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Repetitive element transcript accumulation is associated with inflammaging in humans
Repetitive element transcript accumulation is associated with inflammaging in humans
Chronic, low-grade inflammation increases with aging, contributing to functional declines and diseases that reduce healths...
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
17α-Estradiol (17αE2), a less-feminising enantiomer of 17β-estradiol, has been shown to prolong lifespan an...
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Canine mammary tumors (CMTs) represent a significant health concern in dogs, with a high incidence among intact female dog...
Modulation of neural gene networks by estradiol in old rhesus macaque females
Modulation of neural gene networks by estradiol in old rhesus macaque females
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiolog...
Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats
Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats
The Damaraland mole-rat (DMR; Fukomys damarensis) is a long-lived (~ 20 years) Bathyergid rodent that diver...
Losartan attenuates sex-dependent hypertension, neuroinflammation, and cognitive impairment in the aging male sprague–dawley rat
Losartan attenuates sex-dependent hypertension, neuroinflammation, and cognitive impairment in the aging male sprague–dawley rat
The prevalence of hypertension increases with age and is the leading modifiable risk factor for cognitive impairment and d...
Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach
Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach
Frailty is characterized by loss of physical function and is preferably diagnosed at an early stage (e.g., during pre-frai...
Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan
Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan
Cognitive frailty is considered a clinical entity associated with a high risk for adverse health outcomes. However, its cl...
Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice
Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice
Frailty is a complex condition characterized by a decline in multiple physiological systems, compromising an individual...
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells
Fibroblast growth factor 21 (FGF21) is a key regulator of metabolism and cardiovascular health. However, its upregulation ...
Differential proteomic profiles between cognitive frail and robust older adults from the MELoR cohort
Differential proteomic profiles between cognitive frail and robust older adults from the MELoR cohort
The present study explored for the first time the blood-based proteomic signature that could potentially distinguish older...
Circulating small extracellular vesicles as blood-based biomarkers of muscle health in aging nonhuman primates
Circulating small extracellular vesicles as blood-based biomarkers of muscle health in aging nonhuman primates
Age-associated loss of muscle mass and function and subsequent mobility decline define poor health outcomes, reduced quali...
A multi-stage feature selection method to improve classification of potential super-agers and cognitive decliners using structural brain MRI data—a UK biobank study
A multi-stage feature selection method to improve classification of potential super-agers and cognitive decliners using structural brain MRI data—a UK biobank study
Cognitive aging is described as the age-related decline in areas such as memory, executive function, reasoning, and proces...
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions
Many aspects of inflammation increase with aging in mice and humans. Transcriptomic analysis revealed that many murine ant...
Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice
Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice
Ovarian aging is characterized by declines in follicular reserve and the emergence of mitochondrial dysfunction, reactive ...
A complex systems approach to mosaic loss of the Y chromosome
A complex systems approach to mosaic loss of the Y chromosome
Mosaic loss of Y chromosome (mLOY) is an acquired condition wherein a sizeable proportion of an organ’s cells have l...
The effectiveness of digital technology interventions for cognitive function in older adults: a systematic review and meta-analysis of randomized controlled trials
The effectiveness of digital technology interventions for cognitive function in older adults: a systematic review and meta-analysis of randomized controlled trials
Digital technology interventions (DTIs) are seen as promising interventions to prevent or delay cognitive decline in older...
Judith Campisi (1948–2024): tribute and personal memory
Judith Campisi (1948–2024): tribute and personal memory
Photo courtesy of the Buck Institute for Research on AgingJudith Campisi, who passed ...
Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults
Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults
Visit-to-visit blood pressure variability (BPV) predicts age-related hippocampal atrophy, neurodegeneration, and memory de...
Characterizing dog cognitive aging using spontaneous problem-solving measures: development of a battery of tests from the Dog Aging Project
Characterizing dog cognitive aging using spontaneous problem-solving measures: development of a battery of tests from the Dog Aging Project
Companion dogs are a valuable model for aging research, including studies of cognitive decline and dementia. With advanced...
A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus)
A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus)
17α-estradiol extends healthspan and lifespan in male mice without significant feminization or deleterious effects on...
Right anterior insula ASL hypoperfusion as a diagnostic biomarker of prodromal and mild dementia with Lewy bodies: preliminary evidence using a Bayesian approach
Right anterior insula ASL hypoperfusion as a diagnostic biomarker of prodromal and mild dementia with Lewy bodies: preliminary evidence using a Bayesian approach
Identifying and validating a biomarker with high specificity in early-stage dementia with Lewy bodies (DLB) using a feasib...
Gonadal status modulates large elastic artery stiffness in healthy middle-aged and older men
Gonadal status modulates large elastic artery stiffness in healthy middle-aged and older men
Hypogonadism is a risk factor for cardiovascular disease (CVD) in men related, in part, to increased oxidative stress. Ele...
Identifying sources of bias when testing three available algorithms for quantifying white matter lesions: BIANCA, LPA and LGA
Identifying sources of bias when testing three available algorithms for quantifying white matter lesions: BIANCA, LPA and LGA
Brain magnetic resonance imaging frequently reveals white matter lesions (WMLs) in older adults. They are often associated...
Anti-aging interventions in geriatric mice: insights into the timing of treatment, benefits, and limitations
Anti-aging interventions in geriatric mice: insights into the timing of treatment, benefits, and limitations
Studies aimed at preventing age-associated diseases are fundamental in addressing the challenges posed by an aging populat...
Non-invasive myocardial work as an independent predictor of postprocedural NT-proBNP in elderly patients undergoing transcatheter aortic valve replacement
Non-invasive myocardial work as an independent predictor of postprocedural NT-proBNP in elderly patients undergoing transcatheter aortic valve replacement
Aortic stenosis has become the most prevalent valvular disease with increasing life expectancy and the ageing of the popul...
Discriminative ability of instrumented cognitive-motor assessments to distinguish fallers from non-fallers
Discriminative ability of instrumented cognitive-motor assessments to distinguish fallers from non-fallers
In older populations, sensitive fall risk assessment tools are important to timely intervene and prevent falls. Instrument...
Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL−F/NL−F mice
Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL−F/NL−F mice
Senescent cells accumulate throughout the body and brain contributing to unhealthy aging and Alzheimer’s disease (AD...
Impact of Helicobacter pylori eradication on age-specific risk of incident dementia in patients with peptic ulcer disease: a nationwide population-based cohort study
Impact of Helicobacter pylori eradication on age-specific risk of incident dementia in patients with peptic ulcer disease: a nationwide population-based cohort study
The impact of peptic ulcer disease (PUD) and Helicobacter pylori (H. pylori) eradication therapy on dementia risk in high ...
Sex-specific clinical and neurobiological correlates of fatigue in older adults
Sex-specific clinical and neurobiological correlates of fatigue in older adults
Fatigue is a common and distressful symptom in older people and has been associated with adverse health outcomes. Neverthe...
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