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Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties
To discover natural-derived fungicides, three series of 2-aryl-3,4-dihydroisoquinolinium salts (6–8) containing benz...
Olaparib research update: mechanism, structure and clinical trials
Olaparib research update: mechanism, structure and clinical trials
Current cancer treatments are known for their low selectivity, and life-threatening toxicity. To solve these issue, variou...
Uncaria-derived compounds for cancer treatment: mechanistic insights and therapeutic potential
Uncaria-derived compounds for cancer treatment: mechanistic insights and therapeutic potential
Uncaria is a traditional medicinal plant belonging to the Rubiaceae family, with a particularly strong presence in Asia, C...
Discovery, optimization and biological evaluation of chromone derivatives as novel BRD4 inhibitors
Discovery, optimization and biological evaluation of chromone derivatives as novel BRD4 inhibitors
Bromodomain-containing protein 4 (BRD4), as the reader of epigenetics, could regulate gene transcription by recognizing ac...
Glycyrrhizin and its derivatives: an emerging secondary metabolite arsenal of
Glycyrrhizin and its derivatives: an emerging secondary metabolite arsenal of
The pharmacological characteristics of secondary metabolites and their promising use in agriculture, medicine and industry...
Synthesis, crystal structure, and anticancer activity of organotin(IV) complexes based on chlorine substituted aryl ligands
Synthesis, crystal structure, and anticancer activity of organotin(IV) complexes based on chlorine substituted aryl ligands
Three series of (dimethyl-, dibutyl-, and diphenyl-) new organotin(IV) complexes based on chlorine substituted aryl ligand...
A review on efficacy of phytochemicals in the treatment of trypanosomiasis
A review on efficacy of phytochemicals in the treatment of trypanosomiasis
Trypanosomiasis, which is brought on by trypanosome parasites, is still a serious but often ignored health issue, especial...
Anticancer therapeutic potential of silibinin: current trends, scope and relevance
Anticancer therapeutic potential of silibinin: current trends, scope and relevance
The use of natural plants as powerful sources for the treatment of chronic illnesses has drawn more attention from researc...
Synthesis and evaluation of tetrahydrobenzo[]indole derivatives as glycogen phosphorylase inhibitors
Synthesis and evaluation of tetrahydrobenzo[]indole derivatives as glycogen phosphorylase inhibitors
A series of tetrahydrobenzo[cd]indole derivatives was synthesized by condensation of a fungal metabolite hyphodermin A, a ...
Novel conjugated 5-alkenyl rhodanine tethered 1,4-benzodioxane derivatives as dual-chitinases inhibitors to hinder the growth of Asian corn borer
Novel conjugated 5-alkenyl rhodanine tethered 1,4-benzodioxane derivatives as dual-chitinases inhibitors to hinder the growth of Asian corn borer
OfChtI and OfChi-h are ideal targets for developing agricultural inhibitors against Ostrinia furnacalis. In order to furth...
A mild and catalyst-free α-benzoyloxylation of tertiary amides
A mild and catalyst-free α-benzoyloxylation of tertiary amides
An α-C–H oxygenation of amides using Togni reagent II and an umpolung strategy is reported. α-Benzoyloxy a...
Exploring the potential of isatin hybrids as anticancer agents: recent advances and future prospective
Exploring the potential of isatin hybrids as anticancer agents: recent advances and future prospective
Synthesis of hybrid molecules via molecular hybridization technique has been known to be a promising strategy which involv...
An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 interaction: synthesis, biological evaluation and computational analysis
An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 interaction: synthesis, biological evaluation and computational analysis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained significant public health attention owing to its d...
Design, synthesis, biological evaluation, and in silico studies of imidazo[2,1-][1,3,4]thiadiazole derivatives as cholinesterase inhibitors
Design, synthesis, biological evaluation, and in silico studies of imidazo[2,1-][1,3,4]thiadiazole derivatives as cholinesterase inhibitors
In this study, a series of imidazo[2,1-b][1,3,4]thiadiazole derivatives were designed, synthesized, and evaluated as poten...
Correction: Anticancer therapeutic potential of silibinin: current trends, scope and relevance
Correction: Anticancer therapeutic potential of silibinin: current trends, scope and relevance
Department of Physics, Guru Kashi University, Talwandi Sabo, Bathinda, Punjab, 151302, IndiaAnupam SharmaDepartment of Mic...
A glance into Schiff-based α-glucosidase inhibitors in medicinal chemistry
A glance into Schiff-based α-glucosidase inhibitors in medicinal chemistry
Diabetes mellitus is a chronic disorder characterized by hyperglycemia and is caused by metabolic dysregulation. According...
