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Judith Campisi (1948–2024): tribute and personal memory
Judith Campisi (1948–2024): tribute and personal memory
Photo courtesy of the Buck Institute for Research on AgingJudith Campisi, who passed ...
Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults
Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults
Visit-to-visit blood pressure variability (BPV) predicts age-related hippocampal atrophy, neurodegeneration, and memory de...
Characterizing dog cognitive aging using spontaneous problem-solving measures: development of a battery of tests from the Dog Aging Project
Characterizing dog cognitive aging using spontaneous problem-solving measures: development of a battery of tests from the Dog Aging Project
Companion dogs are a valuable model for aging research, including studies of cognitive decline and dementia. With advanced...
A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus)
A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus)
17α-estradiol extends healthspan and lifespan in male mice without significant feminization or deleterious effects on...
Right anterior insula ASL hypoperfusion as a diagnostic biomarker of prodromal and mild dementia with Lewy bodies: preliminary evidence using a Bayesian approach
Right anterior insula ASL hypoperfusion as a diagnostic biomarker of prodromal and mild dementia with Lewy bodies: preliminary evidence using a Bayesian approach
Identifying and validating a biomarker with high specificity in early-stage dementia with Lewy bodies (DLB) using a feasib...
Gonadal status modulates large elastic artery stiffness in healthy middle-aged and older men
Gonadal status modulates large elastic artery stiffness in healthy middle-aged and older men
Hypogonadism is a risk factor for cardiovascular disease (CVD) in men related, in part, to increased oxidative stress. Ele...
Identifying sources of bias when testing three available algorithms for quantifying white matter lesions: BIANCA, LPA and LGA
Identifying sources of bias when testing three available algorithms for quantifying white matter lesions: BIANCA, LPA and LGA
Brain magnetic resonance imaging frequently reveals white matter lesions (WMLs) in older adults. They are often associated...
Anti-aging interventions in geriatric mice: insights into the timing of treatment, benefits, and limitations
Anti-aging interventions in geriatric mice: insights into the timing of treatment, benefits, and limitations
Studies aimed at preventing age-associated diseases are fundamental in addressing the challenges posed by an aging populat...
Non-invasive myocardial work as an independent predictor of postprocedural NT-proBNP in elderly patients undergoing transcatheter aortic valve replacement
Non-invasive myocardial work as an independent predictor of postprocedural NT-proBNP in elderly patients undergoing transcatheter aortic valve replacement
Aortic stenosis has become the most prevalent valvular disease with increasing life expectancy and the ageing of the popul...
Discriminative ability of instrumented cognitive-motor assessments to distinguish fallers from non-fallers
Discriminative ability of instrumented cognitive-motor assessments to distinguish fallers from non-fallers
In older populations, sensitive fall risk assessment tools are important to timely intervene and prevent falls. Instrument...
Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL−F/NL−F mice
Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL−F/NL−F mice
Senescent cells accumulate throughout the body and brain contributing to unhealthy aging and Alzheimer’s disease (AD...
Impact of Helicobacter pylori eradication on age-specific risk of incident dementia in patients with peptic ulcer disease: a nationwide population-based cohort study
Impact of Helicobacter pylori eradication on age-specific risk of incident dementia in patients with peptic ulcer disease: a nationwide population-based cohort study
The impact of peptic ulcer disease (PUD) and Helicobacter pylori (H. pylori) eradication therapy on dementia risk in high ...
Sex-specific clinical and neurobiological correlates of fatigue in older adults
Sex-specific clinical and neurobiological correlates of fatigue in older adults
Fatigue is a common and distressful symptom in older people and has been associated with adverse health outcomes. Neverthe...
What is normal age-related thigh muscle composition among 45- to 84-year-old adults from the UK Biobank study
What is normal age-related thigh muscle composition among 45- to 84-year-old adults from the UK Biobank study
A loss of skeletal muscle mass and an increase in intramuscular fat are known to occur as we enter middle and older age, b...
Sport and longevity: an observational study of international athletes
Sport and longevity: an observational study of international athletes
The human lifespan is influenced by various factors, with physical activity being a significant contributor. Despite the c...
The RESIST Senior Individuals Cohort: Design, participant characteristics and aims
The RESIST Senior Individuals Cohort: Design, participant characteristics and aims
The number of older adults worldwide is growing exponentially. However, while living longer, older individuals are more su...
Age-related alterations in vortex veins on indocyanine green angiography
Age-related alterations in vortex veins on indocyanine green angiography
To determine age-related alterations in vortex veins in healthy subjects. A total of 228 healthy subjects (aged 4 to 86 ye...
A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers
A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers
Genome-wide association studies (GWAS) in long-lived human populations have led to identification of variants associated w...
Molecular cross-talk between long COVID-19 and Alzheimer’s disease
Molecular cross-talk between long COVID-19 and Alzheimer’s disease
The long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 ...
Neutrophil, lymphocyte count, and neutrophil to lymphocyte ratio predict multimorbidity and mortality—results from the Baltimore Longitudinal Study on Aging follow-up study
Neutrophil, lymphocyte count, and neutrophil to lymphocyte ratio predict multimorbidity and mortality—results from the Baltimore Longitudinal Study on Aging follow-up study
Immunosenescence is the age-related changes in the immune system, namely, progressively higher levels of circulating infla...
The impact of a tDCS and cognitive training intervention on task-based functional connectivity
The impact of a tDCS and cognitive training intervention on task-based functional connectivity
Declines in several cognitive domains, most notably processing speed, occur in non-pathological aging. Given the exponenti...
The role of physical activity in the association between disability and mortality among US older adults: a nationwide prospective cohort study
The role of physical activity in the association between disability and mortality among US older adults: a nationwide prospective cohort study
To examine whether physical activity can mitigate the mortality risk associated with disability in activities of daily liv...
Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue
Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue
The aging of white adipose tissue (WAT) involves senescence of adipose stem and progenitor cells (ASPCs) and dysregulation...
Prognostic accuracy of 70 individual frailty biomarkers in predicting mortality in the Canadian Longitudinal Study on Aging
Prognostic accuracy of 70 individual frailty biomarkers in predicting mortality in the Canadian Longitudinal Study on Aging
The frailty index (FI) uses a deficit accumulation approach to derive a single, comprehensive, and replicable indicator of...
Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer’s disease
Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer’s disease
First-degree relatives of Alzheimer’s disease patients constitute a key population in the search for early markers. ...
Senolytic treatment fails to improve ovarian reserve or fertility in female mice
Senolytic treatment fails to improve ovarian reserve or fertility in female mice
Senescent cell number increases with age in different tissues, leading to greater senescent cell load, proinflammatory str...
Performance of digital technologies in assessing fall risks among older adults with cognitive impairment: a systematic review
Performance of digital technologies in assessing fall risks among older adults with cognitive impairment: a systematic review
Older adults with cognitive impairment (CI) are twice as likely to fall compared to the general older adult population. Tr...
Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults
Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults
Although muscle atrophy may partially account for age-related strength decline, it is further influenced by alterations of...
Early neurological changes in aging cervical spine: insights from PROMIS mobility assessment
Early neurological changes in aging cervical spine: insights from PROMIS mobility assessment
Many studies have shown that the prevalence of degenerative spinal cord compression increases with age. However, most case...
Fisetin modulates the gut microbiota alongside biomarkers of senescence and inflammation in a DSS-induced murine model of colitis
Fisetin modulates the gut microbiota alongside biomarkers of senescence and inflammation in a DSS-induced murine model of colitis
Colitis, a subtype of inflammatory bowel disease (IBD), is a multifactorial disorder characterized by chronic inflammation...
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