SCI时时刷

search
+
Chemical LTP induces confinement of BDNF mRNA under dendritic spines and BDNF protein accumulation inside the spines
Chemical LTP induces confinement of BDNF mRNA under dendritic spines and BDNF protein accumulation inside the spines
The neurotrophin brain-derived neurotrophic factor (BDNF) plays a key role in neuronal development and synaptic plasticity...
Machine learning-based evaluation of spontaneous pain and analgesics from cellular calcium signals in the mouse primary somatosensory cortex using explainable features
Machine learning-based evaluation of spontaneous pain and analgesics from cellular calcium signals in the mouse primary somatosensory cortex using explainable features
IntroductionPain that arises spontaneously is considered more clinically relevant than pain evoked by external stimuli. Ho...
Acetylome analyses provide novel insights into the effects of chronic intermittent hypoxia on hippocampus-dependent cognitive impairment
Acetylome analyses provide novel insights into the effects of chronic intermittent hypoxia on hippocampus-dependent cognitive impairment
IntroductionChronic intermittent hypoxia (CIH) can negatively affect hippocampal function through various molecular mechan...
Interactions between Ras and Rap signaling pathways during neurodevelopment in health and disease
Interactions between Ras and Rap signaling pathways during neurodevelopment in health and disease
The Ras family of small GTPases coordinates tissue development by modulating cell proliferation, cell-cell adhesion, and c...
LRRC25 expression during physiological aging and in mouse models of Alzheimer’s disease and iPSC-derived neurons
LRRC25 expression during physiological aging and in mouse models of Alzheimer’s disease and iPSC-derived neurons
The leucine-rich repeat-containing protein 25 (LRRC25) is relatively a novel protein with no information on its role in ne...
Non-severe thermal burn injuries induce long-lasting downregulation of gene expression in cortical excitatory neurons and microglia
Non-severe thermal burn injuries induce long-lasting downregulation of gene expression in cortical excitatory neurons and microglia
Burn injuries are devastating traumas, often leading to life-long consequences that extend beyond the observable burn scar...
Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics
Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics
The individual and global burden of migraine is of such significance that there are accelerated efforts to develop new the...
Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex
Light-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex
Adaptation of photoreceptor sensitivity to varying light intensities is a fundamental requirement for retinal function and...
Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse
Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse
IntroductionRecently developed fluorescent neurotransmitter indicators have enabled direct measurements of neurotransmitte...
A critical evaluation of “leakage” at the cochlear blood-stria-barrier and its functional significance
A critical evaluation of “leakage” at the cochlear blood-stria-barrier and its functional significance
The blood-labyrinth-barrier (BLB) is a semipermeable boundary between the vasculature and three separate fluid spaces of t...
Genetic loss of the dopamine transporter significantly impacts behavioral and molecular responses to sub-chronic stress in mice
Genetic loss of the dopamine transporter significantly impacts behavioral and molecular responses to sub-chronic stress in mice
Dopaminergic neurotransmission has emerged as a critical determinant of stress susceptibility and resilience. Although the...
Brain, behavior, and physiological changes associated with predator stress–An animal model for trauma exposure in adult and neonatal rats
Brain, behavior, and physiological changes associated with predator stress–An animal model for trauma exposure in adult and neonatal rats
The use of predators and predator odor as stressors is an important and ecologically relevant model for studying the impac...
Corrigendum: ATP6V0C is associated with febrile seizures and epilepsy with febrile seizures plus
Corrigendum: ATP6V0C is associated with febrile seizures and epilepsy with febrile seizures plus
Corrigendum: ATP6V0C Is Associated With Febrile Seizures and Epilepsy With Febrile Seizures PlusName of all authors as the...
Human mutations in SLITRK3 implicated in GABAergic synapse development in mice
Human mutations in SLITRK3 implicated in GABAergic synapse development in mice
This study reports on biallelic homozygous and monoallelic de novo variants in SLITRK3 in three unrelated families present...
