Tutel’yan, V.A., Nikityuk, D.B., Baturin, A.K., et al., Nutriome as the direction of the “main strike”: Determination of physiological needs for macro- and micronutrients, minor BAS of food, Vopr. Pitan., 2020, vol. 89, no. 4, pp. 24–34.

Google Scholar 

Zinovkin, R.A., Kondratenko, N.D., and Zinovkina, L.A., Does Nrf2 play a role of a master regulator of mammalian aging?, Biochemistry (Moscow), 2022, vol. 87, nos. 12–13, pp. 1465–1476.

Saha, S., Buttari, B., Panieri, E., et al., An overview of Nrf2 signaling pathway and its role in inflammation, Molecules, 2020, vol. 25, no. 22, p. 5474.

CAS  PubMed  PubMed Central  Google Scholar 

Yachie, A., Heme oxygenase-1 deficiency and oxidative stress: A review of 9 independent human cases and animal models, Int. J. Mol. Sci., 2021, vol. 22, no. 4, p. 1514.

CAS  PubMed  PubMed Central  Google Scholar 

Yahfoufi, N. et al., The immunomodulatory and anti-inflammatory role of polyphenols, Nutrients, 2018, vol. 10, no. 11, p. 1618.

PubMed  PubMed Central  Google Scholar 

Obeme-Nmom, J.I., Abioye, R.O., Reyes Flores, S.S., and Udenigwe, C.C., Regulation of redox enzymes by nutraceuticals: A review of the roles of antioxidant polyphenols and peptides, Food Funct., 2024, vol. 15, no. 22, pp. 10956–10980.

CAS  PubMed  Google Scholar 

Zhang, L., Xu, L.Y., Tang, F., et al., New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation, J. Pharm. Anal., 2024, vol. 14, no. 6, p. 100930.

PubMed  PubMed Central  Google Scholar 

Zhang, S. et al., Natural polyphenols in metabolic syndrome: Protective mechanisms and clinical applications, Int. J. Mol. Sci., 2021, vol. 22, no. 11, p. 6110.

CAS  PubMed  PubMed Central  Google Scholar 

Singla, R.K. et al., Natural polyphenols: Chemical classification, definition of classes, subcategories, and structures, J. AOAC Int., 2019, vol. 102, no. 5, pp. 1397–1400.

CAS  PubMed  Google Scholar 

Krajka-Kuźniak, V. and Baer-Dubowska, W., Modulation of Nrf2 and NF-κB signaling pathways by naturally occurring compounds in relation to cancer prevention and therapy. Are combinations better than single compounds?, Int. J. Mol. Sci., 2021, vol. 22, no. 15, p. 8223.

PubMed  PubMed Central  Google Scholar 

Lake, B.G., Preparation and characterisation of microsomal fractions for studies on xenobiotic metabolism, in Biochemical Toxicology: A Practical Approach, Oxford: Oxford Univ. Press, 1987, pp. 183–215.

Pokrovskii, A.A. and Tutel’yan, B.A., Lizosomy (Lysosomes), Moscow: Nauka, 1976.

Google Scholar 

McNally, S.J. et al., Optimization of the paired enzyme assay for heme oxygenase activity, Anal. Biochem., 2004, vol. 332, no. 2, pp. 398–400.

CAS  PubMed  Google Scholar 

Benson, A.M., Hunkeler, M.J., and Talalay, P., Increase of NAD(P)H:quinone reductase by dietary antioxidants: Possible role in protection against carcinogenesis and toxicity, Proc. Natl. Acad. Sci. U. S. A., 1980, vol. 77, no. 9, pp. 5216–5220.

CAS  PubMed  PubMed Central  Google Scholar 

Kravchenko, L.V., Avren’eva, L.I., Aksenov, I.V., Balakina, A.S., Guseva, G.V., and Trusov, N.V., Study of the effect of rutin on the protective potential of rats, Vo-pr. Pitan., 2015, vol. 84, no. 3, pp. 22–30.

CAS  Google Scholar 

Tang, Y. et al., 3,4-Dihydroxyphenylacetic acid is a predominant biologically-active catabolite of querceting glycosides, Food Res. Int., 2016, vol. 89, pp. 716–723.

CAS  PubMed  Google Scholar 

Tian, R., Yang, Z., Lu, N., and Peng, Y.Y., Quercetin, but not rutin, attenuated hydrogen peroxide-induced cell damage via heme oxygenase-1 induction in endothelial cells, Arch. Biochem. Biophys., 2019, vol. 676, p. 108157.

CAS  PubMed  Google Scholar 

Chu, C.C., Chen, S.Y., Chyau, C.C., Wang, S.C., Chu, H.L., and Duh, P.D., Djulis (Chenopodium formosanum) and its bioactive compounds protect human lung epithelial A549 cells from oxidative injury induced by particulate matter via Nrf2 signaling pathway, Molecules, 2021, vol. 27, no. 1, p. 253.

