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Analysis of the AP2/ERF transcription factor family in and its role in exogenous melatonin-mediated regulation of salt stress
AP2/ERF transcription factors (TFs) are involved in various regulatory pathways related to plant growth, development, and ...
Functional & Integrative Genomics
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Integrated multi-omics analysis and machine learning refine molecular subtypes and prognosis in hepatocellular carcinoma through O-linked glycosylation genes
O-glycosylation significantly influences cellular physiological processes and disease regulation by modulating the structu...
Functional & Integrative Genomics
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Multiplex CRISPR-Cas9 editing of chlorophyll biosynthesis genes in chickpea via protoplast and -mediated transformation
Chickpea is an important legume consumed worldwide and a rich source of protein. Chickpea is less amenable to recent gene ...
Functional & Integrative Genomics
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CircNOX4 promotes proliferation and resistance by regulating the hsa-miR-6884-5p/YWHAG Axis and ERK signaling pathway in cholangiocarcinoma
The biological function of circular RNAs (circRNAs) has been increasingly implicated in tumor drug resistance. However, th...
Functional & Integrative Genomics
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Comparative transcriptome analysis reveals the function of in alkanol synthesis in sugarcane
The wax of sugarcane buds, especially alkanol, was correlated to sugarcane smut resistance in previous studies. Moreover, ...
Functional & Integrative Genomics
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Correction to: Integration of scRNA-seq and bulk tissue RNA-seq data to identify cancer-associated fibroblast-related gene RGMA as a potential treatment target for esophageal cancer
Cite this articleGao, Y., Bao, S., Wen, B. et al. Correction to: Integration of scRNA-seq and bulk tissue RNA-seq data to ...
Functional & Integrative Genomics
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Whole-Genome analysis of MBBL2 genomic characterization and comparative genomics
This study presents the whole-genome sequencing and comprehensive analysis of Bacillus subtilis MBBL2, a strain isolated f...
Functional & Integrative Genomics
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Comparative pan-genome analysis of and and transcriptomics reveals thermal adaptation in
Huperzia and Phlegmariurus are ancient genera within the Lycopodiaceae family with significant medicinal value and ecologi...
Functional & Integrative Genomics
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Prognostic and therapeutic implications related to glycosylation profiles of cancer-associated fibroblasts in colorectal cancer: insights from single-cell and bulk transcriptomics
Glycosylation, a common post-translational modification of proteins, plays a role in numerous biological processes. Howeve...
Functional & Integrative Genomics
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Transcription factor BrEFM negatively regulates flowering time in Chinese cabbage
Flowering represents a critical developmental transition in plants. In Chinese cabbage, precise regulation of flowering ti...
Functional & Integrative Genomics
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A novel splice-site variant induces non-canonical GC-AG splicing and embryonic arrest in humans
Early embryonic arrest (EEA) represents the predominant cause of assisted reproductive technology (ART) failure. PADI6 was...
Functional & Integrative Genomics
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Plastome structure, evolution and diversity of Frankincense-producing genus
The genus Boswellia is famous for its commercially important frankincense production. Additionally, it has unique ecologic...
Functional & Integrative Genomics
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Correction to: Decoding fungal communication networks: molecular signaling, genetic regulation, and ecological implications
Correction to: Functional & Integrative GenomicsIn the original version of the ma...
Functional & Integrative Genomics
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Comparative analysis of key flavonoid synthesis genes in the transcriptome of and therapeutic target prediction for ulcerative colitis
Cayratia japonica is a traditional Chinese herbal plant rich in flavonoid compounds, with anti-inflammatory and anti-cance...
Functional & Integrative Genomics
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Comparative plastome analysis reveals evolutionary dynamics and codon usage patterns in (Asteraceae)
Plastome evolution in species-rich angiosperm lineages remains poorly understood despite recent advances in phylogenomics,...
