Abirami A, Sinsinwar A, Rajalakshmi P, Brindhab P, Rajesh YBRD, Vadivel V (2022) Antioxidant and cytoprotective properties of loganic acid isolated from seeds of Strychnos potatorum L. against heavy metal induced toxicity in PBMC model. Drug Chem Toxicol 45:239–249. https://doi.org/10.1080/01480545.2019.1681445

Article  PubMed  CAS  Google Scholar 

Adams CM, Clark-Garvey S, Porcu P, Eischen CM (2019) Targeting the Bcl-2 family in B cell lymphoma. Front Oncol 8:636. https://doi.org/10.3389/fonc.2018.00636

Article  PubMed  PubMed Central  Google Scholar 

Ampofo JA, Andoh A, Tetteh W, Bello M (2012) Microbiological profile of some Ghanaian herbal preparations—safety issues and implications for the health professions. Open J Med Microbiol 2:121–130. https://doi.org/10.4236/ojmm.2012.23018

Article  Google Scholar 

Arpino V, Brock M, Gill SE (2015) The role of TIMPs in the regulation of extracellular matrix proteolysis. Matrix Biol 44–46:247–254. https://doi.org/10.1016/j.matbio.2015.03.005

Article  PubMed  CAS  Google Scholar 

Arunachalam KD, Annamalai SK, Arunachalam AM, Kennedy S (2013) Green synthesis of crystalline silver nanoparticles using Indigofera aspalathoides medicinal plant extract for wound healing applications. Asian J Chem 25:S311–S314

CAS  Google Scholar 

Bakar-Ates F, Ozkan E (2023) Atorvastatin induces downregulation of matrix metalloproteinase-2/9 in MDA-MB-231 triple negative breast cancer cells. Med Oncol 40:22. https://doi.org/10.1007/s12032-022-01880-z

Article  CAS  Google Scholar 

Barnes DR, Silvestri V, Leslie G, McGuffog L, Dennis J, Yang X, Adlard J, Agnarsson BA (2022) Breast and prostate cancer risks for male BRCA1 and BRCA2 pathogenic variant carriers using polygenic risk scores. J Natl Cancer Inst 114:109–122. https://doi.org/10.1093/jnci/djab147

Article  PubMed  CAS  Google Scholar 

Bernardo MM, Fridman R (2003) TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP. Biochem J 374:739–745. https://doi.org/10.1042/BJ20030557

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bhagavan NB, Arunachalam S, Dhasarathan P, Kannan ND (2013) Evaluation of anti inflammatory activity of Indigofera aspalathoides Vahl in Swiss albino mice. J Pharm Res 6:350–354. https://doi.org/10.1016/j.jopr.2013.02.018

Article  CAS  Google Scholar 

Bhattacharyya GS, Doval DC, Desai CJ, Chaturvedi H, Sharma S, Somashekhar SP (2020) Overview of breast cancer and implications of overtreatment of early-stage breast cancer: an Indian perspective. JCO Global Oncol 6:789–798. https://doi.org/10.1200/GO.20.00033

Article  Google Scholar 

Boncler M, Różalski M, Krajewska U, Podsędek A, Watala C (2014) Comparison of PrestoBlue and MTT assays of cellular viability in the assessment of anti-proliferative effects of plant extracts on human endothelial cells. J Pharmacol Toxicol Methods 69:9–16. https://doi.org/10.1016/j.vascn.2013.09.003

Article  PubMed  CAS  Google Scholar 

Cullen JM, Breen M(2017) An overview of molecular cancer pathogenesis, prognosis, and diagnosis. In: Meuten DJ (eds), Tumors in domestic animals, 5th ed. John Wiley & Sons. https://doi.org/10.1002/9781119181200.ch1

Deryugina EI, Quigley JP (2006) Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25:9–34. https://doi.org/10.1007/s10555-006-7886-9

Article  PubMed  CAS  Google Scholar 

Dhaheri YA, Attoub S, Arafat K, AbuQamar S, Viallet J, Saleh A, Agha HA, Eid A, Iratni R (2013) Anti-metastatic and anti-tumor growth effects of Origanum majorana on highly metastatic human breast cancer cells: inhibition of nfκb signaling and reduction of nitric oxide production. PLoS One 8:e68808. https://doi.org/10.1371/journal.pone.0068808

