Schonmann Y, Mansfield KE, Hayes JF, Abuabara K, Roberts A, Smeeth L, et al. Atopic eczema in adulthood and risk of depression and anxiety: a population-based cohort study. J Allergy Clin Immunol Pract. 2020;8:248–57.e16.

Article  PubMed  PubMed Central  Google Scholar 

Patel KR, Immaneni S, Singam V, Rastogi S, Silverberg JI. Association between atopic dermatitis, depression, and suicidal ideation: a systematic review and meta-analysis. J Am Acad Dermatol. 2019;80:402–10.

Article  PubMed  Google Scholar 

Umehara Y, Kiatsurayanon C, Trujillo-Paez JV, Chieosilapatham P, Peng G, Yue H, et al. Intractable itch in atopic dermatitis: causes and treatments. Biomedicines. 2021;9:229.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moosa AS, Leng NSY, Kum CL, Tan NC. A qualitative research study on the illness perception of chronic pruritus in older asian adults based on the common-sense model of self-regulation. Health Expect. 2021;24:1801–11.

Article  PubMed  PubMed Central  Google Scholar 

Angley M, Drews-Botsch C, Lewis TT, Badell M, Lim SS, Howards PP. Adverse perinatal outcomes before and after diagnosis of systemic lupus erythematosus among African American women. Arthritis Care Res. 2022;74:904–11.

Article  Google Scholar 

Dong X, Dong X. Peripheral and central mechanisms of itch. Neuron. 2018;98:482–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zeng F, Zeng F, Sugiyama N, Nogami M, Murakami T. A case of rectal dissemination of gastric cancer diagnosed by simultaneous 18F-FDG PET/MRI. Clin Nucl Med. 2023;48:e441–e3.

Article  PubMed  Google Scholar 

Zheng J, Zhang XM, Tang W, Li Y, Wang P, Jin J, et al. An insular cortical circuit required for itch sensation and aversion. Curr Biol. 2024;34:1453–68.e6.

Article  CAS  PubMed  Google Scholar 

Samineni VK, Grajales-Reyes JG, Grajales-Reyes GE, Tycksen E, Copits BA, Pedersen C, et al. Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala. Elife. 2021;10:e68130.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su XY, Chen M, Yuan Y, Li Y, Guo SS, Luo HQ, et al. Central processing of itch in the midbrain reward center. Neuron. 2019;102:858–72.e5.

Article  CAS  PubMed  Google Scholar 

Chen T, Zhu SJ, Xu S, Wang YQ, Aji A, Zhang C, et al. Resting-state fMRI reveals changes within the anxiety and social avoidance circuitry of the brain in mice with psoriasis-like skin lesions. Exp Dermatol. 2023;32:1900–14.

Article  CAS  PubMed  Google Scholar 

Papoiu ADP, Kraft RA, Coghill RC, Yosipovitch G. Butorphanol suppression of histamine itch is mediated by nucleus accumbens and septal nuclei: a pharmacological fMRI study. J Invest Dermatol. 2015;135:560–8.

Article  CAS  PubMed  Google Scholar 

Pan Q, Guo SS, Chen M, Su XY, Gao ZL, Wang Q, et al. Representation and control of pain and itch by distinct prefrontal neural ensembles. Neuron. 2023;111:2414–31.e7.

Article  CAS  PubMed  Google Scholar 

Chen M, He T, Yi XH, Tang MC, Long JH, Wang PJ, et al. Infralimbic cortex-medial striatum projections modulate the itch processing. Exp Neurol. 2022;354:114101.

Article  PubMed  Google Scholar 

Zhang TT, Guo SS, Wang HY, Jing Q, Yi X, Hu ZH, et al. An anterior cingulate cortex-to-midbrain projection controls chronic itch in mice. Neurosci Bull. 2023;39:793–807.

Article  PubMed  Google Scholar 

Ziegler DR, Cullinan WE, Herman JP. Distribution of vesicular glutamate transporter mRNA in rat hypothalamus. J Comp Neurol. 2002;448:217–29.

Article  CAS  PubMed  Google Scholar 

Bai L, Xu H, Collins JF, Ghishan FK. Molecular and functional analysis of a novel neuronal vesicular glutamate transporter. J Biol Chem. 2001;276:36764–9.

Article  CAS  PubMed  Google Scholar 

Vrettou M, Granholm L, Todkar A, Nilsson KW, Wallen-Mackenzie A, Nylander I, et al. Ethanol affects limbic and striatal presynaptic glutamatergic and DNA methylation gene expression in outbred rats exposed to early-life stress. Addict Biol. 2017;22:369–80.

Article  CAS  PubMed  Google Scholar 

Vrettou M, Yan L, Nilsson KW, Wallen-Mackenzie A, Nylander I, Comasco E. DNA methylation of vesicular glutamate transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study. Sci Rep. 2021;11:15322.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mao X, Staiger JF. Multimodal cortical neuronal cell type classification. Pflug Arch. 2024;476:721–33.

Article  CAS  Google Scholar 

Huang ZJ. Toward a genetic dissection of cortical circuits in the mouse. Neuron. 2014;83:1284–302.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harris KD, Shepherd GM. The neocortical circuit: themes and variations. Nat Neurosci. 2015;18:170–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu P, Chen A, Li Y, Xing X, Lu H. Medial prefrontal cortex in neurological diseases. Physiol Genomics. 2019;51:432–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li JN, Wu XM, Zhao LJ, Sun HX, Hong J, Wu FL, et al. Central medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice. Nat Commun. 2023;14:2539.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gaffal E, Cron M, Glodde N, Bald T, Kuner R, Zimmer A, et al. Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation. J Immunol. 2013;190:4929–36.

Article  CAS  PubMed  Google Scholar 

Liu X, Li L, Jiang J, Ge W, Huang Y, Jin Z, et al. Role of type I cannabinoid receptor in sensory neurons in psoriasiform skin inflammation and pruritus. J Invest Dermatol. 2023;143:812–21.e3.

Article  CAS  PubMed  Google Scholar 

Christensen R, Kristensen PK, Bartels EM, Bliddal H, Astrup A. Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Lancet. 2007;370:1706–13.

Article  CAS  PubMed  Google Scholar 

Bilir KA, Anli G, Ozkan E, Gunduz O, Ulugol A. Involvement of spinal cannabinoid receptors in the antipruritic effects of win 55,212-2, a cannabinoid receptor agonist. Clin Exp Dermatol. 2018;43:553–8.

Article  CAS  PubMed  Google Scholar 

Lisboa SF, Borges AA, Nejo P, Fassini A, Guimaraes FS, Resstel LB. Cannabinoid Cb1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: additional evidence. Prog Neuropsychopharmacol Biol Psychiatry. 2015;59:76–83.

Article  CAS  PubMed  Google Scholar 

Imperatore R, Morello G, Luongo L, Taschler U, Romano R, De Gregorio D, et al. Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor Cb(1)R signaling and anxiety-like behavior. J Neurochem. 2015;135:799–813.

Article  CAS  PubMed  Google Scholar 

Nagy-Pal P, Veres JM, Fekete Z, Karlocai MR, Weisz F, Barabas B, et al. Structural organization of perisomatic inhibition in the mouse medial prefrontal cortex. J Neurosci. 2023;43:6972–87.

Article