Cuestas Torres DM, Cardenas FP. Synaptic plasticity in Alzheimer’s disease and healthy aging. Rev Neurosci. 2020;31:245–68.
Hampel H, Mesulam MM, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, et al. The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease. Brain. 2018;141:1917–33.
Article PubMed PubMed Central Google Scholar
2023 Alzheimer’s disease facts and figures. Alzheimers Dement. 2023;19:1598–695.
Loera‐Valencia R, Cedazo‐Minguez A, Kenigsberg PA, Page G, Duarte AI, Giusti P, et al. Current and emerging avenues for Alzheimer’s disease drug targets. J Intern Med. 2019;286:398–437.
Luo ZH, Wang YC, Pang S, Gao S, Liu N, Gao X, et al. Synthesis and bioactivity evaluation of a Novel 1,2,4-Oxadiazole derivative in vitro and in 3×Tg mice. Drug Des Dev Ther. 2022;16:3285–96.
Masters CL, Bateman R, Blennow K, Rowe CC, Sperling RA, Cummings JL. Alzheimer’s disease. Nat Rev Dis Prim. 2015;1:15056.
Kaushik M, Kaushik P, Parvez S. Memory related molecular signatures: The pivots for memory consolidation and Alzheimer’s related memory decline. Ageing Res Rev. 2022;76:101577.
Article CAS PubMed Google Scholar
Su LD, Wang N, Han JH, Shen Y. Group 1 Metabotropic Glutamate receptors in neurological and psychiatric diseases: mechanisms and prospective. Neuroscientist. 2022;28:453–68.
Article CAS PubMed Google Scholar
Dal Prà I, Armato U, Chiarini A. Family C G-protein-coupled receptors in Alzheimer’s disease and therapeutic implications. Front Pharmacol. 2019;10:1282.
Article PubMed PubMed Central Google Scholar
Ferraguti F, Crepaldi L, Nicoletti F. Metabotropic glutamate 1 receptor: current concepts and perspectives. Pharmacol Rev. 2008;60:536–81.
Article CAS PubMed Google Scholar
Hendawy OM. A comprehensive review of recent advances in the biological activities of 1,2,4‐oxadiazoles. Arch der Pharmazie. 2022;355:e2200045.
Biernacki K, Daśko M, Ciupak O, Kubiński K, Rachon J, Demkowicz S. Novel 1,2,4-Oxadiazole derivatives in drug discovery. Pharmaceuticals. 2020;13:111.
Article CAS PubMed PubMed Central Google Scholar
Pang S, Li SY, Cheng HZ, Luo ZH, Qi XL, Guan FF, et al. Discovery of an evodiamine derivative for PI3K/AKT/GSK3β pathway activation and AD pathology improvement in mouse models. Front Mol Neurosci. 2023;15:1025066.
Article PubMed PubMed Central Google Scholar
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, et al. Triple-transgenic model of Alzheimer’s disease with plaques and tangles. Neuron. 2003;39:409–21.
Article CAS PubMed Google Scholar
Webster SJ, Bachstetter AD, Nelson PT, Schmitt FA, Van Eldik LJ. Using mice to model Alzheimer’s dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models. Front Genet. 2014;5:88.
Article PubMed PubMed Central Google Scholar
Du F. Golgi‐Cox staining of neuronal dendrites and dendritic spines with FD Rapid GolgiStain™ Kit. Curr Protoc Neurosci. 2019;88:e69.
Pang S, Luo ZH, Dong W, Gao S, Chen W, Liu N, et al. Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats. Life Sci Alliance. 2022;6:e202201616.
Article PubMed PubMed Central Google Scholar
Dunaevsky A, Risher WC, Ustunkaya T, Singh Alvarado J, Eroglu C. Rapid Golgi analysis method for efficient and unbiased classification of dendritic spines. PLoS One. 2014;9:e107591.
Gao Y, Pei C, Sun XY, Zhang C, Li L, Kong XR. Plasmid pcDNA3.1-s11 constructed based on the S11 segment of grass carp reovirus as DNA vaccine provides immune protection. Vaccine. 2018;36:3613–21.
Article CAS PubMed Google Scholar
Konno T, Melo EP, Chambers JE, Avezov E. Intracellular sources of ROS/H2O2 in health and neurodegeneration: spotlight on endoplasmic reticulum. Cells. 2021;10:233.
Article CAS PubMed PubMed Central Google Scholar
Chen C, Xu D, Zhang ZH, Jia SZ, Cao XC, Chen YB, et al. Cognitive improvement and synaptic deficit attenuation by a multifunctional carbazole-based cyanine in AD mice model through regulation of Ca2+/CaMKII/CREB signaling pathway. Exp Neurol. 2020;327:113210.
Article CAS PubMed Google Scholar
Min D, Guo F, Zhu S, Xu XX, Mao XY, Cao YG, et al. The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer’s disease and vascular dementia. Neurosci Lett. 2013;538:60–5.
Article CAS PubMed Google Scholar
Qin Z, Shi DD, Li WQ, Cheng D, Zhang YD, Zhang S, et al. Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption. J Neuroinflamm. 2023;20:54.
Sanyal S, Sandstrom DJ, Hoeffer CA, Ramaswami M. AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila. Nature. 2002;416:870–674.
Article CAS PubMed Google Scholar
Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS, Boss JM, et al. Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell. 2004;119:1041–54.
Yu JJ, Xie XG, Ma YB, Yang Y, Wang C, Xia GL, et al. Effects and potential mechanism of Ca2+/calmodulin‑dependent protein kinase II pathway inhibitor KN93 on the development of ovarian follicle. Int J Mol Med. 2022;50:121.
Article CAS PubMed PubMed Central Google Scholar
Ni YJ, Deng J, Bai HY, Liu C, Liu X, Wang XF. CaMKII inhibitor KN‐93 impaired angiogenesis and aggravated cardiac remodelling and heart failure via inhibiting NOX2/mtROS/p‐VEGFR2 and STAT3 pathways. J Cell Mol Med. 2022;26:312–25.
Article CAS PubMed Google Scholar
Wang HB, Wang WQ, Wu QJ, Hou YJ, Li HX, Yang HJ, et al. Negative Allosteric modulator of mGluR1 improves long-term neurologic deficits after experimental subarachnoid hemorrhage. ACS Chem Neurosci. 2020;11:2869–80.
Article CAS PubMed Google Scholar
Lavreysen H, Wouters R, Bischoff F, Nóbrega Pereira S, Langlois X, Blokland S, et al. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology. 2004;47:961–72.
Article CAS PubMed Google Scholar
Wang JJ, Sun W, Jia WD, Bian M, Yu LJ. Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review. J Enzym Inhibit Med Chem. 2022;37:2304–19.
Saeedi M, Mehranfar F. Challenges and approaches of drugs such as memantine, donepezil, rivastigmine, and aducanumab in the treatment, control and management of Alzheimer’s disease. Recent Pat Biotechnol. 2022;16:102–21.
Article CAS PubMed Google Scholar
Querfurth HW, LaFerla FM. Alzheimer’s disease. N Engl J Med. 2010;362:329–44.
Article CAS PubMed Google Scholar
Varadharajan A, Davis AD, Ghosh A, Jagtap T, Xavier A, Menon AJ, et al. Guidelines for pharmacotherapy in Alzheimer’s disease - A primer on FDA-approved drugs. J Neurosci Rural Pr. 2023;14:566–73.
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