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Design, synthesis, molecular docking, and biological activity of pyrazolo[3,4-b]pyridines as promising lead candidates against Mycobacterium tuberculosis
Design, synthesis, molecular docking, and biological activity of pyrazolo[3,4-b]pyridines as promising lead candidates against Mycobacterium tuberculosis
Pyrazolo[3,4-b]pyridine is a medicinally privileged structure. We have achieved a new and facile synthesis of a combinator...
A concise review on anti-breast cancer effectiveness of s-triazines through EGFR kinase inhibition
A concise review on anti-breast cancer effectiveness of s-triazines through EGFR kinase inhibition
Today, one of the most common malignancies in women is breast cancer. Despite the large number of commercially available a...
Indazole derivatives as novel inhibitors of monoamine oxidase and D-amino acid oxidase
Indazole derivatives as novel inhibitors of monoamine oxidase and D-amino acid oxidase
The monoamine oxidase (MAO) enzymes metabolize neurotransmitter amines in the peripheral and central tissues, and inhibito...
Unveiling the potential of prodrug and drug-conjugate strategies in treatment of diabetes mellitus and its complications
Unveiling the potential of prodrug and drug-conjugate strategies in treatment of diabetes mellitus and its complications
The 2021 statistics from the International Diabetes Federation reveals that approximately 537 million adults between the a...
Self-assembled amphiphilic bipyridine and bisquinoline cisplatin analogues: synthesis and anticancer properties
Self-assembled amphiphilic bipyridine and bisquinoline cisplatin analogues: synthesis and anticancer properties
We report the synthesis and characterisation of two amphiphilic cisplatin analogues derived from bipyridine and bisquinoli...
Increased rigidity and bioisosteric replacement in the design, synthesis and preliminary evaluation of novel, functionalized 3,3-dialkyl-γ-butyrolactones as sigma-2 ligands
Increased rigidity and bioisosteric replacement in the design, synthesis and preliminary evaluation of novel, functionalized 3,3-dialkyl-γ-butyrolactones as sigma-2 ligands
The sigma-2 (σ2) receptor has been linked to several diseases and conditions including cancer, neuropathic drug addic...
Identification of α-mangostin as a potent inhibitor of β-lactamase OXA-48
Identification of α-mangostin as a potent inhibitor of β-lactamase OXA-48
The production of carbapenemases is a significant mechanism contributing to carbapenem resistance in Enterobacteriaceae. A...
Synthesis and pharmacological evaluation of novel coumarin based triazolyl glycoconjugates as potential antibacterial and anti-proliferative agents
Synthesis and pharmacological evaluation of novel coumarin based triazolyl glycoconjugates as potential antibacterial and anti-proliferative agents
A library of novel coumarin-based triazolyl glycoconjugates is prepared and screened for in vitro antibacterial activity a...
Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity
Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity
Rehmannia glutinosa has been used historically and is now listed in the 2020 Chinese Pharmacopoeia as a traditional Chines...
Research progress on the mechanism of anti-myocardial infarction effect and clinical application of effective components of Salvia miltiorrhiza
Research progress on the mechanism of anti-myocardial infarction effect and clinical application of effective components of Salvia miltiorrhiza
Salvia miltiorrhiza, a plant in the Labiatae family, is a traditional Chinese herb. The small molecular components in S. m...
Bioactivities and the structural modification of Parthenolide: a review
Bioactivities and the structural modification of Parthenolide: a review
Parthenolide, a sesquiterpene lactone derived from Feverfew (Tanacetum parthenium) buds, has attracted significant attenti...
Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation
Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation
In the pursuit of discovering new active metabolites from helicosporous hyphomycetes, rice fermentation products of Neohel...
Indazole derivatives as selective inhibitors of butyrylcholinesterase with effective blood-brain-barrier permeability profile
Indazole derivatives as selective inhibitors of butyrylcholinesterase with effective blood-brain-barrier permeability profile
Alzheimer’s disease (AD) is a chronic disease that is multifactorial. Its underlying cause and mechanisms are yet to...
Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1
Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a DNA repair enzyme that can reduce the efficacy of some anticancer drugs target...
Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors as anti-Alzheimer’s agents through pharmacophore-based virtual screening, molecular docking and experimental validation
Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors as anti-Alzheimer’s agents through pharmacophore-based virtual screening, molecular docking and experimental validation
Alzheimer’s disease (AD) is the most prevalent form of neurodegenerative condition distinguished by the deposition o...
FTase inhibitors and cancer: prospects for use in targeted therapies
FTase inhibitors and cancer: prospects for use in targeted therapies
Farnesyltransferase (FTase) is a key enzyme that catalyzes the farnesylation of Ras protein. It is used to bind RAS protei...
