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Expert consensus on orthodontic treatment of patients with periodontal disease
Expert consensus on orthodontic treatment of patients with periodontal disease
Patients with periodontal disease often require combined periodontal-orthodontic interventions to restore periodontal heal...
Programmed death-ligand 1 regulates ameloblastoma growth and recurrence
Programmed death-ligand 1 regulates ameloblastoma growth and recurrence
Tumor cell-intrinsic programmed death-ligand 1 (PD-L1) signals mediate tumor initiation, progression and metastasis, but t...
Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression
Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression
Oral squamous cell carcinoma (OSCC) progresses from preneoplastic precursors via genetic and epigenetic alterations. Previ...
Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation
Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation
Complement C3 plays a critical role in periodontitis. However, its source, role and underlying mechanisms remain unclear. ...
Inflammation-related collagen fibril destruction contributes to temporomandibular joint disc displacement via NF-κB activation
Inflammation-related collagen fibril destruction contributes to temporomandibular joint disc displacement via NF-κB activation
Temporomandibular joint (TMJ) disc displacement is one of the most significant subtypes of temporomandibular joint disorde...
Single-cell sequencing systematically analyzed the mechanism of Emdogain on the restoration of delayed replantation periodontal membrane
Single-cell sequencing systematically analyzed the mechanism of Emdogain on the restoration of delayed replantation periodontal membrane
The repair of the periodontal membrane is essential for the successful management of periodontal disease and dental trauma...
NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming
NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming
Stem cells play a crucial role in maintaining tissue regenerative capacity and homeostasis. However, mechanisms associated...
Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE−/− Mice on a high-fat diet
Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoE−/− Mice on a high-fat diet
The aim of this study was to explore the impact of chronic apical periodontitis (CAP) on atherosclerosis in apoE−/&#...
Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure
Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure
The consumption of a high-fat diet (HFD) has been linked to osteoporosis and an increased risk of fragility fractures. How...
METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs
METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs
Bisphosphonate-related osteonecrosis of jaw (BRONJ) is characterized by impaired osteogenic differentiation of orofacial b...
A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis
A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis
Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases, yet its association with progress...
Expert consensus on endodontic therapy for patients with systemic conditions
The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic disea...
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC
Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and shaping the tumor mi...
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) associated pain commonly predicts adverse events among patients. This clinical feature...
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
Oral submucous fibrosis (OSF) is a chronic and inflammatory mucosal disease caused by betel quid chewing, which belongs to...
Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis
Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis
A decline in mucosal vascularity is a histological hallmark of oral submucous fibrosis (OSF), a premalignant disease that ...
Digital pathology-based artificial intelligence models for differential diagnosis and prognosis of sporadic odontogenic keratocysts
Digital pathology-based artificial intelligence models for differential diagnosis and prognosis of sporadic odontogenic keratocysts
Odontogenic keratocyst (OKC) is a common jaw cyst with a high recurrence rate. OKC combined with basal cell carcinoma as w...
The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis
The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis
The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectio...
Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss
Tim4 deficiency reduces CD301b+ macrophage and aggravates periodontitis bone loss
Periodontitis is a common chronic inflammatory disease that causes the periodontal bone destruction and may ultimately res...
The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats
The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats
The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth mov...
Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma
Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma
Ameloblastoma is a benign tumor characterized by locally invasive phenotypes, leading to facial bone destruction and a hig...
Expert consensus on difficulty assessment of endodontic therapy
Endodontic diseases are a kind of chronic infectious oral disease. Common endodontic treatment concepts are based on the r...
Expert consensus on irrigation and intracanal medication in root canal therapy
Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant ...
Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral
Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral
Ameloblasts are specialized cells derived from the dental epithelium that produce enamel, a hierarchically structured tiss...
Expert consensus on digital guided therapy for endodontic diseases
Expert consensus on digital guided therapy for endodontic diseases
Digital guided therapy (DGT) has been advocated as a contemporary computer-aided technique for treating endodontic disease...
Dental impact of anti-fibroblast growth factor 23 therapy in X-linked hypophosphatemia
Dental impact of anti-fibroblast growth factor 23 therapy in X-linked hypophosphatemia
Elevated fibroblast growth factor 23 (FGF23) in X-linked hypophosphatemia (XLH) results in rickets and phosphate wasting, ...
Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function
Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function
Periodontitis is caused by overactive osteoclast activity that results in the loss of periodontal supporting tissue and me...
Molecular mechanisms of cellular metabolic homeostasis in stem cells
Molecular mechanisms of cellular metabolic homeostasis in stem cells
Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-r...
Titanium particles in peri-implantitis: distribution, pathogenesis and prospects
Titanium particles in peri-implantitis: distribution, pathogenesis and prospects
Peri-implantitis is one of the most important biological complications in the field of oral implantology. Identifying the ...
Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny
Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny
Tooth root development involves intricate spatiotemporal cellular dynamics and molecular regulation. The initiation of Her...
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