Functional & Integrative Genomics
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Cytosine base editor-mediated high-efficiency myostatin editing in Hu sheep
The cytosine base editor (CBE) enables precise C-to-T substitution without inducing DNA double-strand breaks, which offeri...
Functional & Integrative Genomics
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Genomic insights into the antagonistic activity of PB24 against : implications for biocontrol and plant growth promotion strategies
Biotechnology and sustainable strategies are the way forward for increasing global food production. The use of plant growt...
Functional & Integrative Genomics
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MZB1-Driven Endoplasmic reticulum stress model as a predictor of breast cancer progression and survival
Endoplasmic reticulum (ER) stress and its associated unfolded protein response (UPR) have been demonstrated to play a cruc...
Functional & Integrative Genomics
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Validation of caprine H11 and the Rosa26 platform for transgene integration via CRISPR-based system: investigations on stable transgene expression and genetic biosafety
CRISPR/Cas9 technology is an efficient tool for site-specific livestock gene editing. However, to minimize potential disru...
Functional & Integrative Genomics
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MBTPS1: a membrane-bound transcription factor protease implicated in the pathogenesis of several skin and skeletal disorders
The MBTPS1 gene, which is located on chromosome 16q24, encodes the membrane-bound transcription factor protease site-1 (MB...
Functional & Integrative Genomics
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Gene clusters-based pathway enrichment analysis identifies four pan-cancer subtypes with distinct molecular and clinical features
Pathways-based clustering methods have been proposed to explore tumor heterogeneity. However, such methods are currently d...
Functional & Integrative Genomics
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Serine related gene CCT6A promotes metastasis of hepatocellular carcinoma via interacting with RPS3
Metastasis is responsible for approximately 90% of lethality from solid tumors. Metabolic abnormalities are one of the key...
Functional & Integrative Genomics
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Xuanhong Dingchuan Tang suppresses bronchial asthma inflammation via the microRNA-107-3p/PTGS2/MAPK axis
This study aimed to investigate the mechanism of Xuanhong Dingchuan Tang (XHDCT) in delaying bronchial asthma inflammation...
Functional & Integrative Genomics
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Barley stripe mosaic virus-induced gene silencing for functional validation of abiotic stress in barley
The barley stripe mosaic virus (BSMV) uses its genomic RNA components (alpha, beta, and gamma) as an efficient method for ...
Functional & Integrative Genomics
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Unraveling the organellar genomic landscape of the therapeutic and entheogenic plant Mimosa tenuiflora: insights into genetic, structural, and evolutionary dynamics
Mimosa tenuiflora, popularly known as “Jurema-Preta”, is a perennial tree or shrub native to the tropical regi...
Functional & Integrative Genomics
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Circular RNAs in the pathogenesis of SARS-CoV-2: potential diagnostic biomarkers and therapeutic targets
Since December 2019, the global dissemination of a novel coronavirus has precipitated a notable public health crisis, prom...
Functional & Integrative Genomics
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Towards assembling functional cyanobacterial β-carboxysomes in Oryza sativa chloroplasts
The major limiting factor of photosynthesis in C3 plants is the enzyme, rubisco which inadequately distinguishes between c...
Functional & Integrative Genomics
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A cutting-edge investigation of the multifaceted role of SOX family genes in cancer pathogenesis through the modulation of various signaling pathways
This detailed study examines the complex role of the SOX family in various tumorigenic contexts, offering insights into ho...
Functional & Integrative Genomics
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Epigenetic modification mediated by PHF20/METTL14/HOXA13 signaling axis modulates osteogenic differentiation of mesenchymal stem cells
This study investigates the mechanism of PHF20 in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs)...
Functional & Integrative Genomics
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Application of a high-throughput swarm-based deep neural network Algorithm reveals SPAG5 downregulation as a potential therapeutic target in adult AML
Gene‒gene interactions play pivotal roles in disease pathogenesis and are fundamental in the development of targeted...
Functional & Integrative Genomics
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