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Silibinin: a natural flavonoid with multifaceted anticancer potential and therapeutic challenges
Silibinin: a natural flavonoid with multifaceted anticancer potential and therapeutic challenges
Silibinin, the principal bioactive flavonolignan of Silybum marianum (milk thistle), has emerged as a promising natural ag...
Plant-derived pyroptosis inducers as a therapeutic strategy in drug-resistant cancers
Plant-derived pyroptosis inducers as a therapeutic strategy in drug-resistant cancers
Drug resistance in cancer therapy, often due to the evasion of apoptosis, highlights the need for alternative treatments. ...
Discovery of novel and potent URAT1 inhibitors bearing sulfamide scaffold for the treatment of gout
Discovery of novel and potent URAT1 inhibitors bearing sulfamide scaffold for the treatment of gout
The urate transporter 1 (URAT1) plays an important role in the reabsorption of uric acid, so URAT1 inhibitors are consider...
Exploring antidiabetic potential of plant diterpenes: from mechanisms to clinical insights
Exploring antidiabetic potential of plant diterpenes: from mechanisms to clinical insights
Type 2 diabetes mellitus (DM) is a heterogeneous metabolic disorder characterized by chronic hyperglycemia and glucose int...
Targeting west nile virus replication by xanthine inhibitors
Targeting west nile virus replication by xanthine inhibitors
West Nile Virus (WNV) is a mosquito-borne emerging virus, which can result in the development of meningitis or encephaliti...
Metabolism of 2,2′,5,5′-tetrachlorobiphenyl (PCB52) by a fish cytochrome P450 (CYP2Y) orthologous to the human CYP2ABFGST gene cluster
Metabolism of 2,2′,5,5′-tetrachlorobiphenyl (PCB52) by a fish cytochrome P450 (CYP2Y) orthologous to the human CYP2ABFGST gene cluster
Polychlorinated biphenyls (PCBs) are globally distributed pollutants that continue to pose health risks for humans and wil...
Synthesis and in vitro anti-trypanosomal evaluation of quinolone hydrazide analogues
Synthesis and in vitro anti-trypanosomal evaluation of quinolone hydrazide analogues
African trypanosomiasis is a major health threat to humans and animals in 36 countries within sub-Saharan Africa. We previ...
Increased plasma concentrations of 6-oxo-methylphenidate in carriers following a single oral dose of methylphenidate
Increased plasma concentrations of 6-oxo-methylphenidate in carriers following a single oral dose of methylphenidate
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder, with methylphenidate used as a first-lin...
Research progress on extraction and purification, pharmacological activity, pharmacokinetics and content determination of platycodin D
Research progress on extraction and purification, pharmacological activity, pharmacokinetics and content determination of platycodin D
Platycodin D (PD), a unique oleane-type triterpene saponin found in the roots of Platycodon grandiflorum (Jacq.) A. DC. (P...
Estrogen sulfotransferase inhibitors, triclosan and beyond
Estrogen sulfotransferase inhibitors, triclosan and beyond
The estrogen sulfotransferase (EST), also called sulfotransferase 1E1 (SULT1E1), plays an important role in estrogen homeo...
Improving conformational stability and bacterial membrane interactions of antimicrobial peptides with amphipathic helical structure
Improving conformational stability and bacterial membrane interactions of antimicrobial peptides with amphipathic helical structure
Antimicrobial resistance (AMR) has become a massive concern because it causes the loss of human life and an economic burde...
Novel diazepine-carbamate derivatives as dual-acting butyrylcholinesterase inhibitors and antioxidants for Alzheimer’s disease
Novel diazepine-carbamate derivatives as dual-acting butyrylcholinesterase inhibitors and antioxidants for Alzheimer’s disease
Cholinergic neuron damage and oxidative stress are prominent hypotheses explaining the pathogenesis of Alzheimer’s d...
Glutathione transferases in cats and dogs: diversity, structure, and function
Glutathione transferases in cats and dogs: diversity, structure, and function
Glutathionylation is an important Phase II biotransformation pathway that utilizes glutathione transferases (GSTs) to conj...
The potential of major kavalactones in modulating cytochrome P450 enzymes
The potential of major kavalactones in modulating cytochrome P450 enzymes
Kava, the root of Piper methysticum – plants dominantly cultivated in the South Pacific Islands, is traditionally co...
Peptide halogenation biochemistry: interfacing pharmaceutical deliverables with chemical innovation
Peptide halogenation biochemistry: interfacing pharmaceutical deliverables with chemical innovation
The biosynthetic schemes for the production of halogenated peptidic natural products offer avenues for the discovery of pe...
