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Anticancer potential of delphinidin and its derivatives: therapeutic and mechanistic insights
Anticancer potential of delphinidin and its derivatives: therapeutic and mechanistic insights
Anthocyanins are water-soluble naturally occurring flavonoids present in fruits, flowers, leaves, and roots of fruit plant...
Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants
Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants
A series of 8-(piperazin-1-yl)imidazo[1,2-a]pyrazine derivatives were designed and synthesized as acetylcholinesterase inh...
Insights into computer-aided G-quadruplex prediction in the digital age
Insights into computer-aided G-quadruplex prediction in the digital age
G-quadruplexes are four-stranded non-canonical secondary structures formed by G-rich DNA and RNA sequences. They are struc...
A potent therapeutic scaffold fusing quinazolinone/melatonin for future colorectal cancer interventions: design, one-pot synthesis, biological and ADME-tox modeling studies
A potent therapeutic scaffold fusing quinazolinone/melatonin for future colorectal cancer interventions: design, one-pot synthesis, biological and ADME-tox modeling studies
Colorectal cancer is one of the most incident and lethal cancers in the world. The search for new compounds to treat this ...
A second life for the crystallographic structure of Berenil-dodecanucleotide complex: a computational revisitation thirty years after its publication
A second life for the crystallographic structure of Berenil-dodecanucleotide complex: a computational revisitation thirty years after its publication
This study revisits the pioneering work of Professor Neidle, and co-workers, on the crystal structure of complexes formed ...
Design, synthesis and evaluation of sesamol-derived acetamides as dual inhibitors of monoamine oxidases and cholinesterases
Design, synthesis and evaluation of sesamol-derived acetamides as dual inhibitors of monoamine oxidases and cholinesterases
A set of sesamol-derived acetamides was designed, synthesized, and evaluated against monoamine oxidases (MAO-A and MAO-B) ...
Translating G-quadruplex ligands from bench to bedside: a Stephen Neidle’s legacy
Translating G-quadruplex ligands from bench to bedside: a Stephen Neidle’s legacy
DNA and RNA G-quadruplexes (G4s) are alternative nucleic acid structures that can fold from thousands of guanine (G)-rich ...
Structural insights into G-quadruplex binding by metal complexes: implications for drug design
Structural insights into G-quadruplex binding by metal complexes: implications for drug design
G-quadruplex DNA secondary structures are formed in guanine-rich sequences and have been found to play an important role i...
Extraction and purification, pharmacological action, synthesis and product development of salidroside: a review
Extraction and purification, pharmacological action, synthesis and product development of salidroside: a review
Salidroside (Sal), a natural phenolic glycoside ubiquitous across all species of the Rhodiola genus, has garnered consider...
Design, synthesis, anti-tubercular activity, and computational studies of novel 3-(quinolin-3-yl)-1-phenylprop-2-en-1-one derivatives
Design, synthesis, anti-tubercular activity, and computational studies of novel 3-(quinolin-3-yl)-1-phenylprop-2-en-1-one derivatives
Tuberculosis (TB) is a contagious disease caused by M. tuberculosis (Mtb) affecting people across the globe. Quinoline and...
A review on phytochemical constituents, analytical data, and pharmacological properties of the genus Plumeria
A review on phytochemical constituents, analytical data, and pharmacological properties of the genus Plumeria
The genus Plumeria of the Apocynaceae family has a rich history of traditional medicines supported by empirical evidences....
Medicinal significance of sp2/sp3 hybridized at C-3-substituted indole-containing lead molecules and FDA-approved drugs
Medicinal significance of sp2/sp3 hybridized at C-3-substituted indole-containing lead molecules and FDA-approved drugs
Herein, the privilege in favor of biological importance of indole-containing scaffolds related to the semi-synthetic and e...
Quinazolinone-based subchemotypes for targeting HIV-1 capsid protein: design and synthesis
Quinazolinone-based subchemotypes for targeting HIV-1 capsid protein: design and synthesis
The recent FDA-approval of lenacapavir (LEN, GS-6207) and the subsequent discovery of GSK878 strongly validate HIV-1 capsi...
Synthesis and antiproliferative activity of 7-substituted amide estradiol derivatives
Synthesis and antiproliferative activity of 7-substituted amide estradiol derivatives
The modification of the 7-position in the estradiol structure has drawn significant attention from pharmacologists. In thi...
Iridoid for drug discovery: Structural modifications and bioactivity studies
Iridoid for drug discovery: Structural modifications and bioactivity studies
Iridoid glycosides are a class of chemical structures with various pharmacological activities and have excellent research ...
Synthesis of new Michael acceptors with cinnamamide scaffold as potential anti-breast cancer agents: cytotoxicity and ADME in silico studies
Synthesis of new Michael acceptors with cinnamamide scaffold as potential anti-breast cancer agents: cytotoxicity and ADME in silico studies
In pursuit of potent inhibitors with antiproliferative effects against breast cancer, fifteen new compounds containing a M...
