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The first embryo, the origin of cancer and animal phylogeny. III. The totipotency as revealed by morphogenesis and the neoplasia controlled by cellular differentiation
The first embryo, the origin of cancer and animal phylogeny. III. The totipotency as revealed by morphogenesis and the neoplasia controlled by cellular differentiation
We have extensively described that the neoplastic process (NP) has deep evolutionary roots and we have made specific predi...
Trehalase inhibition in Helicoverpa armigera activates machinery for alternate energy acquisition
Trehalase inhibition in Helicoverpa armigera activates machinery for alternate energy acquisition
Trehalose serves as a primary circulatory sugar in insects which is crucial in energy metabolism and stress recovery. It i...
An in vitro model of adipose tissue-associated macrophages
An in vitro model of adipose tissue-associated macrophages
Obesity-related chronic low-grade inflammation plays a central role in the development of insulin resistance. Macrophages ...
Understanding pathophysiology of GNE myopathy and current progress towards drug development
Understanding pathophysiology of GNE myopathy and current progress towards drug development
GNE myopathy is a rare genetic neuromuscular disease that is caused due to mutations in the GNE gene responsible for siali...
Orphan drug development: Challenges, regulation, and success stories
Orphan drug development: Challenges, regulation, and success stories
Rare diseases, also known as orphan diseases, are diseases with low occurrence in the population. Developing orphan drugs ...
mRNA biotherapeutics landscape for rare genetic disorders
mRNA biotherapeutics landscape for rare genetic disorders
The medical emergency of COVID-19 brought to the forefront mRNA vaccine technology where the mRNA vaccine candidates mRNA-...
Enhancing access to treatment for Gaucher disease in India: The need for indigenous manufacturing
Enhancing access to treatment for Gaucher disease in India: The need for indigenous manufacturing
Gaucher disease (GD) is a prevalent lysosomal storage disorder (LSD) that significantly impacts individuals’ lives. ...
Spinal muscular atrophy: Molecular mechanism of pathogenesis, diagnosis, therapeutics, and clinical trials in the Indian context
Spinal muscular atrophy: Molecular mechanism of pathogenesis, diagnosis, therapeutics, and clinical trials in the Indian context
Spinal muscular atrophy (SMA) is a neuromuscular, rare genetic disorder caused due to loss-of-function mutations in the su...
Recent developments in gene therapy research in India
Recent developments in gene therapy research in India
Inherited genetic disorders are progressive in nature and lead to organ dysfunction or death in severe cases. At present, ...
Dynein functions in galectin-3 mediated processes of clathrin-independent endocytosis
Dynein functions in galectin-3 mediated processes of clathrin-independent endocytosis
Multiple endocytic processes operate in cells in tandem to uptake multiple cargoes involved in diverse cellular functions,...
Finding identical sequence repeats in multiple protein sequences: An algorithm
Finding identical sequence repeats in multiple protein sequences: An algorithm
In recent years, several experimental evidences suggest that amino acid repeats are closely linked to many disease conditi...
Cobra (Naja naja) venom L-amino acid oxidase (NNLAAO70) induces apoptosis and secondary necrosis in human lung epithelial cancer cells
Cobra (Naja naja) venom L-amino acid oxidase (NNLAAO70) induces apoptosis and secondary necrosis in human lung epithelial cancer cells
Snake venom L-amino acid oxidases (LAAOs) are flavoenzymes with diverse physiological and pharmacological effects. These e...
Crosstalk between photosynthesis and respiration in microbes
Crosstalk between photosynthesis and respiration in microbes
Phototrophic organisms harbor two main bioenergetic hubs, photosynthesis and respiration, and these processes dynamically ...
Role of mitochondria and chloroplasts during stomatal closure: Subcellular location of superoxide and H2O2 production in guard cells of Arabidopsis thaliana
Role of mitochondria and chloroplasts during stomatal closure: Subcellular location of superoxide and H2O2 production in guard cells of Arabidopsis thaliana
Stomatal guard cells are unique in that they have more mitochondria than chloroplasts. Several reports emphasized the impo...
From sequence to consequence: Deciphering the complex cis-regulatory landscape
From sequence to consequence: Deciphering the complex cis-regulatory landscape
Cell type-specific expression of genes plays a pivotal role in the development and evolution of multicellular organisms ov...
