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Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zone
Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zone
The resting zone (RZ) in mammalian growth plates is critical for maintaining and regulating chondrocyte turnover during lo...
Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis
Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis
The crosstalk between megakaryocytic lineage cells and the skeletal system has just begun to be explored but remains large...
CD47 is required for mesenchymal progenitor proliferation and fracture repair
CD47 is required for mesenchymal progenitor proliferation and fracture repair
CD47 is a ubiquitous and pleiotropic cell-surface receptor. Disrupting CD47 enhances injury repair in various tissues but ...
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus (T2DM...
LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis
LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis
Osteoarthritis (OA) is one of the most common degenerative joint diseases in the elderly, increasing in prevalence and pos...
Characterizing a new rat model of chronic pain after spine surgery
Characterizing a new rat model of chronic pain after spine surgery
Chronic pain after spine surgery (CPSS) is a complex disorder characterized by multifactorial pathogenesis that occurs in ...
Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain
Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain
Aging is a pivotal risk factor for intervertebral disc degeneration (IVDD) and chronic low back pain (LBP). The restoratio...
SIRT3-PINK1-PKM2 axis prevents osteoarthritis via mitochondrial renewal and metabolic switch
SIRT3-PINK1-PKM2 axis prevents osteoarthritis via mitochondrial renewal and metabolic switch
Maintaining mitochondrial homeostasis is critical for preserving chondrocyte physiological conditions and increasing resis...
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclast is critical in skeletal development and fracture healing, yet the impact and underlying mechanisms of their met...
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Osteoarthritis (OA) is the most common form of arthritic disease, and phenotypic modification of chondrocytes is an import...
Bone targeted nano-drug and nano-delivery
Bone targeted nano-drug and nano-delivery
There are currently no targeted delivery systems to satisfactorily treat bone-related disorders. Many clinical drugs consi...
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone forma...
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Intervertebral disc degeneration (IDD) is a major cause of discogenic pain, and is attributed to the dysfunction of nucleu...
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Heterotopic ossification (HO) is a pathological process that commonly arises following severe polytrauma, characterized by...
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have abysmal five-year overall surviv...
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Musculoskeletal traumatic injuries (MTI) involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonuni...
Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections
Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections
Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its high recurrence rate and imp...
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled border...
Author Correction: FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
Author Correction: FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis
Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease. Early studies hold an opinion that gut microbiota is environmentally a...
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Extracellular matrix (ECM) stiffening is a typical characteristic of cartilage aging, which is a quintessential feature of...
ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
ATP6AP2, a regulator of LRP6/β-catenin protein trafficking, promotes Wnt/β-catenin signaling and bone formation in a cell type dependent manner
Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types, including osteoblast (OB) ...
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling
Degenerated endplate appears with cheese-like morphology and sensory innervation, contributing to low back pain and subseq...
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor
DNAX-associated protein 12 kD size (DAP12) is a dominant immunoreceptor tyrosine-based activation motif (ITAM)-signa...
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral nerve end...
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent tr...
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge, as ...
A new perspective on intervertebral disc calcification—from bench to bedside
A new perspective on intervertebral disc calcification—from bench to bedside
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to unders...
The role and applications of extracellular vesicles in osteoporosis
The role and applications of extracellular vesicles in osteoporosis
Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture...
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized ...
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