Identification of the chemical composition of blue honeyberry leaves ( L. var. ) and their anti-inflammatory activity
Identification of the chemical composition of blue honeyberry leaves ( L. var. ) and their anti-inflammatory activity
Blue honeyberry is a well-known nutritious fruit. Meanwhile, it is also an Oroqen herb in China. However, the chemical con...
Anticancer potential of delphinidin and its derivatives: therapeutic and mechanistic insights
Anticancer potential of delphinidin and its derivatives: therapeutic and mechanistic insights
Anthocyanins are water-soluble naturally occurring flavonoids present in fruits, flowers, leaves, and roots of fruit plant...
Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants
Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants
A series of 8-(piperazin-1-yl)imidazo[1,2-a]pyrazine derivatives were designed and synthesized as acetylcholinesterase inh...
Insights into computer-aided G-quadruplex prediction in the digital age
Insights into computer-aided G-quadruplex prediction in the digital age
G-quadruplexes are four-stranded non-canonical secondary structures formed by G-rich DNA and RNA sequences. They are struc...
A potent therapeutic scaffold fusing quinazolinone/melatonin for future colorectal cancer interventions: design, one-pot synthesis, biological and ADME-tox modeling studies
A potent therapeutic scaffold fusing quinazolinone/melatonin for future colorectal cancer interventions: design, one-pot synthesis, biological and ADME-tox modeling studies
Colorectal cancer is one of the most incident and lethal cancers in the world. The search for new compounds to treat this ...
A second life for the crystallographic structure of Berenil-dodecanucleotide complex: a computational revisitation thirty years after its publication
A second life for the crystallographic structure of Berenil-dodecanucleotide complex: a computational revisitation thirty years after its publication
This study revisits the pioneering work of Professor Neidle, and co-workers, on the crystal structure of complexes formed ...
Design, synthesis and evaluation of sesamol-derived acetamides as dual inhibitors of monoamine oxidases and cholinesterases
Design, synthesis and evaluation of sesamol-derived acetamides as dual inhibitors of monoamine oxidases and cholinesterases
A set of sesamol-derived acetamides was designed, synthesized, and evaluated against monoamine oxidases (MAO-A and MAO-B) ...
Translating G-quadruplex ligands from bench to bedside: a Stephen Neidle’s legacy
Translating G-quadruplex ligands from bench to bedside: a Stephen Neidle’s legacy
DNA and RNA G-quadruplexes (G4s) are alternative nucleic acid structures that can fold from thousands of guanine (G)-rich ...
Structural insights into G-quadruplex binding by metal complexes: implications for drug design
Structural insights into G-quadruplex binding by metal complexes: implications for drug design
G-quadruplex DNA secondary structures are formed in guanine-rich sequences and have been found to play an important role i...
Extraction and purification, pharmacological action, synthesis and product development of salidroside: a review
Extraction and purification, pharmacological action, synthesis and product development of salidroside: a review
Salidroside (Sal), a natural phenolic glycoside ubiquitous across all species of the Rhodiola genus, has garnered consider...
Design, synthesis, anti-tubercular activity, and computational studies of novel 3-(quinolin-3-yl)-1-phenylprop-2-en-1-one derivatives
Design, synthesis, anti-tubercular activity, and computational studies of novel 3-(quinolin-3-yl)-1-phenylprop-2-en-1-one derivatives
Tuberculosis (TB) is a contagious disease caused by M. tuberculosis (Mtb) affecting people across the globe. Quinoline and...
A review on phytochemical constituents, analytical data, and pharmacological properties of the genus Plumeria
A review on phytochemical constituents, analytical data, and pharmacological properties of the genus Plumeria
The genus Plumeria of the Apocynaceae family has a rich history of traditional medicines supported by empirical evidences....
Medicinal significance of sp2/sp3 hybridized at C-3-substituted indole-containing lead molecules and FDA-approved drugs
Medicinal significance of sp2/sp3 hybridized at C-3-substituted indole-containing lead molecules and FDA-approved drugs
Herein, the privilege in favor of biological importance of indole-containing scaffolds related to the semi-synthetic and e...
Quinazolinone-based subchemotypes for targeting HIV-1 capsid protein: design and synthesis
Quinazolinone-based subchemotypes for targeting HIV-1 capsid protein: design and synthesis
The recent FDA-approval of lenacapavir (LEN, GS-6207) and the subsequent discovery of GSK878 strongly validate HIV-1 capsi...
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