Kaempferia diterpenoids and flavonoids: an overview on phytochemistry, biosynthesis, synthesis, pharmacology, and pharmacokinetics
Kaempferia diterpenoids and flavonoids: an overview on phytochemistry, biosynthesis, synthesis, pharmacology, and pharmacokinetics
Kaempferia species have contained various crucial ethnobotanical features, and are being used as traditional folk medicine...
One-pot synthesis and in vitro bioactivity of novel 4-aminopyrazolo[3,4-b]pyridine derivatives as potential antimicrobial compounds
One-pot synthesis and in vitro bioactivity of novel 4-aminopyrazolo[3,4-b]pyridine derivatives as potential antimicrobial compounds
The present paper describes an efficient synthesis of a series of 4-aminopyrazolo[3,4-b]pyridine derivatives 11a–i i...
Characterization of novel angiotensin-I converting enzyme inhibitory peptides derived from Taiwan red quinoa (Chenopodium formosanum Koidz.) seed proteins using two sequential bioassay-guided fractionations
Characterization of novel angiotensin-I converting enzyme inhibitory peptides derived from Taiwan red quinoa (Chenopodium formosanum Koidz.) seed proteins using two sequential bioassay-guided fractionations
Taiwan red quinoa (Chenopodium formosanum Koidz.) is a pseudo-cereal crop native to Taiwan with a rich protein content tha...
Enantioselectivity of pinene against Leishmania amazonensis
Enantioselectivity of pinene against Leishmania amazonensis
Pinene is a major monoterpene described in various plant essential oils. It has two isomers, α- and β-pinene, th...
Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants
Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants
Aiming to develop novel anticonvulsant agents a new series of novel cycloalkanecarboxamide parabanic acid hybrids series 8...
Correction: Structural and stereochemical determinants for hGAT3 inhibition: development of novel conformationally constrained and substituted analogs of (S)-isoserine
Correction: Structural and stereochemical determinants for hGAT3 inhibition: development of novel conformationally constrained and substituted analogs of (S)-isoserine
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Screening of small molecule compounds targeting hnRNPA2 protein
Screening of small molecule compounds targeting hnRNPA2 protein
Heterogeneous nuclear ribonucleoprotein A2, as an RNA binding protein, participates in the processing and metabolism of RN...
Discovery of potent maternal embryonic leucine zipper kinase (MELK) inhibitors of novel chemotypes using structure-based pharmacophores
Discovery of potent maternal embryonic leucine zipper kinase (MELK) inhibitors of novel chemotypes using structure-based pharmacophores
Maternal embryonic leucine zipper kinase (MELK) is a serine-threonine kinase. Several studies have revealed its role as a ...
Design, synthesis, and in silico studies of novel di-(2-aryl hydrozonopropanal) arene derivatives as potent anticancer for targeting A2AR and LRP6 in HCT116 cell
Design, synthesis, and in silico studies of novel di-(2-aryl hydrozonopropanal) arene derivatives as potent anticancer for targeting A2AR and LRP6 in HCT116 cell
Colorectal cancer (CRC) is a frequent malignancy with a poor prognosis and a high fatality rate, unlike other malignancies...
Design, synthesis and antimicrobial activities of 1,2,3-triazole hybrids with amine-ester functionality
Design, synthesis and antimicrobial activities of 1,2,3-triazole hybrids with amine-ester functionality
Due to the notable therapeutic importance of 1,4-disubstituted-1,2,3-triazoles linked with amine and ester groups, a serie...
Novel aloe emodin–hydroxyethyl piperazine hybrid dihydrochloride induces oral cancer CAL-27 cells apoptosis through ROS production, DNA damage and mitochondrial pathways
Novel aloe emodin–hydroxyethyl piperazine hybrid dihydrochloride induces oral cancer CAL-27 cells apoptosis through ROS production, DNA damage and mitochondrial pathways
Oral cancer severely affects the quality of life of patients, and the primary treatment is surgery, due to a lack of speci...
Synthesis of 6,6-Dimethyl-3-azabicyclo [3.1.0]hexane via Ru (II)-catalyzed intramolecular cyclopropanation
Synthesis of 6,6-Dimethyl-3-azabicyclo [3.1.0]hexane via Ru (II)-catalyzed intramolecular cyclopropanation
6,6-Dimethyl-3-azabicyclo[3.1.0]hexane (6,6-DMABH) is a crucial component in several antiviral medications, such as bocepr...
The trimethoxyphenyl (TMP) functional group: a versatile pharmacophore
The trimethoxyphenyl (TMP) functional group: a versatile pharmacophore
The Trimethoxyphenyl (TMP) group serves as a pharmacophore in numerous potent agents exhibiting diverse bioactivity effect...
1,2,3-triazole derivatives as antiviral agents
1,2,3-triazole derivatives as antiviral agents
In the last years, the emergence and spread of viral infections have been described with increased frequency and becomes a...
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