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Injectable Endoplasmin-Loaded Lipid Nanoparticles-Hydrogel Composite for Cartilage Regeneration
Injectable Endoplasmin-Loaded Lipid Nanoparticles-Hydrogel Composite for Cartilage Regeneration
Endoplasmin (ENPL), a heat shock protein 90 family member, promotes chondrogenic differentiation of stem cells by inhibiti...
Implantable Dental Barrier Membranes as Regenerative Medicine in Dentistry: A Comprehensive Review
Implantable Dental Barrier Membranes as Regenerative Medicine in Dentistry: A Comprehensive Review
Periodontitis and bone loss in the maxillofacial and dental areas pose considerable challenges for both functional and aes...
Synthesis of Autotaxin-Inhibiting Lipid Nanoparticles to Regulate Autophagy and Inflammatory Responses in Activated Macrophages
Synthesis of Autotaxin-Inhibiting Lipid Nanoparticles to Regulate Autophagy and Inflammatory Responses in Activated Macrophages
Autotaxin (ATX), an ENPP2 enzyme, regulates lipid signaling by converting lysophosphatidylcholine to lysophosphatidic acid...
Preparation of Highly Functional Spheroid of Endocrine Cells Based on Thermosensitive Glycol Chitosan
Preparation of Highly Functional Spheroid of Endocrine Cells Based on Thermosensitive Glycol Chitosan
Pancreatic islet transplantation holds great potential as a therapeutic approach for treating type 1 diabetes mellitus (T1...
Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle
Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle
Systemic inflammation, often induced by elevated circulating lipopolysaccharide (LPS) levels, is a common consequence of i...
Polynucleotide and Hyaluronic Acid Mixture for Skin Wound Dressing for Accelerated Wound Healing
Polynucleotide and Hyaluronic Acid Mixture for Skin Wound Dressing for Accelerated Wound Healing
Skin wound healing is a complex process requiring coordinated cellular and molecular interactions. Polynucleotides (PN) an...
Advances and Challenges of Tissue Vascular Scaffolds and Supercritical Carbon Dioxide Technology in Cardiovascular Diseases
Advances and Challenges of Tissue Vascular Scaffolds and Supercritical Carbon Dioxide Technology in Cardiovascular Diseases
Atherosclerosis often leads to ischemic heart disease and peripheral artery disease. Traditional revascularization techniq...
Intranasal Administration of Human Neural Crest-Derived Nasal Turbinate Stem Cells Attenuates Microglia Activity in Mild Head Trauma Models
Intranasal Administration of Human Neural Crest-Derived Nasal Turbinate Stem Cells Attenuates Microglia Activity in Mild Head Trauma Models
Mild head trauma often leads to long-term cognitive and neurological deficits. PLX3397, an inhibitor of colony-stimulating...
Branched Polymer Architecture for Modulating Interactions in Material-Bio Interface
Branched Polymer Architecture for Modulating Interactions in Material-Bio Interface
Branched polymers, including star, dendrimers, comb, and biomimetic polymers, are increasingly recognized for their potent...
Evaluation of Bi-layer Silk Fibroin Grafts for Onlay Urethroplasty in a Female Porcine Model of Long Urethral Strictures
Evaluation of Bi-layer Silk Fibroin Grafts for Onlay Urethroplasty in a Female Porcine Model of Long Urethral Strictures
Buccal mucosa urethroplasty represents the primary strategy for reconstruction of long urethral strictures (US). However, ...
Construction of Chitosan Oligosaccharide-Coated Nanostructured Lipid Carriers for the Sustained Release of Strontium Ranelate
Construction of Chitosan Oligosaccharide-Coated Nanostructured Lipid Carriers for the Sustained Release of Strontium Ranelate
Strontium ranelate (SR) is an effective bone regeneration drug; however, its low bioavailability and strong hydrophilicity...
Injectable Human Acellular Adipose Matrix with Crosslinked Hyaluronic Acid and Carboxymethyl Cellulose Gels for Soft Tissue Augmentation
Injectable Human Acellular Adipose Matrix with Crosslinked Hyaluronic Acid and Carboxymethyl Cellulose Gels for Soft Tissue Augmentation
Fillers have become a viable treatment option for addressing volume deficits, whether for aesthetic purposes or due to tra...
Fabrication of 3D Biofunctional Magnetic Scaffolds by Combining Fused Deposition Modelling and Inkjet Printing of Superparamagnetic Iron Oxide Nanoparticles
Fabrication of 3D Biofunctional Magnetic Scaffolds by Combining Fused Deposition Modelling and Inkjet Printing of Superparamagnetic Iron Oxide Nanoparticles
Recently, magnetic composite biomaterials have raised attention in bone tissue engineering as the application of dynamic m...
Exosomes Extracted from Human Umbilical Cord MSCs Contribute to Osteoarthritic Cartilage and Chondrocytes Repair Through Enhancing Autophagy While Suppressing the Wnt/β-Catenin Pathway
Exosomes Extracted from Human Umbilical Cord MSCs Contribute to Osteoarthritic Cartilage and Chondrocytes Repair Through Enhancing Autophagy While Suppressing the Wnt/β-Catenin Pathway
Osteoarthritis (OA), a widespread chronic joint disorder mainly affecting the elderly, currently lacks a definitive cure. ...
Next-Generation Strategies for Enamel Repair and Regeneration: Advances in Biomaterials and Translational Challenges
Next-Generation Strategies for Enamel Repair and Regeneration: Advances in Biomaterials and Translational Challenges
Enamel regeneration and remineralization are critical for restoring enamel integrity, as natural enamel lacks the ability ...
