Exploring Sex, Gender, and Gender-Related Sociocultural Factors in Clinical Decision-Making for Older Adults Using a Prescribing Cascade Vignette: A Transnational Qualitative Study

Rochon PA, Gurwitz JH. The prescribing cascade revisited. Lancet. 2017;389(10081):1778–80. https://doi.org/10.1016/S0140-6736(17)31188-1

Article  PubMed  Google Scholar 

Duerden M, Avery T, Payne R. Polypharmacy and medicines optimisation: making it safe and sound. London: The King’s Fund; 2013. https://assets.kingsfund.org.uk/f/256914/x/0ffd18f8d6/polypharmacy_medicines_optismisation_2013.pdf. Accessed 13 Sept 2024.

Rochon PA, Petrovic M, Cherubini A, Onder G, O'Mahony D, Sternberg SA, Stall NM, Gurwitz JH. Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens. Lancet Healthy Longev. 2021;2(5):e290–300. https://doi.org/10.1016/S2666-7568(21)00054-4

Article  PubMed  Google Scholar 

Trenaman SC, Bowles SK, Kirkland S, Andrew MK. An examination of three prescribing cascades in a cohort of older adults with dementia. BMC Geriatr. 2021;21(1):297. https://doi.org/10.1186/s12877-021-02246-2

Article  PubMed  PubMed Central  Google Scholar 

Gromek KR, Thorpe CT, Aspinall SL, Hanson LC, Niznik JD. Anticholinergic co-prescribing in nursing home residents using cholinesterase inhibitors: Potential deprescribing cascade. J Am Geriatr Soc. 2023;71(1):77–88. https://doi.org/10.1111/jgs.18066.

Article  PubMed  Google Scholar 

Brath H, Mehta N, Savage RD, Gill SS, Wu W, Bronskill SE, et al. What is known about preventing, detecting, and reversing prescribing cascades: a scoping review. J Am Geriatr Soc. 2018;66(11):2079–85. https://doi.org/10.1111/jgs.15543

Article  PubMed  Google Scholar 

Regitz-Zagrosek V, Oertelt-Prigione S, Prescott E, Franconi F, Gerdts E, Foryst-Ludwig A, et al. Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes. Eur Heart J. 2016;37(1):24–34. https://doi.org/10.1093/eurheartj/ehv598

Article  CAS  PubMed  Google Scholar 

Boerner KE, Chambers CT, Gahagan J, Keogh E, Fillingim RB, Mogil JS. Conceptual complexity of gender and its relevance to pain. Pain. 2018;159(11):2137–41.

Article  PubMed  Google Scholar 

Top 20 medical specialties with highest propensity to prescribe branded drugs. Definitive Healthcare. 2024. https://www.definitivehc.com/resources/healthcare-insights/top-20-medical-specialties-highest-propensity-prescribe-branded-drugs. Accessed 13 Sept 2024.

Rochon PA, Gruneir A, Bell CM, Savage R, Gill SS, Wu W, et al. Comparison of prescribing practices for older adults treated by female versus male physicians: a retrospective cohort study. PLoS One. 2018;13(10):e0205524. https://doi.org/10.1371/journal.pone.0205524.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borkhoff CM, Hawker GA, Wright JG. Patient gender affects the referral and recommendation for total joint arthroplasty. Clin Orthop Relat Res. 2011;469(7):1829–37. https://doi.org/10.1007/s11999-011-1879-x

Article  PubMed  PubMed Central  Google Scholar 

Vallabhajosyula S, Ya'Qoub L, Singh M, Bell MR, Gulati R, Cheungpasitporn W, et al. Sex Disparities in the Management and Outcomes of Cardiogenic Shock Complicating Acute Myocardial Infarction in the Young. Circ Heart Fail. 2020;13(10):e007154. https://doi.org/10.1161/CIRCHEARTFAILURE.120.007154

Article  PubMed  PubMed Central  Google Scholar 

Manteuffel M, Williams S, Chen W, Verbrugge RR, Pittman DG, Steinkellner A. Influence of patient sex and gender on medication use, adherence, and prescribing alignment with guidelines. J Womens Health (Larchmt). 2014;23(2):112–9. https://doi.org/10.1089/jwh.2012.3972

Article  PubMed  Google Scholar 

Morgan SG, Weymann D, Pratt B, Smolina K, Gladstone EJ, Raymond C, et al. Sex differences in the risk of receiving potentially inappropriate prescriptions among older adults. Age Ageing. 2016;45(4):535–42. https://doi.org/10.1093/ageing/afw074.

Article  PubMed  PubMed Central  Google Scholar 

Government of Canada CIHR. Sex and gender in health research. CIHR 2021. https://cihr-irsc.gc.ca/e/50833.html. Accessed 13 Sept 2024.

Best DL. Gender concepts: Convergence in cross-cultural research and methodologies. Cross-Cult Res. 2001;35(1):23–43. https://doi.org/10.1177/106939710103500102.

