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Interaction of mycotoxins zearalenone, α-zearalenol, and β-zearalenol with cytochrome P450 (CYP1A2, 2C9, 2C19, 2D6, and 3A4) enzymes and organic anion transporting polypeptides (OATP1A2, OATP1B1, OATP1B3, and OATP2B1)
Interaction of mycotoxins zearalenone, α-zearalenol, and β-zearalenol with cytochrome P450 (CYP1A2, 2C9, 2C19, 2D6, and 3A4) enzymes and organic anion transporting polypeptides (OATP1A2, OATP1B1, OATP1B3, and OATP2B1)
Zearalenone (ZEN) is a mycoestrogen produced by Fusarium fungi. ZEN is a frequent contaminant in cereal-based products, re...
Screening for endocrine disrupting chemicals inhibiting monocarboxylate 8 (MCT8) transporter facilitated thyroid hormone transport using a modified nonradioactive assay
Screening for endocrine disrupting chemicals inhibiting monocarboxylate 8 (MCT8) transporter facilitated thyroid hormone transport using a modified nonradioactive assay
KeywordsEndocrine disrupting chemicalsIn vitro assaysMonocarboxylate 8 transporterSandell-Kolthoff reactionThyroid hormone...
Comparison of in vitro thyroxine (T4) metabolism between Wistar rat and human hepatocyte cultures
Comparison of in vitro thyroxine (T4) metabolism between Wistar rat and human hepatocyte cultures
KeywordsWistar rat and human hepatocytesL-thyroxine metabolismNuclear receptor activationThyroxine-glucuro-conjugationHuma...
Protective role of fetal bovine serum on PLHC-1 spheroids exposed to a mixture of plastic additives: A lipidomic perspective
Protective role of fetal bovine serum on PLHC-1 spheroids exposed to a mixture of plastic additives: A lipidomic perspective
The use of fetal bovine serum (FBS) in cell culture is being questioned for scientific and ethical reasons, prompting the ...
Particulate iron oxide food colorants (E 172) during artificial digestion and their uptake and impact on intestinal cells
Particulate iron oxide food colorants (E 172) during artificial digestion and their uptake and impact on intestinal cells
Iron oxide of various structures is frequently used as food colorant (E 172). The spectrum of colors ranges from yellow ov...
Arsenic trioxide inhibits the response of primary human B cells to influenza virus A in vitro
Arsenic trioxide inhibits the response of primary human B cells to influenza virus A in vitro
Arsenic is a naturally occurring contaminant in aquiferous water reservoirs, on which a significant minority of US househo...
Gill epithelial cell line ASG-10 from Atlantic salmon as a new research tool for solving water quality challenges in aquaculture
Gill epithelial cell line ASG-10 from Atlantic salmon as a new research tool for solving water quality challenges in aquaculture
Here we evaluated the gill epithelial cell line ASG-10 from Atlantic salmon, as an in vitro model for research on known wa...
Fragrances as a trigger of immune responses in different environments
Fragrances as a trigger of immune responses in different environments
Fragrances are mixtures of organic molecules, including esters, aldehydes and alcohols present in a plethora of products (...
ESTIV 2022: Key enabling non-animal technologies for research, education and testing
ESTIV 2022: Key enabling non-animal technologies for research, education and testing
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
A comparison of dermal toxicity models; assessing suitability for safe(r)-by-design decision-making and for screening nanomaterial hazards
A comparison of dermal toxicity models; assessing suitability for safe(r)-by-design decision-making and for screening nanomaterial hazards
KeywordsNanomaterialSafe-by-designHazard screeningDermal toxicityNew approach methodologies (NAMs)Data availabilityIt is p...
Using cell culture systems from the Persian Gulf Arabian yellowfin sea bream, Acanthopagrus arabicus, to assess the effects of dexamethasone on gonad and brain aromatase activity and steroid production
Using cell culture systems from the Persian Gulf Arabian yellowfin sea bream, Acanthopagrus arabicus, to assess the effects of dexamethasone on gonad and brain aromatase activity and steroid production
>4000 pharmaceutical compounds (PCs) up to hundreds of tons are commercially produced, many of which are designed to im...
Characterization of palmitic acid toxicity induced insulin resistance in HepG2 cells.
Characterization of palmitic acid toxicity induced insulin resistance in HepG2 cells.
Insulin is a peptide hormone that plays an important role in the regulation of carbohydrate, fat, and protein metabolism (...
Lovastatin impairs cellular proliferation and enhances hyaluronic acid production in fibroblast-like synoviocytes
Lovastatin impairs cellular proliferation and enhances hyaluronic acid production in fibroblast-like synoviocytes
Cholesterol metabolism is involved in the pathogenesis of osteoarthritis (OA), and a high cholesterol level has been ident...
Simulated gastric leachate of 3D printer metal-fill filaments induces cytotoxic effects in rat and human intestinal models
Simulated gastric leachate of 3D printer metal-fill filaments induces cytotoxic effects in rat and human intestinal models
Three-dimensional (3D) printing, also termed additive manufacturing, has advanced from a commercial industrial process to ...