PubMed  PubMed Central  Google Scholar 

Uskova, M.A., Kravchenko, L.V., Avrenjeva, L.I., and Tutelyan, V.A., Effect of Lactobacillus casei 114001 probiotic on bioactivity of rutin, Bull. Exp. Biol. Med., 2010, vol. 149, pp. 578–582.

CAS  PubMed  Google Scholar 

Cecerska-Heryć, E., Wiśniewska, Z., Serwin, N., et al., Can compounds of natural origin be important in chemoprevention? Anticancer properties of quercetin, resveratrol, and curcumin-a comprehensive review, Int. J. Mol. Sci., 2024, vol. 25, no. 8, p. 4505.

PubMed  PubMed Central  Google Scholar 

Tanigawa, S., Fujii, M., and Hou, D.X., Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin, Free Radical Biol. Med., 2007, vol. 42, no. 11, pp. 1690–1703.

CAS  Google Scholar 

Tabeshpour, J., Hosseinzadeh, H., Hashemzaei, M., and Karimi, G., A review of the hepatoprotective effects of hesperidin, a flavanon glycoside in citrus fruits, against natural and chemical toxicities, Daru, 2020, vol. 28, no. 1, pp. 305–317.

CAS  PubMed  PubMed Central  Google Scholar 

Cui, B., Wang, Y., Jin, J., et al., Resveratrol treats UVB-induced photoaging by anti-MMP expression, through anti-inflammatory, antioxidant, and antiapoptotic properties, and treats photoaging by upregulating VEGF-B expression, Oxid. Med. Cell. Longevity, 2022, p. 6037303.

Shen, C. et al., Resveratrol pretreatment attenuates injury and promotes proliferation of neural stem cells following oxygen-glucose deprivation/reoxygenation by upregulating the expression of Nrf2, HO-1 and NQO1 in vitro, Mol. Med. Rep., 2016, vol. 14, no. 4, pp. 3646–3654.

CAS  PubMed  PubMed Central  Google Scholar 

Tsuji, G., Yumine, A., Kawamura, K., Takemura, M., and Nakahara, T., Induction of semaphorin 3A by resveratrol and pinostilbene via activation of the AHR-NRF2 axis in human keratinocytes, Antioxidants (Basel), 2024, vol. 13, no. 6, p. 732.

CAS  PubMed  PubMed Central  Google Scholar 

Trusov, N.V., Guseva, G.V., Aksenov, I.V., Avren’eva, L.I., Kravchenko, L.V., and Tutelyan, V.A., Effects of combined treatment with resveratrol and indole-3-carbinol, Bull. Exp. Biol. Med., 2010, vol. 149, no. 2, pp. 174–179.

Google Scholar 

Kunnumakkara, A.B. et al., Curcumin, the golden nutraceutical: Multitargeting for multiple chronic diseases, Br. J. Pharmacol., 2017, vol. 174, no. 11, pp. 1325–1348.

CAS  PubMed  Google Scholar 

Liu, Y., Wu, Y.M., and Zhang, P.Y., Protective effects of curcumin and quercetin during benzo(a)pyrene induced lung carcinogenesis in mice, Eur. Rev. Med. Pharmacol. Sci., 2015, vol. 19, no. 9, pp. 1736–1743.

CAS  PubMed  Google Scholar 

Heeba, G.H., Mahmoud, M.E., and El Hanafy, A.A., Anti-inflammatory potential of curcumin and quercetin in rats: Role of oxidative stress, heme oxygenase-1 and TNF-α, Toxicol. Ind. Health, 2014, vol. 30, no. 6, pp. 551–560.

CAS  PubMed  Google Scholar 

Panda, A.K. et al., New insights into therapeutic activity and anticancer properties of curcumin, J. Exp. Pharmacol., 2017, vol. 9, pp. 1–45.

Google Scholar 

Kaur, G., Invally, M., and Chintamaneni, M., Influence of piperine and quercetin on antidiabetic potential of curcumin, J. Integr. Complementary Med., 2016, vol. 13, no. 3, pp. 247–255.

CAS  Google Scholar 

Wu, C.C. et al., Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways, Life Sci., 2006, vol. 78, no. 25, pp. 2889–2897.

CAS  PubMed  Google Scholar 

Wu, T.Y. et al., Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors, AAPS J., 2013, vol. 15, no. 3, pp. 864–874.

CAS  PubMed  PubMed Central  Google Scholar 

Saw, C.L., et al., Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates, Biopharm. Drug Dispos., 2011, vol. 32, no. 5, pp. 289–300.

CAS  PubMed  PubMed Central  Google Scholar