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Effectiveness of epigallocatechin gallate nanoparticles on the in-vivo treatment of Alzheimer’s disease in a rat/mouse model: a systematic review
Effectiveness of epigallocatechin gallate nanoparticles on the in-vivo treatment of Alzheimer’s disease in a rat/mouse model: a systematic review
Alzheimer’s disease (AD) is a neurological disease that causes memory loss over time. Current therapies are limited ...
Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation
Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation
In this study, a combination of nanotechnology, organic synthesis and radiochemistry were utilized in order to design an e...
Fruit vinegar as a promising source of natural anti-inflammatory agents: an up-to-date review
Fruit vinegar as a promising source of natural anti-inflammatory agents: an up-to-date review
Fruit vinegar is one of the most famous fruit byproducts worldwide with several unique properties. There are two types of ...
Electrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode
Electrochemical evaluation of nivolumab used in cancer treatment with differential pulse voltammetry: A novel approach with single-use pencil graphite electrode
Nivolumab is used in a treatment called immunotherapy, which helps the immune system cells to attack cancer cells. The ele...
Ropivacaine suppresses the progression of renal cell carcinoma through regulating the lncRNA RMRP/EZH2/CCDC65 axis
Ropivacaine suppresses the progression of renal cell carcinoma through regulating the lncRNA RMRP/EZH2/CCDC65 axis
Renal cell carcinoma (RCC) is a common malignancy. Local anesthetics were displayed powerful effects against various cance...
Atypical extrapyramidal manifestation of a typical antipsychotic with serotonergic antidepressant
Atypical extrapyramidal manifestation of a typical antipsychotic with serotonergic antidepressant
Typical antipsychotics are known to produce extrapyramidal side effects such as drug induced parkinsonism, acute dystonia,...
Adrenergic receptors blockade alleviates dexamethasone-induced neurotoxicity in adult male Wistar rats: Distinct effects on β-arrestin2 expression and molecular markers of neural injury
Adrenergic receptors blockade alleviates dexamethasone-induced neurotoxicity in adult male Wistar rats: Distinct effects on β-arrestin2 expression and molecular markers of neural injury
Dexamethasone-induced neurotoxicity has been previously reported. However, the molecular mechanisms are still not complete...
Towards greater impact in health technology assessment: System dynamic approach for new and emerging technologies in Iran
Towards greater impact in health technology assessment: System dynamic approach for new and emerging technologies in Iran
As classical health technology assessment models fail to predict the complexities of related impacts, the application of m...
Immediate hypersensitivity reaction to levetiracetam: a case report study
Immediate hypersensitivity reaction to levetiracetam: a case report study
Anticonvulsant drugs are one of the most common causes of delayed hypersensitivity reactions, such as drug reacti...
Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1
Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1
Acute myeloid leukemia (AML) is a hematopoietic malignancy. Chidamide has shown anti-cancer effect in different malignanci...
Utilization patterns of cardiovascular medications in patients with diabetes mellitus; a retrospective cross-sectional study, 2013-17
Utilization patterns of cardiovascular medications in patients with diabetes mellitus; a retrospective cross-sectional study, 2013-17
Diabetes Mellitus (DM) is a prominent health care issue worldwide. One of the most prevalent comorbidities of DM is cardio...
Prophylactic norepinephrine combined with 6% hydroxyethyl starch (130/0.4) co-load infusion for preventing postspinal anesthesia hypotension during cesarean section: a randomized, controlled, dose-finding trial
Prophylactic norepinephrine combined with 6% hydroxyethyl starch (130/0.4) co-load infusion for preventing postspinal anesthesia hypotension during cesarean section: a randomized, controlled, dose-finding trial
Colloid and/or co-load may be more effective than crystalloid for preventing postspinal anesthesia hypotension. We tested ...
Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer
Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer
Several studies have shown that the TGF-β signaling pathway plays a critical role in colorectal cancer (CRC) pathogen...
Identifying natural products for gastric cancer treatment through pharmacophore creation, 3D QSAR, virtual screening, and molecular dynamics studies
Identifying natural products for gastric cancer treatment through pharmacophore creation, 3D QSAR, virtual screening, and molecular dynamics studies
Gastric cancer (GC) is known as the fourth leading cause of cancer-related death and the fifth major cancer in the world, ...
Firstly electrochemical investigetions and determination of anticoagulant drug edoxaban at single-use pencil graphite electrode: an eco-friendly and cost effective voltammetric method
Firstly electrochemical investigetions and determination of anticoagulant drug edoxaban at single-use pencil graphite electrode: an eco-friendly and cost effective voltammetric method
The anticoagulant drug edoxaban has a blood thinning mechanism of action. In this study, a pencil graphite electrode was e...