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties
To discover natural-derived fungicides, three series of 2-aryl-3,4-dihydroisoquinolinium salts (6–8) containing benz...
Olaparib research update: mechanism, structure and clinical trials
Olaparib research update: mechanism, structure and clinical trials
Current cancer treatments are known for their low selectivity, and life-threatening toxicity. To solve these issue, variou...
Uncaria-derived compounds for cancer treatment: mechanistic insights and therapeutic potential
Uncaria-derived compounds for cancer treatment: mechanistic insights and therapeutic potential
Uncaria is a traditional medicinal plant belonging to the Rubiaceae family, with a particularly strong presence in Asia, C...
Discovery, optimization and biological evaluation of chromone derivatives as novel BRD4 inhibitors
Discovery, optimization and biological evaluation of chromone derivatives as novel BRD4 inhibitors
Bromodomain-containing protein 4 (BRD4), as the reader of epigenetics, could regulate gene transcription by recognizing ac...
Glycyrrhizin and its derivatives: an emerging secondary metabolite arsenal of
Glycyrrhizin and its derivatives: an emerging secondary metabolite arsenal of
The pharmacological characteristics of secondary metabolites and their promising use in agriculture, medicine and industry...
Synthesis, crystal structure, and anticancer activity of organotin(IV) complexes based on chlorine substituted aryl ligands
Synthesis, crystal structure, and anticancer activity of organotin(IV) complexes based on chlorine substituted aryl ligands
Three series of (dimethyl-, dibutyl-, and diphenyl-) new organotin(IV) complexes based on chlorine substituted aryl ligand...
A review on efficacy of phytochemicals in the treatment of trypanosomiasis
A review on efficacy of phytochemicals in the treatment of trypanosomiasis
Trypanosomiasis, which is brought on by trypanosome parasites, is still a serious but often ignored health issue, especial...
Anticancer therapeutic potential of silibinin: current trends, scope and relevance
Anticancer therapeutic potential of silibinin: current trends, scope and relevance
The use of natural plants as powerful sources for the treatment of chronic illnesses has drawn more attention from researc...
Synthesis and evaluation of tetrahydrobenzo[]indole derivatives as glycogen phosphorylase inhibitors
Synthesis and evaluation of tetrahydrobenzo[]indole derivatives as glycogen phosphorylase inhibitors
A series of tetrahydrobenzo[cd]indole derivatives was synthesized by condensation of a fungal metabolite hyphodermin A, a ...
Novel conjugated 5-alkenyl rhodanine tethered 1,4-benzodioxane derivatives as dual-chitinases inhibitors to hinder the growth of Asian corn borer
Novel conjugated 5-alkenyl rhodanine tethered 1,4-benzodioxane derivatives as dual-chitinases inhibitors to hinder the growth of Asian corn borer
OfChtI and OfChi-h are ideal targets for developing agricultural inhibitors against Ostrinia furnacalis. In order to furth...
A mild and catalyst-free α-benzoyloxylation of tertiary amides
A mild and catalyst-free α-benzoyloxylation of tertiary amides
An α-C–H oxygenation of amides using Togni reagent II and an umpolung strategy is reported. α-Benzoyloxy a...
Exploring the potential of isatin hybrids as anticancer agents: recent advances and future prospective
Exploring the potential of isatin hybrids as anticancer agents: recent advances and future prospective
Synthesis of hybrid molecules via molecular hybridization technique has been known to be a promising strategy which involv...
An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 interaction: synthesis, biological evaluation and computational analysis
An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 interaction: synthesis, biological evaluation and computational analysis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained significant public health attention owing to its d...
Design, synthesis, biological evaluation, and in silico studies of imidazo[2,1-][1,3,4]thiadiazole derivatives as cholinesterase inhibitors
Design, synthesis, biological evaluation, and in silico studies of imidazo[2,1-][1,3,4]thiadiazole derivatives as cholinesterase inhibitors
In this study, a series of imidazo[2,1-b][1,3,4]thiadiazole derivatives were designed, synthesized, and evaluated as poten...
Correction: Anticancer therapeutic potential of silibinin: current trends, scope and relevance
Correction: Anticancer therapeutic potential of silibinin: current trends, scope and relevance
Department of Physics, Guru Kashi University, Talwandi Sabo, Bathinda, Punjab, 151302, IndiaAnupam SharmaDepartment of Mic...
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