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Genetic diversity and evolution of G12P[6] DS-1-like and G12P[9] AU-1-like Rotavirus strains in Brazil
Genetic diversity and evolution of G12P[6] DS-1-like and G12P[9] AU-1-like Rotavirus strains in Brazil
In the early 2000s, the global emergence of rotavirus (RVA) G12P[8] genotype was noted, while G12P[6] and G12P[9] combinat...
Circular RNAs: a small piece in the heart failure puzzle
Circular RNAs: a small piece in the heart failure puzzle
Cardiovascular disease, specifically heart failure (HF), remains a significant concern in the realm of healthcare, necessi...
Identification of flowering genes in Camellia perpetua by comparative transcriptome analysis
Identification of flowering genes in Camellia perpetua by comparative transcriptome analysis
Camellia perpetua has the excellent characteristic of flowering multiple times throughout the year, which is of great impo...
Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression
Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression
This study was designed to investigate the role of a disintegrin and metalloproteinase domain-like protein decysin 1 (ADAM...
Hypoxia-induced circRTN4IP1 promotes progression and glycolysis of hepatocellular carcinoma cells
Hypoxia-induced circRTN4IP1 promotes progression and glycolysis of hepatocellular carcinoma cells
Hypoxia is one of the hallmarks of solid tumors, especially in hepatocellular carcinoma (HCC). CircRNAs are reported to be...
IGF2 is upregulated by its antisense RNA to potentiate pancreatic cancer progression
IGF2 is upregulated by its antisense RNA to potentiate pancreatic cancer progression
Pancreatic cancer is a deadly cancer. More and more long noncoding RNAs (lncRNAs) have received confirmation to be dysregu...
Benchmarking of bioinformatics tools for NGS-based microRNA profiling with RT-qPCR method
Benchmarking of bioinformatics tools for NGS-based microRNA profiling with RT-qPCR method
MicroRNAs are vital gene expression regulators, extensively studied worldwide. The large-scale characterization of miRNAom...
CFAP61 knockdown aggravates male infertility by inhibiting testosterone secretion by Leydig cells via the MAPK/COX-2 pathway
CFAP61 knockdown aggravates male infertility by inhibiting testosterone secretion by Leydig cells via the MAPK/COX-2 pathway
This study aimed to elucidate the roles of cilia- and flagella-associated protein 61 (CFAP61) in male infertility and its ...
3′-tRF-CysGCA overexpression in HEK-293 cells alters the global expression profile and modulates cellular processes and pathways
3′-tRF-CysGCA overexpression in HEK-293 cells alters the global expression profile and modulates cellular processes and pathways
tRNA fragments (tRFs) are small non-coding RNAs generated through specific cleavage of tRNAs and involved in various biolo...
NLRP3/miR-223-3p axis attenuates neuroinflammation induced by chronic intermittent hypoxia
NLRP3/miR-223-3p axis attenuates neuroinflammation induced by chronic intermittent hypoxia
Obstructive sleep apnea (OSA) is mainly characterized by chronic intermittent hypoxia (CIH) with multiple brain injuries. ...
The cellular trajectories of tumor-associated macrophages decipher the heterogeneity of pancreatic cancer
The cellular trajectories of tumor-associated macrophages decipher the heterogeneity of pancreatic cancer
Emerging evidence indicates that the interactions and dynamic changes among tumor-associated macrophages (TAMs) are pivota...
Comparative transcriptome analysis reveals candidate genes related to the sex differentiation of Schisandra chinensis
Comparative transcriptome analysis reveals candidate genes related to the sex differentiation of Schisandra chinensis
Schisandra chinensis is a monoecious plant with unisex flowers. The fruit of S. chinensis is of high medical with economic...
Combining single-cell RNA sequencing data and transcriptomic data to unravel potential mechanisms and signature genes of the progression of idiopathic pulmonary fibrosis to lung adenocarcinoma and predict therapeutic agents
Combining single-cell RNA sequencing data and transcriptomic data to unravel potential mechanisms and signature genes of the progression of idiopathic pulmonary fibrosis to lung adenocarcinoma and predict therapeutic agents
Patients with idiopathic pulmonary fibrosis (IPF) have a significantly higher prevalence of lung adenocarcinoma (LUAD) tha...
Nrf2 attenuates oxidative stress to mediate the protective effect of ciprofol against cerebral ischemia–reperfusion injury
Nrf2 attenuates oxidative stress to mediate the protective effect of ciprofol against cerebral ischemia–reperfusion injury
Neuroinflammation and oxidative stress damage are involved in the pathogenesis of cerebral ischemia–reperfusion inju...
Validating post-enrichment steps in environmental RNA analysis for improving its availability from water samples
Validating post-enrichment steps in environmental RNA analysis for improving its availability from water samples
Environmental RNA (eRNA) analysis is expected to inclusively provide the physiological information of a population and com...
