Intersociety Commission on Osteoporosis (2017) Guidelines on the Management of Osteoporosis and Fragility Fractures

Kanis JA, Norton N, Harvey NC, Jacobson T, Johansson H, Lorentzon M, McCloskey EV, Willers C, Borgström F. SCOPE 2021: a new scorecard for osteoporosis in Europe. Arch Osteoporos. 2021;16(1):82. https://doi.org/10.1007/s11657-020-00871-9.

PubMed  PubMed Central  Google Scholar 

IASP. https://www.iasp-pain.org/terminology?navItemNumber¼576#Pain. Accessed 13 Dec 2024.

Paolucci T, Saraceni VM, Piccinini G. Management of chronic pain in osteoporosis: challenges and solutions. J Pain Res. 2016;1(9):177–86.

Google Scholar 

Meints SM, Edwards RR. Evaluating psychosocial contributions to chronic pain outcomes. Prog Neuropsychopharmacol Biol Psychiatry. 2018;87(Pt B):168–82. https://doi.org/10.1016/j.pnpbp.2018.01.017. (Epub 2018 Jan 31).

CAS  PubMed  PubMed Central  Google Scholar 

Kuner R, Kuner T. Cellular circuits in the brain and their modulation in acute and chronic pain. Physiol Rev. 2021;101(1):213–58. https://doi.org/10.1152/physrev.00040.2019. (Epub 2020 Jun 11).

CAS  PubMed  Google Scholar 

Alleva J, Hudgins T, Belous J, Kristin OA. Chronic low back pain. Dis Mon. 2016;62(9):330–3. https://doi.org/10.1016/j.disamonth.2016.05.012. (Epub 2016 Jun 22).

PubMed  Google Scholar 

Ossipov MH, Morimura K, Porreca F. Descending pain modulation and chronification of pain. Curr Opin Support Palliat Care. 2014;8(2):143–51. https://doi.org/10.1097/SPC.0000000000000055.

PubMed  PubMed Central  Google Scholar 

Wang W, Wang W, Mei X, et al. Crosstalk between spinal astrocytes and neurons in nerve injury-induced neuropathic pain. PLoS ONE. 2009;4(9): e6973. https://doi.org/10.1371/journal.pone.0006973.

CAS  PubMed  PubMed Central  Google Scholar 

Catalano A, Martino G, Morabito N, Scarcella C, Gaudio A, Basile G, Lasco A. Pain in osteoporosis: from pathophysiology to therapeutic approach. Drug Aging. 2017;34(10):755–65. https://doi.org/10.1007/s40266-017-0492-4.

CAS  Google Scholar 

Clynes MA, Harvey NC, Curtis EM, Fuggle NR, Dennison EM, Cooper C. The epidemiology of osteoporosis. Br Med Bull. 2020;133(1):105–17. https://doi.org/10.1093/bmb/ldaa005.

PubMed  Google Scholar 

Van Staa TP, Dennison EM, Leufkens HG, Cooper C. Epidemiology of fractures in England and Wales. Bone. 2001;29:517–22.

PubMed  Google Scholar 

Pepe J, Agosti P, Cipriani C, Tettamanti M, Nobili A, Colangelo L, Santori R, Cilli M, Minisola S, Reposi investigators. Underdiagnosis and undertreatment of osteoporotic patients admitted in internal medicine wards in Italy between 2010 and 2016 (the REPOSI Register). Endocrine. 2021;71(2):484–93. https://doi.org/10.1007/s12020-020-02553-5.

CAS  PubMed  Google Scholar 

Catalano A, Morabito N, Basile G, Fusco S, Castagna G, Reitano F, Albanese RC, Lasco A. Fracture risk assessment in postmenopausal women referred to an Italian center for osteoporosis: a single day experience in Messina. Clin Cases Miner Bone Metab. 2013;10(3):191–4.

