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Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression
Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression
The incidence of atherosclerosis markedly rises following menopause. Our previous findings demonstrated that elevated foll...
Autophagy: a double-edged sword in ischemia–reperfusion injury
Autophagy: a double-edged sword in ischemia–reperfusion injury
Ischemia–reperfusion (I/R) injury describes the pathological process wherein tissue damage, initially caused by insu...
IGF2BP2: an m6A reader that affects cellular function and disease progression
IGF2BP2: an m6A reader that affects cellular function and disease progression
Insulin-like growth factor 2 messenger RNA (mRNA)-binding protein 2 (IGF2BP2) is a widely studied N6-methyladenosine (m6A)...
Repression of ZNFX1 by LncRNA ZFAS1 mediates tobacco-induced pulmonary carcinogenesis
Repression of ZNFX1 by LncRNA ZFAS1 mediates tobacco-induced pulmonary carcinogenesis
Despite exhaustive research efforts, integrated genetic and epigenetic mechanisms contributing to tobacco-induced initiati...
Troxerutin suppresses the stemness of osteosarcoma via the CD155/SRC/β-catenin signaling axis
Troxerutin suppresses the stemness of osteosarcoma via the CD155/SRC/β-catenin signaling axis
Osteosarcoma is the most prevalent primary malignant bone tumor affecting pediatric and adolescent individuals. However, d...
Tetraspanin 3 promotes NSCLC cell proliferation via regulation of β1 integrin intracellular recycling
Tetraspanin 3 promotes NSCLC cell proliferation via regulation of β1 integrin intracellular recycling
The involvement of tetraspanins in cancer development has been widely implicated. In this study, the function and molecula...
The role and therapeutic potential of itaconate in lung disease
The role and therapeutic potential of itaconate in lung disease
Lung diseases triggered by endogenous or exogenous factors have become a major concern, with high morbidity and mortality ...
Endometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification
Endometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification
Acute transplant rejection is a major component of poor prognoses for organ transplantation. Owing to the multiple complex...
Caspase-8 in inflammatory diseases: a potential therapeutic target
Caspase-8 in inflammatory diseases: a potential therapeutic target
Caspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially garnered attention for its regulatory...
Research progress of ankyrin repeat domain 1 protein: an updated review
Research progress of ankyrin repeat domain 1 protein: an updated review
Ankyrin repeat domain 1 (Ankrd1) is an acute response protein that belongs to the muscle ankyrin repeat protein (MARP) fam...
APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling
APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and apolipoprotein E (APOE) genotypes (APOE2, AP...
ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway
ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway
The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting e...
CircR-loop: a novel RNA:DNA interaction on genome instability
CircR-loop: a novel RNA:DNA interaction on genome instability
CircR-loop, a recently unearthed regulatory mechanism situated at the crossroads of circular RNA and DNA interactions, con...
α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway
α-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4/SLC7A11/GPX4 signaling pathway
Osteoarthritis (OA) is the most common degenerative joint disorder that causes disability in aged individuals, caused by f...
Cuproptosis in cancer: biological implications and therapeutic opportunities
Cuproptosis in cancer: biological implications and therapeutic opportunities
Cuproptosis, a newly identified copper (Cu)-dependent form of cell death, stands out due to its distinct mechanism that se...
The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds
The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds
Chronic nonhealing wounds remain a considerable challenge in clinical treatment due to excessive inflammation and impeded ...
CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA
CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA
Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RN...
High-content image screening to identify chemical modulators for peroxisome and ferroptosis
High-content image screening to identify chemical modulators for peroxisome and ferroptosis
The peroxisome is a dynamic organelle with variety in number, size, shape, and activity in different cell types and physio...
The ancestral type of the R-RAS protein has oncogenic potential
The ancestral type of the R-RAS protein has oncogenic potential
The R-RAS2 is a small GTPase highly similar to classical RAS proteins at the regulatory and signaling levels. The high evo...
N6-methyladenosine-modified circ_104797 sustains cisplatin resistance in bladder cancer through acting as RNA sponges
N6-methyladenosine-modified circ_104797 sustains cisplatin resistance in bladder cancer through acting as RNA sponges
Bladder cancer (BCa) ranks among the predominant malignancies affecting the urinary system. Cisplatin (CDDP) remains a cor...
Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
Acute respiratory distress syndrome (ARDS) is a disease with high mortality and morbidity. Regulator of G protein signalin...
METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis
METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis
The deer antler, a remarkable mammalian appendage, has a growth rate surpassing that of any other known osseous organ. Eme...
Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease
Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease
Alzheimer’s disease (AD) is a chronic illness marked by increasing cognitive decline and nervous system deterioratio...
Metabolite itaconate in host immunoregulation and defense
Metabolite itaconate in host immunoregulation and defense
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune ce...
Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study
Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study
This study aims to explore the emerging trends, dynamic development, and research hotspots of clustered regularly interspa...
Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
PSA is a type of proto-oncogene that is specifically and highly expressed in embryonic and prostate cancer cells, but not ...
Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
Arachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been&nb...
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
Periostin is an extracellular matrix protein that plays a critical role in cell fate determination and tissue remodeling, ...
Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis
Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis
Long-term exposure of humans to air pollution is associated with an increasing risk of cardiovascular diseases (CVDs). Ast...
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