Benzothiazole derivatives as effective α-glucosidase inhibitors: an insight study of structure-activity relationships and molecular targets
Benzothiazole derivatives as effective α-glucosidase inhibitors: an insight study of structure-activity relationships and molecular targets
In treating the major metabolic disorder diabetes mellitus type-2, the α-glucosidase enzyme inhibitors play an effect...
Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria
Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria
Cystinuria is a rare genetic disorder characterized by defective l-cystine reabsorption from the renal proximal tubule, re...
Folate-conjugated organic CO prodrugs: Synthesis and CO release kinetic studies
Folate-conjugated organic CO prodrugs: Synthesis and CO release kinetic studies
Carbon monoxide (CO) is an endogenously produced molecule and has shown efficacy in animal models of inflammation, organ i...
Synthesis of novel benzothieno-[3,2’-f][1,3] oxazepines and their isomeric 2-oxo-2H-spiro[benzothiophene-3,3’-pyrrolines] via 1,4-dipolar cycloaddition reaction and their evaluation as cytotoxic anticancer leads
Synthesis of novel benzothieno-[3,2’-f][1,3] oxazepines and their isomeric 2-oxo-2H-spiro[benzothiophene-3,3’-pyrrolines] via 1,4-dipolar cycloaddition reaction and their evaluation as cytotoxic anticancer leads
This study introduces a novel class of hybrid compounds, namely, benzothieno[3,2’-f][1,3]oxazepines and their isomer...
Recent pharmacological insights about imidazole hybrids: a comprehensive review
Recent pharmacological insights about imidazole hybrids: a comprehensive review
In this review, we evaluated the biological activities of hybrid molecules incorporating imidazoles—a cornerstone in...
Candida albicans ergosterol disorders as a consequence of the new sulfone derivative action mode
Candida albicans ergosterol disorders as a consequence of the new sulfone derivative action mode
A series of novel sulfone derivatives were synthesized and screened in vitro for their cytotoxicity and antifungal activit...
A very promising antibiofilm activity against Candida albicans from an in vitro screening for antimicrobial, antibiofilm and antiproliferative activity of new synthesized 4-cinnamamido- and 2-phenoxyacedamido-1H-pyrazol-5-yl)benzamides
A very promising antibiofilm activity against Candida albicans from an in vitro screening for antimicrobial, antibiofilm and antiproliferative activity of new synthesized 4-cinnamamido- and 2-phenoxyacedamido-1H-pyrazol-5-yl)benzamides
Several new synthesized 4-cinnamamido- and 2-phenoxyacedamido-(1H-pyrazol-5-yl)benzamides were obtained by two multi step ...
The emergence of sulfo-click amidation in kinetic target-guided synthesis
The emergence of sulfo-click amidation in kinetic target-guided synthesis
Sulfo-click is a chemoselective and biocompatible reaction between thioacids and sulfonyl azides that forms highly versati...
Development of semisynthetic saponin immunostimulants
Development of semisynthetic saponin immunostimulants
Many natural saponins demonstrate immunostimulatory adjuvant activities, but they also have some inherent drawbacks that l...
Discovery of HNPC-A188: a novel acaricide containing trifluoroethyl thioether and pyrimidin-4-amine
Discovery of HNPC-A188: a novel acaricide containing trifluoroethyl thioether and pyrimidin-4-amine
Pyrimidifen is an excellent commercial acaricide, but it is not low toxic to mammals. Trifluoroethyl thioether derivatives...
Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents
Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents
Kinetoplastids are a group of flagellated protozoans including medically important parasites of the genus Trypanosoma and ...
Morpholinated curcuminoids against urinary bladder cancer cells: synthesis and anticancer evaluation
Morpholinated curcuminoids against urinary bladder cancer cells: synthesis and anticancer evaluation
Cancers present a significant medical problem despite the development of medical and pharmaceutical sciences leading to a ...
Exploring nucleoside analogs: key targets in the viral life cycle - advancing strategies against SARS-CoV-2
Exploring nucleoside analogs: key targets in the viral life cycle - advancing strategies against SARS-CoV-2
The COVID-19 pandemic has been a major reason behind the increased research aimed at the identification of effective antiv...
Design and synthesis of benzo[d]imidazo-6,7-dihydrobenzo[d] imidazo[2,1-b]thiazol-8(5H)-ones as potent anti-infective agents
Design and synthesis of benzo[d]imidazo-6,7-dihydrobenzo[d] imidazo[2,1-b]thiazol-8(5H)-ones as potent anti-infective agents
In this study, we present a series of 2-(5-chlorothiophen-2-yl)-1H-benzo-[d]-imidazol-2-yl)-6,7-dihydrobenzo-[d]-imidazo[2...
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