Recent Advances in Three-Dimensional Models for Studies of Liver Fibrosis
Recent Advances in Three-Dimensional Models for Studies of Liver Fibrosis
Liver fibrosis is a reversible but complex pathological condition associated with chronic liver diseases, affecting over 1...
Optimal Production of 3D Neuronal Lineage Population by Morphological Classification
Optimal Production of 3D Neuronal Lineage Population by Morphological Classification
The increasing prevalence of neurodegenerative diseases and toxic substance exposure highlights the need for neuronal cell...
Exosomes of Human Fetal Cartilage Progenitor Cells (hFCPCs) Inhibited Interleukin-1β (IL-1β)-Induced Osteoarthritis Phenotype via miR-125b-5p
Exosomes of Human Fetal Cartilage Progenitor Cells (hFCPCs) Inhibited Interleukin-1β (IL-1β)-Induced Osteoarthritis Phenotype via miR-125b-5p
This study investigated anti-inflammatory effects of exosomes derived from human fetal cartilage progenitor cells (hFCPC-E...
Au@Pt Nanoparticles Enhance Maturation and Contraction of Mouse Embryonic Stem Cells-Derived and Neonatal Mouse Cardiomyocytes
Au@Pt Nanoparticles Enhance Maturation and Contraction of Mouse Embryonic Stem Cells-Derived and Neonatal Mouse Cardiomyocytes
Cardiomyocytes derived from pluripotent stem cells (PSCs) hold great promise in heart damage repair in vivo and drug scree...
Platelet-Rich Plasma-Embedded Porous Polycaprolactone Film with a Large Surface Area for Effective Hemostasis
Platelet-Rich Plasma-Embedded Porous Polycaprolactone Film with a Large Surface Area for Effective Hemostasis
Uncontrollable and widespread bleeding caused by surgery or sudden accidents can lead to death if not treated with appropr...
Perfusion Bioreactor Conditioning of Small-diameter Plant-based Vascular Grafts
Perfusion Bioreactor Conditioning of Small-diameter Plant-based Vascular Grafts
Vascular grafts are mainly composed of synthetic materials, but are prone to thrombosis and intimal hyperplasia at small d...
Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-β and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model
Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-β and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model
Keloids and hypertrophic scars result from abnormal collagen accumulation and the inhibition of its degradation. Although ...
Macrophage Polarization: A Novel Target and Strategy for Pathological Scarring
Macrophage Polarization: A Novel Target and Strategy for Pathological Scarring
Abnormal scarring imposes considerable challenges and burdens on the lives of patients and healthcare system. Macrophages ...
Reduced Cell Migration in Human Chondrocyte Sheets Increases Tissue Stiffness and Cartilage Protein Production
Reduced Cell Migration in Human Chondrocyte Sheets Increases Tissue Stiffness and Cartilage Protein Production
Chondrogenic differentiation medium (CDM) is usually used to maintain chondrogenic activity during chondrocyte sheet produ...
Multifunctional Microneedle Patch with Diphlorethohydroxycarmalol for Potential Wound Dressing
Multifunctional Microneedle Patch with Diphlorethohydroxycarmalol for Potential Wound Dressing
Treatment of skin wounds with diverse pathological characteristics presents significant challenges due to the limited spec...
Evaluation of Bi-layer Silk Fibroin Grafts for Inlay Vaginoplasty in a Rat Model
Evaluation of Bi-layer Silk Fibroin Grafts for Inlay Vaginoplasty in a Rat Model
Autologous tissues derived from bowel, buccal mucosa and skin are primarily used to repair or replace diseased vaginal seg...
Rapamycin Attenuates H2O2-Induced Oxidative Stress-Related Senescence in Human Skin Fibroblasts
Rapamycin Attenuates H2O2-Induced Oxidative Stress-Related Senescence in Human Skin Fibroblasts
Oxidative stress plays an important role in the skin aging process. Rapamycin has been shown to have anti-aging effects, b...
Exosomes-Shuttled lncRNA SNHG7 by Bone Marrow Mesenchymal Stem Cells Alleviates Osteoarthritis Through Targeting miR-485-5p/FSP1 Axis-Mediated Chondrocytes Ferroptosis and Inflammation
Exosomes-Shuttled lncRNA SNHG7 by Bone Marrow Mesenchymal Stem Cells Alleviates Osteoarthritis Through Targeting miR-485-5p/FSP1 Axis-Mediated Chondrocytes Ferroptosis and Inflammation
Osteoarthritis (OA), a degenerative joint disorder, is a major reason of disability in adults. Accumulating evidences have...
The Effect of Platelet Fibrin Plasma (PFP) on Postoperative Refractory Wounds: Physiologically Concentrated Platelet Plasma in Wound Repair
The Effect of Platelet Fibrin Plasma (PFP) on Postoperative Refractory Wounds: Physiologically Concentrated Platelet Plasma in Wound Repair
Surgical wounds that can’t complete primary healing three weeks after surgery are called postoperative refractory wo...
Hypoxic Stress Induces Complement-Mediated Lysis of Mesenchymal Stem Cells by Downregulating Factor H and CD59
Hypoxic Stress Induces Complement-Mediated Lysis of Mesenchymal Stem Cells by Downregulating Factor H and CD59
Factor H and membrane inhibitor of reactive lysis (CD59) are key regulators of complement activation. Mesenchymal stem cel...
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