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Evaluation of sex differences in the pharmacokinetics of oral sumatriptan in healthy Korean subjects using population pharmacokinetic modeling
Evaluation of sex differences in the pharmacokinetics of oral sumatriptan in healthy Korean subjects using population pharmacokinetic modeling
AbstractSumatriptan was introduced in 1983, as the first of the triptans, selective 5-hydroxytryptamine (5-HT1B/1D) recept...
Absorption, metabolism, and pharmacokinetic profile of xanthohumol in rats as determined via UPLC‐MS/MS
Absorption, metabolism, and pharmacokinetic profile of xanthohumol in rats as determined via UPLC‐MS/MS
Abstract Xanthohumol, a natural isoflavone from Humulus lupulus L., possesses biological activities. However, the biologic...
Comparison of biomarker and chromatographic analytical approaches to pharmacokinetic study of sitagliptin
Comparison of biomarker and chromatographic analytical approaches to pharmacokinetic study of sitagliptin
Abstract The pharmacokinetic profiling of active compounds is necessary for drug development and application. Approaches t...
COMPRASION OF BIOMARKER AND CHROMATOGRAPHIC ANALYTICAL APPROACHES TO PHARMACOKINETIC STUDY OF SITAGLYPTIN
COMPRASION OF BIOMARKER AND CHROMATOGRAPHIC ANALYTICAL APPROACHES TO PHARMACOKINETIC STUDY OF SITAGLYPTIN
ABSTRACT The pharmacokinetic profiling of active compounds is necessary for drug development and application. Approaches t...
Clinical application of vancomycin population pharmacokinetics model in patients with hematological diseases and neutropenia
Clinical application of vancomycin population pharmacokinetics model in patients with hematological diseases and neutropenia
Abstract To explore the clinical application of a population pharmacokinetics (PPK) model of vancomycin in patients with h...
Evaluation on Absorption Risks of Amentoflavone after Oral Administration in Rats
Evaluation on Absorption Risks of Amentoflavone after Oral Administration in Rats
AbstractThe present study was aimed to systemically assess the absorption risks of amentoflavone (AMF). Physicochemical pr...
Clinical application of vancomycin population pharmacokinetics model in patients with neutropenia
Clinical application of vancomycin population pharmacokinetics model in patients with neutropenia
Abstract Background To explore the clinical application of a population pharmacokinetics (PPK) model of vancomycin in pati...
Comparison of tissue pharmacokinetics of esflurbiprofen plaster with flurbiprofen tablets in patients with knee osteoarthritis: A multicenter randomized controlled trial
Comparison of tissue pharmacokinetics of esflurbiprofen plaster with flurbiprofen tablets in patients with knee osteoarthritis: A multicenter randomized controlled trial
Abstract This open-label, multicenter, prospective, randomized controlled trial aimed to determine the effectiveness of es...
Physiologically based pharmacokinetic modelling of acetaminophen in preterm neonates ‐ the impact of metabolising enzyme ontogeny and reduced cardiac output
Physiologically based pharmacokinetic modelling of acetaminophen in preterm neonates ‐ the impact of metabolising enzyme ontogeny and reduced cardiac output
ABSTRACT In preterm neonates, physiologically based pharmacokinetic (PBPK) models are suited for studying the effects of m...
Impact of age, hypercholesterolemia, and the vitamin D receptor on brain endogenous β‐amyloid peptide accumulation in mice
Impact of age, hypercholesterolemia, and the vitamin D receptor on brain endogenous β‐amyloid peptide accumulation in mice
Abstract Age, hypercholesterolemia, and vitamin D deficiency are risk factors that increase the brain accumulation of path...
Effect of Nigella sativa oil on pharmacokinetics and pharmacodynamics of gliclazide in rats
Effect of Nigella sativa oil on pharmacokinetics and pharmacodynamics of gliclazide in rats
AbstractNigella sativa oil (NSO) has been widely used for its putative anti-hyperglycemic activity. However, little is kno...
Kinetic analysis of cystine uptake and inhibition pattern of sulfasalazine in A549 cells
Kinetic analysis of cystine uptake and inhibition pattern of sulfasalazine in A549 cells
Abstract Cystine/glutamate transporter (xCT) is an antiporter involved in cystine uptake and glutamate efflux. However, th...
Comparative in silico prediction of P‐glycoprotein‐mediated transport for 2010‐2020 US FDA‐approved drugs using six Web‐tools
Comparative in silico prediction of P‐glycoprotein‐mediated transport for 2010‐2020 US FDA‐approved drugs using six Web‐tools
Abstract P-glycoprotein (P-gp) is an efflux pump implicated in pharmacokinetics and drug-drug interactions. The identifica...
Impact of age, hypercholesterolemia and the vitamin D receptor (VDR) on brain endogenous β‐amyloid peptide accumulation in mice
Impact of age, hypercholesterolemia and the vitamin D receptor (VDR) on brain endogenous β‐amyloid peptide accumulation in mice
Abstract Age, hypercholesterolemia, and vitamin D deficiency are risk factors that increase the brain accumulation of path...
Profiling pharmacokinetics of double‐negative T cells and cytokines via a single intravenous administration in NSG mice
Profiling pharmacokinetics of double‐negative T cells and cytokines via a single intravenous administration in NSG mice
Abstract This study was intended to delineate the profile of double-negative T cells (DNTs) in NOD.Cg-Prkdcscid Il2rgtm1wj...
Drug‐Drug Interaction between Diclofenac and Gamma‐Hydroxybutyric Acid
Drug‐Drug Interaction between Diclofenac and Gamma‐Hydroxybutyric Acid
Abstract Gamma hydroxybutyric acid (GHB) has been approved clinically to treat excessive daytime sleepiness and cataplexy ...
In vitro and In silico biopharmaceutic regulatory guidelines for generic bioequivalence for oral products: Comparison among various regulatory agencies
In vitro and In silico biopharmaceutic regulatory guidelines for generic bioequivalence for oral products: Comparison among various regulatory agencies
Abstract Generic drug development is a complex process that involves development of formulation similar to reference produ...
Profiling Pharmacokinetics of DNT cells and Cytokines via a Single Intravenous Administration in NSG Mice
Profiling Pharmacokinetics of DNT cells and Cytokines via a Single Intravenous Administration in NSG Mice
Abstract This study was intended to delineate the profile of double-negative T cells (DNT) in NSG mice and cytokines relea...
Switchability and minimal effect of food on pharmacokinetics of modified release tablet strengths of omecamtiv mecarbil, a cardiac myosin activator
Switchability and minimal effect of food on pharmacokinetics of modified release tablet strengths of omecamtiv mecarbil, a cardiac myosin activator
Abstract Omecamtiv mecarbil (OM) is a cardiac myosin activator in clinical development for the treatment of heart failure....
Population pharmacokinetics of oral levofloxacin in healthy volunteers and dosing optimization for multidrug‐resistant tuberculosis therapy
Population pharmacokinetics of oral levofloxacin in healthy volunteers and dosing optimization for multidrug‐resistant tuberculosis therapy
Abstract Levofloxacin is considered a key component of a multidrug-resistant tuberculosis (MDR-TB) regimen. However, there...
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