Senkyunolide A ameliorates cholestatic liver fibrosis by controlling CLCC1-mediated endoplasmic reticulum Ca2+ release

Chiang JYL, Ferrell JM. Bile acid biology, pathophysiology, and therapeutics. Clin Liver Dis. 2020;15:91–4.

Google Scholar 

Hasegawa S, Yoneda M, Kurita Y, Nogami A, Honda Y, Hosono K, et al. Cholestatic liver disease: current treatment strategies and new therapeutic agents. Drugs. 2021;81:1181–92.

CAS  PubMed  PubMed Central  Google Scholar 

Wu H, Chen C, Ziani S, Nelson LJ, Ávila MA, Nevzorova YA, et al. Fibrotic events in the progression of cholestatic liver disease. Cells. 2021;10:1107.

Zeng J, Fan J, Zhou H. Bile acid-mediated signaling in cholestatic liver diseases. Cell Biosci. 2023;13:77.

CAS  PubMed  PubMed Central  Google Scholar 

Xu YN, Xu W, Zhang X, Wang DY, Zheng XR, Liu W, et al. BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction. Stem Cell Res Ther. 2023;14:45.

CAS  PubMed  PubMed Central  Google Scholar 

Mavila N, Siraganahalli Eshwaraiah M, Kennedy J. Ductular reactions in liver injury, regeneration, and disease progression—an overview. Cells. 2024;13:579.

Wang M, Zhang M, Fu L, Lin J, Zhou X, Zhou P, et al. Liver-targeted delivery of TSG-6 by calcium phosphate nanoparticles for the management of liver fibrosis. Theranostics. 2020;10:36–49.

CAS  PubMed  PubMed Central  Google Scholar 

Xiao WC, Zhang J, Chen SL, Shi YJ, Xiao F, An W. Alleviation of palmitic acid-induced endoplasmic reticulum stress by augmenter of liver regeneration through IP3R-controlled Ca2+ release. J Cell Physiol. 2018;233:6148–57.

CAS  PubMed  Google Scholar 

López-Neblina F, Toledo-Pereyra LH, Toledo AH, Walsh J. Ryanodine receptor antagonism protects the ischemic liver and modulates TNF-alpha and IL-10. J Surg Res. 2007;140:121–8.

PubMed  Google Scholar 

Corazzari M, Gagliardi M, Fimia GM, Piacentini M. Endoplasmic reticulum stress, unfolded protein response, and cancer cell fate. Front Oncol. 2017;7:78.

PubMed  PubMed Central  Google Scholar 

Trampert DC, Nathanson MH. Regulation of bile secretion by calcium signaling in health and disease. Biochim Biophys Acta Mol Cell Res. 2018;1865:1761–70.

CAS  PubMed  Google Scholar 

Cai X, Yu X, Yang J, Lu L, Hua N, Duan X, et al. TRPM2 regulates cell cycle through the Ca2+-CaM-CaMKII signaling pathway to promote HCC. Hepatol Commun. 2023;7:e0101.

Patergnani S, Danese A, Bouhamida E, Aguiari G, Previati M, Pinton P, et al. Various aspects of calcium signaling in the regulation of apoptosis, autophagy, cell proliferation, and cancer. Int J Mol Sci. 2020;21:8323.

CAS  PubMed  PubMed Central  Google Scholar 

Kondratskyi A, Kondratska K, Skryma R, Klionsky DJ, Prevarskaya N. Ion channels in the regulation of autophagy. Autophagy. 2018;14:3–21.

CAS  PubMed  Google Scholar 

Zheng Q, Chen Y, Chen D, Zhao H, Feng Y, Meng Q, et al. Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites. Cell. 2022;185:4082–98.e22.

CAS  PubMed  Google Scholar 

Petrescu AD, Grant S, Williams E, Frampton G, Reinhart EH, Nguyen A, et al. Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis. Sci Rep. 2020;10:16024.

CAS  PubMed  PubMed Central  Google Scholar 

Lu L, Lu T, Wu Y, Wang Y, Ke X, Yang R. Research on the effectiveness and material basis of Ligusticum chuanxiong in alleviating acute liver injury. J Ethnopharmacol. 2023;314:116643.

CAS  PubMed  Google Scholar 

Li Y, Ma Z, Ding M, Jia K, Xu B, Zhou F, et al. Chuanxiong Rhizoma extracts prevent cholestatic liver injury by targeting H3K9ac-mediated and cholangiocyte-derived secretory protein PAI-1 and FN. Chin J Nat Med. 2023;21:694–709.

CAS  PubMed  Google Scholar 

Wu JZ, Li YJ, Huang GR, Xu B, Zhou F, Liu RP, et al. Mechanisms exploration of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma herb-pair for liver fibrosis prevention based on network pharmacology and experimental pharmacology. Chin J Nat Med. 2021;19:241–54.

