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The important role of lactylation in regulating DNA damage repair and tumor chemotherapy resistance
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RGS5+ lymphatic endothelial cells facilitate metastasis and acquired drug resistance of breast cancer through oxidative stress-sensing mechanism
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CYP1B1 Promotes PARPi-Resistance via Histone H1.4 Interaction and Increased Chromatin Accessibility in Ovarian Cancer
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O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma
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An increased prevalence of carbapenem-resistant hypervirulent Klebsiella pneumoniae associated with the COVID-19 pandemic
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CBX4 counteracts cellular senescence to desensitize gastric cancer cells to chemotherapy by inducing YAP1 SUMOylation
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The key role of iroBCDN-lacking pLVPK-like plasmid in the evolution of the most prevalent hypervirulent carbapenem-resistant ST11-KL64 Klebsiella pneumoniae in China
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Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae
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crVDAC3 alleviates ferroptosis by impeding HSPB1 ubiquitination and confers trastuzumab deruxtecan resistance in HER2-low breast cancer
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Folylpolyglutamate synthetase inactivation in relapsed ALL induces a druggable folate metabolic vulnerability
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Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer
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CRISPR-AMRtracker: A novel toolkit to monitor the antimicrobial resistance gene transfer in fecal microbiota
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Cellular and molecular mechanisms of gastrointestinal cancer liver metastases and drug resistance
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Mechanism of staphylococcal resistance to clinically relevant antibiotics
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Unveiling the resistance to therapies in pancreatic ductal adenocarcinoma
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Unraveling the secrets: Evolution of resistance mediated by membrane proteins
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Fusion event mediated by IS903B between chromosome and plasmid in two MCR-9- and KPC-2-co-producing Klebsiella pneumoniae isolates
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Functional relay between Mph(A) enzyme and Mrx efflux pump mediates azithromycin resistance, a novel mechanism of bacterial antimicrobial resistance
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Editorial: ABC transporters and drug resistance
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Plasmid-borne tigecycline resistance gene tet(X4) in Salmonella enterica and Escherichia coli isolates from a pediatric patient with diarrhea
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Development and evaluation of a human CD47/HER2 bispecific antibody for Trastuzumab-resistant breast cancer immunotherapy
Development and evaluation of a human CD47/HER2 bispecific antibody for Trastuzumab-resistant breast cancer immunotherapy
Breast cancer (BC) is the most common malignancy diagnosed in women worldwide, and the second cause of cancer-related deat...
A novel SIK2 inhibitor SIC-19 exhibits synthetic lethality with PARP inhibitors in ovarian cancer
A novel SIK2 inhibitor SIC-19 exhibits synthetic lethality with PARP inhibitors in ovarian cancer
Volume 74, May 2024, 101077Author links open overlay panel, , , , , , , , , , , Highlights•SIC-19 promotes SIK2 protein de...
Targeted dual degradation of HER2 and EGFR obliterates oncogenic signaling, overcomes therapy resistance, and inhibits metastatic lesions in HER2-positive breast cancer models
Targeted dual degradation of HER2 and EGFR obliterates oncogenic signaling, overcomes therapy resistance, and inhibits metastatic lesions in HER2-positive breast cancer models
AimsHuman epidermal growth factor receptor 2 (HER2) is an oncogenic receptor tyrosine kinase amplified in approximately 20...
TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770–5p axis in PDAC
TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770–5p axis in PDAC
PDAC has emerged as the fourth leading cause of cancer related death, which accounts for 8% of overall cancer mortality (S...
Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome
Concurrent inhibition of ALK and SRC kinases disrupts the ALK lung tumor cell proteome
Volume 74, May 2024, 101081Author links open overlay panel, , , , , , , , , AbstractPrecision oncology has revolutionized ...
Circumventing drug resistance in gastric cancer: A spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics
Circumventing drug resistance in gastric cancer: A spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics
Gastric cancer (GC) is a prevalent and deadly disease, ranking as the fifth most common cancer and the third leading cause...
Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis
Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis
AimsCarbapenem-resistant Klebsiella pneumonia (CRKP) is a global threat that varies by region. The global distribution, ev...
Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy
Syk-dependent homologous recombination activation promotes cancer resistance to DNA targeted therapy
Cells employ a series of repair mechanisms to maintain genome integrity following exposure to endogenous or exogenous dama...
Advances in molecular targeted drugs in combination with CAR-T cell therapy for hematologic malignancies
Advances in molecular targeted drugs in combination with CAR-T cell therapy for hematologic malignancies
Volume 74, May 2024, 101082Author links open overlay panel, , , , , , , , AbstractMolecular targeted drugs and chimeric an...
Potential targets and therapeutics for cancer stem cell-based therapy against drug resistance in hepatocellular carcinoma
Potential targets and therapeutics for cancer stem cell-based therapy against drug resistance in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common digestive malignancy, ranking the sixth-most prevalent cancer and the fo...
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