer is distinguished by aggressive behavior, a high risk of recurrence, lymph, and distant metastases. Hypoxia-I...
The cytotoxic effects of prazosin, chlorpromazine, and haloperidol on hepatocellular carcinoma and immortalized non-tumor liver cells
The cytotoxic effects of prazosin, chlorpromazine, and haloperidol on hepatocellular carcinoma and immortalized non-tumor liver cells
Liver cancer annually accounts for over 800,000 cases and 700,000 deaths worldwide. Hepatocellular carcinoma is responsibl...
In vitro anticancer activity of Hirudinaria manillensis methanolic extract and its validation using in silico molecular docking approach
In vitro anticancer activity of Hirudinaria manillensis methanolic extract and its validation using in silico molecular docking approach
Cancer has emerged as a potentially lethal illness, which recently upsurged in the mortality rate. Animal-derived compound...
Novel phloretin-based combinations targeting glucose metabolism in hepatocellular carcinoma through GLUT2/PEPCK axis of action: in silico molecular modelling and in vivo studies
Novel phloretin-based combinations targeting glucose metabolism in hepatocellular carcinoma through GLUT2/PEPCK axis of action: in silico molecular modelling and in vivo studies
Hepatocellular carcinoma (HCC) is commonly associated with disturbances in glucose metabolism and enhanced glycolysis. How...
The evaluation of the anti-cancer effects of Anoectochilus roxburghii on hematological cancers in vitro
The evaluation of the anti-cancer effects of Anoectochilus roxburghii on hematological cancers in vitro
The cause of hematological cancers is the uncontrolled proliferation of hematopoietic and lymphoid tissues, and chemothera...
In vitro evaluation of p-coumaric acid and naringin combination in human epidermoid carcinoma cell line (A431)
In vitro evaluation of p-coumaric acid and naringin combination in human epidermoid carcinoma cell line (A431)
Cancer is considered most detrimental due to high mortality worldwide. Among them, skin cancers play a major part by affec...
The roles of P-selectin in cancer cachexia
The roles of P-selectin in cancer cachexia
P-selectin, a cell adhesion molecule of the selectin family, is expressed on the surface of activated endothelial cells (E...
TGF-β in correlation with tumor progression, immunosuppression and targeted therapy in colorectal cancer
TGF-β in correlation with tumor progression, immunosuppression and targeted therapy in colorectal cancer
Colorectal cancer (CRC) is a complex malignancy responsible for the second-highest cancer deaths worldwide. TGF-β mai...
Musashi-2 (MSI2) promotes neuroblastoma tumorigenesis through targeting MYC-mediated glucose-6-phosphate dehydrogenase (G6PD) transcriptional activation
Musashi-2 (MSI2) promotes neuroblastoma tumorigenesis through targeting MYC-mediated glucose-6-phosphate dehydrogenase (G6PD) transcriptional activation
Neuroblastoma (NB) is the deadliest pediatric solid tumor due to its rapid proliferation. Aberrant expression of MYCN is d...
Combretastatin A-4 suppresses the invasive and metastatic behavior of glioma cells and induces apoptosis in them: in-vitro study
Combretastatin A-4 suppresses the invasive and metastatic behavior of glioma cells and induces apoptosis in them: in-vitro study
The most common primary brain malignancy, glioblastoma multiforme, is tremendously resistant to conventional&...
Whole-exome sequencing reveals mutational profiles of anorectal and gynecological melanoma
Whole-exome sequencing reveals mutational profiles of anorectal and gynecological melanoma
Mucosal melanoma is a rare and highly malignant type of melanoma. Among the sites that mucosal melanoma arises, anorectal ...
Identification of novel inhibitors from Urtica spp against TNBC targeting JAK2 receptor for breast cancer therapy
Identification of novel inhibitors from Urtica spp against TNBC targeting JAK2 receptor for breast cancer therapy
Breast cancer is the most prevalent form of cancer in women globally, and TNBC (triple-negative breast cancer) is its aggr...
Are medical oncologists ready for the artificial intelligence revolution? Evaluation of the opinions, knowledge, and experiences of medical oncologists about artificial intelligence technologies
Are medical oncologists ready for the artificial intelligence revolution? Evaluation of the opinions, knowledge, and experiences of medical oncologists about artificial intelligence technologies
The use of artificial intelligence technologies (AIT) in medicine is increasing worldwide. In this study, it was aimed to ...
HDAC11 mediates the ubiquitin-dependent degradation of p53 and inhibits the anti-leukemia effect of PD0166285
HDAC11 mediates the ubiquitin-dependent degradation of p53 and inhibits the anti-leukemia effect of PD0166285
Cytarabine-resistant acute myeloid leukemia (AML) is a common phenomenon, necessitating the search for new chemotherapeuti...
Novel biomolecules in targeted cancer therapy: a new approach towards precision medicine
Novel biomolecules in targeted cancer therapy: a new approach towards precision medicine
Cancer is a major threat to human life around the globe, and the discovery of novel biomolecules continue to be an urgent&...
