Shi DD, Zhang YD, Ren YY, Peng SY, Yuan TF, Wang Z. Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats. Mol Psychiatry. 2021;26:7296–307.
Article CAS PubMed Google Scholar
Wang M, Perova Z, Arenkiel BR, Li B. Synaptic modifications in the medial prefrontal cortex in susceptibility and resilience to stress. J Neurosci. 2014;34:7485–92.
Article CAS PubMed PubMed Central Google Scholar
Radley JJ, Rocher AB, Rodriguez A, Ehlenberger DB, Dammann M, McEwen BS, et al. Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex. J Comp Neurol. 2008;507:1141–50.
Article PubMed PubMed Central Google Scholar
Qu Y, Yang C, Ren Q, Ma M, Dong C, Hashimoto K. Regional differences in dendritic spine density confer resilience to chronic social defeat stress. Acta Neuropsychiatr. 2018;30:117–22.
Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR 3rd, et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 2013;155:1596–609.
Article CAS PubMed PubMed Central Google Scholar
Yao W, Cao Q, Luo S, He L, Yang C, Chen J, et al. Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine. Mol Psychiatry. 2022;27:1618–29.
Article CAS PubMed Google Scholar
Allen NJ, Eroglu C. Cell Biology of Astrocyte-Synapse Interactions. Neuron. 2017;96:697–708.
Article CAS PubMed PubMed Central Google Scholar
Xie Y, Kuan AT, Wang W, Herbert ZT, Mosto O, Olukoya O, et al. Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development. Cell Rep. 2022;38:110416.
Article CAS PubMed PubMed Central Google Scholar
Cao X, Li LP, Wang Q, Wu Q, Hu HH, Zhang M, et al. Astrocyte-derived ATP modulates depressive-like behaviors. Nat Med. 2013;19:773–7.
Article CAS PubMed Google Scholar
Du Preez A, Onorato D, Eiben I, Musaelyan K, Egeland M, Zunszain PA, et al. Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice. Brain Behav Immun. 2021;91:24–47.
Re GF, Li H, Yang JQ, Li Y, Zhang Z, Wu X, et al. Exercise modulates central and peripheral inflammatory responses and ameliorates methamphetamine-induced anxiety-like symptoms in mice. Front Mol Neurosci. 2022;15:955799.
Article CAS PubMed PubMed Central Google Scholar
Hughes SM, Lillien LE, Raff MC, Rohrer H, Sendtner M. Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture. Nature. 1988;335:70–3.
Article CAS PubMed Google Scholar
Trentin AG, De Aguiar CB, Garcez RC, Alvarez-Silva M. Thyroid hormone modulates the extracellular matrix organization and expression in cerebellar astrocyte: effects on astrocyte adhesion. Glia. 2003;42:359–69.
García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, et al. Astrocytic insulin signaling couples brain glucose uptake with nutrient availability. Cell. 2016;166:867–80.
Article PubMed PubMed Central Google Scholar
Timper K, Del Río-Martín A, Cremer AL, Bremser S, Alber J, Giavalisco P, et al. GLP-1 receptor signaling in astrocytes regulates fatty acid oxidation, mitochondrial integrity, and function. Cell Metab. 2020;31:1189–1205.e1113.
Article CAS PubMed PubMed Central Google Scholar
Müller W, Heinemann U, Berlin K. Cholecystokinin activates CCKB-receptor-mediated Ca-signaling in hippocampal astrocytes. J Neurophysiol. 1997;78:1997–2001.
Anderberg RH, Richard JE, Hansson C, Nissbrandt H, Bergquist F, Skibicka KP. GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality. Psychoneuroendocrinology. 2016;65:54–66.
Article CAS PubMed Google Scholar
Singh L, Lewis AS, Field MJ, Hughes J, Woodruff GN. Evidence for an involvement of the brain cholecystokinin B receptor in anxiety. Proc Natl Acad Sci USA. 1991;88:1130–3.
Article CAS PubMed PubMed Central Google Scholar
Zhang H, Sun Y, Yau SY, Zhou Y, Song X, Zhang HT, et al. Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up-regulating hippocampal PACAP signalling. Br J Pharmacol. 2022;179:4078–91.
Article CAS PubMed Google Scholar
Joo KM, Chung YH, Kim MK, Nam RH, Lee BL, Lee KH, et al. Distribution of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors (VPAC1, VPAC2, and PAC1 receptor) in the rat brain. J Comp Neurol. 2004;476:388–413.
Article CAS PubMed Google Scholar
Oliveira JF, Araque A. Astrocyte regulation of neural circuit activity and network states. Glia. 2022;70:1455–66.
Article CAS PubMed PubMed Central Google Scholar
Lezmy J. How astrocytic ATP shapes neuronal activity and brain circuits. Curr Opin Neurobiol. 2023;79:102685.
Article CAS PubMed Google Scholar
Bonvento G, Bolaños JP. Astrocyte-neuron metabolic cooperation shapes brain activity. Cell Metab. 2021;33:1546–64.
Article CAS PubMed Google Scholar
Wu Z, He K, Chen Y, Li H, Pan S, Li B, et al. A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo. Neuron. 2022;110:770–782.e775.
Article CAS PubMed Google Scholar
Lezmy J, Arancibia-Cárcamo IL, Quintela-López T, Sherman DL, Brophy PJ, Attwell D. Astrocyte Ca2+-evoked ATP release regulates myelinated axon excitability and conduction speed. Science. 2021;374:eabh2858.
Article CAS PubMed PubMed Central Google Scholar
Ryu JK, Kim J, Choi SH, Oh YJ, Lee YB, Kim SU, et al. ATP-induced in vivo neurotoxicity in the rat striatum via P2 receptors. Neuroreport. 2002;13:1611–5.
Article CAS PubMed Google Scholar
Arimura A, Somogyvari-Vigh A, Weill C, Fiore RC, Tatsuno I, Bay V, et al. PACAP functions as a neurotrophic factor. Ann N. Y Acad Sci. 1994;739:228–43.
Article CAS PubMed Google Scholar
Shioda S, Ohtaki H, Nakamachi T, Dohi K, Watanabe J, Nakajo S, et al. Pleiotropic functions of PACAP in the CNS: neuroprotection and neurodevelopment. Ann N. Y Acad Sci. 2006;1070:550–60.
Article CAS PubMed Google Scholar
Velasco ER, Florido A, Flores Á, Senabre E, Gomez-Gomez A, Torres A, et al. PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus. Nat Commun. 2022;13:4374.
Article CAS PubMed PubMed Central Google Scholar
Lee EY, Chan LC, Wang H, Lieng J, Hung M, Srinivasan Y, et al. PACAP is a pathogen-inducible resident antimicrobial neuropeptide affording rapid and contextual molecular host defense of the brain. Proc Natl Acad Sci USA 2021;118:e1917623117.
Le N, Sayers S, Mata-Pacheco V, Wagner EJ. The PACAP paradox: dynamic and surprisingly pleiotropic actions in the central regulation of energy homeostasis. Front Endocrinol (Lausanne). 2022;13:877647.
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