Comparison of different transient gene expression systems for the production of a new humanized anti-HER2 monoclonal antibody (Hersintuzumab)
Comparison of different transient gene expression systems for the production of a new humanized anti-HER2 monoclonal antibody (Hersintuzumab)
Producing therapeutic proteins can be done quickly and on a large scale through Transient Gene Expression (TGE). Chinese h...
Designing and psychometric evaluation of pharmacists' attitude toward ethical challenges questionnaire in pharmacy practice: A mixed‑method study
Designing and psychometric evaluation of pharmacists' attitude toward ethical challenges questionnaire in pharmacy practice: A mixed‑method study
Knowledge advancement exposes the pharmacists to new ethical and professional challenges in providing pharmaceutical care....
Clove volatile oil-loaded nanoemulsion reduces the anxious-like behavior in adult zebrafish
Clove volatile oil-loaded nanoemulsion reduces the anxious-like behavior in adult zebrafish
Clove volatile oil (CVO) and its major compound, eugenol (EUG), have anxiolytic effects, but their clinical use has been i...
A self-healable and bioadhesive acacia gum polysaccharide-based injectable hydrogel for wound healing acceleration
A self-healable and bioadhesive acacia gum polysaccharide-based injectable hydrogel for wound healing acceleration
The present study aimed at developing an injectable hydrogel based on acacia gum (AG) for wound healing acceleration. The ...
Correction: Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies
Correction: Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies
Centro de Ciências Médicas e Farmacêuticas, Universidade Estadual do Oeste do Paraná, Cascavel, BrazilLarissa Toigo, Eduar...
COVID-19: A novel holistic systems biology approach to predict its molecular mechanisms (in vitro) and repurpose drugs
COVID-19: A novel holistic systems biology approach to predict its molecular mechanisms (in vitro) and repurpose drugs
COVID-19 strangely kills some youth with no history of physical weakness, and in addition to the lungs, it may even direct...
Tenofovir alafenamide plus dolutegravir as a switch strategy in HIV-infected patients: a pilot randomized controlled trial
Tenofovir alafenamide plus dolutegravir as a switch strategy in HIV-infected patients: a pilot randomized controlled trial
Currently, two-drug antiretroviral regimens are emerging fields in life-long treatment in people living with HIV. This ran...
In silico screening, synthesis, characterization and biological evaluation of novel anticancer agents as potential COX-2 inhibitors
In silico screening, synthesis, characterization and biological evaluation of novel anticancer agents as potential COX-2 inhibitors
Cyclooxygenase enzyme is frequently overexpressed in various types of cancer and found to play a crucial role in poor prog...
A neuroprotective dose of trehalose is harmless to metabolic organs: comprehensive histopathological analysis of liver, pancreas, and kidney
A neuroprotective dose of trehalose is harmless to metabolic organs: comprehensive histopathological analysis of liver, pancreas, and kidney
Trehalose is a non-reducing disaccharide synthesized by lower organisms. It has recently received special attention becaus...
The use of therapeutic drug monitoring to highlight an over-looked drug-drug interaction leading to imatinib treatment failure
The use of therapeutic drug monitoring to highlight an over-looked drug-drug interaction leading to imatinib treatment failure
Chronic oral anticancer therapies, are increasingly prescribed and present new challenges including the enhanced risk of o...
Simulation of drug-drug interactions between breast cancer chemotherapeutic agents and antiemetic drugs
Simulation of drug-drug interactions between breast cancer chemotherapeutic agents and antiemetic drugs
Chemotherapy-induced nausea and vomiting are commonly experienced side effects in breast cancer (BCa) patients. Antiemetic...
Network pharmacology: a systems perspective possible underpinning approach for oral cancer treatment
Network pharmacology: a systems perspective possible underpinning approach for oral cancer treatment
Chandran U, Mehendale N, Patil S, Chaguturu R, Patwardhan B. Network Pharmacology. In: Patwardhan B, Chaguturu R, editors....
Cardiac safety profile of type II kinase inhibitors: Analysis of post-marketing reports from databases of European Medicine Agency & World Health Organization
Cardiac safety profile of type II kinase inhibitors: Analysis of post-marketing reports from databases of European Medicine Agency & World Health Organization
Targeted therapy with type II kinase inhibitors (KIs) is one of the preferred choices in cancer treatment. However, type I...
Fabrication, characterization and evaluation of a new designed botulinum toxin-cell penetrating peptide nanoparticulate complex
Fabrication, characterization and evaluation of a new designed botulinum toxin-cell penetrating peptide nanoparticulate complex
To have a better and longer effect, botulinum neurotoxin (BoNT) is injected several times in a treatment course, which cou...
Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies
Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies
This scoping review aims to present flavonoid compounds' promising effects and possible mechanisms of action on potent...
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