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Sleep deprivation whips up cytokine storm
A new mouse model of sleep deprivation reveals a potent pathway by which sleep-related changes in prostaglandin D2 in the ...
TCRs and AI: the future is now
A preprint by Fast et al. describes TAPIR, a computational tool for predicting TCR–pMHC interactions.
Adipose tissue maintains healthy joint fibroblasts via cortisol signalling
A preprint by Faust et al. determines mechanisms of crosstalk between adipocytes and fibroblasts in the joint relevant to ...
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations
The approval of the first immune checkpoint inhibitors provided a paradigm shift for the treatment of malignancies across ...
Neonatal monocytes suppress adult TH17 cell responses in skin
A preprint by Dhariwala et al. reports that monocytes in the skin of newborn mice suppress microbiota-driven inflammatory ...
Brain regulatory T cells
Brain regulatory T cells
The brain, long thought to be isolated from the peripheral immune system, is increasingly recognized to be integrated into...
Author Correction: Protein kinases: drug targets for immunological disorders
Authors and AffiliationsDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Nationa...
Communicating science effectively in times of crisis: time for reflection
Communicating science effectively in times of crisis: time for reflection
Gary Koretzky served as president of the American Association of Immunologists (AAI) from 2021 to 2022. During this tenure...
Lipid metabolism extinguishes cGAS–STING-induced inflammation
Lipid metabolism extinguishes cGAS–STING-induced inflammation
Liver X receptor (LXR) signalling can inhibit the DNA-sensing cGAS–STING inflammatory pathway through degradation of...
Role of the microbiota in response to and recovery from cancer therapy
Role of the microbiota in response to and recovery from cancer therapy
Our understanding of how the microbiota affects the balance between response to and failure of cancer treatment by modulat...
Low serotonin linked to long COVID
Low serotonin linked to long COVID
A study shows that individuals with long COVID have low levels of serotonin, which explains the neurocognitive impairments...
Host IgM facilitates mating in Leishmania
The parasite Leishmania, which causes the debilitating disease leishmaniasis, is spread by sandflies and affects millions ...
Gut fungi have lasting effect on immune response to severe COVID-19
A study by Kusakabe et al. reports increased antibody responses to specific fungi in individuals with severe COVID-19, par...
NMDAR-directed CAAR T cells show promise for autoimmune encephalitis
N-methyl-d-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis. It is usually treated by un...
IBEX: a user-friendly and open-source solution for high-plex immunostaining
IBEX: a user-friendly and open-source solution for high-plex immunostaining
In this Tools of the Trade article, Leanne Arakkal (of the Ronald Germain group) describes a technique for highly multiple...
The cancer-immune dialogue in the context of stress
The cancer-immune dialogue in the context of stress
Although there is little direct evidence supporting that stress affects cancer incidence, it does influence the evolution,...
Turning on anti-tumour T cells via MTAP
Chromosomal region 9p21 is the most common homozygously deleted region in cancer and this has been attributed to the loss ...
Protective roles for γδ T cells in inflammatory bowel disease
Here, Dart et al. describe a role for butyrophilin-like (BTNL) molecules in mediating the selection of tissue-protective γ...
Tracking the infant immune response to SARS-CoV-2
This study used a multi-omics approach to assess immune responses in infants and young children before, during and after a...
Daughters forget, mothers remember
Mother mice retain a small population of latent regulatory T cells from each pregnancy that remembers their offspring and ...
Human immune organoids: a tool to study vaccine responses
In this Tools of the Trade article, Lisa Wagar (while in the Mark Davis lab) developed an in vitro immune organoid system ...
The distinctive immune features of long COVID
A large, cross-sectional immune-profiling study provides insights into the biological features of long COVID.
The brain tumour microenvironment imparts neutrophils with pro-tumour properties
The brain tumour microenvironment imparts neutrophils with pro-tumour properties
Neutrophils associated with brain tumours show a more immune-suppressive and proangiogenic phenotype.
MR1 antigen presentation to MAIT cells and other MR1-restricted T cells
MR1 antigen presentation to MAIT cells and other MR1-restricted T cells
MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell immunity. Distinct MHC molecules b...
Anti-cytokine autoantibodies: mechanistic insights and disease associations
Anti-cytokine autoantibodies: mechanistic insights and disease associations
Anti-cytokine autoantibodies (ACAAs) are increasingly recognized as modulating disease severity in infection, inflammation...
Author Correction: The immunology of long COVID
Authors and AffiliationsDepartment of Immunology and Inflammation, Imperial College London, Hammersmith Hospital, London, ...
Brief diet changes affect immunity
A new study shows that even a short-term switch to a low-fibre diet suppresses immunity to bacterial infection and comprom...
Lymphatic expression of TBX1 helps to heal the heart
This study by Wang et al. identifies a role for the T-box transcription factor TBX1 in mediating tissue repair after myoca...
Lung-migrating helminths can enhance immunity to SARS-CoV-2
There have been conflicting views on whether helminth infections modulate disease outcomes during SARS-CoV-2 infection. In...
A protective role for interferon-ε in ovarian cancer
Interferon-ε (IFNε) is a unique type I IFN that is constitutively expressed by epithelial cells in the female reproductive...
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