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Therapeutic role of hucMSC-sEV-enriched miR-13896 in cisplatin-induced acute kidney injury through M2 macrophage polarization
Therapeutic role of hucMSC-sEV-enriched miR-13896 in cisplatin-induced acute kidney injury through M2 macrophage polarization
Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles (hucMSC-sEV) have recently garnered attent...
Molecular mechanism of ZC3H13 -mediated ferroptosis in doxorubicin resistance of triple negative breast cancer
Molecular mechanism of ZC3H13 -mediated ferroptosis in doxorubicin resistance of triple negative breast cancer
Triple negative breast cancer (TNBC) continues to be the most aggressive subtype of breast cancer that frequently develops...
Glycolysis regulates palatal mesenchyme proliferation through axis via classical and non-classical pathways
Glycolysis regulates palatal mesenchyme proliferation through axis via classical and non-classical pathways
Abnormal embryonic development leads to the formation of cleft palate (CP) which is difficult to be detected by genetic sc...
Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65
Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65
Acute lung injury (ALI), which poses a significant public health threat, is commonly caused by sepsis. ALI is associated w...
The microRNA-mediated apoptotic signaling axis in male reproduction: a possible and targetable culprit in male infertility
The microRNA-mediated apoptotic signaling axis in male reproduction: a possible and targetable culprit in male infertility
Recently, infertility has emerged as a significant and prevalent public health concern warranting considerable attention. ...
Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathway
Andrographolide ameliorates sepsis-induced acute liver injury by attenuating endoplasmic reticulum stress through the FKBP1A-mediated NOTCH1/AK2 pathway
Andrographolide (AP) has been shown to possess anti-inflammatory activities. In this study, the impact of AP in sepsis-ind...
Transcriptomic changes in oxidative stress, immunity, and cancer pathways caused by cannabis vapor on alveolar epithelial cells
Transcriptomic changes in oxidative stress, immunity, and cancer pathways caused by cannabis vapor on alveolar epithelial cells
As legalization of cannabis increases worldwide, vaping cannabis is gaining popularity due to the belief that it is less h...
Targeted nanoparticle delivery system for tumor-associated macrophage reprogramming to enhance TNBC therapy
Targeted nanoparticle delivery system for tumor-associated macrophage reprogramming to enhance TNBC therapy
Triple-negative breast cancer (TNBC) poses as a daunting and intricate manifestation of breast cancer, highlighted by few ...
Exosome-mediated effects of BRCA1 on cardiovascular artery disease
Exosome-mediated effects of BRCA1 on cardiovascular artery disease
The progression of coronary artery disease atherosclerosis (CAD) is closely associated with cardiomyocyte apoptosis and in...
CUL1-neddylation contributes to K29-linked ubiquitination on p27 for autophagic degradation in sorafenib-resistant liver cancer
CUL1-neddylation contributes to K29-linked ubiquitination on p27 for autophagic degradation in sorafenib-resistant liver cancer
Sorafenib has demonstrated great efficacy in liver cancer, however, its application as first-line treatment has been hampe...
Olfactory mucosal mesenchymal stem cell-derived exosome Lnc A2M-AS1 ameliorates oxidative stress by regulating TP53INP1-mediated mitochondrial autophagy through interacting with IGF2BP1 in Parkinson’s diseases
Olfactory mucosal mesenchymal stem cell-derived exosome Lnc A2M-AS1 ameliorates oxidative stress by regulating TP53INP1-mediated mitochondrial autophagy through interacting with IGF2BP1 in Parkinson’s diseases
Exosome Lnc A2M-AS1 from olfactory mucosa mesenchymal stem cells (OM-MSCs) can ameliorate oxidative stress by improving mi...
Myeloid cells are involved in tumor immunity, metastasis and metabolism in tumor microenvironment
Myeloid cells are involved in tumor immunity, metastasis and metabolism in tumor microenvironment
Bone marrow-derived cells in the tumor microenvironment, including macrophages, neutrophils, dendritic cells, myeloid-deri...
Insights into emerging mechanisms of ferroptosis: new regulators for cancer therapeutics
Insights into emerging mechanisms of ferroptosis: new regulators for cancer therapeutics
Ferroptosis is an iron-dependent form of regulated cell death characterized by the accumulation of iron-dependent lipid pe...
Sodium fluoride promotes myopia progression via the activation of the ferroptosis pathway by PIEZO1 and pharmacological targeting PIEZO1 represents an innovative approach for myopia treatment
Sodium fluoride promotes myopia progression via the activation of the ferroptosis pathway by PIEZO1 and pharmacological targeting PIEZO1 represents an innovative approach for myopia treatment
Sodium fluoride-induced ocular damage constitutes a significant public health concern globally; however, the precise molec...