New implications for prion diseases therapy and prophylaxis
New implications for prion diseases therapy and prophylaxis
Prion diseases are rare, fatal, progressive neurodegenerative disorders that affect both animal and human. Human prion dis...
Invertebrate genetic models of amyotrophic lateral sclerosis
Invertebrate genetic models of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by the progressive dea...
Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling
Neuromodulator regulation and emotions: insights from the crosstalk of cell signaling
The unraveling of the regulatory mechanisms that govern neuronal excitability is a major challenge for neuroscientists wor...
Correlation of telomere length in brain tissue with peripheral tissues in living human subjects
Correlation of telomere length in brain tissue with peripheral tissues in living human subjects
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant...
Non-canonical retinoid signaling in neural development, regeneration and synaptic function
Non-canonical retinoid signaling in neural development, regeneration and synaptic function
Canonical retinoid signaling via nuclear receptors and gene regulation is critical for the initiation of developmental pro...
Post-translational modifications of beta-amyloid alter its transport in the blood-brain barrier in vitro model
Post-translational modifications of beta-amyloid alter its transport in the blood-brain barrier in vitro model
One of the hallmarks of Alzheimer's disease (AD) is the accumulation of beta-amyloid peptide (Aβ) leading to formation...
Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures
Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures
Combined antiretroviral therapy (cART) has greatly decreased mortality and morbidity among persons with HIV; however, neur...
DNMT1 downregulation as well as its overexpression distinctly affect mostly overlapping genes implicated in schizophrenia, autism spectrum, epilepsy, and bipolar disorders
DNMT1 downregulation as well as its overexpression distinctly affect mostly overlapping genes implicated in schizophrenia, autism spectrum, epilepsy, and bipolar disorders
Data on schizophrenia (SZ), epilepsy (EPD) and bipolar disorders (BPD) suggested an association of DNMT1 overexpression wh...
Corrigendum: Role of α2δ-3 in regulating calcium channel localization at presynaptic active zones during homeostatic plasticity
Corrigendum: Role of α2δ-3 in regulating calcium channel localization at presynaptic active zones during homeostatic plasticity
• please read through all the templates before choosing • pick the most relevant text template(s) from the following page ...
Exosomal microRNAs: implications in the pathogenesis and clinical applications of subarachnoid hemorrhage
Exosomal microRNAs: implications in the pathogenesis and clinical applications of subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is a severe acute neurological disorder with a high fatality rate. Early brain injury (EBI) ...
Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis
Neuronal deletion of phosphatase and tensin homolog in mice results in spatial dysregulation of adult hippocampal neurogenesis
Adult neurogenesis is a persistent phenomenon in mammals that occurs in select brain structures in both healthy and diseas...
Editorial: Molecular signalling and pathways contributing to neurodevelopmental disorders: insights into potential therapeutic avenues
Editorial: Molecular signalling and pathways contributing to neurodevelopmental disorders: insights into potential therapeutic avenues
Over the last decade, there has been growing interest and important developments in the understanding of mechanisms involv...
Synaptic circuits involving gastrin-releasing peptide receptor-expressing neurons in the dorsal horn of the mouse spinal cord
Synaptic circuits involving gastrin-releasing peptide receptor-expressing neurons in the dorsal horn of the mouse spinal cord
The superficial dorsal horn (SDH) of the spinal cord contains a diverse array of neurons. The vast majority of these are i...
Spinal GABA transporter 1 contributes to evoked-pain related behavior but not resting pain after incision injury
Spinal GABA transporter 1 contributes to evoked-pain related behavior but not resting pain after incision injury
The inhibitory function of GABA at the spinal level and its central modulation in the brain are essential for pain percept...
Editorial: RNA binding proteins in neuroscience
Editorial: RNA binding proteins in neuroscience
Unraveling the complexities of brain function relies on the precise coordination of gene expression in different neural su...
It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease
It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease
The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in ...
阅读更多
format_indent_increase