Meta-analysis of transcriptomics studies identifies novel attributes and set of genes involved in iron homeostasis in rice
Meta-analysis of transcriptomics studies identifies novel attributes and set of genes involved in iron homeostasis in rice
Iron (Fe) is an important micronutrient for humans as well as for plant growth and development. Rice employs multiple mech...
Long noncoding RNA LINC00482 silencing sensitizes non-small cell lung cancer cells to cisplatin by downregulating CLASRP via E2F1
Long noncoding RNA LINC00482 silencing sensitizes non-small cell lung cancer cells to cisplatin by downregulating CLASRP via E2F1
Long noncoding RNA LINC00482 (LINC00482) is dysregulated in non-small cell lung cancer cells (NSCLC). Herein, this researc...
Novel insights into molecular signatures and pathogenic cell populations shared by systemic lupus erythematosus and vascular dementia
Novel insights into molecular signatures and pathogenic cell populations shared by systemic lupus erythematosus and vascular dementia
Although vascular dementia (VD) and systemic lupus erythematosus (SLE) may share immune-mediated pathophysiologic processe...
Mitochondria-related lncRNAs: predicting prognosis, tumor microenvironment and treatment response in lung adenocarcinoma
Mitochondria-related lncRNAs: predicting prognosis, tumor microenvironment and treatment response in lung adenocarcinoma
Lung cancer is the most common type of malignant tumor that affects people in China and even across the globe, as it exhib...
DAB2IP stabilizes p27Kip1 via suppressing PI3K/AKT signaling in clear cell renal cell carcinoma
DAB2IP stabilizes p27Kip1 via suppressing PI3K/AKT signaling in clear cell renal cell carcinoma
Renal cell carcinoma (RCC) is the most lethal of the urologic malignancies. We previously discovered that DAB2IP, a novel ...
Architecture and topologies of gene regulatory networks associated with breast cancer, adjacent normal, and normal tissues
Architecture and topologies of gene regulatory networks associated with breast cancer, adjacent normal, and normal tissues
Most cancer studies employ adjacent normal tissues to tumors (ANTs) as controls, which are not completely normal and repre...
Depletion of PIEZO1 expression is accompanied by upregulating p53 signaling in mice with perioperative neurocognitive disorder
Depletion of PIEZO1 expression is accompanied by upregulating p53 signaling in mice with perioperative neurocognitive disorder
As the common complications observed in surgical elder patients, perioperative neurocognitive disorders (PND) cause a seri...
IL-1R8 expression in DLBCL regulates NK cell recruitment and influences patient prognosis
IL-1R8 expression in DLBCL regulates NK cell recruitment and influences patient prognosis
The precise biological function of Interleukin-1 receptor 8 (IL-1R8) in diffuse large B-cell lymphoma (DLBCL) is still not...
Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1
Long non-coding RNA MIR22HG suppresses the chondrogenic differentiation of human adipose-derived stem cells by interacting with CTCF to upregulate CRLF1
Improved chondrogenic differentiation of mesenchymal stem cells (MSCs) by genetic regulation is a potential method for reg...
Genome-wide association study for boll weight in Gossypium hirsutum races
Genome-wide association study for boll weight in Gossypium hirsutum races
High yield has always been an essential target in almost all of the cotton breeding programs. Boll weight (BW) is a key co...
De novo genome assembly and annotation of the medicinal plant Tinospora cordifolia (Willd.) Miers ex Hook. f. & Thom’s
De novo genome assembly and annotation of the medicinal plant Tinospora cordifolia (Willd.) Miers ex Hook. f. & Thom’s
Indian natural climbing shrub Tinospora cordifolia, often known as “Guduchi” and “Amrita,” is a hi...
CDK6 is a novel predictive and prognosis biomarker correlated with immune infiltrates in multiple human neoplasms, including small cell lung carcinoma
CDK6 is a novel predictive and prognosis biomarker correlated with immune infiltrates in multiple human neoplasms, including small cell lung carcinoma
The roles of cyclin-dependent kinase 6 (CDK6) in various cancers, including small cell lung carcinoma (SCLC), remain uncle...
A new efficient referential genome compression technique for FastQ files
A new efficient referential genome compression technique for FastQ files
Hospitals and medical laboratories create a tremendous amount of genome sequence data every day for use in research, surge...
Xihuang pill facilitates glioma cell pyroptosis via the POU4F1/STAT3 axis
Xihuang pill facilitates glioma cell pyroptosis via the POU4F1/STAT3 axis
Glioma is the most common malignancy in the central nervous system. This study aims to disclose the impacts of Xihuang pil...
DNA hypomethylation by fisetin preserves mitochondria functional genes and contributes to the protection of I/R rat heart
DNA hypomethylation by fisetin preserves mitochondria functional genes and contributes to the protection of I/R rat heart
Myocardial I/R can alter the expression of different sets of cardiac genes that negatively influence the I/R outcome via e...
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