CAS  PubMed  Google Scholar 

Li Y, Li F, Ding M, Ma Z, Li S, Qu J, et al. Chuanxiong Rhizoma extracts prevent liver fibrosis via targeting CTCF-c-MYC-H19 pathway. Chin Herb Med. 2024;16:82–93.

CAS  PubMed  Google Scholar 

Huang Y, Ni N, Hong Y, Lin X, Feng Y, Shen L. Progress in traditional Chinese medicine for the treatment of migraine. Am J Chin Med. 2020;48:1731–48.

PubMed  Google Scholar 

Shao M, Lv D, Zhou K, Sun H, Wang Z. Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway. Pharm Biol. 2022;60:535–42.

CAS  PubMed  PubMed Central  Google Scholar 

Lei W, Deng YF, Hu XY, Ni JN, Jiang M, Bai G. Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-κB expression. Biomed Pharmacother. 2019;117:109074.

CAS  PubMed  Google Scholar 

Duan S, Li X, Han J, Yang Y, Luo R, Cai Y, et al. Transcriptotype-driven discovery of apigenin as a therapy against cholestatic liver fibrosis: through inhibition of PANoptosis and following type-I interferon responses. Antioxidants. 2024;13:256.

CAS  PubMed  PubMed Central  Google Scholar 

Li X, Liu R, Yang J, Sun L, Zhang L, Jiang Z, et al. The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice. Hepatology. 2017;66:869–84.

CAS  PubMed  Google Scholar 

Ji R, Chen J, Xie Y, Dou X, Qing B, Liu Z, et al. Multi-omics profiling of cholangiocytes reveals sex-specific chromatin state dynamics during hepatic cystogenesis in polycystic liver disease. J Hepatol. 2023;78:754–69.

CAS  PubMed  Google Scholar 

Jia K, Zhang Y, Luo R, Liu R, Li Y, Wu J, et al. Acteoside ameliorates hepatic ischemia-reperfusion injury via reversing the senescent fate of liver sinusoidal endothelial cells and restoring compromised sinusoidal networks. Int J Biol Sci. 2023;19:4967–88.

CAS  PubMed  PubMed Central  Google Scholar 

Hu Y, Bao X, Zhang Z, Chen L, Liang Y, Qu Y, et al. Hepatic progenitor cell-originated ductular reaction facilitates liver fibrosis through activation of hedgehog signaling. Theranostics. 2024;14:2379–95.

CAS  PubMed  PubMed Central  Google Scholar 

Alpini G, Glaser SS, Ueno Y, Rodgers R, Phinizy JL, Francis H, et al. Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion. Gastroenterology. 1999;116:179–86.

CAS  PubMed  Google Scholar 

Wang Y, Aoki H, Yang J, Peng K, Liu R, Li X, et al. The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. Hepatology. 2017;65:2005–18.

CAS  PubMed  Google Scholar 

Santos-Laso A, Izquierdo-Sanchez L, Rodrigues PM, Huang BQ, Azkargorta M, Lapitz A, et al. Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: new therapeutic targets. Liver Int. 2020;40:1670–85.

CAS  PubMed  PubMed Central  Google Scholar 

Che Y, Xu W, Ding C, He T, Xu X, Shuai Y, et al. Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions. Cell Rep. 2023;42:112011.

CAS  PubMed  Google Scholar 

Hu M, Feng X, Liu Q, Liu S, Huang F, Xu H. The ion channels of endomembranes. Physiol Rev. 2024;104:1335–85.

CAS  PubMed  PubMed Central  Google Scholar 

Filadi R, Greotti E, Pizzo P. Highlighting the endoplasmic reticulum-mitochondria connection: focus on Mitofusin 2. Pharmacol Res. 2018;128:42–51.

CAS  PubMed  Google Scholar 

Park JH, Kim HK, Jung H, Kim KH, Kang MS, Hong JH, et al. NecroX-5 prevents breast cancer metastasis by AKT inhibition via reducing intracellular calcium levels. Int J Oncol. 2017;50:185–92.

CAS  PubMed  Google Scholar 

Guo L, Mao Q, He J, Liu X, Piao X, Luo L, et al. Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies. Cell Res. 2023;33:497–515.

CAS  PubMed  PubMed Central  Google Scholar 

Banales JM, Huebert RC, Karlsen T, Strazzabosco M, LaRusso NF, Gores GJ. Cholangiocyte pathobiology. Nat Rev Gastroenterol Hepatol. 2019;16:269–81.

PubMed  PubMed Central  Google Scholar 

Arruda AP, Hotamisligil GS. Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes. Cell Metab. 2015;22:381–97.

CAS  PubMed  PubMed Central 

Comments (0)

No login
gif