Drugs and Healthy Aging

2024 World Population Data Sheet. Washington, DC: Population Reference Bureau; 2024. Available from: https://2024-wpds.prb.org/. Accessed 3 Mar 2025.

Lenfant C. Shattuck lecture—clinical research to clinical practice—lost in translation? N Engl J Med. 2003;349(9):868–74.

PubMed  Google Scholar 

Payne CF. Expansion, compression, neither, both? Divergent patterns in healthy, disability-free, and morbidity-free life expectancy across US birth cohorts, 1998–2016. Demography. 2022;59(3):949–73.

PubMed  Google Scholar 

Fries JF. Aging, natural death, and the compression of morbidity. N Engl J Med. 1980;303(3):130–5.

CAS  PubMed  Google Scholar 

Michel JP, Sadana R. “Healthy aging” concepts and measures. J Am Med Dir Assoc. 2017;18(6):460–4.

PubMed  Google Scholar 

Beard JR, Officer A, de Carvalho IA, Sadana R, Pot AM, Michel JP, et al. The World report on ageing and health: a policy framework for healthy ageing. Lancet. 2016;387(10033):2145–54.

PubMed  Google Scholar 

Cherubini A, Denkinger M, Knol W, Gudmundsson A. How to improve drug evaluation in older patients: the perspective of the European Geriatric Medicine Society (EuGMS). J Am Geriatr Soc. 2024;72(9):2928–32.

PubMed  Google Scholar 

Hilmer SN, Schwartz J, Petrovic M, Walker LE, Thurmann P, Le Couteur DG. Addressing the gaps in evaluation of new drugs for older adults: strategies from the International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee. J Am Geriatr Soc. 2024;72(9):2942–50.

Lombardi F, Paoletti L, Carrieri B, Dell’Aquila G, Fedecostante M, Di Muzio M, et al. Underprescription of medications in older adults: causes, consequences and solutions—a narrative review. Eur Geriatr Med. 2021;12(3):453–62.

CAS  PubMed  Google Scholar 

Hilmer SN, Gnjidic D. The effects of polypharmacy in older adults. Clin Pharmacol Ther. 2009;85(1):86–8.

CAS  PubMed  Google Scholar 

Olshansky SJ, Willcox BJ, Demetrius L, Beltran-Sanchez H. Implausibility of radical life extension in humans in the twenty-first century. Nat Aging. 2024;4(11):1635–42.

Christensen K, Doblhammer G, Rau R, Vaupel JW. Ageing populations: the challenges ahead. Lancet. 2009;374(9696):1196–208.

PubMed  PubMed Central  Google Scholar 

Sierra F. The emergence of geroscience as an interdisciplinary approach to the enhancement of health span and life span. Cold Spring Harb Perspect Med. 2016;6(4): a025163.

PubMed  PubMed Central  Google Scholar 

Wu H, Le Couteur DG, Hilmer SN. Mortality trends of stroke and dementia: changing landscapes and new challenges. J Am Geriatr Soc. 2021;69(10):2888–98.

PubMed  Google Scholar 

Nanna MG, Abdullah A, Mortensen MB, Navar AM. Primary prevention statin therapy in older adults. Curr Opin Cardiol. 2023;38(1):11–20.

PubMed  Google Scholar 

Force USPST, Mangione CM, Barry MJ, Nicholson WK, Cabana M, Chelmow D, et al. Statin use for the primary prevention of cardiovascular disease in adults: US Preventive Services Task Force recommendation statement. JAMA. 2022;328(8):746–53.

Google Scholar 

Taylor F, Huffman MD, Macedo AF, Moore TH, Burke M, Davey Smith G, et al. Statins for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013;2013(1):CD004816.

PubMed  PubMed Central  Google Scholar 

Marcellaud E, Jost J, Tchalla A, Magne J, Aboyans V. Statins in primary prevention in people over 80 years. Am J Cardiol. 2023;187:62–73.

CAS  PubMed  Google Scholar 

Peixoto C, Choudhri Y, Francoeur S, McCarthy LM, Fung C, Dowlatshahi D, et al. Discontinuation versus continuation of statins: a systematic review. J Am Geriatr Soc. 2024;72(11):3567–87.

PubMed  Google Scholar 

Pilleron S, Bastiaannet E. Epidemiology of cancer in older adults: a systematic review. Curr Oncol Rep. 2024;26(9):1021–46.

PubMed  Google Scholar 

White MC, Holman DM, Goodman RA, Richardson LC. Cancer risk among older adults: time for cancer prevention to go silver. Gerontologist. 2019;59(Suppl 1):S1–6.

PubMed  Google Scholar 

US Preventative Task Force, Owens DK, Davidson KW, Krist AH, Barry MJ, Cabana M, et al. Medication use to reduce risk of breast cancer: US Preventive Services Task Force recommendation statement. JAMA. 2019;322(9):857–67.

Google Scholar 

Bozkurt B. Contemporary pharmacological treatment and management of heart failure. Nat Rev Cardiol. 2024;21(8):545–55.

