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Long non-coding RNA LRTOR drives osimertinib resistance in non-small cell lung cancer by boosting YAP positive feedback loop
Volume 83, November 2025, 101245Author links open overlay panel, , , , , , , , , , , , , , , , , , , AbstractThe therapeut...
Targeting CLK1/SRSF7 axis-dependent alternative splicing sensitizes pancreatic ductal adenocarcinoma to chemotherapy and immunotherapy
ALG8alpha-1,3-glucosyltransferase 8ANRILantisense noncoding RNA at the INK4 locusASOantisense oligonucleotidesATMataxia-te...
Defining homologous recombination deficiency status in pancreatic ductal adenocarcinoma: Clinical implications for evaluating response to platinum chemotherapy
Volume 83, November 2025, 101291Author links open overlay panel, , , , , , , , , , , AbstractAimsPancreatic ductal adenoca...
HSA-templated synergistic platform boosts radiotherapy via enhanced radiosensitization and ferroptosis induction
Radiotherapy efficacy in cancer treatment is frequently compromised by tumor radioresistance, limited immune activation, a...
Proteasomes suppress anticancer drug-induced cytotoxicity by inhibiting mitochondrial protein import and promoting ROS-BNIP3-mediated mitophagy
According to the International Agency for Research on Cancer, an estimated 1.998 million new cancer cases and 9.74 million...
RNF217-KEAP1-NRF2 feedback loop confers therapeutic resistance by inhibiting ferroptosis in esophageal squamous cell carcinoma
Esophageal cancer is one of the most common malignant tumors and the seventh leading cause of cancer-related deaths worldw...
Engineering nanoplatforms of bacterial outer membrane vesicles to overcome cancer therapy resistance
Volume 83, November 2025, 101277Author links open overlay panel, , , , , , , AbstractResistance to cancer therapy is drive...
EMT and cancer stem cells: Drivers of therapy resistance and promising therapeutic targets
Recent advancements in oncology and biology, along with the emergence of innovative techniques such as next-generation seq...
Targeted therapy in acute myeloid leukemia: Resistance and overcoming strategy
Acute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by the uncontrolled clonal expansion ...
Emerging role of sialylation in cancer therapy resistance: Mechanisms and therapeutic implications
ALKAnaplastic lymphoma kinaseBACE1Beta-site amyloid precursor protein-cleaving enzymeBCP-ALLB-cell precursor acute lymphob...
The role of synthetic lethality in overcoming cancer therapy resistance: Emerging paradigm and recent advances
Cancer remains a leading cause of mortality worldwide, posing a significant challenge to human health. Despite remarkable ...
Targeting DNA damage response pathways in tumor drug resistance: Mechanisms, clinical implications, and future directions
Targeting DNA damage response (DDR) pathways has become a promising strategy for overcoming tumor drug resistance, particu...
Overcoming delivery challenges of antimicrobial peptides for clinical translation: From nanocarriers to molecular modifications
Since Alexander Fleming's discovery of penicillin in 1928, antibiotics have played a crucial role in saving lives and ushe...
Erratum to “A highly potent small-molecule antagonist of exportin-1 selectively eliminates CD44+ CD24- enriched breast cancer stem-like cells” [Drug Resist. Updates 66 (2023) 100903]
Volume 83, November 2025, 101297Author links open overlay panel, , , , , , , , , , , , , View Abstract© 2022 The Author(s)...
Staphylococcus aureus manipulates osteocytes to cause persistent chronic osteomyelitis and antibiotic resistance via pyroptosis pathway suppression
Osteomyelitis is a progressive inflammatory condition of the skeletal system, caused by microbial infection and subsequent...
Overcoming multidrug resistance using small molecule dynamic inhibitors by hijacking nascent and inducing turnover of mature ABCG2 for degradation in lysosomes
Targeted protein degradation (TPD) is an attractive strategy for drug discovery by eliminating a protein of interest (Zhao...
Gamma-synuclein drives bevacizumab resistance in colorectal cancer via VEGFR2 activation and angiogenesis
Volume 84, January 2026, 101299Author links open overlay panel, , , , , , AbstractBackgroundResistance to Bevacizumab (Bev...
Polymeric micellar paclitaxel, cisplatin, and tislelizumab as first-line therapy for advanced unresectable esophageal squamous cell carcinoma: A phase II study with resistance profiling in poor responders
Esophageal carcinoma constitutes a major global health burden, ranking as the seventh most common malignancy and the sixth...
Post-translational modifications in drug resistance
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Acquired resistance to tyrosine kinase targeted therapy: mechanism and tackling strategies
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Modeling the epidemiologic impact of age-targeted vaccination for drug-resistant tuberculosis
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Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling
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AI-driven visualization tool for analyzing data and predicting drug-resistant outbreaks
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Global phylogeography and antibiotic resistance characteristics of Morganella: An epidemiological, spatial, comparative genomic study
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Dynamic evolution of KPC-230-mediated resistance to ceftazidime-avibactam during the treatment of carbapenem-resistant Klebsiella pnenmoniae
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Association of idealized amphiphiles and protease inhibitors: Conferring antimicrobial peptides with stable antibacterial activity under physiological conditions to combat multidrug-resistant bacteria
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N6-methyladenosine modification of 3'tRF-AlaAGC impairs PD-1 blockade efficacy by promoting lactic acid accumulation in the tumor microenvironment of gastric carcinoma
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Wip1 phosphatase activator QGC-8–52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells
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Peptide-based PET/CT imaging visualizes PD-L1-driven radioresistance in glioblastoma
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Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement
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