Article  Google Scholar 

Borhani P, Rochon PA, Carrieri B, Dalton K, Lawson A, Li J, Mason R, McCarthy LM, Paoletti L, Santini S, Sivayoganathan K, Sternberg S, Zwas DR, Savage RD; iKASCADE Team. Exploring physician gender bias in the initiation of prescribing cascades for older men and women: a qualitative clinical vignette study protocol. BMJ Open. 2023;13(7):e070405. https://doi.org/10.1136/bmjopen-2022-070405

Tong A, Sainsbury P, Craig J. Consolidated criteria for reporting qualitative research (COREQ): a 32-item checklist for interviews and focus groups. Int J Qual Health Care. 2007;19(6):349–57. https://doi.org/10.1093/intqhc/mzm042

Article  PubMed  Google Scholar 

Sica D. Calcium channel blocker-related periperal edema: can it be resolved? J Clin Hypertens (Greenwich). 2003;5(4):291–97. https://doi.org/10.1111/j.1524-6175.2003.02402.x

Article  PubMed  Google Scholar 

Makani H, Bangalore S, Romero J, Htyte N, Berrios RS, Makwana H, et al. Peripheral edema associated with calcium channel blockers: incidence and withdrawal rate--a meta-analysis of randomized trials. J Hypertens. 2011;29(7):1270–80. https://doi.org/10.1097/HJH.0b013e3283472643

Article  CAS  PubMed  Google Scholar 

Savage RD, Visentin JD, Bronskill SE, Wang X, Gruneir A, Giannakeas V, et al. Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults With Hypertension. JAMA Intern Med. 2020;180(5):643–51. https://doi.org/10.1001/jamainternmed.2019.7087

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vouri SM, van Tuyl JS, Olsen MA, Xian H, Schootman M. An evaluation of a potential calcium channel blocker-lower-extremity edema-loop diuretic prescribing cascade. J Am Pharm Assoc (2003). 2018;58(5):534–539.e4. https://doi.org/10.1016/j.japh.2018.06.014.

Evans SC, Roberts MC, Keeley JW, Blossom J, Amaro CM, Garcia AM, et al. Vignette methodologies for studying clinicians' decision-making: Validity, utility, and application in ICD-11 field studies. Int J Clin Health Psychol. 2015;15(2):160–70. https://doi.org/10.1016/j.ijchp.2014.12.001

Article  PubMed  PubMed Central  Google Scholar 

FitzGerald C, Hurst S. Implicit bias in healthcare professionals: a systematic review. BMC Med Ethics. 2017;18(1):19. https://doi.org/10.1186/s12910-017-0179-8.

Article  PubMed  PubMed Central  Google Scholar 

Leighton JP. Think-aloud interview procedures. Using think-aloud interviews and cognitive labs in educational research. 2017:97–140. https://doi.org/10.1093/acprof:oso/9780199372904.001.0001.

Breathett K, Yee E, Pool N, Hebdon M, Crist JD, Yee RH, et al. Association of Gender and Race With Allocation of Advanced Heart Failure Therapies. JAMA Netw Open. 2020;3(7):e2011044. https://doi.org/10.1001/jamanetworkopen.2020.11044.

Article  PubMed  PubMed Central  Google Scholar 

Eccles DW, Arsal G. The think aloud method: what is it and how do I use it? Qualitative research in sport. Exerc Health. 2017;9(4):514–31. https://doi.org/10.1080/2159676X.2017.1331501

Article  Google Scholar 

Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol. 2006;3(2):77–101. https://doi.org/10.1191/1478088706qp063oa

Article  Google Scholar 

Jenkins EK, Slemon A, Haines-Saah RJ, Oliffe J. A guide to multisite qualitative analysis. Qual Health Res. 2018;28(12):1969–77. https://doi.org/10.1177/1049732318786703

Article  PubMed  Google Scholar 

Weir MR, Rosenberger C, Fink JC. Pilot study to evaluate a water displacement technique to compare effects of diuretics and ACE inhibitors to alleviate lower extremity edema due to dihydropyridine calcium antagonists. Am J Hypertens. 2001;14(9):963–68. https://doi.org/10.1016/s0895-7061(01)02167-7.

Article  CAS  PubMed  Google Scholar 

Brater DC. Pharmacology of diuretics. Am J Med Sci. 2000;319(1):38–50. https://doi.org/10.1097/00000441-200001000-00004.

Article  CAS  PubMed  Google Scholar 

Sica DA. Diuretic-related side effects: development and treatment. J Clin Hypertens (Greenwich). 2004;6(9):532–40. https://doi.org/10.1111/j.1524-6175.2004.03789.x

Article  PubMed  Google Scholar 

Berry SD, Mittleman MA, Zhang Y, Solomon DH, Lipsitz LA, Mostofsky E, et al. New loop diuretic prescriptions may be an acute risk factor for falls in the nursing home. Pharmacoepidemiol Drug Saf. 2012;21(5):560–63. https://doi.org/10.1002/pds.3256.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kelly J, Chamber J. Inappropriate use of loop diuretics in elderly patients. Age Ageing. 2000;29(6):489–93. https://doi.org/10.10

Comments (0)

No login
gif