Ruscogenin Suppresses Non-small Cell Lung Cancer Growth and Invasion by Activating p38 Signaling

Adams JM, Cory S (2007) The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26:1324–1337. https://doi.org/10.1038/sj.onc.1210220

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bologna-Molina R, Mosqueda-Taylor A, Molina-Frechero N, Mori-Estevez AD, Sánchez-Acuña G (2013) Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors. Med Oral Patol Oral Cir Bucal 18:e174-179. https://doi.org/10.4317/medoral.18573

Article  PubMed  Google Scholar 

Cao G, Jiang N, Hu Y, Zhang Y, Wang G, Yin M, Ma X, Zhou K, Qi J, Yu B, Kou J (2016) Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway. Int J Mol Sci 17. https://doi.org/10.3390/ijms17091418

Chen JY, Feng L (2021) Traditional Chinese Medicine reverses resistance to epidermal growth factor receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer: a narrative review. J Tradit Chin Med 41:650–656. https://doi.org/10.19852/j.cnki.jtcm.2021.03.017

Article  PubMed  Google Scholar 

Chen Y, Nowak I, Huang J, Keng PC, Sun H, Xu H, Wei G, Lee SO (2014) Erk/MAP kinase signaling pathway and neuroendocrine differentiation of non-small-cell lung cancer. J Thorac Oncol 9:50–58. https://doi.org/10.1097/jto.0000000000000034

Article  CAS  PubMed  Google Scholar 

Cicenas J, Zalyte E, Rimkus A, Dapkus D, Noreika R, Urbonavicius S (2017). JNK, p38, ERK, and SGK1 Inhibitors in Cancer. Cancers (Basel) 10. https://doi.org/10.3390/cancers10010001

Duma N, Santana-Davila R, Molina JR (2019) Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment. Mayo Clin Proc 94:1623–1640. https://doi.org/10.1016/j.mayocp.2019.01.013

Article  CAS  PubMed  Google Scholar 

Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674. https://doi.org/10.1016/j.cell.2011.02.013

Article  CAS  PubMed  Google Scholar 

Hua H, Zhu Y, Song YH (2018) Ruscogenin suppressed the hepatocellular carcinoma metastasis via PI3K/Akt/mTOR signaling pathway. Biomed Pharmacother 101:115–122. https://doi.org/10.1016/j.biopha.2018.02.031

Article  CAS  PubMed  Google Scholar 

Kou J, Sun Y, Lin Y, Cheng Z, Zheng W, Yu B, Xu Q (2005) Anti-inflammatory activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents. Biol Pharm Bull 28:1234–1238. https://doi.org/10.1248/bpb.28.1234

Article  CAS  PubMed  Google Scholar 

Kou J, Tian Y, Tang Y, Yan J, Yu B (2006) Antithrombotic activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents. Biol Pharm Bull 29:1267–1270. https://doi.org/10.1248/bpb.29.1267

Article  CAS  PubMed  Google Scholar 

Lee B, Sandhu S, McArthur G (2015) Cell cycle control as a promising target in melanoma. Curr Opin Oncol 27:141–150. https://doi.org/10.1097/cco.0000000000000159

Article  CAS  PubMed  Google Scholar 

Li Z, Feiyue Z, Gaofeng L (2021) Traditional Chinese medicine and lung cancer–From theory to practice. Biomed Pharmacother 137:111381. https://doi.org/10.1016/j.biopha.2021.111381

Article  PubMed  Google Scholar 

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402–408. https://doi.org/10.1006/meth.2001.1262

Article  CAS  PubMed  Google Scholar 

Lv Y, Wu X, Chen J, Shao F (2021) Ruscogenin attenuated tight junction injury and tumor migration in colorectal liver metastasis mice via regulating TRAP1. Transl Cancer Res 10:1470–1483. https://doi.org/10.21037/tcr-20-2968

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malhotra J, Malvezzi M, Negri E, La Vecchia C, Boffetta P (2016) Risk factors for lung cancer worldwide. Eur Respir J 48:889–902. https://doi.org/10.1183/13993003.00359-2016

Article  PubMed  Google Scholar 

Paul CD, Mistriotis P, Konstantopoulos K (2017) Cancer cell motility: lessons from migration in confined spaces. Nat Rev Cancer 17:131–140. https://doi.org/10.1038/nrc.2016.123

Article  CAS  PubMed  Google Scholar 

Pfeffer CM, Singh ATK (2018) Apoptosis: a target for anticancer therapy. Int J Mol Sci 19:448. https://doi.org/10.3390/ijms19020448

Qi HW, Xin LY, Xu X, Ji XX, Fan LH (2014) Epithelial-to-mesenchymal transition markers to predict response of Berberine in suppressing lung cancer invasion and metastasis. J Transl Med 12:22. https://doi.org/10.1186/1479-5876-12-22

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smith BN, Bhowmick NA (2016) Role of EMT in Metastasis and Therapy Resistance. J Clin Med 5. https://doi.org/10.3390/jcm5020017

Song Z, Xiang X, Li J, Deng J, Fang Z, Zhang L, Xiong J (2020) Ruscogenin induces ferroptosis in pancreatic cancer cells. Oncol Rep 43:516–524. https://doi.org/10.3892/or.2019.7425

Article  CAS  PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 71:209–249. https://doi.org/10.3322/caac.21660

Article  CAS  PubMed  Google Scholar 

Wagner EF, Nebreda AR (2009) Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9:537–549. https://doi.org/10.1038/nrc2694

Article  CAS  PubMed  Google Scholar 

Wang K, Chen Q, Shao Y, Yin S, Liu C, Liu Y, Wang R, Wang T, Qiu Y, Yu H (2021) Anticancer activities of TCM and their active components against tumor metastasis. Biomed Pharmacother 133:111044. https://doi.org/10.1016/j.biopha.2020.111044

Article  CAS  PubMed  Google Scholar 

Wei Z, Chen J, Zuo F, Guo J, Sun X, Liu D, Liu C (2023) Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review. J Ethnopharmacol 300:115748. https://doi.org/10.1016/j.jep.2022.115748

Article  CAS  PubMed  Google Scholar 

Ying Q, Wu G (2017) Molecular mechanisms involved in podocyte EMT and concomitant diabetic kidney diseases: an update. Ren Fail 39:474–483. https://doi.org/10.1080/0886022x.2017.1313164

Article  PubMed  PubMed Central  Google Scholar 

Yuan M, Huang LL, Chen JH, Wu J, Xu Q (2019) The emerging treatment landscape of targeted therapy in non-small-cell lung cancer. Signal Transduct Target Ther 4:61. https://doi.org/10.1038/s41392-019-0099-9

Article  PubMed  PubMed Central  Google Scholar 

Zaman S, Wang R, Gandhi V (2014) Targeting the apoptosis pathway in hematologic malignancies. Leuk Lymphoma 55:1980–1992. https://doi.org/10.3109/10428194.2013.855307

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Leighl NB, Wu YL, Zhong WZ (2019) Emerging therapies for non-small cell lung cancer. J Hematol Oncol 12:45. https://doi.org/10.1186/s13045-019-0731-8

Article  PubMed  PubMed Central  Google Scholar 

Zhao J, He B, Seshadri VD, Xu S (2022) Anticancer Effect of Ruscogenin in B(a)P-Induced Lung Cancer in Mice via Modulation of Proinflammatory Cytokines and Mitochondrial Enzymes. Appl Biochem Biotechnol 194:5862–5877. https://doi.org/10.1007/s12010-022-04042-z

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif