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The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds
The direct binding of bioactive peptide Andersonin-W1 to TLR4 expedites the healing of diabetic skin wounds
Chronic nonhealing wounds remain a considerable challenge in clinical treatment due to excessive inflammation and impeded ...
CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA
CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA
Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RN...
High-content image screening to identify chemical modulators for peroxisome and ferroptosis
High-content image screening to identify chemical modulators for peroxisome and ferroptosis
The peroxisome is a dynamic organelle with variety in number, size, shape, and activity in different cell types and physio...
The ancestral type of the R-RAS protein has oncogenic potential
The ancestral type of the R-RAS protein has oncogenic potential
The R-RAS2 is a small GTPase highly similar to classical RAS proteins at the regulatory and signaling levels. The high evo...
N6-methyladenosine-modified circ_104797 sustains cisplatin resistance in bladder cancer through acting as RNA sponges
N6-methyladenosine-modified circ_104797 sustains cisplatin resistance in bladder cancer through acting as RNA sponges
Bladder cancer (BCa) ranks among the predominant malignancies affecting the urinary system. Cisplatin (CDDP) remains a cor...
Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
Acute respiratory distress syndrome (ARDS) is a disease with high mortality and morbidity. Regulator of G protein signalin...
METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis
METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis
The deer antler, a remarkable mammalian appendage, has a growth rate surpassing that of any other known osseous organ. Eme...
Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease
Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease
Alzheimer’s disease (AD) is a chronic illness marked by increasing cognitive decline and nervous system deterioratio...
Metabolite itaconate in host immunoregulation and defense
Metabolite itaconate in host immunoregulation and defense
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune ce...
Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study
Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study
This study aims to explore the emerging trends, dynamic development, and research hotspots of clustered regularly interspa...
Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
PSA is a type of proto-oncogene that is specifically and highly expressed in embryonic and prostate cancer cells, but not ...
Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
Arachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been&nb...
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
Periostin is an extracellular matrix protein that plays a critical role in cell fate determination and tissue remodeling, ...
Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis
Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis
Long-term exposure of humans to air pollution is associated with an increasing risk of cardiovascular diseases (CVDs). Ast...
N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2′-O methylation
N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2′-O methylation
The unique expression pattern endows oncofetal genes with great value in cancer diagnosis and treatment. However, only a f...
Cellular senescence in skeletal disease: mechanisms and treatment
Cellular senescence in skeletal disease: mechanisms and treatment
The musculoskeletal system supports the movement of the entire body and provides blood production while acting as an endoc...
GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells
GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells
The pulmonary surfactant that lines the air–liquid surface within alveoli is a protein–lipid mixture essential...
Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury
Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury
To investigate the mechanism of action of Srg3 in acute lung injury caused by sepsis. First, a sepsis-induced acute lung i...
Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1/p38-MAPK axis
Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1/p38-MAPK axis
Hypervirulent Klebsiella pneumoniae (hvKp) infection-induced sepsis-associated acute lung injury (ALI) has emerged as a si...
Retraction Note: MicroRNA-325-3p inhibits cell proliferation and induces apoptosis in hepatitis B virusrelated hepatocellular carcinoma by downregulation of aquaporin 5
Retraction Note: MicroRNA-325-3p inhibits cell proliferation and induces apoptosis in hepatitis B virusrelated hepatocellular carcinoma by downregulation of aquaporin 5
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction
Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction
Ubiquitin–proteasome-system-mediated clearance of misfolded proteins is essential for cells to maintain proteostasis...
Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer
Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer
Mitochondrial transfer regulates intercellular communication, and mitochondria regulate cell metabolism and cell survival....
A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells
A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells
Zinc finger protein X-linked (ZFX) has been shown to promote the growth of tumor cells, including leukemic cells. However,...
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
The mitochondrial gene MCCC2, a subunit of the heterodimer of 3-methylcrotonyl-CoA carboxylase, plays a pivotal role in ca...
N6-methyladenosine modification—a key player in viral infection
N6-methyladenosine modification—a key player in viral infection
N6-methyladenosine (m6A) modification is a dynamic, reversible process and is the most prevalent internal modification of ...
Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice
Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice
Lupus nephritis (LN) is associated with significant mortality and morbidity, while effective therapeutics and biomarkers a...
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
Hepatic fibrosis is a common consequence of chronic liver diseases without approved antifibrotic therapies. Long noncoding...
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
During aging and after traumatic injuries, cartilage and bone cells are exposed to various pathophysiologic mediators, inc...
Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
Osteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main pathological change, is the ...
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