PubMed  Google Scholar 

Felsenberg D, Silman AJ, Lunt M, Armbrecht G, Ismail AA, Finn JD, Cockerill WC, Banzer D, Benevolenskaya LI, Bhalla A, Bruges Armas J, et al. Incidence of vertebral fracture in europe: results from the European Prospective Osteoporosis Study (EPOS). J Bone Miner Res. 2002;17:716–24.

CAS  PubMed  Google Scholar 

Li L, Bennett-Brown K, Morgan C, Dattani R. Hip fractures. Br J Hosp Med (Lond). 2020;81(8):1–10. https://doi.org/10.12968/hmed.2020.0215. Accessed 13 Dec 2024.

CAS  PubMed  Google Scholar 

Fernandez MA, Griffin XL, Costa ML. Management of hip fracture. Br Med Bull. 2015;115(1):165–72. https://doi.org/10.1093/bmb/ldv036.

CAS  PubMed  Google Scholar 

Friedman SM, Mendelson DA. Epidemiology of fragility fractures. Clin Geriatr Med. 2014;30(2):175–81. https://doi.org/10.1016/j.cger.2014.01.001. (Epub 2014 Mar 6).

PubMed  Google Scholar 

Seitz DP, Adunuri N, Gill SS, Rochon PA. Prevalence of dementia and cognitive impairment among older adults with hip fractures. J Am Med Dir Assoc. 2011;12(8):556–64.

PubMed  Google Scholar 

Royal College of Physicians. National Hip Fracture Database 2019 annual report. 2020. https://www.nhfd.co.uk/20/hipfractureR.nsf/docs/2019Report

Alsoof D, Anderson G, McDonald CL, Basques B, Kuris E, Daniels AH. Diagnosis and management of vertebral compression fracture. Am J Med. 2022;135(7):815–21.

PubMed  Google Scholar 

Hoy D, Brooks P, Blyth F, Buchbinder R. The epidemiology of low back pain. Best Pract Res Clin Rheumatol. 2010;24(6):769–81. https://doi.org/10.1016/j.berh.2010.10.002.

CAS  PubMed  Google Scholar 

Oleksik A, Lips P, Dawson A, Minshall ME, Shen W, Cooper C, Kanis J. Health-related quality of life in postmenopausal women with low BMD with or without prevalent vertebral fractures [In Process Citation]. J Bone Miner Res. 2000;15:1384–92.

CAS  PubMed  Google Scholar 

Al-Sari UA, Tobias J, Clark E. Health-related quality of life in older people with osteoporotic vertebral fractures: a systematic review and meta-analysis. Osteoporos Int. 2016;27:2891–900. https://doi.org/10.1007/s00198-016-3648-x.

CAS  PubMed  Google Scholar 

Ardoino I, Franchi C, Nobili A, Mannucci PM, Corli O, REPOSI Investigators. Pain and frailty in hospitalized older adults. Pain Ther. 2020;9(2):727–40. https://doi.org/10.1007/s40122-020-00202-3.

PubMed  PubMed Central  Google Scholar 

Shen Y, Huang X, Wu J, Lin X, Zhou X, Zhu Z, Pan X, Xu J, Qiao J, Zhang T, Ye L, Jiang H, Ren Y, Shan PF. The global burden of osteoporosis, low bone mass, and its related fracture in 204 countries and territories, 1990–2019. Front Endocrinol (Lausanne). 2022;20(13): 882241. https://doi.org/10.3389/fendo.2022.882241.

Google Scholar 

Kaji H. Interaction between muscle and bone. J Bone Metab. 2014;21(1):29–40. https://doi.org/10.11005/jbm.2014.21.1.29. (Epub 2014 Feb 28).

PubMed  PubMed Central  Google Scholar 

Vellucci R, Terenzi R, Kanis JA, et al. Understanding osteoporotic pain and its pharmacological treatment. Osteoporosis Int. 2018;29:1477–91. https://doi.org/10.1007/s00198-018-4476-y.