PubMed  Google Scholar 

Duong MH, Gnjidic D, McLachlan AJ, Sakiris MA, Goyal P, Hilmer SN. The prevalence of adverse drug reactions and adverse drug events from heart failure medications in frail older adults: a systematic review. Drugs Aging. 2022;39(8):631–43.

CAS  PubMed  PubMed Central  Google Scholar 

Sanders NA, Supiano MA, Lewis EF, Liu J, Claggett B, Pfeffer MA, et al. The frailty syndrome and outcomes in the TOPCAT trial. Eur J Heart Fail. 2018;20(11):1570–7.

CAS  PubMed  Google Scholar 

Butt JH, Jhund PS, Belohlavek J, de Boer RA, Chiang CE, Desai AS, et al. Efficacy and safety of dapagliflozin according to frailty in patients with heart failure: a prespecified analysis of the DELIVER trial. Circulation. 2022;146(16):1210–24.

CAS  PubMed  PubMed Central  Google Scholar 

Dale W, Klepin HD, Williams GR, Alibhai SMH, Bergerot C, Brintzenhofeszoc K, et al. Practical assessment and management of vulnerabilities in older patients receiving systemic cancer therapy: ASCO guideline update. J Clin Oncol. 2023;41(26):4293–312.

PubMed  Google Scholar 

Eichhorst B, Robak T, Montserrat E, Ghia P, Niemann CU, Kater AP, et al. Chronic lymphocytic leukaemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021;32(1):23–33.

CAS  PubMed  Google Scholar 

Nekhlyudov L, Mollica MA, Jacobsen PB, Mayer DK, Shulman LN, Geiger AM. Developing a quality of cancer survivorship care framework: implications for clinical care, research, and policy. J Natl Cancer Inst. 2019;111(11):1120–30.

PubMed  PubMed Central  Google Scholar 

Loibl S, Andre F, Bachelot T, Barrios CH, Bergh J, Burstein HJ, et al. Early breast cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol. 2024;35(2):159–82.

CAS  PubMed  Google Scholar 

Hadji P, Aapro MS, Body JJ, Gnant M, Brandi ML, Reginster JY, et al. Management of aromatase inhibitor-associated bone loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: joint position statement of the IOF, CABS, ECTS, IEG, ESCEO IMS, and SIOG. J Bone Oncol. 2017;7:1–12.

PubMed  PubMed Central  Google Scholar 

Crocker TF, Lam N, Ensor J, Jordao M, Bajpai R, Bond M, et al. Community-based complex interventions to sustain independence in older people, stratified by frailty: a systematic review and network meta-analysis. Health Technol Assess. 2024;28(48):1–194.

PubMed  PubMed Central  Google Scholar 

Bhatt AS, Bhatt DL, Steg PG, Szarek M, Cannon CP, Leiter LA, et al. Effects of sotagliflozin on health status in patients with worsening heart failure: results from SOLOIST-WHF. J Am Coll Cardiol. 2024;84(12):1078–88.

CAS  PubMed  Google Scholar 

Birks J. Cholinesterase inhibitors for Alzheimer’s disease. Cochrane Database Syst Rev. 2006;2006(1):CD005593.

PubMed  PubMed Central  Google Scholar 

Hilmer SN, Mager DE, Simonsick EM, Cao Y, Ling SM, Windham BG, et al. A drug burden index to define the functional burden of medications in older people. Arch Intern Med. 2007;167(8):781–7.

PubMed  Google Scholar 

Liu BM, Kouladjian O’Donnell L, Redston MR, Fujita K, Thillainadesan J, Gnjidic D, et al. Association of the Drug Burden Index (DBI) exposure with outcomes: a systematic review. J Am Geriatr Soc. 2024;72(2):589–603.

PubMed  Google Scholar 

Izquierdo M, Fiatarone SM. Promoting resilience in the face of ageing and disease: the central role of exercise and physical activity. Ageing Res Rev. 2023;88: 101940.

CAS  PubMed  Google Scholar 

White R. Drugs and nutrition: how side effects can influence nutritional intake. Proc Nutr Soc. 2010;69(4):558–64.

CAS  PubMed  Google Scholar 

Langford AV, Schneider CR, Reeve E, Gnjidic D. Minimising harm and managing pain: deprescribing opioids in older adults. Drugs Aging. 2024;41(11):863–71.

PubMed  PubMed Central  Google Scholar 

Chervova O, Panteleeva K, Chernysheva E, Widayati TA, Baronik ZF, Hrbkova N, et al. Breaking new ground on human health and well-being with epigenetic clocks: a systematic review and meta-analysis of epigenetic age acceleration associations. Ageing Res Rev. 2024;102: 102552.

CAS  PubMed  Google Scholar 

Warner B, Ratner E, Datta A, Lendasse A. A systematic review of phenotypic and epigenetic clocks used for aging and mortality quantification in humans. Aging (Albany NY). 2024;16(17):12414–27.

CAS  PubMed  PubMed Central  Google Scholar 

Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194–217.

CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif