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Chrysin 7-O-β-D-glucuronide, a dual inhibitor of SARS-CoV-2 3CLpro and PLpro, for the prevention and treatment of COVID-19
Chrysin 7-O-β-D-glucuronide, a dual inhibitor of SARS-CoV-2 3CLpro and PLpro, for the prevention and treatment of COVID-19
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) resulted in the coronavirus disease 2019 (CO...
Micafungin twice-a-week for prophylaxis of invasive Aspergillus infections in children with acute lymphoblastic leukaemia: A controlled cohort study
Micafungin twice-a-week for prophylaxis of invasive Aspergillus infections in children with acute lymphoblastic leukaemia: A controlled cohort study
The 5-year overall survival of childhood acute lymphoblastic leukemia (ALL) has increased to ∼90% [1]. To further improve ...
Prevalence of and risk factors for intestinal colonisation by multidrug-resistant Gram-negative bacteria in patients with haematological malignancies: A systematic review and meta-analysis
Prevalence of and risk factors for intestinal colonisation by multidrug-resistant Gram-negative bacteria in patients with haematological malignancies: A systematic review and meta-analysis
Patients with haematological malignancies (HM patients) are at high risk of infections [1] because of neutropenia, mucosal...
Comparing the efficacy and safety of a first-line regimen with emtricitabine/tenofovir alafenamide fumarate plus either bictegravir or dolutegravir: Results from clinical practice
Comparing the efficacy and safety of a first-line regimen with emtricitabine/tenofovir alafenamide fumarate plus either bictegravir or dolutegravir: Results from clinical practice
Over the last decade, according to international guidelines [1,2], integrase strand transfer inhibitors have become the co...
Intra-operative redosing of cefepime in massive blood loss: population vs individualized approaches
Intra-operative redosing of cefepime in massive blood loss: population vs individualized approaches
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Comment on: Clinical efficacy and safety of novel antibiotics for complicated urinary tract infection: A systematic review and meta-analysis of randomized controlled trials
Comment on: Clinical efficacy and safety of novel antibiotics for complicated urinary tract infection: A systematic review and meta-analysis of randomized controlled trials
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Activity of aztreonam/avibactam and ceftazidime/avibactam against Enterobacterales with carbapenemase-independent carbapenem resistance
Activity of aztreonam/avibactam and ceftazidime/avibactam against Enterobacterales with carbapenemase-independent carbapenem resistance
Enterobacterales with carbapenemase-independent resistance to carbapenems are sometimes being selected during therapy and,...
A systematic review of peptide nucleic acids (PNAs) with antibacterial activities: efficacy, potential and challenges
A systematic review of peptide nucleic acids (PNAs) with antibacterial activities: efficacy, potential and challenges
Peptide nucleic acids (PNAs) are synthetic molecules that are like DNA/RNA, but with different building blocks. They have ...
Emergence and plasmid cointegration-based evolution of NDM-1-producing ST107 Citrobacter freundii high-risk resistant clone in China
Emergence and plasmid cointegration-based evolution of NDM-1-producing ST107 Citrobacter freundii high-risk resistant clone in China
Carbapenem-resistant Citrobacter freundii (CRCF) poses an enormous challenge in the health care setting. However, the epid...
Global trends in non-susceptibility rates of Streptococcus pneumoniae isolates to ceftriaxone: Data from the antimicrobial testing leadership and surveillance (ATLAS) programme, 2016–21
Global trends in non-susceptibility rates of Streptococcus pneumoniae isolates to ceftriaxone: Data from the antimicrobial testing leadership and surveillance (ATLAS) programme, 2016–21
Ceftriaxone is one of the most important beta-lactams suggested for the treatment of severe and non-severe community-acqui...
The efficacy of telavancin in comparison with linezolid on endotracheal tube biofilm in pigs with methicillin-resistant Staphylococcus aureus pneumonia
The efficacy of telavancin in comparison with linezolid on endotracheal tube biofilm in pigs with methicillin-resistant Staphylococcus aureus pneumonia
BackgroundThe effect of systemic treatment of ventilator-associated pneumonia (VAP) with telavancin, a semisynthetic lipog...
Clinical efficacy of cefiderocol-based regimens in patients with carbapenem-resistant Acinetobacter baumannii infections: A systematic review with meta-analysis
Clinical efficacy of cefiderocol-based regimens in patients with carbapenem-resistant Acinetobacter baumannii infections: A systematic review with meta-analysis
Funding: This research was supported by EU funding within the NextGeneration EU-MUR PNRR Extended Partnership initiative o...
Metagenomics Next-Generation Sequencing (mNGS) Reveals Emerging Infection Induced by Klebsiella pneumoniae
Metagenomics Next-Generation Sequencing (mNGS) Reveals Emerging Infection Induced by Klebsiella pneumoniae
Hospital-acquired infections are a major global public health issue. Multidrug-resistant (MDR) bacteria have provoked grea...
Financial conflicts of interest among infectious disease journal editors in the USA
Financial conflicts of interest among infectious disease journal editors in the USA
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Assessing the State of Antibacterial Drug Discovery through Patent Analysis
Assessing the State of Antibacterial Drug Discovery through Patent Analysis
Available online 8 December 2023, 107051Author links open overlay panel, , , , , , , AbstractPatent filings suggest increa...
