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Upregulation of CoQ shifts ferroptosis dependence from GPX4 to FSP1 in acquired radioresistance
Upregulation of CoQ shifts ferroptosis dependence from GPX4 to FSP1 in acquired radioresistance
Acquired radioresistance is the primary cause of treatment failure in radiotherapy, which is considered as one of the prim...
Global Spread characteristics of CTX-M-type Extended-spectrum β-lactamases: a genomic epidemiology analysis
Global Spread characteristics of CTX-M-type Extended-spectrum β-lactamases: a genomic epidemiology analysis
The problem of bacterial resistance due to the massive and unregulated use of antibiotics is one of the most important pub...
Rewiring chaperone-mediated autophagy in cancer by a prion-like chemical inducer of proximity to counteract adaptive immune resistance
Rewiring chaperone-mediated autophagy in cancer by a prion-like chemical inducer of proximity to counteract adaptive immune resistance
Chaperone-mediated autophagy (CMA), a proteolytic system contributing to the degradation of intracellular proteins in lyso...
Dynamic within-host cefiderocol heteroresistance caused by blaSHV-12 amplification in pandrug-resistant and hypervirulent Klebsiella pneumoniae sequence type 11
Dynamic within-host cefiderocol heteroresistance caused by blaSHV-12 amplification in pandrug-resistant and hypervirulent Klebsiella pneumoniae sequence type 11
Klebsiella pneumoniae (Kp) is becoming an important clinical opportunist due to its highly varied antimicrobial resistance...
Vaccine effects on COVID-19 infection with bivalent boosting by age group
Vaccine effects on COVID-19 infection with bivalent boosting by age group
This paper examines time-series vaccine effectiveness on COVID-19 infection with/without a bivalent booster dose by 6 age ...
TRAIL-driven targeting and reversing cervical cancer radioresistance by seleno-nanotherapeutics through regulating cell metabolism
TRAIL-driven targeting and reversing cervical cancer radioresistance by seleno-nanotherapeutics through regulating cell metabolism
Globally, cervical cancer is a major health concern for women, with about 604,000 new cases and 342,000 deaths estimated i...
Cefiderocol: Clinical application and emergence of resistance
Cefiderocol: Clinical application and emergence of resistance
Antibiotic resistance has significantly impacted humankind, primarily due to the prolonged misuse of antibacterial drugs (...
Deciphering the genetic basis of resistome and virulome diversity among multidrug-resistant Mycoplasma hominis
Deciphering the genetic basis of resistome and virulome diversity among multidrug-resistant Mycoplasma hominis
Mycoplasma hominis is one of the smallest pathogens responsible for a diverse range of infections, including non-gonococca...
Progress in characterizing ABC multidrug transporters in zebrafish
Progress in characterizing ABC multidrug transporters in zebrafish
The ATP-binding cassette (ABC) transporter gene superfamily encodes membrane proteins that transport their substrates in a...
Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005-2023
Global distribution and genomic characteristics of carbapenemase-producing Escherichia coli among humans, 2005-2023
Antibiotic resistance represents a global public health crisis and poses a significant challenge worldwide (Laxminarayan e...
Radioiodine-refractory differentiated thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance
Radioiodine-refractory differentiated thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance
Radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) is difficult to treat with radioactive iodine because of t...
Deciphering the genetic basis of resistome and virulome diversity among multidrug-resistant Mycoplasma hominis
Deciphering the genetic basis of resistome and virulome diversity among multidrug-resistant Mycoplasma hominis
Mycoplasma hominis is one of the smallest pathogens responsible for a diverse range of infections, including non-gonococca...
Combating Bacterial Infections with Host Defense Peptides: Shifting Focus from Bacteria to Host Immunity
Combating Bacterial Infections with Host Defense Peptides: Shifting Focus from Bacteria to Host Immunity
The continued ravages of multidrug-resistant (MDR) bacteria threaten public health and food security (Breidenstein et al.,...
Overexpression of ABCC1 and ABCG2 Confers Resistance to Talazoparib, a Poly (ADP-Ribose) Polymerase Inhibitor
Overexpression of ABCC1 and ABCG2 Confers Resistance to Talazoparib, a Poly (ADP-Ribose) Polymerase Inhibitor
Multidrug resistance (MDR) is a term used to describe the resistance of cancer cells to multiple chemotherapeutic drugs, w...
The Role of Histone H1.2 in Pancreatic Cancer Metastasis and Chemoresistance
The Role of Histone H1.2 in Pancreatic Cancer Metastasis and Chemoresistance
Pancreatic cancer (PC) remains one of the deadliest cancers globally, with a 5-year survival rate of less than 10% (Siegel...
