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Physiologic Insults and Individualized Treatments in Traumatic Brain Injury*
Physiologic Insults and Individualized Treatments in Traumatic Brain Injury*
1 Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD. 2 Department of Ane...
The Omicron Paradox: Is It Omicron or Is It What Happened During the Omicron Period?*
The Omicron Paradox: Is It Omicron or Is It What Happened During the Omicron Period?*
The emergence of variants of concern (VOCs), each with potential differences in their virulence and ability to evade the i...
Advancing Global Validation and Implementation of Adult Sepsis Event Surveillance*
Advancing Global Validation and Implementation of Adult Sepsis Event Surveillance*
In 2020, the World Health Organization (WHO) issued its first report on the global epidemiology and burden of sepsis (1). ...
Lessons From the LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P) Trial*
Lessons From the LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P) Trial*
LIPIDS IN SEPSIS Water-based multicellular metazoans (all of us) have evolved mechanism for handling endogenous...
Not So Fast—Pressing the Brakes on Sympathetic Hyperactivity After Traumatic Brain Injury*
Not So Fast—Pressing the Brakes on Sympathetic Hyperactivity After Traumatic Brain Injury*
Department of Neurology, Division of Neurocritical Care, Program in Trauma, R. Adams Cowley Shock Trauma Center, Un...
Fibrotic-Like Pulmonary Radiographic Patterns in COVID-19 Chronic Critical Illness: Extraordinary Association Between Obesity and Interleukin-6 Levels
Fibrotic-Like Pulmonary Radiographic Patterns in COVID-19 Chronic Critical Illness: Extraordinary Association Between Obesity and Interleukin-6 Levels
1 Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and...
Case-Mix and the Limitations of Standardized Mortality Ratios for ICU Performance and Benchmarking
Case-Mix and the Limitations of Standardized Mortality Ratios for ICU Performance and Benchmarking
1 Department of Critical Care and Postgraduate Program in Translational Medicine, D’Or Institute for Research and E...
The Relationship Between Manifestation of Diabetes Insipidus and Estimated Glomerular Filtration Rate in Brain Death: Implications Require Clarification
The Relationship Between Manifestation of Diabetes Insipidus and Estimated Glomerular Filtration Rate in Brain Death: Implications Require Clarification
1 Department of Pediatrics, and John Dossetor Health Ethics Center, University of Alberta, Edmonton, AB, Canada. ...
Hypoxia-Inducible Factor-1: A Bridge Between Plasma Nitric Oxide and Adverse Outcomes in Critically Ill Patients
Hypoxia-Inducible Factor-1: A Bridge Between Plasma Nitric Oxide and Adverse Outcomes in Critically Ill Patients
1 Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and...
ICU Resource Strain and Patient Outcomes
ICU Resource Strain and Patient Outcomes
All authors: Critical Care Medicine, West China Hospital, Sichuan University, Sichuan, China. This study was ...
How Reliable Are Serum Levetiracetam Levels to Be Used as a Primary Endpoint?
How Reliable Are Serum Levetiracetam Levels to Be Used as a Primary Endpoint?
1 Department of Pharmacy Practice, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riy...
Should Fludrocortisone be Added to Hydrocortisone in Septic Shock? Probably Yes, Based on Available Evidence*
Should Fludrocortisone be Added to Hydrocortisone in Septic Shock? Probably Yes, Based on Available Evidence*
1 The Pulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Bosto...
More Evidence That We Should be Using Resuscitative Extracorporeal Membrane Oxygen Among the “Not Quite Dead Yet?”: The Importance of Signs of Life Before Extracorporeal Cardiopulmonary Resuscitation Cannulation*
More Evidence That We Should be Using Resuscitative Extracorporeal Membrane Oxygen Among the “Not Quite Dead Yet?”: The Importance of Signs of Life Before Extracorporeal Cardiopulmonary Resuscitation Cannulation*
Extracorporeal membrane oxygen (ECMO) is well established as a resuscitative adjunct or treatment modality in severe respi...
Death Foretold: Are We Truly Improving Outcome Prediction After Cardiac Arrest or Nurturing Self-Fulfilling Prophecies?*
Death Foretold: Are We Truly Improving Outcome Prediction After Cardiac Arrest or Nurturing Self-Fulfilling Prophecies?*
Predicting the potential for neurologic recovery—or lack thereof—after hypoxic-ischemic brain injury is a cornerstone of p...
