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The Relationship Between Manifestation of Diabetes Insipidus and Estimated Glomerular Filtration Rate in Brain Death: Implications Require Clarification
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Hypoxia-Inducible Factor-1: A Bridge Between Plasma Nitric Oxide and Adverse Outcomes in Critically Ill Patients
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ICU Resource Strain and Patient Outcomes
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How Reliable Are Serum Levetiracetam Levels to Be Used as a Primary Endpoint?
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Should Fludrocortisone be Added to Hydrocortisone in Septic Shock? Probably Yes, Based on Available Evidence*
1 The Pulmonary Center, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Bosto...
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More Evidence That We Should be Using Resuscitative Extracorporeal Membrane Oxygen Among the “Not Quite Dead Yet?”: The Importance of Signs of Life Before Extracorporeal Cardiopulmonary Resuscitation Cannulation*
Extracorporeal membrane oxygen (ECMO) is well established as a resuscitative adjunct or treatment modality in severe respi...
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Death Foretold: Are We Truly Improving Outcome Prediction After Cardiac Arrest or Nurturing Self-Fulfilling Prophecies?*
Predicting the potential for neurologic recovery—or lack thereof—after hypoxic-ischemic brain injury is a cornerstone of p...
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Bridging Heartbeats: The Promise of Extracorporeal Cardiopulmonary Resuscitation in Pediatric Cardiac Critical Care*
In-hospital cardiac arrest occurs in 3%–4% of children recovering from cardiac surgery. Nearly half of them do not survive...
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Extracorporeal Cardiopulmonary Resuscitation in Children With Primary Noncardiac Diagnoses: Untangling a Complex Intervention*
1 Department of Cardiology, Boston Children’s Hospital, Boston, MA. 2 Department of Pediatrics, Harvard Medic...
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Safety, Surge, and Strain: Where and When Does Risk Occur in Critical Care?*
COVID-19 challenged critical care in many ways, but also provided a unique opportunity to study the global impact of a sin...
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In the Critically Ill Obese Should We Tip the Scale With More Protein?*
1 Department of Research, Barnes-Jewish Hospital, St. Louis, MO. 2 Department of Gastroenterology, University...
Critical Care Medicine
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Physiology-Based Indications to Improve Outcome of Awake Extracorporeal Membrane Oxygenation*
Acute hypoxemic respiratory failure (AHRF) and its more severe form, acute respiratory distress syndrome (ARDS), imply a d...
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Measuring Strain in the ICU*
What are our limits? The best team in the best hospital can reach a point where patients’ needs exceed the institution’s c...
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Buprenorphine: Its Emerging Role as a Strategy to Reduce Full Opioid Agonist Use in the ICU*
Pain is common in critically ill adults at both rest and during procedures. Opioids have remained the analgesic mainstay i...
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Seizures After Acute Subdural Hemorrhage: Call for More Monitoring*
Departments of Neurology and Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA. *See also ...
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POSTCARDS from a SIESTA: Crossing the Translational and Generalizability Gap for Predictive Models of Acute Respiratory Distress Syndrome-Related Mortality*
In this issue of Critical Care Medicine, the study by Villar et al (1) tests a new mortality prediction score in Spanish I...
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Are We Ready for Biomarker-Guided Immune Modulation in Critical Care?*
1 Division of Critical Care Medicine, Department of Medicine, Western University, London, ON, Canada. 2 Depar...
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Measuring Bundle Implementation Work Requires a Calibrated Scale*
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Climbing the Evidence Pyramid: Developing an Evidence-Based Approach to the Provision of Venovenous Extracorporeal Membrane Oxygenation*
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Is It Time to Reconsider the Concept of “Salvage Therapy” in Refractory Shock?*
Distributive shock is the most common form of circulatory failure and is characterized by a systemic arterial tone insuffi...
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Trajectory After Tracheostomy: Sobering Data for Decision Makers*
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Harmonizing ICU Admission, Discharge, and Transfer Criteria to Improve Critical Care Capability
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Apples and Oranges—All ‘Vitamin C’ May Not Be Created Equal
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Immediate Fluid Bolus or Norepinephrine in Endotoxic Shock
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Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process*
OBJECTIVES: To address areas in which there is no consensus for the technologies, effort, and tra
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Does CytoSorb Pose Unique Challenges to Pooled Estimates in Meta-Analysis?*
Systematic review and meta-analysis has transformed the way we interpret and apply evidence-based medicine (1). While nume...
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Prone Positioning in Acute Respiratory Distress Syndrome: Don’t Stop Believing...*
All authors: Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, UC San D...
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