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The danger theory of immunity revisited
The danger theory of immunity revisited
The danger theory of immunity, introduced by Polly Matzinger in 1994, posits that tissue stress, damage or infection has a...
Adipokines: masterminds of metabolic inflammation
Adipokines: masterminds of metabolic inflammation
Adipose tissue is an immunologically active organ that controls host physiology, partly through the release of mediators t...
Viral infection and antiviral immunity in the oral cavity
Viral infection and antiviral immunity in the oral cavity
Individual tissues have distinct antiviral properties garnered through various mechanisms, including physical characterist...
Innate lymphoid cell control of neuronal synapse development
Innate lymphoid cell control of neuronal synapse development
ILC2s promote inhibitory synapse formation in the postnatal mouse brain through the production of IL-13.
Integrating natural commensals and pathogens into preclinical mouse models
Integrating natural commensals and pathogens into preclinical mouse models
Fundamental discoveries in many aspects of mammalian physiology have been made using laboratory mice as research models. T...
Redefining PD1 as a guardian of stem-like T cells
A preprint by Hor et al. shows that PD1 signalling regulates the maintenance of a high-affinity, stem-like T cell subset i...
Mitochondria in monocyte-derived cells promote tissue damage in multiple sclerosis
A preprint by Villar-Vesga et al. shows that monocyte-derived cells in the central nervous system produce mitochondrial re...
Elixir for DCs
Elixir for DCs
Age-associated defects in dendritic cells can be corrected by hyperactivating adjuvants containing an oxidized phospholipi...
Understanding NK cell heterogeneity
Two papers in Nature Immunology provide a comprehensive atlas of human natural killer cells in health and in different typ...
How bile acids and the microbiota interact to shape host immunity
How bile acids and the microbiota interact to shape host immunity
Bile acids are increasingly appearing in the spotlight owing to their novel impacts on various host processes. Similarly, ...
Pyroptotic cell products promote tissue repair
Pyroptotic cell products promote tissue repair
The pyroptotic secretome can be beneficial in promoting tissue repair.
CD28 co-stimulation: novel insights and applications in cancer immunotherapy
CD28 co-stimulation: novel insights and applications in cancer immunotherapy
Substantial progress in understanding T cell signalling, particularly with respect to T cell co-receptors such as the co-s...
How neuroinflammation weakens muscles
How neuroinflammation weakens muscles
Neuroinflammation in response to infection or chronic disease can cause non-neural symptoms such as fatigue and muscle pai...
Early life antibiotics have lasting effects on the lung epithelium
Early life antibiotics have lasting effects on the lung epithelium
Transient depletion of the gut microbiome by antibiotics in early life reduces systemic levels of the metabolite indole-3-...
Location matters: mapping antigen receptors within tissues
Location matters: mapping antigen receptors within tissues
In this Tools of the Trade article, Camilla Engblom and colleagues describe their elegant technique ‘Spatial VDJR...
Sleep deprivation whips up cytokine storm
A new mouse model of sleep deprivation reveals a potent pathway by which sleep-related changes in prostaglandin D2 in the ...
TCRs and AI: the future is now
A preprint by Fast et al. describes TAPIR, a computational tool for predicting TCR–pMHC interactions.
Adipose tissue maintains healthy joint fibroblasts via cortisol signalling
A preprint by Faust et al. determines mechanisms of crosstalk between adipocytes and fibroblasts in the joint relevant to ...
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations
The approval of the first immune checkpoint inhibitors provided a paradigm shift for the treatment of malignancies across ...
Neonatal monocytes suppress adult TH17 cell responses in skin
A preprint by Dhariwala et al. reports that monocytes in the skin of newborn mice suppress microbiota-driven inflammatory ...
Brain regulatory T cells
Brain regulatory T cells
The brain, long thought to be isolated from the peripheral immune system, is increasingly recognized to be integrated into...
Author Correction: Protein kinases: drug targets for immunological disorders
Authors and AffiliationsDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Nationa...
Communicating science effectively in times of crisis: time for reflection
Communicating science effectively in times of crisis: time for reflection
Gary Koretzky served as president of the American Association of Immunologists (AAI) from 2021 to 2022. During this tenure...
Lipid metabolism extinguishes cGAS–STING-induced inflammation
Lipid metabolism extinguishes cGAS–STING-induced inflammation
Liver X receptor (LXR) signalling can inhibit the DNA-sensing cGAS–STING inflammatory pathway through degradation of...
Role of the microbiota in response to and recovery from cancer therapy
Role of the microbiota in response to and recovery from cancer therapy
Our understanding of how the microbiota affects the balance between response to and failure of cancer treatment by modulat...
Low serotonin linked to long COVID
Low serotonin linked to long COVID
A study shows that individuals with long COVID have low levels of serotonin, which explains the neurocognitive impairments...
Host IgM facilitates mating in Leishmania
The parasite Leishmania, which causes the debilitating disease leishmaniasis, is spread by sandflies and affects millions ...
Gut fungi have lasting effect on immune response to severe COVID-19
A study by Kusakabe et al. reports increased antibody responses to specific fungi in individuals with severe COVID-19, par...
NMDAR-directed CAAR T cells show promise for autoimmune encephalitis
N-methyl-d-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis. It is usually treated by un...
IBEX: a user-friendly and open-source solution for high-plex immunostaining
IBEX: a user-friendly and open-source solution for high-plex immunostaining
In this Tools of the Trade article, Leanne Arakkal (of the Ronald Germain group) describes a technique for highly multiple...
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