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Genetic counseling referral rates and genetic testing outcomes in women with young breast cancer: a 20-year Canadian review
Genetic counseling referral rates and genetic testing outcomes in women with young breast cancer: a 20-year Canadian review
Despite guidelines recommending genetic testing for all cases of very young breast cancer (VYBC), poor uptake has been rep...
Long-term outcomes of volume de-escalation for breast nodal irradiation
Long-term outcomes of volume de-escalation for breast nodal irradiation
NCCN recommendations suggest irradiating chest wall/breast only + regional node irradiation (RNI) of the undis...
Considerations for hereditary breast and ovarian cancer syndrome molecular diagnosis: experience from the clinical practice
Considerations for hereditary breast and ovarian cancer syndrome molecular diagnosis: experience from the clinical practice
The implementation of the next-generation sequencing (NGS) in clinical practice has improved the genetic diagnosis of Here...
High risk surveillance MRI may not be necessary in BRCA1/2 mutation carriers over 70 years old
High risk surveillance MRI may not be necessary in BRCA1/2 mutation carriers over 70 years old
The risk of developing breast cancer up to age 80 for women with BRCA1/2 mutations is approximately 69–72%. The risk...
The impact of coadministration of venlafaxine, citalopram or gabapentin on the metabolic activation of tamoxifen
The impact of coadministration of venlafaxine, citalopram or gabapentin on the metabolic activation of tamoxifen
Tamoxifen undergoes metabolic activation by cytochrome P450 (CYP) enzymes to metabolites with more potent anti-estrogenic ...
Use of adjuvant capecitabine in older patients with early-stage triple-negative breast cancer
Use of adjuvant capecitabine in older patients with early-stage triple-negative breast cancer
Patients with triple-negative breast cancer (TNBC) who have residual disease after neoadjuvant chemotherapy (NACT) benefit...
The natural history of ductal carcinoma in situ: development, validation, and estimated outcomes of the SimDCIS model
The natural history of ductal carcinoma in situ: development, validation, and estimated outcomes of the SimDCIS model
To develop a novel simulation model for ductal carcinoma in situ (DCIS), fully validate it, and provide new estimates for ...
Second primary non-breast cancers in young breast cancer survivors
Second primary non-breast cancers in young breast cancer survivors
We evaluated the incidence, timing, and risk factors for second primary non-breast cancers (SPNBC) among young breast canc...
Incidence of local breast cancer recurrence with delayed radiation therapy
Incidence of local breast cancer recurrence with delayed radiation therapy
The purpose of this research was to examine the probability of ipsilateral breast cancer recurrence in individuals whose R...
Tamoxifen modulates nutrition deprivation-induced ER stress through AMPK-mediated ER-phagy in breast cancer cells
Tamoxifen modulates nutrition deprivation-induced ER stress through AMPK-mediated ER-phagy in breast cancer cells
Rapid proliferation and nutrition starvation in the tumor microenvironment pose significant challenges to cellular protein...
Ferroptosis as a promising targeted therapy for triple negative breast cancer
Ferroptosis as a promising targeted therapy for triple negative breast cancer
Triple negative breast cancer (TNBC) is a challenging subtype characterized by the absence of estrogen receptor (ER), prog...
Spectrum of germline pathogenic variants in Brazilian hereditary breast/ovarian cancer cases
Spectrum of germline pathogenic variants in Brazilian hereditary breast/ovarian cancer cases
To define the spectrum of germline pathogenic variants (PVs) and copy number variant (CNV) in cancer susceptibility genes ...