Development of natural cosmetic emulsion using the by-product of Lecythis pisonis seed
Development of natural cosmetic emulsion using the by-product of Lecythis pisonis seed
Natural products and their biological activities are nowadays the subjects of interest for the pharmaceutical industries, ...
In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
In vitro test methods for evaluating high molecular weight polyethylene oxide polymer induced hemolytic and thrombotic potential
The misuse and abuse of prescription opioids represents a major public health issue in the United States and worldwide (Hu...
Hsa_circ_0003356 suppresses gastric cancer progression via miR-556-5p/FKBP5 axis
Hsa_circ_0003356 suppresses gastric cancer progression via miR-556-5p/FKBP5 axis
Despite of the substantial improvements in medical technology in the past decades, there is still a rapid growth in global...
In vitro assessment of cytotoxicity of spent fluid catalytic cracking refinery catalysts on cell lines and identification of critical toxic metals
In vitro assessment of cytotoxicity of spent fluid catalytic cracking refinery catalysts on cell lines and identification of critical toxic metals
Fluid catalytic cracking (FCC) process plays an important role in petroleum refining industry, and FCC catalyst is the key...
Transcriptional landscape of human keratinocyte models exposed to 60-GHz millimeter-waves
Transcriptional landscape of human keratinocyte models exposed to 60-GHz millimeter-waves
The requirement of new kind of frequency for technological development are increasing. Among all radiofrequencies, millime...
Transcriptomic profile of human iPSC-derived podocyte-like cells exposed to a panel of xenobiotics
Transcriptomic profile of human iPSC-derived podocyte-like cells exposed to a panel of xenobiotics
Podocytes play a critical role in the formation and maintenance of the glomerular filtration barrier and injury to these c...
Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy
Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy
Hepatocellular carcinoma (HCC) is considered a major problem worldwide. It is the fifth most common cancer and the second ...
Electromagnetic field (50 Hz) enhance metabolic potential and induce adaptive/reprogramming response mediated by the increase of N6-methyladenosine RNA methylation in adipose-derived mesenchymal stem cells in vitro
Electromagnetic field (50 Hz) enhance metabolic potential and induce adaptive/reprogramming response mediated by the increase of N6-methyladenosine RNA methylation in adipose-derived mesenchymal stem cells in vitro
Mesenchymal stem cells (MSCs) are multipotent cells that play an important role in tissue homeostasis and regeneration by ...
Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes
Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes
PurposeThe inhibitory effect of Apatinib on cytochrome P450 (CYP450) enzymes has been studied. However, it is unknown whet...
A multiparametric and orthogonal approach indicates low toxicity for zein nanoparticles in a repellent formulation
A multiparametric and orthogonal approach indicates low toxicity for zein nanoparticles in a repellent formulation
Arthropods can transmit pathogens and infect other organisms, contributing to endemics worldwide (Benelli, 2015; Benelli a...
Pyruvate dehydrogenase is a potential mitochondrial off-target for gentamicin based on in silico predictions and in vitro inhibition studies
Pyruvate dehydrogenase is a potential mitochondrial off-target for gentamicin based on in silico predictions and in vitro inhibition studies
KeywordsIn silico predictionsDrug-induced kidney injuryPyruvate dehydrogenaseMitochondriaOff-targetData availabilityThe ra...
Phototoxic action of meloxicam contributes to dysregulation of redox homeostasis in normal human skin cells – Molecular and biochemical analysis of antioxidant enzymes in melanocytes and fibroblasts
Phototoxic action of meloxicam contributes to dysregulation of redox homeostasis in normal human skin cells – Molecular and biochemical analysis of antioxidant enzymes in melanocytes and fibroblasts
The World Health Organization defines an adverse drug reaction (ADR) as “a response to a drug that is harmful and unintend...
Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae
Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae
Gallic acid (GA) and ellagic acid (EA) are natural compounds known for their antioxidant properties and potential health b...
DEHP and DINP accelerate aging effects in male and female of Drosophila melanogaster depend on AKT/FOXO pathway
DEHP and DINP accelerate aging effects in male and female of Drosophila melanogaster depend on AKT/FOXO pathway
Phthalates are commonly used as plasticizers to improve the durability, resistance, and flexibility of polyvinyl chloride ...
Newly synthesized derivatives with a thiosemicarbazide group reduce the viability of cancer cell lines. Acute toxicity assessment in Zebrafish (Danio rerio) early life stages
Newly synthesized derivatives with a thiosemicarbazide group reduce the viability of cancer cell lines. Acute toxicity assessment in Zebrafish (Danio rerio) early life stages
Cancers are the most common cause of death worldwide, and the number is still increasing in developing countries (Wild et ...
Cytotoxic and genotoxic effects of triphenyl phosphate on root tip cells of Allium cepa L.
Cytotoxic and genotoxic effects of triphenyl phosphate on root tip cells of Allium cepa L.
Currently, different polymer types are used for producing various consumer products ranging from electric and electronic d...
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