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Oral esketamine in patients with treatment-resistant depression: a double-blind, randomized, placebo-controlled trial with open-label extension
Oral esketamine in patients with treatment-resistant depression: a double-blind, randomized, placebo-controlled trial with open-label extension
About one-third of patients with depression do not achieve adequate response to current treatment options. Although intrav...
Resting state functional connectivity modifications in monoaminergic circuits underpin fatigue development in patients with multiple sclerosis
Resting state functional connectivity modifications in monoaminergic circuits underpin fatigue development in patients with multiple sclerosis
Dysregulation of monoaminergic networks might have a role in the pathogenesis of fatigue in multiple sclerosis (MS). We in...
Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT
Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT
Cognitive dysfunctions are core-enduring symptoms of schizophrenia, with important sex-related differences. Genetic varian...
Immunophenotypes in psychosis: is it a premature inflamm-aging disorder?
Immunophenotypes in psychosis: is it a premature inflamm-aging disorder?
Immunopsychiatric field has rapidly accumulated evidence demonstrating the involvement of both innate and adaptive immune ...
Chronometric TMS-fMRI of personalized left dorsolateral prefrontal target reveals state-dependency of subgenual anterior cingulate cortex effects
Chronometric TMS-fMRI of personalized left dorsolateral prefrontal target reveals state-dependency of subgenual anterior cingulate cortex effects
Transcranial magnetic stimulation (TMS) applied to a left dorsolateral prefrontal cortex (DLPFC) area with a specific conn...
Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression
Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression
Depression’s link to serotonin dysregulation is well-known. The monoamine theory posits that depression results from...
Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor
Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor
Recent studies have consistently demonstrated that the regulation of chromatin and gene transcription plays a pivotal role...
Active forgetting and neuropsychiatric diseases
Active forgetting and neuropsychiatric diseases
Recent and pioneering animal research has revealed the brain utilizes a variety of molecular, cellular, and network-level ...
Correction: Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
Feinstein Institutes for Medical Research, Institute of Behavioral Science, Manhasset, NY, USAMiklos Argyelan, Brian Angul...
Oxytocin activity in the paraventricular and supramammillary nuclei of the hypothalamus is essential for social recognition memory in rats
Oxytocin activity in the paraventricular and supramammillary nuclei of the hypothalamus is essential for social recognition memory in rats
Oxytocin plays an important role in modulating social recognition memory. However, the direct implication of oxytocin neur...
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methyl...
“Puberty age gap”: new method of assessing pubertal timing and its association with mental health problems
“Puberty age gap”: new method of assessing pubertal timing and its association with mental health problems
Puberty is linked to mental health problems during adolescence, and in particular, the timing of puberty is thought to be ...
Choroid plexus and perivascular space enlargement in neuropsychiatric systemic lupus erythematosus
Choroid plexus and perivascular space enlargement in neuropsychiatric systemic lupus erythematosus
Choroid plexus (CP) enlargement is proposed as a marker of neuroinflammation in immune-mediated conditions. CP involvement...
The neural signature of psychomotor disturbance in depression
The neural signature of psychomotor disturbance in depression
Up to 70% of patients with major depressive disorder present with psychomotor disturbance (PmD), but at the present time u...
Germline PTEN genotype-dependent phenotypic divergence during the early neural developmental process of forebrain organoids
Germline PTEN genotype-dependent phenotypic divergence during the early neural developmental process of forebrain organoids
PTEN germline mutations account for ~0.2–1% of all autism spectrum disorder (ASD) cases, as well as ~17% of ASD pati...
Molecular consequences of PQBP1 deficiency, involved in the X-linked Renpenning syndrome
Molecular consequences of PQBP1 deficiency, involved in the X-linked Renpenning syndrome
Mutations in the PQBP1 gene (polyglutamine-binding protein-1) are responsible for a syndromic X-linked form of neurodevelo...
The role of polyunsaturated fatty acids in the neurobiology of major depressive disorder and suicide risk
The role of polyunsaturated fatty acids in the neurobiology of major depressive disorder and suicide risk
Long-chain polyunsaturated fatty acids (LC-PUFAs) are obtained from diet or derived from essential shorter-chain fatty aci...
Microglia shape AgRP neuron postnatal development via regulating perineuronal net plasticity
Microglia shape AgRP neuron postnatal development via regulating perineuronal net plasticity
The hypothalamus plays a crucial role in controlling metabolism and energy balance, with Agouti-related protein (AgRP) neu...
Clarity on the blazing trail: clearing the way for amyloid-removing therapies for Alzheimer’s disease
Clarity on the blazing trail: clearing the way for amyloid-removing therapies for Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with a complex pathogenesis. Senile plaques com...
Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory
Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory
Two forms of plasticity, synaptic and intrinsic, are neural substrates for learning and memory. Abnormalities in homeostat...
Correction: Targeting NLRP3 inflammasome for neurodegenerative disorders
Correction to: Molecular Psychiatry, published online 5 September 2023In this article, an incorrect table...
Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnet...
Impaired neural stress resistance and loss of REST in bipolar disorder
Impaired neural stress resistance and loss of REST in bipolar disorder
Neurodevelopmental changes and impaired stress resistance have been implicated in the pathogenesis of bipolar disorder (BD...
Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear
Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear
Social interactions are critical for mammalian survival and evolution. Dysregulation of social behavior often leads to psy...
Integrative transcriptome- and DNA methylation analysis of brain tissue from the temporal pole in suicide decedents and their controls
Integrative transcriptome- and DNA methylation analysis of brain tissue from the temporal pole in suicide decedents and their controls
Suicide rates have increased steadily world-wide over the past two decades, constituting a serious public health crisis th...
Synergistic psychedelic - NMDAR modulator treatment for neuropsychiatric disorders
Synergistic psychedelic - NMDAR modulator treatment for neuropsychiatric disorders
Modern research data suggest a therapeutic role for serotonergic psychedelics in depression and other neuropsychiatric dis...
The effects of methylphenidate and atomoxetine on Drosophila brain at single-cell resolution and potential drug repurposing for ADHD treatment
The effects of methylphenidate and atomoxetine on Drosophila brain at single-cell resolution and potential drug repurposing for ADHD treatment
The stimulant methylphenidate (MPH) and the non-stimulant atomoxetine (ATX) are frequently used for the treatment of atten...
An umbrella review of candidate predictors of response, remission, recovery, and relapse across mental disorders
An umbrella review of candidate predictors of response, remission, recovery, and relapse across mental disorders
We aimed to identify diagnosis-specific/transdiagnostic/transoutcome multivariable candidate predictors (MCPs) of key outc...
Clinical characteristics indexing genetic differences in bipolar disorder – a systematic review
Clinical characteristics indexing genetic differences in bipolar disorder – a systematic review
Bipolar disorder is a heterogenous condition with a varied clinical presentation. While progress has been made in identify...
Modelling the overlap and divergence of autistic and schizotypal traits on hippocampal subfield volumes and regional cerebral blood flow
Modelling the overlap and divergence of autistic and schizotypal traits on hippocampal subfield volumes and regional cerebral blood flow
Psychiatric disorders show high co-morbidity, including co-morbid expressions of subclinical psychopathology across multip...
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