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and assessment of curcumin loaded bile salt stabilized nanovesicles for oral delivery
and assessment of curcumin loaded bile salt stabilized nanovesicles for oral delivery
Bile salts enriched nanovesicles (bilosomes) have been attention worthy in the past few years due to their distinctive eff...
The effect of biosynthesized zinc oxide nanoparticles on gene expression and apoptosis in triple-negative breast cancer cells
The effect of biosynthesized zinc oxide nanoparticles on gene expression and apoptosis in triple-negative breast cancer cells
Some forms of breast cancer such as triple-negative phenotype, are serious challenge because of high metastatic cases, hig...
Evaluation of the consumption pattern and efficacy of Linezolid in COVID-19 hospitalized patients in a hospital in Tehran-Iran
Evaluation of the consumption pattern and efficacy of Linezolid in COVID-19 hospitalized patients in a hospital in Tehran-Iran
The inappropriate use of antibiotics increases the costs of treatment, antibiotic resistance, increased disease length and...
Vancomycin- induced leukocytoclastic vasculitis in a patient with end-stage renal disease: a case report and literature review
Vancomycin- induced leukocytoclastic vasculitis in a patient with end-stage renal disease: a case report and literature review
Leukocytoclastic vasculitis (LCV) is a small-vessel inflammatory condition that can rarely occur as an adverse drug reacti...
Efficacy and safety of different dosages of rituximab for myasthenia gravis: a single-arm meta-analysis
Efficacy and safety of different dosages of rituximab for myasthenia gravis: a single-arm meta-analysis
Rituximab (RTX) is one of the treatment options for refractory myasthenia gravis (MG), yet the optimal dosing schedule rem...
The impact of Mill. on gastrointestinal disorders: a comprehensive analysis through clinical trials, systematic review, and meta-analysis
The impact of Mill. on gastrointestinal disorders: a comprehensive analysis through clinical trials, systematic review, and meta-analysis
Rosa damascena Mill. has been studied in clinical trials for the treatment of diverse gastrointestinal diseases. The aim o...
Stearyl amine tailored spanlastics embedded within tetronic nanogel for boosting the repurposed anticancer potential of mebendazole: formulation, in vitro profiling, cytotoxicity assessment, and in vivo permeation analysis
Stearyl amine tailored spanlastics embedded within tetronic nanogel for boosting the repurposed anticancer potential of mebendazole: formulation, in vitro profiling, cytotoxicity assessment, and in vivo permeation analysis
Mebendazole (MBZ) is an anthelmintic drug that was repurposed as an anti-cancer agent. This study aimed at formulating MBZ...
Synthesis and optimization of fluoxetine-loaded polymeric nanoparticles for dual therapeutic applications in cancer and depression
Synthesis and optimization of fluoxetine-loaded polymeric nanoparticles for dual therapeutic applications in cancer and depression
Fluoxetine, an antidepressant, has shown potential anticancer effects. However, its therapeutic efficacy is limited by its...
Profiling metoprolol enantiomers in urine of hypertensive patients
Profiling metoprolol enantiomers in urine of hypertensive patients
Metoprolol, a widely used β-blocker, is administered as a racemic mixture, with (S)-metoprolol being more pharmacolog...
Cleaning validation in pharmaceutical quality control laboratories: a structured protocol for contamination risk mitigation
Cleaning validation in pharmaceutical quality control laboratories: a structured protocol for contamination risk mitigation
Cleaning activities are critical in pharmaceutical manufacturing to prevent cross-contamination of Active Pharmaceutical I...
Glucocorticoid withdrawal syndrome: Disproportionality analysis of cases using VigiBase data
Glucocorticoid withdrawal syndrome: Disproportionality analysis of cases using VigiBase data
Glucocorticoids are associated with withdrawal syndrome, but specific glucocorticoid types that cause severe conditions re...
Efficacy of dostarlimab in recurrent or advanced mismatch Repair-Deficient endometrial Cancer as a Single-Agent therapy: A systematic review and Meta-Analysis
Efficacy of dostarlimab in recurrent or advanced mismatch Repair-Deficient endometrial Cancer as a Single-Agent therapy: A systematic review and Meta-Analysis
The effectiveness of PD-1 inhibitors for treating endometrial cancer (EC) remains a topic of debate. Guidelines lack consi...
Drug repositioning: examining antipsychotic drugs and their anticancer effects
Drug repositioning: examining antipsychotic drugs and their anticancer effects
Cancer leads the list of causes of death worldwide, and the search for new and rapid treatment options for this disease ha...