Cisplatin-activated ERβ/DCAF8 positive feedback loop induces chemoresistance in non-small cell lung cancer via PTEN/Akt axis
Cisplatin-activated ERβ/DCAF8 positive feedback loop induces chemoresistance in non-small cell lung cancer via PTEN/Akt axis
High levels of the estrogen receptor β (ERβ) predict poor prognosis following platinum-containing adjuvant chemotherapies ...
CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress
CRISPR/Cas9 screens unravel miR-3689a-3p regulating sorafenib resistance in hepatocellular carcinoma via suppressing CCS/SOD1-dependent mitochondrial oxidative stress
KeywordsIn vivo CRISPR/Cas9 screenSorafenibMiR-3689a-3pDrug resistance of hepatocellular carcinomaCCSData availability sta...
Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance
Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance
Drug resistance remains a major challenge in cancer treatment, necessitating the development of novel strategies to overco...
ABCC4 Impacts Megakaryopoiesis and Protects Megakaryocytes against 6-Mercaptopurine Induced Cytotoxicity
ABCC4 Impacts Megakaryopoiesis and Protects Megakaryocytes against 6-Mercaptopurine Induced Cytotoxicity
Production of platelets by their progenitors, the megakaryocytes (MKs) is referred to as megakaryopoiesis. Megakaryocyte p...
Cuproptosis: a novel therapeutic target for overcoming cancer drug resistance
Cuproptosis: a novel therapeutic target for overcoming cancer drug resistance
Available online 11 November 2023, 101018Author links open overlay panel, , , , , , , , , AbstractCuproptosis is a newly i...
MYC expression and Fatty acid oxidation in EGFR-TKI acquired resistance
MYC expression and Fatty acid oxidation in EGFR-TKI acquired resistance
Available online 13 November 2023, 101019Author links open overlay panel, , , AbstractThis report expands on our previous ...
Radioiodine-refractory thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance
Radioiodine-refractory thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance
Radioiodine refractory differentiated thyroid cancer (RAIR-DTC) is difficult to treat with radioactive iodine because of t...
Antibiotic failure: Beyond antimicrobial resistance
Antibiotic failure: Beyond antimicrobial resistance
Available online 18 October 2023, 101012Author links open overlay panel, , AbstractDespite significant progress in antibio...
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2
Available online 10 October 2023, 101011Author links open overlay panel, , ABSTRACTThe overexpression of the human ATP-bin...
Pdr5: A Master of Asymmetry
Pdr5: A Master of Asymmetry
Available online 7 October 2023, 101010Author links open overlay panel, AbstractPdr5 is a founding member of a large (pdr)...
Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1)
Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1)
Human P-glycoprotein (P-gp) or ABCB1 is overexpressed in many cancers and has been implicated in altering the bioavailabil...
Antibody evasion associated with the RBD significant mutations in several emerging SARS-CoV-2 variants and its subvariants
Antibody evasion associated with the RBD significant mutations in several emerging SARS-CoV-2 variants and its subvariants
Since the origin of the wild strain of SARS-CoV-2, several variants have emerged, which were designated as VOC, VOI, and V...
Effective targeting of breast cancer by the inhibition of P-glycoprotein mediated removal of toxic lipid peroxidation byproducts from drug tolerant persister cells
Effective targeting of breast cancer by the inhibition of P-glycoprotein mediated removal of toxic lipid peroxidation byproducts from drug tolerant persister cells
List of abbreviationsABCATP-binding cassette (ABC)DTPDrug-tolerant persisterMMPMatched molecular pairP-gpP-glycoprotein (A...
The definition and global epidemiology of nonmobile colistin resistance (NMCR-3) determinants in Aeromonas from 1968 to 2022
The definition and global epidemiology of nonmobile colistin resistance (NMCR-3) determinants in Aeromonas from 1968 to 2022
KeywordsNonmobile colistin resistanceNMCR-3AeromonasNatural reservoir/progenitorMCR-3/5/7Global prevalenceData availabilit...
CircPTEN suppresses human clear cell renal carcinoma progression and resistance to mTOR inhibitors by targeting epigenetic modification
CircPTEN suppresses human clear cell renal carcinoma progression and resistance to mTOR inhibitors by targeting epigenetic modification
Available online 2 September 2023, 101003Author links open overlay panel, , , , , , , , , , , , AbstractRenal cell carcino...
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