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Innate immune control of synapse development
Innate lymphoid cells regulate inhibitory synapse formation in the mouse cortex during early postnatal life.
Structural neural plasticity evoked by rapid-acting antidepressant interventions
Structural neural plasticity evoked by rapid-acting antidepressant interventions
A feature in the pathophysiology of major depressive disorder (MDD), a mood disorder, is the impairment of excita...
Ruminating on replay during the awake state
In this Journal Club, Anna Gillespie discusses how the discovery of hippocampal replay during the awake state reshaped our...
Echolocation over long distances
Bats use echolocation to navigate long distances without relying on other sensory information.
An interoceptive circuit regulating energy balance
Interoceptive, feeding-related inputs are integrated by BDNF-expressing neurons in the ventromedial hypothalamus that proj...
Neural circuit basis of pathological anxiety
Neural circuit basis of pathological anxiety
Anxiety disorders are the most prevalent mental health conditions worldwide. Unfortunately, the understanding of the preci...
Targeting TYK2 to target tau
Studies in human cell lines and transgenic mouse models show that non-receptor tyrosine-protein kinase TYK2 phosphorylates...
Structural MRI of brain similarity networks
Structural MRI of brain similarity networks
Recent advances in structural MRI analytics now allow the network organization of individual brains to be comprehensively ...
Fear bypasses the amygdala
Innate fear-like responses are thought to involve the amygdala, but here a tetra-synaptic pathway is identified that media...
How the brain’s primary processing units compute to give rise to intelligence
Ning-long Xu discusses a 1999 paper that outlined a mechanism by which cortical pyramidal neurons integrate layer-specific...
Barriers and brain fog
One of the long-term sequelae associated with SARS-CoV-2 infection is ‘brain fog’, which is shown in this stud...
Coding corners
Neurons in the mouse subiculum encode concave and convex geometrical environmental features.
mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment
mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment
Epilepsy remains a major health concern as anti-seizure medications frequently fail, and there is currently no treatment t...
Natural primate neurobiology
A new study captures nearly the full repertoire of primate natural behaviour and reveals that highly distributed cortical ...
A structural role for SynGAP
The synaptic protein SynGAP exerts its effects on synaptic plasticity via a structural role rather than its GTPase-activat...
Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases
Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases
The selective vulnerability of specific neuronal subtypes is a hallmark of neurodegenerative diseases. In this Review, I s...
Preparing for motherhood
In mice, specific pools of adult neural stem cells are recruited during pregnancy to support postpartum maternal behaviour.
The neurobiology of SARS-CoV-2 infection
The neurobiology of SARS-CoV-2 infection
Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated 55–60% of those infected de...
The long COVID haul
Ongoing systemic and neurocognitive impairments that continue in a subset of individuals after infection with SARS-CoV-2 i...
The generative grammar of the brain: a critique of internally generated representations
The generative grammar of the brain: a critique of internally generated representations
The past decade of progress in neurobiology has uncovered important organizational principles for network preconfiguration...
Sleep and circadian rhythmicity as entangled processes serving homeostasis
Sleep and circadian rhythmicity as entangled processes serving homeostasis
Sleep is considered essential for the brain and body. A predominant concept is that sleep is regulated by circadian rhythm...
From local APP expression to network dysfunction
In mice, localized mutant APP expression in the CA3 hippocampal region leads to progressive network dysfunction and hippoc...
Human neuronal maturation comes of age: cellular mechanisms and species differences
Human neuronal maturation comes of age: cellular mechanisms and species differences
The delayed and prolonged postmitotic maturation of human neurons, compared with neurons from other species, may contribut...
Sometimes science needs a stubborn mind: the discovery of dopamine
Federica De Lazzari describes Arvid Carlsson’s 1957 paper, which provided evidence for the importance of dopamine in...
Playing tag at the axon
A new biotinylation-based approach identifies previously unknown cell surface proteins of the axonal initial segment (AIS)...
How deep is the brain? The shallow brain hypothesis
How deep is the brain? The shallow brain hypothesis
Deep learning and predictive coding architectures commonly assume that inference in neural networks is hierarchical. Howev...
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Detection, processing and reinforcement of social cues: regulation by the oxytocin system
Many social behaviours are evolutionarily conserved and are essential for the healthy development of an ...
Coding number estimates
A new study shows that, in a numerical judgement task, individuals show differences in neuronal coding of numbers below an...
Boundary deprivation does not prevent grid cell maturation
Grid cells develop in rats soon after they leave the nest. Here, Ulsaker-Janke et al. show that preventing exposure to str...
Caught in a trap
Ketamine is ‘trapped’ in the pores of NMDA receptors in the lateral habenula, mediating sustained antidepressa...
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