Himalayan flora: targeting various molecular pathways in lung cancer
Himalayan flora: targeting various molecular pathways in lung cancer
The fatal amplification of lung cancer across the globe and the limitations of current treatment strategies emphasize the ...
Lysates from the probiotic bacterium Streptococcus thermophilus enhances the survival of T cells and triggers programmed cell death in neuroblastoma cells
Lysates from the probiotic bacterium Streptococcus thermophilus enhances the survival of T cells and triggers programmed cell death in neuroblastoma cells
Neuroblastoma is the most common brain solid tumor in infancy. Despite the availability of numerous approaches like immuno...
Identification by molecular dynamic simulation and in vitro validation of SISB-A1, N-[1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-yl]-2-[(2-oxo-4-phenyl-2H-chromen-7-yl) oxy], as an inhibitor of the AblT315I mutant kinase to combat imatinib resistance in chronic myeloid leukemia
Identification by molecular dynamic simulation and in vitro validation of SISB-A1, N-[1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-yl]-2-[(2-oxo-4-phenyl-2H-chromen-7-yl) oxy], as an inhibitor of the AblT315I mutant kinase to combat imatinib resistance in chronic myeloid leukemia
The discovery of imatinib, a specific inhibitor of Abl kinase, revolutionized the therapeutic approach to chronic myeloid ...
Synergistic induction of apoptosis in liver cancer cells: exploring the combined potential of doxorubicin and XL-888
Synergistic induction of apoptosis in liver cancer cells: exploring the combined potential of doxorubicin and XL-888
Combination therapy has been frequently preferred in treating various types of cancer in recent years. Targeted cancer the...
Decoding dysregulated angiogenesis in HTLV-1 asymptomatic carriers compared to healthy individuals
Decoding dysregulated angiogenesis in HTLV-1 asymptomatic carriers compared to healthy individuals
Human T-cell lymphotropic virus type 1 (HTLV-1) is the first identified human retrovirus responsible for two significant d...
Diosmetin induces apoptosis and protective autophagy in human gastric cancer HGC-27 cells via the PI3K/Akt/FoxO1 and MAPK/JNK pathways
Diosmetin induces apoptosis and protective autophagy in human gastric cancer HGC-27 cells via the PI3K/Akt/FoxO1 and MAPK/JNK pathways
Gastric cancer represents a significant global health concern, necessitating the exploration of novel therapeutic options....
Network pharmacology-based anti-colorectal cancer activity of piperlonguminine in the ethanolic root extract of Piper longum L
Network pharmacology-based anti-colorectal cancer activity of piperlonguminine in the ethanolic root extract of Piper longum L
Colorectal cancer (CRC) has the second highest incidence and fatality rates of any malignancy, at 10.2 and 9.2%, respectiv...
A multitier virtual screening of antagonists targeting PD-1/PD-L1 interface for the management of triple-negative breast cancer
A multitier virtual screening of antagonists targeting PD-1/PD-L1 interface for the management of triple-negative breast cancer
Immunotherapies are promising therapeutic options for the management of triple-negative breast cancer because of its high ...
Involving stemness factors to improve CAR T-cell-based cancer immunotherapy
Involving stemness factors to improve CAR T-cell-based cancer immunotherapy
Treatment with chimeric antigen receptor (CAR) T cells indicated remarkable clinical responses with liquid cancers such as...
Solanum nigrum Linn.: Advances in anti-cancer activity and mechanism in digestive system tumors
Solanum nigrum Linn.: Advances in anti-cancer activity and mechanism in digestive system tumors
Cancer has currently become a serious public health issue in many countries worldwide, and tumors of the digestive system ...
Toxicity evaluation of synthetic glucocorticoids against breast cancer cell lines MDA-MB-231, MCF-7 and human embryonic kidney HEK293
Toxicity evaluation of synthetic glucocorticoids against breast cancer cell lines MDA-MB-231, MCF-7 and human embryonic kidney HEK293
In this study, we conducted a comprehensive assessment of the cytotoxicity of three glucocorticoids, namely Hydrocortisone...
Dysregulated ceramides metabolism via PTPN11 exposes a metabolic vulnerability to breast cancer metastasis
Dysregulated ceramides metabolism via PTPN11 exposes a metabolic vulnerability to breast cancer metastasis
Breast cancer is a prevalent malignant tumor, posing a significant threat to women's health globally due to its increa...
C2orf48 promotes the progression of nasopharyngeal carcinoma by regulating high mobility group AT-hook 2
C2orf48 promotes the progression of nasopharyngeal carcinoma by regulating high mobility group AT-hook 2
Recurrence and metastasis are the major factors affecting the survival of nasopharyngeal carcinoma (NPC), and the mechanis...
Deregulation of cytokine affecting oral neutrophil subsets in oral cancer
Deregulation of cytokine affecting oral neutrophil subsets in oral cancer
The most prevalent form of leukocytes in human blood, neutrophils, is regarded as an essential part of the innate immune s...
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