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Cigarette sidestream smoke-induced cellular senescence and the protective role of histone H2AX

Cigarette smoke contains thousands of chemicals and many chemicals impose health hazards including carcinogenic, cardiovas...

Toxicology In Vitro

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Zinc finger transcription factor ZNF384 mitigates LPS-induced ferroptosis and inflammation in lung epithelial cells by activating SESN2-mediated autophagy

Sepsis, a complex and rapidly developing clinical condition, is characterized by systemic inflammatory response syndrome c...

Toxicology In Vitro

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Selective JAK-1 inhibitor Upadacitinib and peptide PD29 modulate the JAK and TGF-β/Smad signaling pathways reducing experimental dermal fibrosis

Systemic sclerosis (SSc) is a multifactorial autoimmune connective tissue disease characterized by dermal fibrosis, chroni...

Toxicology In Vitro

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Haemostasis-altering effects of Milos viper (Macrovipera schweizeri) venom

Haemotoxicity is one of the primary symptoms of viperid envenomation, manifesting in cardiovascular and haemostatic distur...

Toxicology In Vitro

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The effect of organic solvents on the in vitro transport activity of three OATP isoforms

PurposeIn vitro studies of transporter activity often require the addition of organic solvents such as dimethyl sulfoxide ...

Toxicology In Vitro

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Ozone and particulate matter co-exposure at the air-liquid interface: Establishing an approach to assess pollutant interactions in vitro

BackgroundAir pollution is a complex mixture of gases and particulates that varies spatially and temporally, making attrib...

Toxicology In Vitro

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Antibiotics reduce intestinal bile acid reuptake in an in vitro model system

Enterohepatic circulation of bile acids is a highly efficient process that is important for bile acid homeostasis. The aim...

Toxicology In Vitro

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Association between drug-induced heart failure and CYP1A1, CYP1B1, and CYP3A4 inhibition: Utility of cytochrome P450 inhibition assay for evaluating cardiotoxicity of drug candidates

Cytochrome P450 (P450 or CYP) is a family of drug-metabolizing enzymes that contribute to the metabolism and disposition o...

Toxicology In Vitro

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Effects of Penthorum chinense pursh and gallic acid on embryonic and cardiac development in zebrafish (Danio rerio)

Penthorum chinense Pursh (P. chinense) has long been esteemed in traditional Chinese medicine for its remarkable medicinal...

Toxicology In Vitro

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Cadmium sulfide nanoparticles (CdSNPs) modulate key oncogenic pathways in PA1 ovarian cancer cells: Insights from transcriptomic analysis

RNA sequencing (RNA-seq) has transformed cancer research by providing a detailed analysis of gene expression in cancerous ...

Toxicology In Vitro

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In vitro metabolic clearance of malathion in rats and humans

Malathion (Diethyl[(dimethoxyphosphinothioyl)thio] succinate) is an organophosphorus (OP) insecticide. It is a widely used...

Toxicology In Vitro

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Integrative toxicity assessment of tocotrienol-rich fraction from palm oil using in silico methods and zebrafish embryotoxicity model

Palm oil, derived from the fruit of the palm plant (Elaeis guineensis), is among the most widely consumed edible oils (Ede...

Toxicology In Vitro

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Species differences in microsomal metabolism of hydroxychloroquine

Chloroquine (CQ) and hydroxychloroquine (HCQ) are established 4-aminoquinoline antimalarials with therapeutic applications...

Toxicology In Vitro

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Corrigendum to “Tetrazolium–based colorimetric assays underestimat the direct antitumor effects of bevacizumab” [Toxicology in vitro 91 (2023) 105631]

Volume 107, August 2025, 106061Author links open overlay panelPei Wei a, Min Wang b, Mao Lin c, Zhiyong Wang aShow morePre...

Toxicology In Vitro

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Molecular mechanistic approach to reveal decitabine's effect on DNMT gene modulation and its inhibitory role in heavy metal-induced proliferation in urinary bladder cancer cell line

Bladder cancer is the ninth most diagnosed cancer worldwide, with over 6 lakh new cases and approximately 2.2 lakh deaths ...

Toxicology In Vitro

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Transcriptomic dose-response by UVC and heavy ion radiation reveal pathways to immune impairment

Significant health risk has been brought about by increased level of irradiation from ozone holes, industrial pollutants a...

Toxicology In Vitro

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Toxicoproteomic study of fipronil in SH-SY5Y cells reveals induction of endoplasmic reticulum stress and necrotic cell death as neurodegenerative mechanisms

As a consequence of improved life expectancies, the world population is increasing and the worldwide prevalence of age-rel...

Toxicology In Vitro

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Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing

In vitro genotoxicity tests are extensively used by regulatory agencies worldwide to identify chemicals that induce geneti...

Toxicology In Vitro

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Use of centromeric probe to identify micronuclei origin and its advantages in genetic toxicology studies

Exposure of the human population to physical agents such as radiation, biological agents, and chemicals can be very high, ...

Toxicology In Vitro

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Detection of skin sensitization hazards in medical device materials using a combination of three alternative in vitro testing methods

This study attempted to detect the skin sensitization hazards of medical device materials by combining multiple in vitro a...

Toxicology In Vitro

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Ex vivo skin diffusion and decontamination studies of titanium dioxide nanoparticles