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fares J, Fares MY, Khachfe HH, Salhab HA, Fares Y (2020) Molecular principles of metastasis: a hallmark of cancer revisited. Signal Transduct Target Ther 5:28. https://doi.org/10.1038/s41392-020-0134-x

Article  PubMed  PubMed Central  Google Scholar 

Fitzgerald M, Heinrich M, Booker A (2020) Medicinal plant analysis: a historical and regional discussion of emergent complex techniques. Front Pharmacol 10:1480. https://doi.org/10.3389/fphar.2019.01480

Article  PubMed  PubMed Central  CAS  Google Scholar 

Foda HD, Zucker S (2001) Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis. Drug Discov Today 6:478–482. https://doi.org/10.1016/s1359-6446(01)01752-4

Article  PubMed  CAS  Google Scholar 

Greenwell M, Rahman PKSM (2015) Medicinal plants: their use in anticancer treatment. Int J Pharm Sci Res 6:4103–4112. https://doi.org/10.13040/IJPSR.0975-8232.6(10).4103-12

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gupta GP, Massagué J (2006) Cancer metastasis: building a framework. Cell 127:679–695. https://doi.org/10.1016/j.cell.2006.11.001

Article  PubMed  CAS  Google Scholar 

Haldar PK, Bhattacharya S, Bala A, Kar B, Mazumdera UK, Dewanjee S (2010) Chemopreventive role of Indigofera aspalathoides against 20-methylcholanthrene-induced carcinogenesis in mouse. Toxicol Environ Chem 92:1749–1763. https://doi.org/10.1080/02772241003783703

Article  CAS  Google Scholar 

Kim B, Kim H, Jung S, Moon A, Noh DY, Lee ZH, Kim HJ, Kim H (2020) A CTGF-RUNX2-RANKL axis in breast and prostate cancer cells promotes tumor progression in bone. J Bone Miner Res 35:155–166. https://doi.org/10.1002/jbmr.3869

Article  PubMed  CAS  Google Scholar 

Liu K, Liu P, Liu R, Wu X (2009) Dual AO/EB staining to detect apoptosis in osteosarcoma cells compared with flow cytometry. Med Sci Monit Basic Res 21:15–20. https://doi.org/10.12659/MSMBR.893327

Article  Google Scholar 

Mahajan P, Oli RG, Jachak SM, Bharate SB, Chaudhuri B (2016) Antioxidant and antiproliferative activity of indigocarpan, a pterocarpan from Indigofera aspalathoides. J Pharm Pharmacol 68:1331–1339. https://doi.org/10.1111/jphp.12609

Article  PubMed  CAS  Google Scholar 

Majumder M, Debnath S, Gajbhiye RL, Saikia R, Gogoi B, Samanta SK, Das DK, Biswas K, Jaisankar P, Mukhopadhyay R (2019) Ricinus communis L. fruit extract inhibits migration/invasion, induces apoptosis in breast cancer cells and arrests tumor progression in vivo. Sci Rep 9:14493. https://doi.org/10.1038/s41598-019-50769-x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Minh TN, Xuan TD, Tran H, Van TM, Andriana Y, Khanh TD, Quan NV, Ahmad A (2019) Isolation and purification of bioactive compounds from the stem bark of Jatropha podagrica. Molecules 24:889. https://doi.org/10.3390/molecules24050889

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ongusaha PP, Kwak JC, Zwible AJ, Macip S, Higashiyama S, Taniguchi N, Fang L, Lee SW (2004) HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res 64:5283–5290. https://doi.org/10.1158/0008-5472.CAN-04-0925

Article  PubMed  CAS  Google Scholar 

Opferman JT, Kothari A (2018) Anti-apoptotic BCL-2 family members in development. Cell Death Differ 25:37–45. https://doi.org/10.1038/cdd.2017.170

Article  PubMed  CAS  Google Scholar 

Paramashivam SK, Dhiraviam KN (2022) Identification of an active biomarker in the serum of rats treated with Indigofera aspalathoides extract and the anticancer potential of rat serum metabolite. Pharm Chem J 55:1208–1214. https://doi.org/10.1007/s11094-022-02560-y

Article  CAS  Google Scholar 

Perera WH, Meepagala KM, Fronczek FR, Cook DD, Wedge DE, Duke SO (2019) Bioassay-guided isolation and structure elucidation of fungicidal and herbicidal compounds from Ambrosia salsola (Asteraceae). Molecules 24:835. https://doi.org/10.3390/molecules24050835

Article  PubMed  PubMed Central  CAS