Early endolysosomal dysfunction is a contributing factor to gadolinium-based contrast agent mouse renal proximal tubule epithelial cell injury
Early endolysosomal dysfunction is a contributing factor to gadolinium-based contrast agent mouse renal proximal tubule epithelial cell injury
The prevalence of contrast-enhanced magnetic resonance imaging (MRI) examinations and the absence of safer alternatives to...
Lamin A/C regulates cerebellar granule cell maturation
Lamin A/C regulates cerebellar granule cell maturation
Lamin A/C is a nuclear type V intermediate filament protein part of the meshwork structure underlying the inner nuclear me...
Targeting B4GALT3 in BMSCs-EVs for Therapeutic Control of HCC via NF-κB pathway inhibition
Targeting B4GALT3 in BMSCs-EVs for Therapeutic Control of HCC via NF-κB pathway inhibition
Examining the communications in the tumor microenvironment (TME) specific to hepatocellular carcinoma (HCC), this explorat...
Dysregulation of the circ-Hdac4/miR-30c/RBPJ axis in decidua impairs placental function in preeclampsia
Dysregulation of the circ-Hdac4/miR-30c/RBPJ axis in decidua impairs placental function in preeclampsia
Embryo implantation relies on complex mother-fetus interactions. Abnormal decidualization can cause various pregnancy comp...
Based exploration of the diagnostic value of oxidative stress-related key genes in chronic obstructive pulmonary disease
Based exploration of the diagnostic value of oxidative stress-related key genes in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) ranks as the third most common contributor to global mortality. Oxidative str...
Effect of the MIAT/microRNA 130a-3p/Pdgfra axis on retinal microglia activation in mice with chronic retinal hypoperfusion injury
Effect of the MIAT/microRNA 130a-3p/Pdgfra axis on retinal microglia activation in mice with chronic retinal hypoperfusion injury
This paper aimed to address the function of the MIAT/miR-130a-3p/Pdgfra axis in retinal microglia activation in chronic re...
Mesenchymal stem cell-based therapy for paraquat-induced lung injury
Mesenchymal stem cell-based therapy for paraquat-induced lung injury
Paraquat poisoning results in significant pulmonary damage, but current treatments are only minimally effective in repairi...
Screening persistent organic pollutants for effects on testosterone and estrogen synthesis at human-relevant concentrations using H295R cells in 96-well plates
Screening persistent organic pollutants for effects on testosterone and estrogen synthesis at human-relevant concentrations using H295R cells in 96-well plates
Many persistent organic pollutants (POPs) are suspected endocrine disruptors and it is important to investigate their effe...
Cocaine-derived hippuric acid activates mtDNA-STING signaling in alcoholic liver disease: Implications for alcohol and cocaine co-abuse
Cocaine-derived hippuric acid activates mtDNA-STING signaling in alcoholic liver disease: Implications for alcohol and cocaine co-abuse
The simultaneous abuse of alcohol-cocaine is known to cause stronger and more unpredictable cellular damage in the liver, ...
Metal ions overloading and cell death
Metal ions overloading and cell death
Cell death maintains cell morphology and homeostasis during development by removing damaged or obsolete cells. The concent...
hucMSC-Ex alleviates inflammatory bowel disease in mice by enhancing M2-type macrophage polarization via the METTL3-Slc37a2-YTHDF1 axis
hucMSC-Ex alleviates inflammatory bowel disease in mice by enhancing M2-type macrophage polarization via the METTL3-Slc37a2-YTHDF1 axis
Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) have emerged as a new treatment strategy for infla...
Comprehensive mapping of immune perturbations associated with aplastic anemia
Comprehensive mapping of immune perturbations associated with aplastic anemia
Aplastic anemia (AA) is an immune-mediated syndrome characterized by bone marrow failure. Therefore, comprehending the cel...
tRNA modifications and tRNA-derived small RNAs: new insights of tRNA in human disease
tRNA modifications and tRNA-derived small RNAs: new insights of tRNA in human disease
tRNAs are codon decoders that convert the transcriptome into the proteome. The field of tRNA research is excited by the in...
MicroRNA-155 and its exosomal form: Small pieces in the gastrointestinal cancers puzzle
MicroRNA-155 and its exosomal form: Small pieces in the gastrointestinal cancers puzzle
Gastrointestinal (GI) cancers are common cancers that are responsible for a large portion of global cancer fatalities. Due...
The role of GDF15 in attenuating noise-induced hidden hearing loss by alleviating oxidative stress
The role of GDF15 in attenuating noise-induced hidden hearing loss by alleviating oxidative stress
Noise-induced hidden hearing loss (HHL) is a newly uncovered form of hearing impairment that causes hidden damage to the c...
Hepsin as a potential therapeutic target for alleviating acetaminophen-induced hepatotoxicity via gap-junction regulation and oxidative stress modulation
Hepsin as a potential therapeutic target for alleviating acetaminophen-induced hepatotoxicity via gap-junction regulation and oxidative stress modulation
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver damage, highlighting the limitations of current eme...
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