Tumor cell type and gene marker identification by single layer perceptron neural network on single-cell RNA sequence data
Tumor cell type and gene marker identification by single layer perceptron neural network on single-cell RNA sequence data
Tumors have drawn increasing attention recently because of their heterogeneous interior structures. Particularly, single-c...
Visual plant anatomy: From science to education and vice versa
Visual plant anatomy: From science to education and vice versa
Plant biology, mainly plant anatomy, is a less attractive area for students at high school and university, but not much re...
A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis
A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis
We investigated the relationship between neutrophil apoptosis and endoplasmic reticulum stress (ERS) in sepsis and its mec...
Predicting and reducing potential parasite infection between migratory livestock and resident Asiatic ibex of Pin valley, India
Predicting and reducing potential parasite infection between migratory livestock and resident Asiatic ibex of Pin valley, India
Disease cross-transmission between wild and domestic ungulates can negatively impact livelihoods and wildlife conservation...
The road to herbaria: Teaching and learning about biology, aesthetics, and the history of botany
The road to herbaria: Teaching and learning about biology, aesthetics, and the history of botany
Having recently published a book on herbaria, collections of preserved plants, I look back on my career teaching biology a...
Host-directed therapy against tuberculosis: Concept and recent developments
Host-directed therapy against tuberculosis: Concept and recent developments
Tuberculosis (TB) continues to remain at the forefront of the infectious disease burden globally, albeit with some aberrat...
Early discoveries on enzyme deficiencies in lysosomal storage diseases: The Indian contribution
Early discoveries on enzyme deficiencies in lysosomal storage diseases: The Indian contribution
The discovery of enzyme deficiencies in lysosomal storage disorders began with two discoveries made in 1963. One of these ...
Roxburgh was right: Aponogeton microphyllus and Aponogeton undulatus are distinct species
Roxburgh was right: Aponogeton microphyllus and Aponogeton undulatus are distinct species
Aponogeton microphyllus, previously placed under the synonymy of A. undulatus, is recognized here as a distinct species ba...
Global genome and transcription-coupled nucleotide excision repair pathway in prokaryotes
Global genome and transcription-coupled nucleotide excision repair pathway in prokaryotes
In all cells—from bacteria to humans—nucleotide excision repair (NER) is a highly conserved, versatile DNA rep...
SARS-CoV-2 testing and its role in understanding the evolving landscape of the pandemic in Bangladesh
SARS-CoV-2 testing and its role in understanding the evolving landscape of the pandemic in Bangladesh
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is readily transmitted from person to person. We evaluated th...
MiR-499 enhances Porphyromonas gingivalis LPS-induced inflammatory response in macrophages by targeting NRIP1 via JAK/STAT pathway
MiR-499 enhances Porphyromonas gingivalis LPS-induced inflammatory response in macrophages by targeting NRIP1 via JAK/STAT pathway
MicroRNA functions as an important part of the activity and development of immune cells. miR-499 has been demonstrated to ...
Characterization of prolycopene-accumulated Tan406 mutant of Solanum lycopersicum
Characterization of prolycopene-accumulated Tan406 mutant of Solanum lycopersicum
Significant progress has been made in understanding carotenoid biosynthesis in tomato (Solanum lycopersicum), and most pat...
Cystinosis: Status of research and treatment in India and the world
Cystinosis: Status of research and treatment in India and the world
Cystinosis is an autosomally inherited rare genetic disorder in which cystine accumulates in the lysosome. The defect aris...
Pathway analysis of host responses to dengue virus serotype 2 infection and inhibition of viral envelope protein by naringenin from Ganoderma lucidum
Pathway analysis of host responses to dengue virus serotype 2 infection and inhibition of viral envelope protein by naringenin from Ganoderma lucidum
Dengue fever cases are spiking over the last two decades. Incessant efforts are still being made to gain deeper insights o...
Characterization of complete mitochondrial genomes of five noctuoid moths (Lepidoptera: Noctuoidea) and their phylogenetic implications
Characterization of complete mitochondrial genomes of five noctuoid moths (Lepidoptera: Noctuoidea) and their phylogenetic implications
In this study, the complete mitochondrial genomes of five noctuoid moth species, namely, Paectes cristatrix, Hemichloridia...
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