Acute kidney injury associated with colistin sulfate vs. polymyxin B sulfate therapy: A real-world, retrospective cohort study
Acute kidney injury associated with colistin sulfate vs. polymyxin B sulfate therapy: A real-world, retrospective cohort study
Volume 63, Issue 1, January 2024, 107031Author links open overlay panel, , , , , Highlights•This study was the largest to ...
Effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide in HIV late presenters
Effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide in HIV late presenters
Volume 63, Issue 1, January 2024, 107016Author links open overlay panel, , , , , , , , , , , Highlights•Effectiveness of B...
Conversion to colistin susceptibility by tigecycline exposure in colistin-resistant Klebsiella pneumoniae and its implications to combination therapy
Conversion to colistin susceptibility by tigecycline exposure in colistin-resistant Klebsiella pneumoniae and its implications to combination therapy
Carbapenems have been regarded as potent antibiotics for Gram-negative pathogens [1]. However, they show diminished effect...
Clinical efficacy of cefiderocol-based regimens in patients affected by carbapenem-resistant Acinetobacter baumannii infections: a systematic review with meta-analysis
Clinical efficacy of cefiderocol-based regimens in patients affected by carbapenem-resistant Acinetobacter baumannii infections: a systematic review with meta-analysis
Available online 5 December 2023, 107047Author links open overlay panel, , , , AbstractObjectivesTo perform a systematic r...
Daptomycin non-susceptible Staphylococcus argenteus isolated from a patient without prior antibiotic exposure
Daptomycin non-susceptible Staphylococcus argenteus isolated from a patient without prior antibiotic exposure
Available online 3 December 2023, 107046Author links open overlay panel, , , , Section snippetsDeclarationsFunding: No fun...
Financial conflicts of interest among infectious disease journal editors in the United States
Financial conflicts of interest among infectious disease journal editors in the United States
Available online 4 December 2023, 107045Author links open overlay panelSection snippetsAcknowledgmentsI would like to than...
Rapid ART initiation with bictegravir/emtricitabine/tenofovir alafenamide in individuals presenting with advanced HIV disease (Rainbow study)
Rapid ART initiation with bictegravir/emtricitabine/tenofovir alafenamide in individuals presenting with advanced HIV disease (Rainbow study)
AIDSAcute Immunodeficiency SyndromeARTAntiretroviral TherapyBAIBeck Anxiety InventoryBDIBeck Depression InventoryBIC/FTC/T...
Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis
Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis
Tuberculous meningitis (TB meningitis) is the most devastating form of tuberculosis (TB) and there is a critical need to o...
Clinical significance of mutations in dihydropteroate synthase in Pneumocystis jirovecii pneumonia among non-HIV-infected patients
Clinical significance of mutations in dihydropteroate synthase in Pneumocystis jirovecii pneumonia among non-HIV-infected patients
Pneumocystis jirovecii (PJ) is one of the most important fungal pathogens that causes pneumonia in immunocompromised patie...
Implementation and validation of a Bayesian method for accurately forecasting duration of optimal pharmacodynamic target attainment with dalbavancin during long-term use for subacute and chronic staphylococcal infections
Implementation and validation of a Bayesian method for accurately forecasting duration of optimal pharmacodynamic target attainment with dalbavancin during long-term use for subacute and chronic staphylococcal infections
Dalbavancin is a long-acting lipoglycopeptide that is highly effective against most Gram-positive bacteria [1,2]. This ant...
Clinical efficacy of ceftazidime/avibactam combination therapy for severe hospital-acquired pulmonary infections caused by carbapenem-resistant and difficult-to-treat Pseudomonas aeruginosa
Clinical efficacy of ceftazidime/avibactam combination therapy for severe hospital-acquired pulmonary infections caused by carbapenem-resistant and difficult-to-treat Pseudomonas aeruginosa
Severe hospital-acquired pulmonary infections (sHAPi) can cause high hospital costs in critically ill patients and risks o...
BPI23-Fcγ alleviates lethal multi-drug-resistant Acinetobacter baumannii infection by enhancing bactericidal activity and orchestrating neutrophil function
BPI23-Fcγ alleviates lethal multi-drug-resistant Acinetobacter baumannii infection by enhancing bactericidal activity and orchestrating neutrophil function
Due to the inappropriate use of antibiotics, antibiotic resistance poses a significant threat to human health globally. An...
Effect of pre-hospitalization use of oral antiviral agents on reducing critical illness and mortality for patients with COVID-19 pneumonia
Effect of pre-hospitalization use of oral antiviral agents on reducing critical illness and mortality for patients with COVID-19 pneumonia
The COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2, has led to significant morbidity and mortality worldwid...
Characterization and outcomes of difficult-to-treat patients starting modern first-line ART regimens: Data from the ICONA cohort
Characterization and outcomes of difficult-to-treat patients starting modern first-line ART regimens: Data from the ICONA cohort
ObjectivesTreatment failures to modern antiretroviral therapy (ART) raise concerns, as they could reduce future options. E...
Development of inhalation powders containing lactic acid bacteria with antimicrobial activity against Pseudomonas aeruginosa
Development of inhalation powders containing lactic acid bacteria with antimicrobial activity against Pseudomonas aeruginosa
ObjectivesThe aim of the project was to develop and characterise powders containing a probiotic (Lactiplantibacillus plant...
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