Bridging Heartbeats: The Promise of Extracorporeal Cardiopulmonary Resuscitation in Pediatric Cardiac Critical Care*
Bridging Heartbeats: The Promise of Extracorporeal Cardiopulmonary Resuscitation in Pediatric Cardiac Critical Care*
In-hospital cardiac arrest occurs in 3%–4% of children recovering from cardiac surgery. Nearly half of them do not survive...
Extracorporeal Cardiopulmonary Resuscitation in Children With Primary Noncardiac Diagnoses: Untangling a Complex Intervention*
Extracorporeal Cardiopulmonary Resuscitation in Children With Primary Noncardiac Diagnoses: Untangling a Complex Intervention*
1 Department of Cardiology, Boston Children’s Hospital, Boston, MA. 2 Department of Pediatrics, Harvard Medic...
Safety, Surge, and Strain: Where and When Does Risk Occur in Critical Care?*
Safety, Surge, and Strain: Where and When Does Risk Occur in Critical Care?*
COVID-19 challenged critical care in many ways, but also provided a unique opportunity to study the global impact of a sin...
In the Critically Ill Obese Should We Tip the Scale With More Protein?*
In the Critically Ill Obese Should We Tip the Scale With More Protein?*
1 Department of Research, Barnes-Jewish Hospital, St. Louis, MO. 2 Department of Gastroenterology, University...
Physiology-Based Indications to Improve Outcome of Awake Extracorporeal Membrane Oxygenation*
Physiology-Based Indications to Improve Outcome of Awake Extracorporeal Membrane Oxygenation*
Acute hypoxemic respiratory failure (AHRF) and its more severe form, acute respiratory distress syndrome (ARDS), imply a d...
Measuring Strain in the ICU*
Measuring Strain in the ICU*
What are our limits? The best team in the best hospital can reach a point where patients’ needs exceed the institution’s c...
Buprenorphine: Its Emerging Role as a Strategy to Reduce Full Opioid Agonist Use in the ICU*
Buprenorphine: Its Emerging Role as a Strategy to Reduce Full Opioid Agonist Use in the ICU*
Pain is common in critically ill adults at both rest and during procedures. Opioids have remained the analgesic mainstay i...
Seizures After Acute Subdural Hemorrhage: Call for More Monitoring*
Seizures After Acute Subdural Hemorrhage: Call for More Monitoring*
Departments of Neurology and Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA. *See also ...
POSTCARDS from a SIESTA: Crossing the Translational and Generalizability Gap for Predictive Models of Acute Respiratory Distress Syndrome-Related Mortality*
POSTCARDS from a SIESTA: Crossing the Translational and Generalizability Gap for Predictive Models of Acute Respiratory Distress Syndrome-Related Mortality*
In this issue of Critical Care Medicine, the study by Villar et al (1) tests a new mortality prediction score in Spanish I...
Are We Ready for Biomarker-Guided Immune Modulation in Critical Care?*
Are We Ready for Biomarker-Guided Immune Modulation in Critical Care?*
1 Division of Critical Care Medicine, Department of Medicine, Western University, London, ON, Canada. 2 Depar...
Measuring Bundle Implementation Work Requires a Calibrated Scale*
Measuring Bundle Implementation Work Requires a Calibrated Scale*
Both authors: Pulmonary, Allergy and Critical Care Division, Department of Medicine, Perelman School of Medicine, U...
Climbing the Evidence Pyramid: Developing an Evidence-Based Approach to the Provision of Venovenous Extracorporeal Membrane Oxygenation*
Climbing the Evidence Pyramid: Developing an Evidence-Based Approach to the Provision of Venovenous Extracorporeal Membrane Oxygenation*
1 Department of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN...
Is It Time to Reconsider the Concept of “Salvage Therapy” in Refractory Shock?*
Is It Time to Reconsider the Concept of “Salvage Therapy” in Refractory Shock?*
Distributive shock is the most common form of circulatory failure and is characterized by a systemic arterial tone insuffi...
Trajectory After Tracheostomy: Sobering Data for Decision Makers*
Trajectory After Tracheostomy: Sobering Data for Decision Makers*
1 Department of Medicine, Jersey City Medical Center, Jersey City, NJ. 2 Critical Care Consult Service, Divis...
Harmonizing ICU Admission, Discharge, and Transfer Criteria to Improve Critical Care Capability
Harmonizing ICU Admission, Discharge, and Transfer Criteria to Improve Critical Care Capability
1 Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medici...
Apples and Oranges—All ‘Vitamin C’ May Not Be Created Equal
Apples and Oranges—All ‘Vitamin C’ May Not Be Created Equal
1 Department of Intensive Care, Royal Adelaide Hospital, Adelaide, SA, Australia. 2 Preclinical Critical Care...
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