CAS  Google Scholar 

Iwahashi S, Hashida R, Matsuse H, Higashi E, Bekki M, Iwanaga S, Hara K, Higuchi T, Hirakawa Y, Kubota A, Imagawa H, Muta Y, et al. The impact of sarcopenia on low back pain and quality of life in patients with osteoporosis. BMC Musculoskeletal Disorder. 2022;23(1):142. https://doi.org/10.1186/s12891-022-05086-2.

Google Scholar 

Wang J, Lu HX, Wang J. Cannabinoid receptors in osteoporosis and osteoporotic pain: a narrative update of review. J Pharm Pharmacol. 2019;71(10):1469–74. https://doi.org/10.1111/jphp.13135. (Epub 2019 Jul 11).

CAS  PubMed  Google Scholar 

Mediati RD, Vellucci R, Dodaro L. Pathogenesis and clinical aspects of pain in patients with osteoporosis. Clin Cases Miner Bone Metab. 2014;11(3):169–72.

PubMed  PubMed Central  Google Scholar 

Andriessen AS, Donnelly CR, Ji RR. Reciprocal interactions between osteoclasts and nociceptive sensory neurons in bone cancer pain. Pain Rep. 2021;6(1): e867. https://doi.org/10.1097/PR9.0000000000000867.

PubMed  PubMed Central  Google Scholar 

Vlaeyen JWS, Maher CG, Wiech K, Van Zundert J, Meloto CB, Diatchenko L, Battié MC, Goossens M, Koes B, Linton SJ. Low back pain. Nat Rev Dis Primers. 2018;4(1):52. https://doi.org/10.1038/s41572-018-0052-1.

PubMed  Google Scholar 

Vachon-Presseau E, Tétreault P, Petre B, Huang L, Berger SE, Torbey S, Baria AT, Mansour AR, Hashmi JA, Griffith JW, Comasco E, Schnitzer TJ, Baliki MN, Apkarian AV. Corticolimbic anatomical characteristics predetermine risk for chronic pain. Brain. 2016;139(Pt 7):1958–70. https://doi.org/10.1093/brain/aww100.

PubMed  PubMed Central  Google Scholar 

Mathew J, Adhia DB, Smith ML, De Ridder D, Mani R. Can EEG-Neurofeedback training enhance effective connectivity in people with chronic secondary musculoskeletal pain? A secondary analysis of a feasibility randomized controlled clinical trial. Brain Behav. 2025;15(6): e70541. https://doi.org/10.1002/brb3.70541.

PubMed  PubMed Central  Google Scholar 

Dember LM, Hsu JY, Mehrotra R, Cavanaugh KL, Kalim S, Charytan DM, Fischer MJ, Jhamb M, Johansen KL, Becker WC, Pellegrino B, Eneanya ND, Schrauben SJ, Pun PH, Unruh ML, Morasco BJ, Mehta M, Miyawaki N, Penfield J, Bernardo L, Brintz CE, Cheatle MD, Doorenbos AZ, Heapy AA, Keefe FJ, Krebs EE, Kuzla N, Nigwekar SU, Schmidt RJ, Steel JL, Wetmore JB, White DM, Kimmel PL, Cukor D, HOPE Consortium. Pain coping skills training for patients receiving hemodialysis: The HOPE Consortium Randomized Clinical Trial. JAMA Intern Med. 2025;185(2):197–207. https://doi.org/10.1001/jamainternmed.2024.7140.

PubMed  Google Scholar 

Ricciardi L, Silvestro O, Martino G, Catalano A, Vicario CM, Lund-Jacobsen T, Schwarz P, Sapienza D, Gangemi S, Pioggia G, Giorgianni CM. Health-related quality of life in severe hypersensitivity reactions: focus on severe allergic asthma and hymenoptera venom anaphylaxis-a cross-sectional study. Front Psychol. 2024;23(15):1394954. https://doi.org/10.3389/fpsyg.2024.1394954.

Google Scholar 

Wizeman TM, Pardue M-L, editors. Exploring the biological contributions to human health: does sex matter? Washington DC: National Academy Press; 2001. (First (2001). Maruis Mattis. Oxford University Press: London).

Google Scholar