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Therapeutic drug monitoring of isavuconazole: Trends and update
Isavuconazole (ISA) is a triazole antifungal agent that has been approved for the treatment of invasive aspergillosis or m...
Flavonols interrupt internalized bacteria hijacking cellular responses via suppressing oxidative stress induced cellular apoptotic death
The misuse of antibiotics has led to a range of health issues associated with resistant bacterial infections worldwide [1]...
Disrupting bacterial metabolism by targeting LDH reverses Streptococcus suis aminoglycoside resistance
Streptococcus suis (S. suis) is a significant zoonotic pathogen that substantially threatens to both swine and humans, par...
Molecular epidemiology and genomic insights into Enterobacter cloacae complex co-harbouring blaKPC and mcr: Implications for resistance gene transmission
Enterobacter cloacae complex (ECC), as one of the common pathogens in Carbapenem-resistant Enterobacteriaceae (CRE), can c...
Therapeutic effect of taxifolin on bacterial meningitis associated with inhibition of PI3K/AKT and MAPK signalling
Bacterial meningitis (BM), characterized by bacterial invasion of the meninges and subsequent intense inflammatory respons...
Evaluation of the Roche cobas MTB and MTB-RIF/INH for detecting Mycobacterium tuberculosis complex and resistance to isoniazid and rifampicin: A prospective, multicenter diagnostic accuracy study
Tuberculosis (TB) is a preventable and curable disease, yet it continues to pose a substantial global health challenge. Ac...
Extraintestinal pathogenic Escherichia coli (ExPEC) O-serotype distribution and antibiotic resistance profiles among the aging population in China: A longitudinal, multi-center study
Extraintestinal pathogenic Escherichia coli (ExPEC) comprises a pathogenic group of E. coli, which can colonize non-intest...
A Single Amino acid in PBP1a drives high-level penicillin and amoxicillin resistance in streptococcus suis
Streptococcus suis is an important pathogen in the pig industry, causing meningitis, pneumonia, arthritis, and septicemia ...
Model-informed precision dosing of vancomycin in Chinese adult patients receiving renal replacement therapy: Systematic evaluation of published pharmacokinetic models and dosing regimen simulations
Acute kidney injury (AKI) in critically ill patients is associated with acute morbidity and mortality [1]. Approximately h...
Optimizing linezolid dosing for nosocomial urinary tract infections in critically ill patients with renal impairment
Urinary tract infections (UTIs) represent one of the most prevalent bacterial infections among hospitalized patients, cont...
Population pharmacokinetics and pharmacodynamics of eravacycline in patients with complicated intra-abdominal infections and community acquired bacterial pneumonia: Support for a fixed-dose treatment regimen
Eravacycline, a parent tetracycline antibiotic, has been approved for the treatment of complicated intra-abdominal infecti...
Esculetin mitigates MRSA pathogenicity via innovative multitarget inhibition of staphylococcus aureus sortase a, coagulase, and von Willebrand factor-binding protein
Staphylococcus aureus is an opportunistic and formidable human pathogen implicated in a wide array of infections, ranging ...
Interferon-based optimal antiviral strategies in underage patients with chronic hepatitis B: A propensity score-weighted cohort study
Hepatitis B virus (HBV) infection remains a global public health problem [1]. Chronic HBV infection can increase the risk ...
Epidemiology, treatment and outcomes of bloodstream infections due to MBL-producing enterobacterales in France: A retrospective study
Volume 66, Issue 6, December 2025, 107630Author links open overlay panel, HIGHLIGHTS•Nationwide cohort of 156 MBL-producin...
Evaluation of the effect of two adjuvants co-administered with nasal recombinant hemagglutinin influenza vaccine on immune cells in mice
Volume 66, Issue 6, December 2025, 107617Author links open overlay panel, , , , , , , Highlights•Two adjuvants were effect...
Enhanced Targeted NGS Assay for Comprehensive Diagnosis in Tuberculosis and Drug-Resistant Tuberculosis Patients
Tuberculosis (TB) remains one of the leading causes of mortality from infectious diseases worldwide. In 2023, there were 1...
Emergence of a novel transferable megaplasmid driving blaVIM-24 and tmexCD3-toprJ3 dissemination in clinical Pseudomonas fulva isolates
Pseudomonas fulva is an aerobic, non-fermenting, Gram-negative, oxidase-variable bacterium that Iizuka and Komagata first ...
Emergence of Stenotrophomonas maltophilia resistant to trimethoprim-sulfamethoxazole carrying IMP-8 metallo-betalactamase in Spain
Volume 66, Issue 6, December 2025, 107597Author links open overlay panel, , , , , References (5)There are more references ...
Enhanced endotoxin release by select generic meropenem formulations in Pseudomonas aeruginosa
Volume 66, Issue 6, December 2025, 107593Author links open overlay panel, , References (7)There are more references availa...
Emergence of the IncHI2-ST3 plasmid co-harbouring blaNDM-5, mcr-1.1, and fosA3 in Escherichia coli from a healthy individual in China
Volume 66, Issue 6, December 2025, 107615Author links open overlay panel, , , , , , References (14)There are more referenc...
Whole genome sequencing revealed high occurrence of antimicrobial resistance genes in bacteria isolated from poultry manure
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Integrons are key players in the spread of beta-lactamase-encoding genes
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Characterization of a novel KPC-2 variant, KPC-228, conferring resistance to ceftazidime–avibactam in an ST11-KL64 hypervirulent Klebsiella pneumoniae
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Molecular investigation of an epidemic dissemination of vancomycin-resistant Enterococcus faecium sequence type 80 in Guangdong province, China
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Comparing ceftazidime/avibactam and polymyxin B for treating carbapenem-resistant organisms infections: A propensity score-matched retrospective cohort study
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An integrative and translational PK/PD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae
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Novel Hsp90α inhibitor inhibits HSV-1 infection by suppressing the Akt/β-catenin pathway
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Population pharmacokinetics and pharmacodynamics of HFB30132A, a monoclonal antibody against SARS-CoV-2, in healthy Chinese and US subjects
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Clinical outcomes of a twice-daily metronidazole dosing strategy for Bacteroides spp. bloodstream infections
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The hidden threat: Klebsiella pneumoniae may develop co-resistance to colistin and cefiderocol under pressure of colistin
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