Pre-emptive hydrocortisone therapy in early septic shock: a double-blind, allocation-concealed, pilot randomized controlled trial
Pre-emptive hydrocortisone therapy in early septic shock: a double-blind, allocation-concealed, pilot randomized controlled trial
Sepsis, a major global health issue, often progresses to septic shock with high morbidity and mortality. Corticosteroids e...
The effect of FeO biosynthesized through the green synthesis of and HA in the targeted delivery of 5-Fluorouracil to HCT116 cell line
The effect of FeO biosynthesized through the green synthesis of and HA in the targeted delivery of 5-Fluorouracil to HCT116 cell line
The administration of 5-FU as the first chemotherapeutic agent for colorectal cancer, showed difficulties including short ...
Co-delivery of SN38 and rapamycin albumin bound nanoparticles against breast Cancer
Co-delivery of SN38 and rapamycin albumin bound nanoparticles against breast Cancer
The co-delivery of two therapeutic agents within a single nanoparticle platform offers a potential strategy to improve tre...
Evaluation and comparison of the anti-proliferative and anti-metastatic effects of urolithin A and urolithin B against esophageal cancer cells: an in vitro and in silico study
Evaluation and comparison of the anti-proliferative and anti-metastatic effects of urolithin A and urolithin B against esophageal cancer cells: an in vitro and in silico study
Esophageal squamous cell carcinoma (ESCC) is a prevalent and lethal cancer, with traditional treatments often ineffective....
Prediction of naloxone dose in opioids toxicity based on machine learning techniques (artificial intelligence)
Prediction of naloxone dose in opioids toxicity based on machine learning techniques (artificial intelligence)
Treatment management for opioid poisoning is critical and, at the same time, requires specialized knowledge and skills. Th...
Ameliorative effect of Melatonin on 5-Fluorouracil-induced reproductive toxicity in male rats
Ameliorative effect of Melatonin on 5-Fluorouracil-induced reproductive toxicity in male rats
5-Fluorouracil (5-FU) is an antimetabolite chemotherapeutic agent that can cause oxidative stress and complications in nor...
Structure based exploration of mitochondrial alpha carbonic anhydrase inhibitors as potential leads for anti-obesity drug development
Structure based exploration of mitochondrial alpha carbonic anhydrase inhibitors as potential leads for anti-obesity drug development
Obesity has emerged as a major health challenge globally in the last two decades. Dysregulated fatty acid metabolism and d...
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
Rhinovirus (RV) infection is a major cause of common colds and asthma exacerbations, with no antiviral drug available. Cur...
Cellular and molecular aspects of drug resistance in cancers
Cellular and molecular aspects of drug resistance in cancers
Cancer drug resistance is a multifaceted phenomenon. The present review article aims to comprehensively analyze the cellul...
Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery
Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery
Amphotericin B (AMB) is a drug used to treat vulvovaginal candidiasis (VVC), which is a fungal infection affecting the vag...
Trends analysis and future study of the pharmaceutical industry field: a scoping review
Trends analysis and future study of the pharmaceutical industry field: a scoping review
The main aim of this study was to explore and understand the emerging developments, changes, and patterns shaping the futu...
Electroceuticals: Unlocking the promise of therapies
Electroceuticals: Unlocking the promise of therapies
Electroceuticals refers to the constantly growing disciplines of bioelectric and bioelectronic medication. These include a...
High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test
High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test
High-performance liquid chromatography (HPLC) has emerged as a highly sensitive and versatile analytical technique for qua...
Oral regimen for high dose methotrexate urine alkalinization: a systematic review and meta-analysis
Oral regimen for high dose methotrexate urine alkalinization: a systematic review and meta-analysis
Urine alkalinization prevents nephrotoxicity in patients receiving high-dose methotrexate (HDMTX). While the standard appr...
Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/Prdx3 pathway
Dexmedetomidine alleviates Hypoxia/reoxygenation-induced mitochondrial dysfunction in cardiomyocytes via activation of Sirt3/Prdx3 pathway
Myocardial ischemia/reperfusion injury (MIRI) seriously threatens the health of people. The mitochondrial dysfunction in c...
Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report
Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report
A persistent difficult-to-treat cough can be exhausting. Iron is an essential element that plays an important role in regu...
Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies
Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies
The efficient delivery of drugs from dry powder inhaler (DPI) formulations is associated with the complex interaction betw...
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