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Pediatric case of immune-mediated necrotizing myopathy with anti-HMGCR antibodies and dermatomyositis skin rash
Pediatric case of immune-mediated necrotizing myopathy with anti-HMGCR antibodies and dermatomyositis skin rash
A 9-year-old girl from Mayotte (a south-east African island) presented with progressive symmetrical proximo-distal muscle ...
Defects in B-lymphopoiesis and B-cell maturation underlie prolonged B-cell depletion in ANCA-associated vasculitis
Defects in B-lymphopoiesis and B-cell maturation underlie prolonged B-cell depletion in ANCA-associated vasculitis
IntroductionAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises granulomatosis with polyangii...
2023 EULAR classification criteria for hand osteoarthritis
2023 EULAR classification criteria for hand osteoarthritis
IntroductionHand osteoarthritis (OA) mainly affects the distal interphalangeal (DIP), proximal interphalangeal (PIP) and t...
Racial variability in immune responses only partially explains differential systemic sclerosis disease severity
Racial variability in immune responses only partially explains differential systemic sclerosis disease severity
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From fibrositis to fibromyalgia to nociplastic pain: how rheumatology helped get us here and where do we go from here?
From fibrositis to fibromyalgia to nociplastic pain: how rheumatology helped get us here and where do we go from here?
A historical perspective on our understanding of fibromyalgiaIn 2017, the International Association for the Study of Pain ...
B-cell depletion in autoimmune diseases
B-cell depletion in autoimmune diseases
B cells have a pivotal function in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, multiple scleros...
Correspondence on 'EULAR recommendations for the management of systemic lupus erythematosus: 2023 update by Fanouriakis et al
Correspondence on 'EULAR recommendations for the management of systemic lupus erythematosus: 2023 update by Fanouriakis et al
We read with great interest the new EULAR guidelines1 for the management of systemic lupus erythematosus (SLE), and we app...
Referral of patients with suspected polymyalgia rheumatica: how complete is our view of 'planet PMR?
Referral of patients with suspected polymyalgia rheumatica: how complete is our view of 'planet PMR?
Polymyalgia rheumatica (PMR) is the second most common inflammatory rheumatic disease after rheumatoid arthritis in person...
HLA-B27 and the role of specific T cell receptors in the pathogenesis of spondyloarthritis
HLA-B27 and the role of specific T cell receptors in the pathogenesis of spondyloarthritis
The pathogenesis of axial spondyloarthritis (axSpA), although not entirely clear yet, is largely based on genes, the stron...
Pathological autoantibody internalisation in myositis
Pathological autoantibody internalisation in myositis
WHAT IS ALREADY KNOWN ON THIS TOPICAutoantibodies targeting intracellular proteins are common in various autoimmune diseas...
Association between premature vascular smooth muscle cells senescence and vascular inflammation in Takayasus arteritis
Association between premature vascular smooth muscle cells senescence and vascular inflammation in Takayasus arteritis
IntroductionTakayasu’s arteritis (TAK) is a chronic large-vessel vasculitis (LVV) characterised by inflammation of the aor...
Paraspinal tophi
Paraspinal tophi
A young adult patient with gout was incidentally found to have a large mass on the right lumbar spine and sacrum during an...
Response to: Correspondence on 'Current myositis clinical trials and tribulations by Saygin et al
Response to: Correspondence on 'Current myositis clinical trials and tribulations by Saygin et al
We thank Azevedo et al 1 for their correspondence in response to the publication of our viewpoint entitled ‘Myositis Clini...
Dysregulation of immune checkpoint molecules as a characteristic of autoimmune congenital heart block
Dysregulation of immune checkpoint molecules as a characteristic of autoimmune congenital heart block
Autoimmune congenital heart block (CHB) represents a severe manifestation of neonatal lupus syndrome due to placental tran...
Distinct pulmonary patterns in ANCA-associated vasculitides: insights from a retrospective single center cohort study
Distinct pulmonary patterns in ANCA-associated vasculitides: insights from a retrospective single center cohort study
ANCA-associated vasculitides (AAV) comprise granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eos...
Belimumab corticosteroid-sparing treatment in systemic lupus erythematosus: a real-life observational study (BESST study)
Belimumab corticosteroid-sparing treatment in systemic lupus erythematosus: a real-life observational study (BESST study)
Data about the impact of Belimumab on corticosteroid sparing in real life are scarce. To assess the corticosteroid-sparing...