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Prediction of naloxone dose in opioids toxicity based on machine learning techniques (artificial intelligence)
Prediction of naloxone dose in opioids toxicity based on machine learning techniques (artificial intelligence)
Treatment management for opioid poisoning is critical and, at the same time, requires specialized knowledge and skills. Th...
Ameliorative effect of Melatonin on 5-Fluorouracil-induced reproductive toxicity in male rats
Ameliorative effect of Melatonin on 5-Fluorouracil-induced reproductive toxicity in male rats
5-Fluorouracil (5-FU) is an antimetabolite chemotherapeutic agent that can cause oxidative stress and complications in nor...
Structure based exploration of mitochondrial alpha carbonic anhydrase inhibitors as potential leads for anti-obesity drug development
Structure based exploration of mitochondrial alpha carbonic anhydrase inhibitors as potential leads for anti-obesity drug development
Obesity has emerged as a major health challenge globally in the last two decades. Dysregulated fatty acid metabolism and d...
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
Rhinovirus (RV) infection is a major cause of common colds and asthma exacerbations, with no antiviral drug available. Cur...
Cellular and molecular aspects of drug resistance in cancers
Cellular and molecular aspects of drug resistance in cancers
Cancer drug resistance is a multifaceted phenomenon. The present review article aims to comprehensively analyze the cellul...
Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery
Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery
Amphotericin B (AMB) is a drug used to treat vulvovaginal candidiasis (VVC), which is a fungal infection affecting the vag...
Trends analysis and future study of the pharmaceutical industry field: a scoping review
Trends analysis and future study of the pharmaceutical industry field: a scoping review
The main aim of this study was to explore and understand the emerging developments, changes, and patterns shaping the futu...
Electroceuticals: Unlocking the promise of therapies
Electroceuticals: Unlocking the promise of therapies
Electroceuticals refers to the constantly growing disciplines of bioelectric and bioelectronic medication. These include a...
High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test
High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test
High-performance liquid chromatography (HPLC) has emerged as a highly sensitive and versatile analytical technique for qua...
Oral regimen for high dose methotrexate urine alkalinization: a systematic review and meta-analysis
Oral regimen for high dose methotrexate urine alkalinization: a systematic review and meta-analysis
Urine alkalinization prevents nephrotoxicity in patients receiving high-dose methotrexate (HDMTX). While the standard appr...
Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/Prdx3 pathway
Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/Prdx3 pathway
Myocardial ischemia/reperfusion injury (MIRI) seriously threatens the health of people. The mitochondrial dysfunction in c...
Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report
Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report
A persistent difficult-to-treat cough can be exhausting. Iron is an essential element that plays an important role in regu...
Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies
Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies
The efficient delivery of drugs from dry powder inhaler (DPI) formulations is associated with the complex interaction betw...
Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin
Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin
It has been reported that High-Fructose (HF) consumption, considered one of the etiological factors of Metabolic Syndrome ...
Public interest in drug-related problems reflected in information search trends: an infodemiological study
Public interest in drug-related problems reflected in information search trends: an infodemiological study
The analysis of how people search and “navigate” the internet to obtain health-related information and how the...
Repurposing metformin as a potential anticancer agent using in silico technique
Repurposing metformin as a potential anticancer agent using in silico technique
The focus on repurposing readily available, well-known drugs for new, creative uses has grown recently. One such medicatio...
Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy
Structure-activity relationship of pharmacophores and toxicophores: the need for clinical strategy
Sometimes clinical efficacy and potential risk of therapeutic and toxic agents are difficult to predict over a long period...
Evaluating the effect of sodium alginate and sodium carboxymethylcellulose on pulmonary delivery of levofloxacin spray-dried microparticles
Evaluating the effect of sodium alginate and sodium carboxymethylcellulose on pulmonary delivery of levofloxacin spray-dried microparticles
Patients with cystic fibrosis commonly suffer from lung infections caused by Pseudomonas aeruginosa. Recently, the Levoflo...
Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma
Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma
Melanoma poses a significant threat to human health, making the development of a safe and effective treatment a crucial ch...
Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish
Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish
Several countries’ most incorrectly discarded medicines are acetaminophen (ACM), metamizole (MTZ), and nimesulide (N...
Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication
Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication
COVID-19 pandemic has turned our world upside down by meddling with our normal lives. While there is no definitive drug ag...
Hybrid derivatives containing dimethyl fumarate and benzothiazole scaffolds for the potential treatment of multiple sclerosis; in silico & in vivo study
Hybrid derivatives containing dimethyl fumarate and benzothiazole scaffolds for the potential treatment of multiple sclerosis; in silico & in vivo study
Multiple Sclerosis (MS) is a chronic autoimmune, inflammatory neurological disease of the CNS. Riluzole and dimethyl fumar...
Dispersive micro-solid phase extraction based on two MOFs as highly effective adsorbents for analysis of nilotinib in plasma and wastewater
Dispersive micro-solid phase extraction based on two MOFs as highly effective adsorbents for analysis of nilotinib in plasma and wastewater
Nilotinib (NIL) is a prescription medication employed in the treatment of specific types of leukemia, namely chronic myelo...
Population Pharmacokinetics of Loxoprofen and its alcoholic metabolites in healthy Korean men
Population Pharmacokinetics of Loxoprofen and its alcoholic metabolites in healthy Korean men
Loxoprofen has been actively used clinically to relieve musculoskeletal pain and inflammatory symptoms. However, there are...
A review of the ethnomedicinal, phytochemical, and pharmacological properties of the Ferulago genus based on Structure–Activity Relationship (SAR) of coumarins
A review of the ethnomedicinal, phytochemical, and pharmacological properties of the Ferulago genus based on Structure–Activity Relationship (SAR) of coumarins
The Ferluago W.D.J. Koch genus includes 48 accepted perennial herbs that are distributed in the Mediterranean region, Sout...
Effectiveness of epigallocatechin gallate nanoparticles on the in-vivo treatment of Alzheimer’s disease in a rat/mouse model: a systematic review
Effectiveness of epigallocatechin gallate nanoparticles on the in-vivo treatment of Alzheimer’s disease in a rat/mouse model: a systematic review
Alzheimer’s disease (AD) is a neurological disease that causes memory loss over time. Current therapies are limited ...
Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation
Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation
In this study, a combination of nanotechnology, organic synthesis and radiochemistry were utilized in order to design an e...
Fruit vinegar as a promising source of natural anti-inflammatory agents: an up-to-date review
Fruit vinegar as a promising source of natural anti-inflammatory agents: an up-to-date review
Fruit vinegar is one of the most famous fruit byproducts worldwide with several unique properties. There are two types of ...
Electrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode
Electrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode
Nivolumab is used in a treatment called immunotherapy, which helps the immune system cells to attack cancer cells. The ele...
Ropivacaine suppresses the progression of renal cell carcinoma through regulating the lncRNA RMRP/EZH2/CCDC65 axis
Ropivacaine suppresses the progression of renal cell carcinoma through regulating the lncRNA RMRP/EZH2/CCDC65 axis
Renal cell carcinoma (RCC) is a common malignancy. Local anesthetics were displayed powerful effects against various cance...
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